CY2052B1 - Polymyxin conjugates - Google Patents

Polymyxin conjugates

Info

Publication number
CY2052B1
CY2052B1 CY9802052A CY9802052A CY2052B1 CY 2052 B1 CY2052 B1 CY 2052B1 CY 9802052 A CY9802052 A CY 9802052A CY 9802052 A CY9802052 A CY 9802052A CY 2052 B1 CY2052 B1 CY 2052B1
Authority
CY
Cyprus
Prior art keywords
polymyxin
conjugates
polymyxin conjugates
bloodstream
potent
Prior art date
Application number
CY9802052A
Other languages
English (en)
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of CY2052B1 publication Critical patent/CY2052B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CY9802052A 1989-11-15 1998-04-30 Polymyxin conjugates CY2052B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43748789A 1989-11-15 1989-11-15

Publications (1)

Publication Number Publication Date
CY2052B1 true CY2052B1 (en) 1998-04-30

Family

ID=23736660

Family Applications (1)

Application Number Title Priority Date Filing Date
CY9802052A CY2052B1 (en) 1989-11-15 1998-04-30 Polymyxin conjugates

Country Status (17)

Country Link
EP (1) EP0428486B1 (es)
JP (1) JPH082917B2 (es)
KR (1) KR0184858B1 (es)
AT (1) ATE111746T1 (es)
AU (1) AU639952B2 (es)
CA (1) CA2029997A1 (es)
CY (1) CY2052B1 (es)
DE (1) DE69012747T2 (es)
DK (1) DK0428486T3 (es)
ES (1) ES2063326T3 (es)
HK (1) HK49696A (es)
HU (1) HU210901A9 (es)
IE (1) IE65268B1 (es)
IL (1) IL96326A (es)
MY (1) MY104520A (es)
NZ (1) NZ236050A (es)
ZA (1) ZA909187B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660267B1 (en) 1992-12-21 2003-12-09 Promega Corporation Prevention and treatment of sepsis
US6579696B1 (en) * 1992-12-21 2003-06-17 Promega Corporation Polymyxin B conjugates
US5545721A (en) * 1992-12-21 1996-08-13 Ophidian Pharmaceuticals, Inc. Conjugates for the prevention and treatment of sepsis
JPH08504824A (ja) * 1992-12-21 1996-05-28 オフィディアン ファーマシューティカルズ，インコーポレーテッド 敗血症の予防および治療
US6180134B1 (en) 1993-03-23 2001-01-30 Sequus Pharmaceuticals, Inc. Enhanced ciruclation effector composition and method
JP3828145B2 (ja) * 1993-09-22 2006-10-04 ヘンリー エム．ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン 免疫原性構成物の製造のための新規シアン化試薬を使った可溶性炭水化物の活性化方法
US5849301A (en) * 1993-09-22 1998-12-15 Henry M. Jackson Foundation For The Advancement Of Military Medicine Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents
JP2581425B2 (ja) * 1993-11-12 1997-02-12 株式会社島津製作所 ペプチド合成用支持体及びそれを用いて製造されたペプチド
DE122009000056I1 (de) * 1995-03-22 2010-01-28 Jackson H M Found Military Med Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden
CA2215933C (en) * 1995-03-22 2009-10-13 Andrew Lees Producing immunogenic constructs using soluble carbohydrates activated via organic cyanylating reagents
US5691304A (en) * 1995-05-25 1997-11-25 Novartis Ag Improved process for preparing polymyxin B/dextran conjugates
US6309646B1 (en) 1996-05-09 2001-10-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates
US5998381A (en) * 1996-12-06 1999-12-07 Ophidian Pharmaceuticals, Inc. Compounds that bind bacterial pili
IT1312110B1 (it) 1999-05-18 2002-04-04 Istituto Biochimico Pavese Pha Addotti antibiotico-polimero polisaccaridico naturale
DE10129369C1 (de) 2001-06-21 2003-03-06 Fresenius Kabi De Gmbh Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats
AT507846B1 (de) * 2009-01-22 2011-12-15 Fresenius Medical Care De Gmbh Sorptionsmittel für endotoxine
CA2961700C (en) * 2014-10-03 2023-03-07 Xellia Pharmaceuticals Aps Aqueous solution of colistimethate sodium
DK3528830T3 (da) * 2016-10-21 2022-12-19 Algipharma As Polymyxin-alginat-oligomer-konjugater

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7702261L (sv) * 1976-03-02 1977-09-07 Pharmaco Inc Forfarande for att immobilisera antimikrobiella emnen
JPS5813519A (ja) * 1981-07-16 1983-01-26 Seikagaku Kogyo Co Ltd エンドトキシン吸着材及びそれを用いるエンドトキシンの除去方法
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer

Also Published As

Publication number Publication date
CA2029997A1 (en) 1991-05-16
MY104520A (en) 1994-04-30
DE69012747D1 (de) 1994-10-27
KR910009274A (ko) 1991-06-28
AU639952B2 (en) 1993-08-12
ES2063326T3 (es) 1995-01-01
IL96326A0 (en) 1991-08-16
JPH03220198A (ja) 1991-09-27
ATE111746T1 (de) 1994-10-15
DK0428486T3 (da) 1995-01-09
HU210901A9 (en) 1995-09-28
NZ236050A (en) 1993-04-28
IE904105A1 (en) 1991-05-22
HK49696A (en) 1996-03-29
DE69012747T2 (de) 1995-03-16
JPH082917B2 (ja) 1996-01-17
ZA909187B (en) 1992-07-29
EP0428486B1 (en) 1994-09-21
IL96326A (en) 1995-07-31
AU6655590A (en) 1991-05-23
EP0428486A1 (en) 1991-05-22
IE65268B1 (en) 1995-10-18
KR0184858B1 (ko) 1999-05-01

Similar Documents

Publication Publication Date Title
CY2052B1 (en) Polymyxin conjugates
EP0364509A4 (en) CELLULAR TOXIC CONJUGATES.
AU7759291A (en) Oligonucleotide-transport agent disulfide conjugates
AU6290090A (en) Bi-or trispecific (fab)3 or (fab)4 conjugates
HU9200302D0 (en) 1,3-oxatiolane-nucleotide analogues
DK0555361T3 (da) Pulverformige farvepræparater og fremgangsmåde til fremstilling deraf
GB2226711B (en) Duct.
HU911678D0 (en) N-phosphonomethylglycine based herbicide preparations
MY107450A (en) Method for preparing interferon alpha-2 crystals.
AU625718B2 (en) Tracheobronchodilator
GB2247211B (en) Return envelope mailer
ZA911978B (en) Lipopeptide derivatives
AU8876591A (en) Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
CS168391A3 (en) Aqueous preparations based on hydrogen peroxide
ZA918381B (en) Pharmaceutical compositions.
GB9013779D0 (en) Self-lubricating,two stage variable compressor
EP0608215A4 (en) ANTINEOPLASTIC AGENTS BASED ON QUINOBENZOXAZINE, QUINOBENZOTHIAZINES AND PYRIDO-ACRIDINE.
GB9414102D0 (en) Sucking action doll
GB9021393D0 (en) Peroxide compositions
GB2218005B (en) Table game.
AU3441589A (en) An antiinflammation, tights-like garment
NZ240927A (en) Dibenz-oxa-thiocinones; preparatory processes, uses, and pharmaceutical compositions
IE901924L (en) 1,2-dioxetanes.
AR244964A1 (es) Una mesa plegable mejorada.
CA66652S (en) Toy puppet stage