LU88633I2 - Dorzolamide et ses sels pharmaceutiquement acceptables (Trusopt R) - Google Patents
Dorzolamide et ses sels pharmaceutiquement acceptables (Trusopt R)Info
- Publication number
- LU88633I2 LU88633I2 LU88633C LU88633C LU88633I2 LU 88633 I2 LU88633 I2 LU 88633I2 LU 88633 C LU88633 C LU 88633C LU 88633 C LU88633 C LU 88633C LU 88633 I2 LU88633 I2 LU 88633I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- trusopt
- dorzolamide
- pharmaceutically acceptable
- acceptable salts
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Lubricants (AREA)
- Photosensitive Polymer And Photoresist Processing (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Dental Preparations (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/067,326 US4797413A (en) | 1986-05-14 | 1987-06-26 | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use |
US07/208,314 US4863922A (en) | 1984-12-12 | 1988-06-15 | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use |
Publications (1)
Publication Number | Publication Date |
---|---|
LU88633I2 true LU88633I2 (fr) | 1995-09-01 |
Family
ID=26747752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU88633C LU88633I2 (fr) | 1987-06-26 | 1988-06-23 | Dorzolamide et ses sels pharmaceutiquement acceptables (Trusopt R) |
Country Status (18)
Country | Link |
---|---|
US (1) | US4863922A (fr) |
EP (1) | EP0296879B1 (fr) |
JP (1) | JPH0631247B2 (fr) |
AT (1) | ATE86998T1 (fr) |
AU (1) | AU616664B2 (fr) |
CA (2) | CA1328262C (fr) |
CY (1) | CY1772A (fr) |
DE (2) | DE3879292T2 (fr) |
DK (1) | DK167684B1 (fr) |
ES (1) | ES2053738T4 (fr) |
GR (1) | GR3007407T3 (fr) |
IE (1) | IE62255B1 (fr) |
IL (1) | IL86822A (fr) |
LU (1) | LU88633I2 (fr) |
NL (1) | NL950006I2 (fr) |
NZ (1) | NZ225166A (fr) |
PT (1) | PT87832B (fr) |
SG (1) | SG24394G (fr) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1320487C (fr) * | 1987-08-03 | 1993-07-20 | George D. Hartman | Thieno (2,3-.beta.)thiophen-2-sulfonamides utilises comme agents antig laucome |
US5260453A (en) * | 1988-09-23 | 1993-11-09 | Ortho Pharmaceutical Corporation | Substituted thienopyrans as antihypertensive agents |
US4876271A (en) * | 1988-12-20 | 1989-10-24 | Merck & Co., Inc. | Substituted thieno[3,2-b]thiophene-2-sulfonamides as topically active carbonic anhydrase inhibitors |
US4929549A (en) * | 1989-02-08 | 1990-05-29 | Merck & Co., Inc. | 5-carbamoylthieno[2,3-b]thiophene-2-sulfon-amides as topically active carbonic anhydrase inhibitors |
US4946859A (en) * | 1989-07-31 | 1990-08-07 | Merck & Co., Inc. | 4-(2-methyl-2-hydroxypropylamino)-5,6-dihydrothieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide |
US5120757A (en) * | 1989-07-31 | 1992-06-09 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents |
CA2028496A1 (fr) * | 1989-10-31 | 1991-05-01 | Tohru Nakao | Composes de thiophene et leurs applications pharmaceutiques |
JP3031498B2 (ja) * | 1990-04-12 | 2000-04-10 | メルク エンド カムパニー インコーポレーテッド | 抗緑内障剤としての置換芳香族スルホンアミド類 |
IE911192A1 (en) * | 1990-04-12 | 1991-10-23 | Merck & Co Inc | Substituted aromatic sulfonamides as antiglaucoma agents |
US5045561A (en) * | 1990-04-12 | 1991-09-03 | Merck & Co., Inc. | Substituted furan sulfonamides as antiglaucoma agents |
US5157129A (en) * | 1990-04-18 | 1992-10-20 | Merck & Co., Inc. | Enantiospecific synthesis of s-(+)-5,6-dihydro-4-(r-amino)-4h-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide |
