WO1993014120A1 - Variant inhibiteur de la protease humaine de type kunitz - Google Patents

Variant inhibiteur de la protease humaine de type kunitz Download PDF

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Publication number
WO1993014120A1
WO1993014120A1 PCT/DK1993/000003 DK9300003W WO9314120A1 WO 1993014120 A1 WO1993014120 A1 WO 1993014120A1 DK 9300003 W DK9300003 W DK 9300003W WO 9314120 A1 WO9314120 A1 WO 9314120A1
Authority
WO
WIPO (PCT)
Prior art keywords
lys
variant according
gly
arg
amino acid
Prior art date
Application number
PCT/DK1993/000003
Other languages
English (en)
Inventor
Fanny Norris
Kjeld Norris
Søren Erik BJØRN
Lars Christian Petersen
Ole Hvilsted Olsen
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Priority to DE69310499T priority Critical patent/DE69310499D1/de
Priority to JP5511991A priority patent/JPH07506241A/ja
Priority to KR1019940702352A priority patent/KR940703855A/ko
Priority to AU33458/93A priority patent/AU675925B2/en
Priority to EP93902104A priority patent/EP0621870B1/fr
Publication of WO1993014120A1 publication Critical patent/WO1993014120A1/fr
Priority to NO942551A priority patent/NO942551L/no
Priority to FI943232A priority patent/FI943232A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Prostheses (AREA)

Abstract

Variant du domaine III des inhibiteurs de protéase de thromboplastine tissulaire (TFPI), inhibiteur de la protéase humaine de type Kunitz; le variant comprend la séquence d'acides aminés (I) dans laquelle X1 représente H ou 1 à 5 résidus d'acide aminé survenant naturellement à l'exception de Cys, X2 à X15 représentent chacun indépendamment un résidu d'acide aminé survenant naturellement, et X16 représente OH ou 1 à 5 résidus d'acide aminé survenant naturellement à l'exception de Cys, à condition qu'au moins un des résidus d'acide aminé X1 à X16 soit différent du résidu d'acide aminé correspondant de la séquence naturelle.
PCT/DK1993/000003 1992-01-07 1993-01-07 Variant inhibiteur de la protease humaine de type kunitz WO1993014120A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE69310499T DE69310499D1 (de) 1992-01-07 1993-01-07 Inhibitorvariante der menschlichen protease vom kunitz-typ
JP5511991A JPH07506241A (ja) 1992-01-07 1993-01-07 ヒト　クニツ−タイプ　プロテアーゼ阻害剤変異体
KR1019940702352A KR940703855A (ko) 1992-01-07 1993-01-07 사람 쿠니즈형 프로테아제 저해제 변이체(a human kunitz-type protease inhibitor variant)
AU33458/93A AU675925B2 (en) 1992-01-07 1993-01-07 A human kunitz-type protease inhibitor variant
EP93902104A EP0621870B1 (fr) 1992-01-07 1993-01-07 Variant inhibiteur de la protease humaine de type kunitz
NO942551A NO942551L (no) 1992-01-07 1994-07-06 Humanproteaseinhibitorvariant av Kunitz-type
FI943232A FI943232A (fi) 1992-01-07 1994-07-06 Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK9200004 1992-01-07
ATPCT/DK92/00004 1992-01-07

Publications (1)

Publication Number Publication Date
WO1993014120A1 true WO1993014120A1 (fr) 1993-07-22

Family

ID=8153774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1993/000003 WO1993014120A1 (fr) 1992-01-07 1993-01-07 Variant inhibiteur de la protease humaine de type kunitz

Country Status (15)

