CY1998A - Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl) benzenes - Google Patents

Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl) benzenes

Info

Publication number
CY1998A
CY1998A CY199897A CY199897A CY1998A CY 1998 A CY1998 A CY 1998A CY 199897 A CY199897 A CY 199897A CY 199897 A CY199897 A CY 199897A CY 1998 A CY1998 A CY 1998A
Authority
CY
Cyprus
Prior art keywords
tetrazol
synthesis
substituted
ortho
benzenes
Prior art date
Application number
CY199897A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24061644&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1998(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CY1998A publication Critical patent/CY1998A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Battery Electrode And Active Subsutance (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
CY199897A 1990-05-02 1997-12-05 Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl) benzenes CY1998A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/517,889 US5039814A (en) 1990-05-02 1990-05-02 Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes

Publications (1)

Publication Number Publication Date
CY1998A true CY1998A (en) 1997-12-05

Family

ID=24061644

Family Applications (1)

Application Number Title Priority Date Filing Date
CY199897A CY1998A (en) 1990-05-02 1997-12-05 Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl) benzenes

Country Status (15)

Country Link
US (1) US5039814A (ro)
EP (1) EP0455423B1 (ro)
JP (1) JPH0717619B2 (ro)
AT (1) ATE146461T1 (ro)
CA (1) CA2041620C (ro)
CY (1) CY1998A (ro)
DE (1) DE69123632T2 (ro)
DK (1) DK0455423T3 (ro)
ES (1) ES2095907T3 (ro)
GR (1) GR3022107T3 (ro)
HK (1) HK59497A (ro)
IE (1) IE911455A1 (ro)
LV (1) LV11893B (ro)
PT (1) PT97528B (ro)
RO (1) RO110339B1 (ro)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5256654A (en) * 1991-10-24 1993-10-26 American Home Products Corporation Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US5283242A (en) * 1991-10-24 1994-02-01 American Home Products Corporation Substituted benzimidazoles and quinazolines as antihypertensives
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
US5252753A (en) * 1991-11-01 1993-10-12 Ortho Pharmaceutical Corporation Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
DE69233208T2 (de) * 1991-11-18 2004-07-08 E.I. Du Pont De Nemours And Co., Wilmington Tetrazolylphenylborsäureintermediate zur synthese von aii rezeptor antagonisten
EP0550313A1 (fr) * 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
FR2688503B1 (fr) * 1992-03-16 1994-05-06 Synthelabo Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle].
FR2696745B1 (fr) * 1992-10-12 1995-05-12 Synthelabo Procédé de préparation de dérivés de phényltétrazole.
FR2696746B1 (fr) * 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
CA2111662C (en) * 1992-12-17 2004-11-23 Hiroaki Yanagisawa Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease
US5567815A (en) * 1994-07-18 1996-10-22 Bridgestone Corporation Teritary amine containing antonic initiators used in preparing polymers and process for the preparation thereof
WO1996009301A1 (en) * 1994-09-20 1996-03-28 Wakunaga Seiyaku Kabushiki Kaisha Process for producing n-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
KR100354802B1 (ko) * 1994-10-20 2002-12-26 한국화학연구원 테트라졸유도체의제조방법
US5760220A (en) * 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
CZ390097A3 (cs) * 1995-06-07 1998-06-17 American Home Products Corporation Způsob přípravy derivátů bifenylu
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
ES2264641B1 (es) * 2005-06-17 2008-03-01 Quimica Sintetica, S.A. Procedimiento para la obtencion de derivados de bencimidazol y sus intermedios.
EP2081892A4 (en) 2006-11-17 2014-03-05 Donald F Weaver COMPOUNDS AND METHOD FOR THE TREATMENT OF PROTEIN DISAPPEARANCE
CN103274926B (zh) 2007-12-17 2016-08-10 联合治疗公司 一种制备Remodulin中的活性成分曲前列素的改良方法
ES2658139T3 (es) 2010-06-03 2018-03-08 United Therapeutics Corporation Producción de treprostinil
CN103476762B (zh) 2011-03-02 2015-04-22 联合治疗公司 用于生产曲前列环素的中间体的合成
CA2964804C (en) 2014-10-20 2019-04-02 United Therapeutics Corporation Synthesis of intermediate for producing prostacyclin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3534113A (en) * 1968-02-08 1970-10-13 Lithium Corp Preparation of aryllithium compounds by metalation
CH530980A (de) * 1969-03-05 1972-11-30 Sandoz Ag Verfahren zur Herstellung von Imidazo(2,1-a)isoindolen
US4620025A (en) * 1984-08-01 1986-10-28 Merck & Co., Inc. Process for the preparation of biphenyl intermediates
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4870186A (en) * 1987-05-22 1989-09-26 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids

Also Published As

Publication number Publication date
DE69123632T2 (de) 1997-05-15
RO110339B1 (ro) 1995-12-29
CA2041620A1 (en) 1991-11-03
IE911455A1 (en) 1991-11-06
LV11893B (en) 1998-03-20
EP0455423A3 (en) 1992-12-09
CA2041620C (en) 2003-03-11
JPH04225966A (ja) 1992-08-14
HK59497A (en) 1997-05-16
ES2095907T3 (es) 1997-03-01
ATE146461T1 (de) 1997-01-15
GR3022107T3 (en) 1997-03-31
PT97528B (pt) 1998-08-31
EP0455423A2 (en) 1991-11-06
PT97528A (pt) 1992-01-31
DK0455423T3 (da) 1997-06-09
EP0455423B1 (en) 1996-12-18
JPH0717619B2 (ja) 1995-03-01
LV11893A (en) 1997-12-20
US5039814A (en) 1991-08-13
DE69123632D1 (de) 1997-01-30

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