US5091409A (en) * | 1990-05-17 | 1992-02-25 | Merck & Co., Inc. | 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides |
US5093332A (en) * | 1990-10-01 | 1992-03-03 | Merck & Co., Inc. | Substituted thieno(2,3-b)(1,4)thiazine-6-sulfonamides as antiglaucoma agents |
EP0480745A3 (en) * | 1990-10-12 | 1992-07-29 | Merck & Co. Inc. | Substituted dihydrothieno-thiophene-2-sulfonamides and dioxides thereof |
US5216020A (en) * | 1990-10-12 | 1993-06-01 | Merck & Co., Inc. | Substituted 4,5-dihydrothieno(2,3-b)thiophene-2-sulfonamides and 6,6-dioxides thereof |
IL101537A (en) * | 1991-04-17 | 1997-11-20 | Merck & Co Inc | OPHTHALMIC COMPOSITIONS COMPRISING COMBINATIONS OF A CARBONIC ANHYDRASE INHIBITOR AND A b-ADRENERGIC ANTAGONIST |
SG84487A1 (en) | 1991-04-17 | 2001-11-20 | Merck & Co Inc | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist |
JPH0830067B2 (ja) * | 1991-10-15 | 1996-03-27 | メルク エンド カムパニー インコーポレーテッド | 三環チエノチオピラン類 |
US5932572A (en) * | 1992-02-21 | 1999-08-03 | Alcon Laboratories, Inc. | Topical anti-glaucoma compositions |
ATE169499T1 (de) * | 1992-02-21 | 1998-08-15 | Alcon Lab Inc | Topische antiglaukoma zusammensetzungen, enthaltend karbonhydrasehemmer und beta-blocker |
AU4729193A (en) * | 1992-08-28 | 1994-03-29 | Zeneca Limited | Enzymatic asymmetric reduction process to produce 4 h-thieno(2,3-6)thio pyrane derivatives |
JP3279671B2 (ja) * | 1992-09-28 | 2002-04-30 | 鐘淵化学工業株式会社 | チエノチオピラン誘導体の製造方法 |
TW265343B (fr) * | 1993-03-22 | 1995-12-11 | Merck & Co Inc | |
US6316443B1 (en) | 1994-08-04 | 2001-11-13 | Merck & Co., Inc. | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist |
TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
FR2754712B1 (fr) | 1996-10-17 | 1999-09-03 | Merck Sharp Dohme Chibret Lab | Compositions ophtalmiques |
JP4000505B2 (ja) | 1999-12-01 | 2007-10-31 | 第一三共株式会社 | 緑内障を治療するための併用剤 |
CA2396319A1 (fr) | 2000-01-18 | 2001-07-26 | Merck & Co., Inc. | Compositions ophthalmiques pour traiter l'hypertension oculaire |
US6548535B2 (en) * | 2000-01-18 | 2003-04-15 | Merck & Co., Inc. | Method for treating ocular hypertension |
ES2177415B1 (es) * | 2000-09-04 | 2004-10-16 | Ragactives, S.L. | Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios. |
US20040254230A1 (en) * | 2001-12-03 | 2004-12-16 | Ogidigben Miller J. | Method for treating ocular hypertension |
US20050124595A1 (en) * | 2002-03-15 | 2005-06-09 | Goetz Michael A. | Compositions and methods for treating glaucoma and ocular hypertension |
WO2003103664A1 (fr) * | 2002-06-06 | 2003-12-18 | Merck Frosst Canada & Co. | Derives d'imidazolidine-2-one disubstitues en 1,5 utiles en tant qu'agonistes du recepteur ep4 dans le traitement de troubles oculaires et de maladies osseuses |
US20050256117A1 (en) * | 2002-06-14 | 2005-11-17 | Meng Hsin Chen | Ophthalmic compositions for treating ocular hypertension |
EP1515974A4 (fr) * | 2002-06-17 | 2007-02-28 | Merck & Co Inc | Nouveaux bloqueurs de canaux maxi k, methodes d'utilisation et procedes de fabrication associes |
EP1515730A4 (fr) * | 2002-06-17 | 2005-07-20 | Merck & Co Inc | Nouveaux inhibiteurs de canaux maxi k, methodes d'utilisation et procede de fabrication associe |
CA2488845A1 (fr) * | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | Compositions ophtalmiques destinees a traiter l'hypertension oculaire |
CA2495917A1 (fr) * | 2002-08-28 | 2004-03-11 | Merck Frosst Canada & Co. | Derives de l'oxazolidin-2-one et de la thiazolidin-2-one antagonistes du recepteur ep4, pour le traitement du glaucome |
