CY1772A - Substituted aromatic sulfonamides as antiglaucoma agents - Google Patents
Substituted aromatic sulfonamides as antiglaucoma agentsInfo
- Publication number
- CY1772A CY1772A CY177295A CY177295A CY1772A CY 1772 A CY1772 A CY 1772A CY 177295 A CY177295 A CY 177295A CY 177295 A CY177295 A CY 177295A CY 1772 A CY1772 A CY 1772A
- Authority
- CY
- Cyprus
- Prior art keywords
- substituted aromatic
- aromatic sulfonamides
- antiglaucoma agents
- sulfonamides
- antiglaucoma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Lubricants (AREA)
- Photosensitive Polymer And Photoresist Processing (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/067,326 US4797413A (en) | 1986-05-14 | 1987-06-26 | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use |
US07/208,314 US4863922A (en) | 1984-12-12 | 1988-06-15 | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1772A true CY1772A (en) | 1995-10-20 |
Family
ID=26747752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY177295A CY1772A (en) | 1987-06-26 | 1995-10-20 | Substituted aromatic sulfonamides as antiglaucoma agents |
Country Status (18)
Country | Link |
---|---|
US (1) | US4863922A (fr) |
EP (1) | EP0296879B1 (fr) |
JP (1) | JPH0631247B2 (fr) |
AT (1) | ATE86998T1 (fr) |
AU (1) | AU616664B2 (fr) |
CA (2) | CA1328262C (fr) |
CY (1) | CY1772A (fr) |
DE (2) | DE3879292T2 (fr) |
DK (1) | DK167684B1 (fr) |
ES (1) | ES2053738T4 (fr) |
GR (1) | GR3007407T3 (fr) |
IE (1) | IE62255B1 (fr) |
IL (1) | IL86822A (fr) |
LU (1) | LU88633I2 (fr) |
NL (1) | NL950006I2 (fr) |
NZ (1) | NZ225166A (fr) |
PT (1) | PT87832B (fr) |
SG (1) | SG24394G (fr) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1320487C (fr) * | 1987-08-03 | 1993-07-20 | George D. Hartman | Thieno (2,3-.beta.)thiophen-2-sulfonamides utilises comme agents antig laucome |
US5260453A (en) * | 1988-09-23 | 1993-11-09 | Ortho Pharmaceutical Corporation | Substituted thienopyrans as antihypertensive agents |
US4876271A (en) * | 1988-12-20 | 1989-10-24 | Merck & Co., Inc. | Substituted thieno[3,2-b]thiophene-2-sulfonamides as topically active carbonic anhydrase inhibitors |
US4929549A (en) * | 1989-02-08 | 1990-05-29 | Merck & Co., Inc. | 5-carbamoylthieno[2,3-b]thiophene-2-sulfon-amides as topically active carbonic anhydrase inhibitors |
US4946859A (en) * | 1989-07-31 | 1990-08-07 | Merck & Co., Inc. | 4-(2-methyl-2-hydroxypropylamino)-5,6-dihydrothieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide |
US5120757A (en) * | 1989-07-31 | 1992-06-09 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents |
CA2028496A1 (fr) * | 1989-10-31 | 1991-05-01 | Tohru Nakao | Composes de thiophene et leurs applications pharmaceutiques |
IE911192A1 (en) * | 1990-04-12 | 1991-10-23 | Merck & Co Inc | Substituted aromatic sulfonamides as antiglaucoma agents |
JP3031498B2 (ja) * | 1990-04-12 | 2000-04-10 | メルク エンド カムパニー インコーポレーテッド | 抗緑内障剤としての置換芳香族スルホンアミド類 |
US5045561A (en) * | 1990-04-12 | 1991-09-03 | Merck & Co., Inc. | Substituted furan sulfonamides as antiglaucoma agents |
US5157129A (en) * | 1990-04-18 | 1992-10-20 | Merck & Co., Inc. | Enantiospecific synthesis of s-(+)-5,6-dihydro-4-(r-amino)-4h-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide |
US5091409A (en) * | 1990-05-17 | 1992-02-25 | Merck & Co., Inc. | 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides |
US5093332A (en) * | 1990-10-01 | 1992-03-03 | Merck & Co., Inc. | Substituted thieno(2,3-b)(1,4)thiazine-6-sulfonamides as antiglaucoma agents |
US5216020A (en) * | 1990-10-12 | 1993-06-01 | Merck & Co., Inc. | Substituted 4,5-dihydrothieno(2,3-b)thiophene-2-sulfonamides and 6,6-dioxides thereof |
EP0480745A3 (en) * | 1990-10-12 | 1992-07-29 | Merck & Co. Inc. | Substituted dihydrothieno-thiophene-2-sulfonamides and dioxides thereof |
IL101537A (en) * | 1991-04-17 | 1997-11-20 | Merck & Co Inc | OPHTHALMIC COMPOSITIONS COMPRISING COMBINATIONS OF A CARBONIC ANHYDRASE INHIBITOR AND A b-ADRENERGIC ANTAGONIST |
