CZ164594A3 - Human variant of kunitz-type protease inhibitor - Google Patents

Human variant of kunitz-type protease inhibitor Download PDF

Info

Publication number
CZ164594A3
CZ164594A3 CZ941645A CZ164594A CZ164594A3 CZ 164594 A3 CZ164594 A3 CZ 164594A3 CZ 941645 A CZ941645 A CZ 941645A CZ 164594 A CZ164594 A CZ 164594A CZ 164594 A3 CZ164594 A3 CZ 164594A3
Authority
CZ
Czechia
Prior art keywords
lys
variant
amino acid
arg
gly
Prior art date
Application number
CZ941645A
Other languages
Czech (cs)
English (en)
Inventor
Fanny Norris
Kjeld Norris
Soren Erik Bjorn
Lars Christian Petersen
Ole Hvilsted Olsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of CZ164594A3 publication Critical patent/CZ164594A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Prostheses (AREA)
CZ941645A 1992-01-07 1993-01-07 Human variant of kunitz-type protease inhibitor CZ164594A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK9200004 1992-01-07

Publications (1)

Publication Number Publication Date
CZ164594A3 true CZ164594A3 (en) 1994-12-15

Family

ID=8153774

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ941645A CZ164594A3 (en) 1992-01-07 1993-01-07 Human variant of kunitz-type protease inhibitor

Country Status (15)

Country Link
EP (1) EP0621870B1 (fr)
JP (1) JPH07506241A (fr)
AT (1) ATE152735T1 (fr)
AU (1) AU675925B2 (fr)
CA (1) CA2127250A1 (fr)
CZ (1) CZ164594A3 (fr)
DE (1) DE69310499D1 (fr)
FI (1) FI943232A0 (fr)
HU (1) HUT70294A (fr)
IL (1) IL104326A0 (fr)
NO (1) NO942551L (fr)
NZ (1) NZ246568A (fr)
RU (1) RU94045952A (fr)
WO (1) WO1993014120A1 (fr)
ZA (1) ZA9397B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE529444T1 (de) 1994-01-11 2011-11-15 Dyax Corp Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
WO1995021601A2 (fr) * 1994-01-11 1995-08-17 Protein Engineering Corporation Proteines de 'domaine de kunitz' a activite antikallikreine, et leurs analogues
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5589359A (en) 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
DE69528591T2 (de) * 1994-08-05 2003-02-20 Chiron Corp Herstellung des inhibitors fuer die komplexbildung des gewebefaktors
ZA963619B (en) 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
AU5854096A (en) * 1995-05-08 1996-11-29 Scios Inc. Kunitz type protease inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
HU226419B1 (en) 1996-03-11 2008-12-29 Aerovance Human bikunin
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
PT2311432E (pt) 2002-06-07 2015-02-09 Dyax Corp Polipeptídeos de domínio kunitz modificado e sua utilização para a redução de isquemia ou aparecimento de uma resposta inflamatória sistémica associada a um procedimento cirúrgico
DK1542710T3 (da) * 2002-08-28 2012-10-15 Dyax Corp Fremgangsmåde til konservering af organer og væv
US6989369B2 (en) 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
WO2005021557A2 (fr) 2003-08-29 2005-03-10 Dyax Corp. Inhibiteurs de protease poly-pegylee
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
ES2661002T3 (es) * 2005-12-29 2018-03-27 The Regents Of The University Of California Procedimientos y composiciones relacionadas con el dominio Kunitz I mutante de TFPI-2
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
ES2773766T3 (es) 2008-12-19 2020-07-14 Baxalta GmbH Inhibidores de TFPI y métodos de uso
AU2010203712A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
CN101798346B (zh) * 2009-02-06 2013-05-29 复旦大学 一种酵母表达的长效重组人组织因子途径抑制物
LT2521568T (lt) 2010-01-06 2018-12-10 Dyax Corp. Plazmos kalikreiną surišantys baltymai
AU2011227714B2 (en) 2010-03-19 2014-09-04 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
CN105713092B (zh) 2011-01-06 2019-09-10 戴埃克斯有限公司 血浆前激肽释放酶结合蛋白
CA2867363C (fr) 2012-03-21 2023-02-28 Baxter International Inc. Inhibiteurs de la voie du facteur tissulaire (tfpi) et procedes d'utilisation
AU2016366557B2 (en) 2015-12-11 2024-01-25 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner

Also Published As

Publication number Publication date
ATE152735T1 (de) 1997-05-15
NZ246568A (en) 1996-02-27
FI943232A (fi) 1994-07-06
WO1993014120A1 (fr) 1993-07-22
CA2127250A1 (fr) 1993-07-22
IL104326A0 (en) 1993-05-13
FI943232A0 (fi) 1994-07-06
NO942551D0 (no) 1994-07-06
NO942551L (no) 1994-09-07
EP0621870B1 (fr) 1997-05-07
HUT70294A (en) 1995-09-28
RU94045952A (ru) 1996-10-10
JPH07506241A (ja) 1995-07-13
DE69310499D1 (de) 1997-06-12
AU3345893A (en) 1993-08-03
EP0621870A1 (fr) 1994-11-02
ZA9397B (en) 1993-08-10
AU675925B2 (en) 1997-02-27
HU9401992D0 (en) 1994-09-28

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