JP2006505572A (ja) * | 2002-10-25 | 2006-02-16 | メルク フロスト カナダ アンド カンパニー | Ep4受容体アゴニストとしての2−ピロリドン |
CN1791402A (zh) * | 2003-03-27 | 2006-06-21 | 麦克公司 | 治疗眼高压的眼科组合物 |
EP1828198B1 (fr) | 2004-12-20 | 2011-02-09 | SK Holdings Co., Ltd. | Procede servant a separer des composes thiophenes optiquement purs en utilisant la chromatographie a lit mobile simule |
MX2007007923A (es) * | 2004-12-28 | 2007-11-14 | Usv Ltd | Procedimiento para preparar clorhidrato de 5,6-dihidro-4-(s)- (etilamino)-6-(s)metil-4h-tieno[2,3b]tiopiran-2-sulfonamida-7,7- dioxido. |
US7109353B2 (en) * | 2004-12-28 | 2006-09-19 | Council Of Scientific And Industrial Research | Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl |
ATE438649T1 (de) * | 2006-04-21 | 2009-08-15 | Zach System Spa | Verfahren zur herstellung von dorzolamid |
EP1918293A1 (fr) * | 2006-10-02 | 2008-05-07 | Sandoz AG | Procédé pour la préparation d'acide 4-oxo-thieno[2,3b]thiopyran-2-yl-sulfonique |
AU2008220104B2 (en) | 2007-02-28 | 2012-09-27 | Asahi Kasei Pharma Corporation | Sulfonamide derivative |
KR20100031571A (ko) * | 2007-05-07 | 2010-03-23 | 시플라 리미티드 | 도르졸라미드의 제조방법 |
WO2009105140A2 (fr) | 2007-12-11 | 2009-08-27 | Viamet Pharmaceuticals, Inc. | Inhibiteurs de métalloenzymes utilisant des fractions de liaison à un métal en combinaison avec des fractions de ciblage |
WO2010061398A1 (fr) * | 2008-11-27 | 2010-06-03 | Suven Life Sciences Limited | Procédé pour la préparation de chlorhydrate de dorzolamide et ses intermédiaires |
ES2543643T3 (es) | 2011-03-10 | 2015-08-20 | Zach System S.P.A. | Proceso de reducción asimétrica |
ITMI20121165A1 (it) * | 2012-07-03 | 2014-01-04 | Zach System Spa | Processo di riduzione asimmetrica |
CN103497202B (zh) * | 2013-10-23 | 2015-12-02 | 武汉武药科技有限公司 | 盐酸多佐胺中间体的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4416890A (en) * | 1981-07-13 | 1983-11-22 | Merck & Co., Inc. | Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure |
US4386098A (en) * | 1981-11-03 | 1983-05-31 | Merck & Co., Inc. | 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure |
US4426388A (en) * | 1982-04-02 | 1984-01-17 | Merck & Co., Inc. | 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure |
US4499103A (en) * | 1983-03-17 | 1985-02-12 | Merck & Co., Inc. | Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure |
EP0189690B1 (fr) * | 1984-12-12 | 1989-03-01 | Merck & Co. Inc. | Sulfonamides aromatiques substitués, leur préparation et compositions ophtalmiques les contenant |
US4677115A (en) * | 1984-12-12 | 1987-06-30 | Merck & Co., Inc. | Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof |
US4731368A (en) * | 1986-12-08 | 1988-03-15 | Merck & Co., Inc. | Thienopyridine sulfonamides and their ophthalmological formulation |
-
1988
- 1988-06-15 US US07/208,314 patent/US4863922A/en not_active Expired - Lifetime
- 1988-06-21 IL IL86822A patent/IL86822A/xx not_active IP Right Cessation
- 1988-06-23 LU LU88633C patent/LU88633I2/fr unknown
- 1988-06-23 EP EP88305786A patent/EP0296879B1/fr not_active Expired - Lifetime
- 1988-06-23 CA CA000570227A patent/CA1328262C/fr not_active Expired - Lifetime
- 1988-06-23 DE DE8888305786T patent/DE3879292T2/de not_active Expired - Lifetime
- 1988-06-23 ES ES88305786T patent/ES2053738T4/es not_active Expired - Lifetime
- 1988-06-23 DE DE19575017C patent/DE19575017I2/de active Active