SG84487A1 (en) | 1991-04-17 | 2001-11-20 | Merck & Co Inc | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist |
JPH0830067B2 (ja) * | 1991-10-15 | 1996-03-27 | メルク エンド カムパニー インコーポレーテッド | 三環チエノチオピラン類 |
AU677577B2 (en) * | 1992-02-21 | 1997-05-01 | Alcon Laboratories, Inc. | Topical antiglaucoma compositions comprising carbonic anhydrase inhibitors and beta-blockers |
US5932572A (en) * | 1992-02-21 | 1999-08-03 | Alcon Laboratories, Inc. | Topical anti-glaucoma compositions |
KR100319837B1 (ko) * | 1992-08-28 | 2002-04-22 | 커스티 마가렛 핀더 | 4h-티에노(2,3-6)티오피란유도체를제조하기위한효소적비대칭환원방법 |
JP3279671B2 (ja) * | 1992-09-28 | 2002-04-30 | 鐘淵化学工業株式会社 | チエノチオピラン誘導体の製造方法 |
TW265343B (fr) * | 1993-03-22 | 1995-12-11 | Merck & Co Inc | |
US6316443B1 (en) | 1994-08-04 | 2001-11-13 | Merck & Co., Inc. | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist |
TW438587B (en) * | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
FR2754712B1 (fr) | 1996-10-17 | 1999-09-03 | Merck Sharp Dohme Chibret Lab | Compositions ophtalmiques |
JP4000505B2 (ja) | 1999-12-01 | 2007-10-31 | 第一三共株式会社 | 緑内障を治療するための併用剤 |
JP2003520245A (ja) * | 2000-01-18 | 2003-07-02 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症を治療するための眼科組成物 |
US6548535B2 (en) * | 2000-01-18 | 2003-04-15 | Merck & Co., Inc. | Method for treating ocular hypertension |
ES2177415B1 (es) * | 2000-09-04 | 2004-10-16 | Ragactives, S.L. | Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios. |
US20040254230A1 (en) * | 2001-12-03 | 2004-12-16 | Ogidigben Miller J. | Method for treating ocular hypertension |
WO2003077845A2 (fr) * | 2002-03-15 | 2003-09-25 | Merck & Co., Inc. | Compositions et methodes de traitement du glaucome et de l'hypertension oculaire |
CA2487977A1 (fr) * | 2002-06-06 | 2003-12-18 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Derives d'imidazolidine-2-one disubstitues en 1,5 utiles en tant qu'agonistes du recepteur ep4 dans le traitement de troubles oculaires et de maladies osseuses |
US20050256117A1 (en) * | 2002-06-14 | 2005-11-17 | Meng Hsin Chen | Ophthalmic compositions for treating ocular hypertension |
CA2488752A1 (fr) * | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | Nouveaux bloqueurs de canaux maxi k, methodes d'utilisation et procedes de fabrication associes |
JP2005532361A (ja) * | 2002-06-17 | 2005-10-27 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症の治療用の眼科用組成物 |
AU2003245531A1 (en) * | 2002-06-17 | 2003-12-31 | Merck & Co., Inc. | Novel maxi-k channel blockers, methods of use and process for making the same |
JP2006504679A (ja) * | 2002-08-28 | 2006-02-09 | メルク フロスト カナダ アンド カンパニー | 緑内障の治療においてep4受容体作動薬として使用するためのオキサゾリジン−2−オンおよびチアゾリジン−2−オン誘導体 |
CA2502914A1 (fr) * | 2002-10-25 | 2004-05-06 | Merck Frosst Canada & Co. | Agonistes des recepteurs ep<sb>4</sb> |
EP1610776A4 (fr) * | 2003-03-27 | 2007-03-28 | Merck & Co Inc | Compositions ophtalmiques pour traiter une hypertension oculaire |
ATE497964T1 (de) | 2004-12-20 | 2011-02-15 | Sk Holdings Co Ltd | Verfahren zur trennung von optisch reinen thiophenverbindungen unter anwendung von simulierter bewegtbettchromatographie |
AU2004326111A1 (en) * | 2004-12-28 | 2006-07-06 | Council Of Scientific And Industrial Research | Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCI |
US7109353B2 (en) * | 2004-12-28 | 2006-09-19 | Council Of Scientific And Industrial Research | Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl |
PT2010544E (pt) * | 2006-04-21 | 2009-11-03 | Zach System Spa | Processo de preparação de dorzolamida |
EP1918293A1 (fr) * | 2006-10-02 | 2008-05-07 | Sandoz AG | Procédé pour la préparation d'acide 4-oxo-thieno[2,3b]thiopyran-2-yl-sulfonique |
AU2008220104B2 (en) | 2007-02-28 | 2012-09-27 | Asahi Kasei Pharma Corporation | Sulfonamide derivative |
NZ580781A (en) * | 2007-05-07 | 2011-11-25 | Cipla Ltd | Process for preparing dorzolamide |