Country Link
EP (1) EP0621870B1 (fr)
JP (1) JPH07506241A (fr)
AT (1) ATE152735T1 (fr)
AU (1) AU675925B2 (fr)
CA (1) CA2127250A1 (fr)
CZ (1) CZ164594A3 (fr)
DE (1) DE69310499D1 (fr)
FI (1) FI943232A (fr)
HU (1) HUT70294A (fr)
IL (1) IL104326A0 (fr)
NO (1) NO942551L (fr)
NZ (1) NZ246568A (fr)
RU (1) RU94045952A (fr)
WO (1) WO1993014120A1 (fr)
ZA (1) ZA9397B (fr)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021601A2 (fr) * 1994-01-11 1995-08-17 Protein Engineering Corporation Proteines de 'domaine de kunitz' a activite antikallikreine, et leurs analogues
US5563123A (en) * 1994-08-05 1996-10-08 Chiron Corporation Chimeric proteins
WO1996035788A2 (fr) * 1995-05-08 1996-11-14 Scios, Inc. Peptides inhibiteurs de proteases de type kunitz
WO1996039519A1 (fr) * 1995-06-05 1996-12-12 Genentech, Inc. Inhibiteurs de kallicreine plasmique de type kunitz
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US6010880A (en) * 1994-01-11 2000-01-04 Dyax Corp. Inhibitors of human plasmin derived from the kunitz domains
US6103500A (en) * 1994-08-05 2000-08-15 Chiron Corporation Production of tissue factor pathway inhibitor
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
US6583108B1 (en) 1996-03-11 2003-06-24 Bayer Corporation Human bikunin
EP1484339A3 (fr) * 1994-01-11 2005-03-02 Dyax Corporation Protéines de "Domaine de Kunitz" a actvité antikallikreine et acides nucléiques les codant
US6906033B2 (en) 1995-05-08 2005-06-14 Scios Nova, Inc. Protease inhibitor peptides
JP2005537006A (ja) * 2002-08-28 2005-12-08 ダイアックス、コープ 臓器及び組織の保存方法
US6989369B2 (en) 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
US7064107B2 (en) 2002-06-07 2006-06-20 Dyax Corp. Prevention and reduction of blood loss
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
EP1976985A2 (fr) * 2005-12-29 2008-10-08 The Regents of the University of California Office of Technology Transfer Methodes et compositions associees au domaine kunitz mutant i de tfpi-2
US7550427B2 (en) 2003-08-29 2009-06-23 Dyax Corp. Poly-pegylated protease inhibitors
US8450275B2 (en) 2010-03-19 2013-05-28 Baxter International Inc. TFPI inhibitors and methods of use
US8466108B2 (en) 2008-12-19 2013-06-18 Baxter International Inc. TFPI inhibitors and methods of use
US8637454B2 (en) 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
US8816055B2 (en) 2011-01-06 2014-08-26 Dyax Corp. Plasma kallikrein binding proteins
US8822653B2 (en) 2010-01-06 2014-09-02 Dyax Corp. Plasma kallikrein binding proteins
US8962563B2 (en) 2009-12-21 2015-02-24 Baxter International, Inc. TFPI inhibitors and methods of use
US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101798346B (zh) * 2009-02-06 2013-05-29 复旦大学 一种酵母表达的长效重组人组织因子途径抑制物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nature, Volume 338, April 1989, THOMAS J. GIRARD et al., "Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor". *

