CY2022A - 8-Alkoxyquinolonecarboxylic acid and salts thereof excellent in the selective toxicity and process of preparing the same - Google Patents

8-Alkoxyquinolonecarboxylic acid and salts thereof excellent in the selective toxicity and process of preparing the same

Info

Publication number
CY2022A
CY2022A CY202298A CY202298A CY2022A CY 2022 A CY2022 A CY 2022A CY 202298 A CY202298 A CY 202298A CY 202298 A CY202298 A CY 202298A CY 2022 A CY2022 A CY 2022A
Authority
CY
Cyprus
Prior art keywords
salts
preparing
same
selective toxicity
alkoxyquinolonecarboxylic
Prior art date
Application number
CY202298A
Other languages
English (en)
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26346239&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2022(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of CY2022A publication Critical patent/CY2022A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CY202298A 1986-01-21 1998-02-20 8-Alkoxyquinolonecarboxylic acid and salts thereof excellent in the selective toxicity and process of preparing the same CY2022A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1088086 1986-01-21
JP61220149A JPH089597B2 (ja) 1986-01-21 1986-09-18 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法

Publications (1)

Publication Number Publication Date
CY2022A true CY2022A (en) 1998-02-20

Family

ID=26346239

Family Applications (1)

Application Number Title Priority Date Filing Date
CY202298A CY2022A (en) 1986-01-21 1998-02-20 8-Alkoxyquinolonecarboxylic acid and salts thereof excellent in the selective toxicity and process of preparing the same

Country Status (11)