- 1988-06-23 AT AT88305786T patent/ATE86998T1/de not_active IP Right Cessation
- 1988-06-24 IE IE193388A patent/IE62255B1/en not_active IP Right Cessation
- 1988-06-24 AU AU18387/88A patent/AU616664B2/en not_active Expired
- 1988-06-24 DK DK348588A patent/DK167684B1/da not_active IP Right Cessation
- 1988-06-24 NZ NZ225166A patent/NZ225166A/en unknown
- 1988-06-24 PT PT87832A patent/PT87832B/pt not_active IP Right Cessation
- 1988-06-25 JP JP63156053A patent/JPH0631247B2/ja not_active Expired - Lifetime
-
1991
- 1991-05-13 CA CA000616070A patent/CA1329211C/fr not_active Expired - Lifetime
-
1993
- 1993-03-18 GR GR930400593T patent/GR3007407T3/el unknown
-
1994
- 1994-02-17 SG SG24394A patent/SG24394G/en unknown
-
1995
- 1995-04-27 NL NL950006C patent/NL950006I2/nl unknown
- 1995-10-20 CY CY177295A patent/CY1772A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DK348588D0 (da) | 1988-06-24 |
ES2053738T3 (es) | 1994-08-01 |
DE3879292T2 (de) | 1993-09-09 |
DK348588A (da) | 1989-02-24 |
CA1329211C (fr) | 1994-05-03 |
ES2053738T4 (es) | 2011-12-29 |
PT87832A (pt) | 1989-05-31 |
AU1838788A (en) | 1989-01-05 |
AU616664B2 (en) | 1991-11-07 |
JPH01100174A (ja) | 1989-04-18 |
GR3007407T3 (fr) | 1993-07-30 |
DE19575017I2 (de) | 2008-11-20 |
IE881933L (en) | 1988-12-26 |
ATE86998T1 (de) | 1993-04-15 |
NZ225166A (en) | 1991-05-28 |
IL86822A0 (en) | 1988-11-30 |
JPH0631247B2 (ja) | 1994-04-27 |
SG24394G (en) | 1994-06-10 |
DE3879292D1 (de) | 1993-04-22 |
EP0296879A1 (fr) | 1988-12-28 |
DK167684B1 (da) | 1993-12-06 |
NL950006I1 (nl) | 1995-06-16 |
IL86822A (en) | 1992-01-15 |
NL950006I2 (nl) | 1997-02-03 |
PT87832B (pt) | 1992-10-30 |
EP0296879B1 (fr) | 1993-03-17 |
CA1328262C (fr) | 1994-04-05 |
US4863922A (en) | 1989-09-05 |
CY1772A (en) | 1995-10-20 |
IE62255B1 (en) | 1995-01-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LU88633I2 (fr) | Dorzolamide et ses sels pharmaceutiquement acceptables (Trusopt R) | |
NL300098I1 (nl) | Thiophene sulfonamides useful as carbonic anhydrase inhibitors. | |
IE853143L (en) | Aromatic sulfonamides, antiglaucoma agents | |
DK154287D0 (da) | Substituerede oxadiazol-derivater, fremgangsmaade til fremstilling deraf og mellemprodukter til brug ved fremgangsmaaden samt laegemiddel indeholdende oxadiazolerne | |
EP0594602A4 (fr) | Inhibiteurs d'anhydrase carbonique du thiadiazole sulfonamide a activite topique oculaire. | |
NO893400L (no) | Hiv protease inhibitorer egnet for behandling av aids. | |
LU88576I2 (fr) | RISPERIDONE et ses sels pharmaceutiquement acceptables (Risperdal R) | |
DK429788D0 (da) | Thieno(2,3-beta)thiophen-2-sulfonamid og farmaceutisk praeparat indeholdende en saadan forbindelse | |
DE69023459D1 (de) | Behandlung von pulmonarer Disfunktion mit 15-Keto-prostaglandin-Derivaten. | |
ATE50257T1 (de) | Kristalline form von benzothiazindioxydsalz. | |
IT8820050A0 (it) | Metodo e apparecchiatura relativa per la produzione di una capsula trasparente. | |
IE892586L (en) | Use of zofenopril for the treatment of rheumatoid arthritis | |
ES2085607T3 (es) | Taco expansible de material sintetico. | |
IL86752A (en) | Thiophene derivatives and their preparation and their use as intermediates in the preparation of n-(2,4-dimethylthien-3-yl) -n-(1-methoxyprop-2-yl) - chloroacetamide | |
ITRM910200A1 (it) | Procedimento per la produzione di lenti oftalmiche a contatto. | |
NO894189D0 (no) | 4-amino-3-acylkinolonderivater og deres anvendelse som inhibitorer av mavesyresekresjon. |