EP2234608A2 (fr) | 2007-12-11 | 2010-10-06 | Viamet Pharmaceuticals, Inc. | Inhibiteurs de métalloenzymes utilisant des fractions de liaison à un métal en combinaison avec des fractions de ciblage |
WO2010061398A1 (fr) * | 2008-11-27 | 2010-06-03 | Suven Life Sciences Limited | Procédé pour la préparation de chlorhydrate de dorzolamide et ses intermédiaires |
PL2683724T3 (pl) | 2011-03-10 | 2015-10-30 | Zach System Spa | Sposób redukcji asymetrycznej |
ITMI20121165A1 (it) * | 2012-07-03 | 2014-01-04 | Zach System Spa | Processo di riduzione asimmetrica |
CN103497202B (zh) * | 2013-10-23 | 2015-12-02 | 武汉武药科技有限公司 | 盐酸多佐胺中间体的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4416890A (en) * | 1981-07-13 | 1983-11-22 | Merck & Co., Inc. | Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure |
US4386098A (en) * | 1981-11-03 | 1983-05-31 | Merck & Co., Inc. | 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure |
US4426388A (en) * | 1982-04-02 | 1984-01-17 | Merck & Co., Inc. | 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure |
US4499103A (en) * | 1983-03-17 | 1985-02-12 | Merck & Co., Inc. | Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure |
DE3568431D1 (en) * | 1984-12-12 | 1989-04-06 | Merck & Co Inc | Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them |
US4677115A (en) * | 1984-12-12 | 1987-06-30 | Merck & Co., Inc. | Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof |
US4731368A (en) * | 1986-12-08 | 1988-03-15 | Merck & Co., Inc. | Thienopyridine sulfonamides and their ophthalmological formulation |
-
1988
- 1988-06-15 US US07/208,314 patent/US4863922A/en not_active Expired - Lifetime
- 1988-06-21 IL IL86822A patent/IL86822A/xx not_active IP Right Cessation
- 1988-06-23 CA CA000570227A patent/CA1328262C/fr not_active Expired - Lifetime
- 1988-06-23 EP EP88305786A patent/EP0296879B1/fr not_active Expired - Lifetime
- 1988-06-23 LU LU88633C patent/LU88633I2/fr unknown
- 1988-06-23 AT AT88305786T patent/ATE86998T1/de not_active IP Right Cessation
- 1988-06-23 DE DE8888305786T patent/DE3879292T2/de not_active Expired - Lifetime
- 1988-06-23 ES ES88305786T patent/ES2053738T4/es not_active Expired - Lifetime
- 1988-06-23 DE DE19575017C patent/DE19575017I2/de active Active
- 1988-06-24 IE IE193388A patent/IE62255B1/en not_active IP Right Cessation
- 1988-06-24 NZ NZ225166A patent/NZ225166A/en unknown
- 1988-06-24 AU AU18387/88A patent/AU616664B2/en not_active Expired
- 1988-06-24 PT PT87832A patent/PT87832B/pt not_active IP Right Cessation
- 1988-06-24 DK DK348588A patent/DK167684B1/da not_active IP Right Cessation
- 1988-06-25 JP JP63156053A patent/JPH0631247B2/ja not_active Expired - Lifetime
-
1991
- 1991-05-13 CA CA000616070A patent/CA1329211C/fr not_active Expired - Lifetime
-
1993
- 1993-03-18 GR GR930400593T patent/GR3007407T3/el unknown
-
1994
- 1994-02-17 SG SG24394A patent/SG24394G/en unknown
-
1995
- 1995-04-27 NL NL950006C patent/NL950006I2/nl unknown
- 1995-10-20 CY CY177295A patent/CY1772A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0296879B1 (fr) | 1993-03-17 |
NZ225166A (en) | 1991-05-28 |
IE881933L (en) | 1988-12-26 |
DK348588D0 (da) | 1988-06-24 |
CA1328262C (fr) | 1994-04-05 |
NL950006I1 (nl) | 1995-06-16 |
EP0296879A1 (fr) | 1988-12-28 |
LU88633I2 (fr) | 1995-09-01 |
ES2053738T4 (es) | 2011-12-29 |
DK167684B1 (da) | 1993-12-06 |
IE62255B1 (en) | 1995-01-11 |
JPH0631247B2 (ja) | 1994-04-27 |
DK348588A (da) | 1989-02-24 |
US4863922A (en) | 1989-09-05 |
DE3879292T2 (de) | 1993-09-09 |
PT87832A (pt) | 1989-05-31 |
AU1838788A (en) | 1989-01-05 |
PT87832B (pt) | 1992-10-30 |
ATE86998T1 (de) | 1993-04-15 |
AU616664B2 (en) | 1991-11-07 |
NL950006I2 (nl) | 1997-02-03 |
DE3879292D1 (de) | 1993-04-22 |
IL86822A (en) | 1992-01-15 |
CA1329211C (fr) | 1994-05-03 |
ES2053738T3 (es) | 1994-08-01 |
SG24394G (en) | 1994-06-10 |
JPH01100174A (ja) | 1989-04-18 |
DE19575017I2 (de) | 2008-11-20 |
GR3007407T3 (fr) | 1993-07-30 |
IL86822A0 (en) | 1988-11-30 |
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