Country Link
US (2) US4980470A (nl)
EP (1) EP0230295B1 (nl)
JP (1) JPH089597B2 (nl)
KR (1) KR940007308B1 (nl)
CN (1) CN1021052C (nl)
CA (1) CA1340316C (nl)
CY (1) CY2022A (nl)
DE (2) DE3789878T2 (nl)
HK (1) HK79797A (nl)
HU (1) HU203339B (nl)
NL (1) NL300110I2 (nl)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
JP2598737B2 (ja) * 1986-01-21 1997-04-09 杏林製薬 株式会社 選択毒性に優れた８−アルコキシキノロンカルボン酸およびその塩並びにその製造方法
CN1019114B (zh) * 1986-03-31 1992-11-18 三共株式会社 喹啉-3-羟酸衍生物的制备方法
DE3615767A1 (de) * 1986-05-10 1987-11-12 Bayer Ag Verfahren zur herstellung von 4-hydroxy-chinolin-3-carbonsaeuren
DE3635846C2 (de) * 1986-10-22 1995-08-03 Teves Gmbh Alfred Blockiergeschützte Bremsanlage mit Antriebsschlupfregelung
JPH0778033B2 (ja) * 1986-12-04 1995-08-23 宇部興産株式会社 ２，４，５−トリフルオロ−３−ヒドロキシ安息香酸及びその製造法
US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
JPH0395177A (ja) * 1988-05-19 1991-04-19 Chugai Pharmaceut Co Ltd 新規キノロンカルボン酸誘導体
US5039682A (en) * 1988-06-21 1991-08-13 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
US5103040A (en) * 1988-06-21 1992-04-07 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
US5233091A (en) * 1988-06-21 1993-08-03 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
US5104868A (en) * 1988-06-21 1992-04-14 Pfizer Inc. Tricyclic derivatives of 7-substituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acids and esters
FI95130C (fi) * 1988-07-20 1995-12-27 Sankyo Co Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
WO1990002123A1 (en) * 1988-08-23 1990-03-08 Pfizer Inc. Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
US5385913A (en) * 1989-10-06 1995-01-31 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
WO1991004972A1 (en) * 1989-10-06 1991-04-18 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
CA2036516A1 (en) * 1990-02-19 1991-08-20 Yoshikazu Asahina Optically active 8-methoxyouinolonecarboxylic acid derivatives, their preparative processes and their intermediates
WO1991017988A1 (en) * 1990-05-11 1991-11-28 Chugai Seiyaku Kabushiki Kaisha Novel fluoroquinolone antimicrobial
JP2644610B2 (ja) * 1990-06-12 1997-08-25 三共株式会社 キノロンカルボン酸誘導体
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
US5258528A (en) * 1990-11-30 1993-11-02 Warner-Lambert Company Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group
WO1992009579A1 (en) * 1990-11-30 1992-06-11 Yoshitomi Pharmaceutical Industries, Ltd. Quinolonecarboxylic acid compound and its use
US5342846A (en) * 1990-12-05 1994-08-30 Synphar Laboratories, Inc. 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
JP3165742B2 (ja) * 1991-07-16 2001-05-14 中外製薬株式会社 キノロンカルボン酸誘導体の製造方法
US5869661A (en) * 1991-07-16 1999-02-09 Chugai Seiyaku Kabushiki Kaisha Method of producing a quinolonecarboxylic acid derivative
US5276041A (en) * 1991-11-08 1994-01-04 Kaken Pharmaceutical Co., Ltd. Oxime derivatives
DE69331003T2 (de) * 1992-01-31 2002-06-20 Chugai Seiyaku K.K., Tokio/Tokyo Kristalle von derivaten von chinozon carbonsäure-hydraten
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
CA2152828A1 (en) * 1993-03-16 1994-07-07 Shin-Ichi Uesato 8-methoxy-quinolonecarboxylic acid derivatives
TW252107B (nl) * 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
JP3449658B2 (ja) * 1994-12-21 2003-09-22 杏林製薬株式会社 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
CA2210007A1 (en) * 1995-01-24 1996-08-01 Yasuo Ito Quinoline carboxylic acid
JP2698339B2 (ja) * 1996-07-12 1998-01-19 三共株式会社 ８−メトキシキノロンカルボン酸誘導体の製造中間体
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
HUP0100051A3 (en) 1997-09-15 2002-08-28 Procter & Gamble Antimicrobial quinolones, their compositions and uses
DE19751948A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
DE19820801A1 (de) * 1998-05-09 1999-11-25 Gruenenthal Gmbh Orale Arzneiformen mit reproduzierbarer Wirkstofffreisetzung von Gatifloxacin oder pharmazeutisch verwendbaren Salzen oder Hydraten
JP5138128B2 (ja) 1998-08-21 2013-02-06 千寿製薬株式会社 水性液剤
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
CN1343128B (zh) 1999-03-17 2010-04-21 第一制药株式会社 药物组合物
DE19962470A1 (de) * 1999-12-22 2001-07-12 Schulz Hans Herrmann Verwendung von Chemotherapeutika
WO2001057017A1 (fr) * 2000-02-01 2001-08-09 Kyorin Pharmaceutical Co., Ltd. Sel de sulfate de quinolone d'acide carboxylique et son utilisation
DK1262477T3 (da) * 2000-02-09 2008-12-01 Daiichi Sankyo Co Ltd Antibakterielle midler, der er virksomme mod syrefaste bakterier og indeholder pyridoncarboxylsyrer som aktiv ingrediens
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
TWI287987B (en) * 2000-08-14 2007-10-11 Senju Pharma Co Cytokine inhibitor
US6413969B1 (en) * 2000-09-13 2002-07-02 Bristol-Myers Squibb Company Gatifloxacin pentahydrate
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6589955B2 (en) 2001-06-20 2003-07-08 Bristol-Myers Squibb Company Pediatric formulation of gatifloxacin
EP1492535B1 (en) * 2002-04-08 2005-10-26 Dr. Reddy's Laboratories Ltd. Anhydrous crystalline forms i and ii of 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl) 4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (gatifloxacin)