Cited By (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1484339A3 (fr) * 1994-01-11 2005-03-02 Dyax Corporation Protéines de "Domaine de Kunitz" a actvité antikallikreine et acides nucléiques les codant
US8663629B2 (en) 1994-01-11 2014-03-04 Dyax Corp. Kallikrein-binding “kunitz domain” proteins and analogues thereof
US7628983B2 (en) 1994-01-11 2009-12-08 Dyax Corp. Kallikrein-binding “Kunitz domain” proteins and analogues thereof
WO1995021601A2 (fr) * 1994-01-11 1995-08-17 Protein Engineering Corporation Proteines de 'domaine de kunitz' a activite antikallikreine, et leurs analogues
US6010880A (en) * 1994-01-11 2000-01-04 Dyax Corp. Inhibitors of human plasmin derived from the kunitz domains
US7919462B2 (en) 1994-01-11 2011-04-05 Dyax Corp. Inhibitors of human plasmin derived from the Kunitz domains
US8283321B2 (en) 1994-01-11 2012-10-09 Dyax Corp. Kallikrein-binding “Kunitz domain” proteins and analogues thereof
US6071723A (en) * 1994-01-11 2000-06-06 Dyax Corp. Inhibitors of human plasmin derived from the Kunitz domains
US8431359B2 (en) 1994-01-11 2013-04-30 Dyax Corp. Nucleic acids encoding polypeptide inhibitors of human plasmin derived from the Kunitz domains
US6103499A (en) * 1994-01-11 2000-08-15 Dyax Corp. Inhibitors of human plasmin derived from the Kunitz domains
US6423498B1 (en) 1994-01-11 2002-07-23 Dyax Corp. Variegated Kunitz domain peptide library and uses thereof
US5795865A (en) * 1994-01-11 1998-08-18 Dyax Corp. Kallikrein-inhibiting "kunitz domain" proteins and analogues thereof
WO1995021601A3 (fr) * 1994-01-11 1995-09-21 Protein Eng Corp Proteines de 'domaine de kunitz' a activite antikallikreine, et leurs analogues
US6953674B2 (en) 1994-01-11 2005-10-11 Dyax Corp. Inhibitors of human plasmin derived from the kunitz domains
US5994125A (en) * 1994-01-11 1999-11-30 Dyax Corp. Kallikrein-inhibiting "Kunitz Domain" proteins and analogues thereof
US5880256A (en) * 1994-03-04 1999-03-09 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5863893A (en) * 1994-03-04 1999-01-26 Genentech, Inc. Factor VIIa inhibitors from kunitz domain proteins
US5834244A (en) * 1994-03-04 1998-11-10 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5696088A (en) * 1994-08-05 1997-12-09 Chiron Corporation Chimeric proteins
US6103500A (en) * 1994-08-05 2000-08-15 Chiron Corporation Production of tissue factor pathway inhibitor
US5563123A (en) * 1994-08-05 1996-10-08 Chiron Corporation Chimeric proteins
US6783960B2 (en) 1994-08-05 2004-08-31 Chiron Corporation Chimeric proteins
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
WO1996035788A2 (fr) * 1995-05-08 1996-11-14 Scios, Inc. Peptides inhibiteurs de proteases de type kunitz
WO1996035788A3 (fr) * 1995-05-08 1996-12-12 Scios Inc Peptides inhibiteurs de proteases de type kunitz
US6906033B2 (en) 1995-05-08 2005-06-14 Scios Nova, Inc. Protease inhibitor peptides
WO1996039519A1 (fr) * 1995-06-05 1996-12-12 Genentech, Inc. Inhibiteurs de kallicreine plasmique de type kunitz
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
US7019123B2 (en) 1996-03-11 2006-03-28 Bayer Corporation Human bikunin
US7452859B2 (en) 1996-03-11 2008-11-18 Aerovance, Inc. Human bikunin
US6583108B1 (en) 1996-03-11 2003-06-24 Bayer Corporation Human bikunin
US7704949B2 (en) 2002-06-07 2010-04-27 Dyax Corp. Kallikrein-inhibitor therapies
US7851442B2 (en) 2002-06-07 2010-12-14 Dyax Corp. Prevention and reduction of blood loss
US11344610B2 (en) 2002-06-07 2022-05-31 Takeda Pharmaceutical Company Limited Prevention and reduction of blood loss
US10245307B2 (en) 2002-06-07 2019-04-02 Dyax Corp. Prevention and reduction of blood loss
US8710007B2 (en) 2002-06-07 2014-04-29 Dyax Corp. Prevention and reduction of blood loss
US9480733B2 (en) 2002-06-07 2016-11-01 Dyax Corp. Prevention and reduction of blood loss
US7064107B2 (en) 2002-06-07 2006-06-20 Dyax Corp. Prevention and reduction of blood loss
US9114144B2 (en) 2002-06-07 2015-08-25 Dyax Corp. Kallikrein-inhibitor therapies
US7811991B2 (en) 2002-06-07 2010-10-12 Dyax Corp. Prevention and reduction of blood loss
US8124586B2 (en) 2002-06-07 2012-02-28 Dyax Corp. Prevention and reduction of blood loss
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