US7423153B2 (en) * 2002-05-10 2008-09-09 Teva Pharmaceutical Industries Ltd. Crystalline forms of gatifloxacin
CN1665504A (zh) * 2002-05-10 2005-09-07 特瓦制药工业有限公司 新晶型的加替沙星
WO2003099815A1 (en) 2002-05-28 2003-12-04 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
PL375437A1 (en) * 2002-08-14 2005-11-28 Teva Pharmaceutical Industries Ltd. Synthesis of gatifloxacin
US20060258677A1 (en) * 2003-02-15 2006-11-16 Teva Pharmaceutical Industries Ltd. Novel crystalline forms of gatifloxacin and processes for preparation
WO2004087688A1 (en) * 2003-04-02 2004-10-14 Hetero Drugs Limited Novel crystalline forms of gatifloxacin
CA2525862A1 (en) * 2003-05-13 2004-11-25 Cadila Healthcare Limited Process for preparing omega-anhydrous gatifloxacin
WO2004101547A1 (en) * 2003-05-19 2004-11-25 Hetero Drugs Limited Purification methods of gatifloxacin and a novel form of gatifloxacin
ATE366734T1 (de) 2003-09-04 2007-08-15 Wockhardt Ltd Benzochinolizin-2-carbonsäureargininsalz- tetrahydrat
ES2232311B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Forma cristalina de gatifloxacino.
WO2005118546A1 (en) * 2004-06-04 2005-12-15 Matrix Laboratories Ltd Novel crystalline forms of gatifloxacin
SI21799A (sl) * 2004-06-30 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek za pripravo gatifloksacina in regeneracija razpadnih produktov
WO2006009143A1 (ja) * 2004-07-21 2006-01-26 Kyorin Pharmaceutical Co., Ltd. （３ｓ）－３－ヒドロキシメチル－７－オキソピリドベンゾオキサジン－６－カルボン酸エステルの製造方法
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
CN100341855C (zh) * 2005-02-22 2007-10-10 南京澳新医药科技有限公司 7－取代－8－甲氧基氟喹诺酮羧酸衍生物、制法、制剂及其用途
US20060247255A1 (en) * 2005-05-02 2006-11-02 Patel Satishkumar A Method for preparing a stable gatifloxacin composition
US7365201B2 (en) 2006-03-02 2008-04-29 Apotex Pharmachem Inc. Process for the preparation of the boron difluoride chelate of quinolone-3-carboxylic acid
AU2007225088B2 (en) 2006-03-13 2012-09-13 Kyorin Pharmaceutical Co., Ltd Aminoquinolones as GSK-3 inhibitors
WO2007110834A2 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company Malate salts, and polymorphs of (3s,5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
JP2009531418A (ja) 2006-03-28 2009-09-03 ザ プロクター アンド ギャンブル カンパニー キノロン中間体調製のためのカップリング方法
JP4876165B2 (ja) 2006-03-28 2012-02-15 ザ プロクター アンド ギャンブル カンパニー キノロン中間体を調製するための水素化物還元法
JPWO2008044734A1 (ja) 2006-10-12 2010-02-18 杏林製薬株式会社 ガチフロキサシン含有水性液剤
WO2008044733A1 (fr) 2006-10-12 2008-04-17 Kyorin Pharmaceutical Co., Ltd. Préparation liquide aqueuse à pénétration de gatifloxacine intraoculaire améliorée
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
CA2621616A1 (en) * 2007-02-19 2008-08-19 Alcon Research, Ltd. Topical gatifloxacin formulations
TWI362386B (en) 2007-03-30 2012-04-21 Daiichi Sankyo Co Ltd A production method for the qunolon-carboxylic acid derivative
CN101855228B (zh) 2007-09-11 2012-10-24 杏林制药株式会社 作为gsk-3抑制剂的氰基氨基喹诺酮和四唑并氨基喹诺酮
CA2699152C (en) 2007-09-12 2015-11-24 Activx Biosciences, Inc. Spirocyclic aminoquinolones as gsk-3 inhibitors
EP2406266B1 (en) 2009-03-11 2013-12-25 Kyorin Pharmaceutical Co., Ltd. 7-cycloalkylaminoquinolones as gsk-3 inhibitors
CN102757419B (zh) * 2012-08-08 2015-03-11 四川百利药业有限责任公司 一种加替沙星的纯化方法
CA2903435A1 (en) 2013-03-08 2014-09-12 Allergan Inc. Antibiotic conjugates directly linked with steroid drugs
CA2899500A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Cyclosporine a-steroid conjugates
EP2969004A4 (en) 2013-03-15 2016-09-21 Melinta Therapeutics Inc METHOD FOR THE TREATMENT OF INFECTIONS IN OVERWEIGHT AND ADIPOSIVE PATIENTS USING ANTIBIOTICS
EP2957561A1 (en) 2014-06-18 2015-12-23 Université Paris 6 Pierre et Marie Curie UPMC Novel fluoroquinolones and use thereof to treat bacterial infections
KR101537911B1 (ko) * 2014-11-11 2015-07-23 한서대학교 산학협력단 제어 방출형 가티플록사신 제제 및 이의 제조방법
CN110122493B (zh) * 2019-06-14 2022-04-12 山东省联合农药工业有限公司 喹诺酮类化合物用于防治有用植物中细菌性有害生物的用途
CN114716373B (zh) * 2022-04-14 2023-01-10 内蒙古源宏精细化工有限公司 一种加替沙星环合酯的制备方法
CN114989165A (zh) * 2022-05-30 2022-09-02 青岛大学附属医院 一种抗持留菌和生物膜菌的化合物或组合物及其用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS604820B2 (ja) * 1979-02-26 1985-02-06 大塚製薬株式会社 キノリンカルボン酸誘導体
US4777175A (en) * 1982-09-09 1988-10-11 Warner-Lambert Company Antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
CS274601B2 (en) * 1983-07-27 1991-09-15 Dainippon Pharmaceutical Co Method of 1,8-naphthyridine derivative production
ZA85853B (en) * 1984-02-17 1986-09-24 Warner Lambert Co Antibacterial agents
IL74244A (en) * 1984-02-17 1988-06-30 Warner Lambert Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
JPS60178867A (ja) * 1984-02-24 1985-09-12 Dai Ichi Seiyaku Co Ltd ジハロゲノキノリン誘導体
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
JPH0635457B2 (ja) * 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法
JPS63198664A (ja) * 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
JPH0395177A (ja) * 1988-05-19 1991-04-19 Chugai Pharmaceut Co Ltd 新規キノロンカルボン酸誘導体

Also Published As

Publication number Publication date
CN1021052C (zh) 1993-06-02
EP0230295A3 (en) 1987-11-04
US5043450A (en) 1991-08-27
HU203339B (en) 1991-07-29
US4980470A (en) 1990-12-25
EP0230295B1 (en) 1994-05-25
AU6769087A (en) 1987-07-23
NL300110I1 (nl) 2003-02-03
DE3789878T2 (de) 1995-01-05
CN87100580A (zh) 1987-08-19
AU610491B2 (en) 1991-05-23
HUT43583A (en) 1987-11-30
HK79797A (en) 1997-06-20
KR870007128A (ko) 1987-08-17
JPS62252772A (ja) 1987-11-04
EP0230295A2 (en) 1987-07-29
JPH089597B2 (ja) 1996-01-31
KR940007308B1 (ko) 1994-08-12
DE3789878D1 (de) 1994-06-30
DE10299006I1 (de) 2002-07-04
CA1340316C (en) 1999-01-12
NL300110I2 (nl) 2003-05-01
DE10299006I2 (de) 2002-11-07

Similar Documents

Publication Publication Date Title
CY2022A (en) 8-Alkoxyquinolonecarboxylic acid and salts thereof excellent in the selective toxicity and process of preparing the same
IL84653A (en) Amino-alpha-carboxyethylidenethiazoleacetic acid derivatives and processes for the preparation thereof
ZA875671B (en) Titanocenes and their use
ZA857273B (en) Isoxazolecarboxylic acid derivatives,their preparation and their use
EP0237955A3 (en) Quinolonecarboxylic acid derivatives and their preparation
EP0256981A3 (en) Titanocenes and their use
HUT35641A (en) Process for preparing 1-benzyl-amino-alkyl-pirrolidinones and acid addition salts thereof
GB2177089B (en) Thiazolidinecarboxylic acid derivatives and process for preparing same
AR244674A1 (es) Procedimiento para preparar derivados de acidos 3,4-dihidro-3-tioxo-2h-1,4-bensoxa (o tia)zin-4-aceticos.
EP0264106A3 (en) 5-substituted amino-4-hydroxy-pentanoic acid derivatives and their use
ZA877974B (en) Herbicidal agents containing -iminocarboxylic acid anilides and new -iminocarboxylic acid anilides and process for their preparation
PT84199A (en) Process for the preparation of amine derivatives and use thereof
NZ218856A (en) Aminoglycosides of 3,21-dihydroxy-14,21-epoxy-24-nor-cholanic acid and derivatives
GB2215721B (en) Process for preparing n-phosphonomethyl-imino-diacetic acid and acid chloride
GB2138808B (en) B-amino acid derivatives and their preparation
DE3561945D1 (en) Diaminoalcohols, their preparation and their use as acid gas removal agents
EP0264060A3 (en) Anticoagulating substance and preparation process thereof
IL76137A0 (en) 3-hydroxy-4-phenoxypentanoic acid derivatives and their preparation
EP0271829A3 (en) Delta-hydroxy-beta-lysine derivatives and their production
AU610491C (en) 8-alkoxyquinolonecarboxylic acid and salts thereof excellent in the selective toxicity and process of preparing the same
DE3572976D1 (en) Acrylamidobenzoic acid derivatives and their use
EG18199A (en) Benzoylurea derivatives their production and their use
IL73884A (en) Aspidosperimidine-3-carboxylic acid derivatives and their use in preparing vincristine
EP0433779A3 (en) Process for the preparation of sulfonyl urea salts and their use as herbizides
PT82808A (en) Process for the preparation of 1,6-dimethyl-2-halogen-10-alpha-metoxy-ergoline-8beta-methanol 5-bromonicotinate (2-halonicergoline) derivatives and their acid addition salts