US8034775B2 (en) 2002-06-07 2011-10-11 Dyax Corp. Kallikrein-inhibitor therapies
JP2011078417A (ja) * 2002-08-28 2011-04-21 Dyax Corp 臓器及び組織の保存方法
JP2005537006A (ja) * 2002-08-28 2005-12-08 ダイアックス、コープ 臓器及び組織の保存方法
US7718617B2 (en) 2002-08-28 2010-05-18 Dyax Corp. Methods for preserving organs and tissues
US7166576B2 (en) 2002-08-28 2007-01-23 Dyax Corp. Methods for preserving organs and tissues
US6989369B2 (en) 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
US7550427B2 (en) 2003-08-29 2009-06-23 Dyax Corp. Poly-pegylated protease inhibitors
US8716225B2 (en) 2004-09-27 2014-05-06 Dyax Corp. Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US8188045B2 (en) 2004-09-27 2012-05-29 Dyax Corp. Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US9757437B2 (en) 2004-09-27 2017-09-12 Dyax Corp. Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
EP1976985A2 (fr) * 2005-12-29 2008-10-08 The Regents of the University of California Office of Technology Transfer Methodes et compositions associees au domaine kunitz mutant i de tfpi-2
EP2653542A1 (fr) * 2005-12-29 2013-10-23 The Regents of The University of California Methodes et compositions associées au domaine kunitz mutant I de TFPI-2
EP1976985A4 (fr) * 2005-12-29 2009-04-29 Univ California Methodes et compositions associees au domaine kunitz mutant i de tfpi-2
US8993719B2 (en) 2005-12-29 2015-03-31 The Regents Of The University Of California Methods and compositions related to mutant Kunitz domain I of TFPI-2
EP3088522A1 (fr) * 2005-12-29 2016-11-02 The Regents of the University of California Methodes et compositions associees au domaine kunitz mutant i de tfpi-2
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
US9873720B2 (en) 2008-12-19 2018-01-23 Baxalta GmbH TFPI inhibitors and methods of use
US11001613B2 (en) 2008-12-19 2021-05-11 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
US9777051B2 (en) 2008-12-19 2017-10-03 Baxalta GmbH TFPI inhibitors and methods of use
US8466108B2 (en) 2008-12-19 2013-06-18 Baxter International Inc. TFPI inhibitors and methods of use
US8637454B2 (en) 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
US8962563B2 (en) 2009-12-21 2015-02-24 Baxter International, Inc. TFPI inhibitors and methods of use
US10336832B2 (en) 2010-01-06 2019-07-02 Dyax Corp. Methods of inhibiting plasma kallikrein in edema patient
US11505620B2 (en) 2010-01-06 2022-11-22 Takeda Pharmaceutical Company Limited Methods of detecting plasma kallikrein
US8822653B2 (en) 2010-01-06 2014-09-02 Dyax Corp. Plasma kallikrein binding proteins
US9556230B2 (en) 2010-03-19 2017-01-31 Baxalta GmbH TFPI inhibitors and methods of use
US10201586B2 (en) 2010-03-19 2019-02-12 Baxalta GmbH TFPI inhibitors and methods of use
US9018167B2 (en) 2010-03-19 2015-04-28 Baxter International Inc. TFPI inhibitors and methods of use
US8450275B2 (en) 2010-03-19 2013-05-28 Baxter International Inc. TFPI inhibitors and methods of use
US11793855B2 (en) 2010-03-19 2023-10-24 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
US9266964B2 (en) 2011-01-06 2016-02-23 Dyax Corp. Method of treating hereditary angioedema using plasma kallikrein binding antibodies
US10370453B2 (en) 2011-01-06 2019-08-06 Dyax Corp. Plasma kallikrein binding proteins
US8816055B2 (en) 2011-01-06 2014-08-26 Dyax Corp. Plasma kallikrein binding proteins
US11401346B2 (en) 2011-01-06 2022-08-02 Takeda Pharmaceutical Company Limited Nucleic acids encoding plasma kallikrein binding proteins
US10800816B2 (en) 2012-03-21 2020-10-13 Baxalta GmbH TFPI inhibitors and methods of use
US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Also Published As

Publication number Publication date
JPH07506241A (ja) 1995-07-13
FI943232A0 (fi) 1994-07-06
HU9401992D0 (en) 1994-09-28
NZ246568A (en) 1996-02-27
AU675925B2 (en) 1997-02-27
ZA9397B (en) 1993-08-10
IL104326A0 (en) 1993-05-13
EP0621870B1 (fr) 1997-05-07
ATE152735T1 (de) 1997-05-15
CA2127250A1 (fr) 1993-07-22
RU94045952A (ru) 1996-10-10
CZ164594A3 (en) 1994-12-15
NO942551D0 (no) 1994-07-06
FI943232A (fi) 1994-07-06
DE69310499D1 (de) 1997-06-12
AU3345893A (en) 1993-08-03
HUT70294A (en) 1995-09-28
EP0621870A1 (fr) 1994-11-02
NO942551L (no) 1994-09-07

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