CY1124247T1 - Πρωτεϊνες συγχωνευσης υποδοχεα ενος βραχιονα τυπου ι και τυπου ii και χρηση αυτων - Google Patents
Πρωτεϊνες συγχωνευσης υποδοχεα ενος βραχιονα τυπου ι και τυπου ii και χρηση αυτωνInfo
- Publication number
- CY1124247T1 CY1124247T1 CY20211100341T CY211100341T CY1124247T1 CY 1124247 T1 CY1124247 T1 CY 1124247T1 CY 20211100341 T CY20211100341 T CY 20211100341T CY 211100341 T CY211100341 T CY 211100341T CY 1124247 T1 CY1124247 T1 CY 1124247T1
- Authority
- CY
- Cyprus
- Prior art keywords
- type
- tgf
- extracellular domain
- polypeptide complexes
- arm
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Σε συγκεκριμένες μορφές, η αποκάλυψη παρέχει διαλυτά σύμπλοκα ετερομερικού πολυπεπτιδίου ενός βραχίονα που περιλαμβάνουν μία εξωκυτταρική επικράτεια ενός υποδοχέα κινάσης σερίνης/θρεονίνης τύπου Ι της οικογένειας TGF-βήτα ή μία εξωκυτταρική επικράτεια ενός υποδοχέα κινάσης σερίνης/θρεονίνης τύπου II της οικογένειας TGF-βήτα. Σε μερικές υλοποιήσεις, η αποκάλυψη παρέχει διαλυτά σύμπλοκα πολυπεπτιδίου ενός βραχίονα που περιλαμβάνουν μία εξωκυτταρική επικράτεια ενός υποδοχέα τύπου II που επιλέγεται από: ActRIIA, ActRIIB, TGFBRII, BMPRII και MISRII. Σε μερικές υλοποιήσεις, η αποκάλυψη παρέχει διαλυτά σύμπλοκα πολυπεπτιδίου ενός βραχίονα που περιλαμβάνουν μία εξωκυτταρική επικράτεια ενός υποδοχέα τύπου Ι που επιλέγεται από: ALK1, ALK2, ALK3, ALK4, ALK5, ALK6 και ALK7. Ενδεχομένως το διαλυτό σύμπλοκο είναι ένα ετεροδιμερές. Σε συγκεκριμένες μορφές, τέτοια διαλυτά σύμπλοκα πολυπεπτιδίου μπορούν να χρησιμοποιούνται για τη θεραπεία ή την πρόληψη διαφόρων καταστάσεων που σχετίζονται με TGF-βήτα, όπου συμπεριλαμβάνονται μεταξύ άλλων νόσοι και διαταραχές που σχετίζονται, παραδείγματος χάριν, με καρκίνο, μυς, οστά, λίπος, ερυθρά αιμοσφαίρια, μεταβολισμό, ίνωση και άλλους ιστούς που προσβάλλονται από έναν ή περισσότερους προσδέτες της υπεροικογένειας TGF-βήτα.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143579P | 2015-04-06 | 2015-04-06 | |
| US201562259422P | 2015-11-24 | 2015-11-24 | |
| PCT/US2016/026275 WO2016164501A1 (en) | 2015-04-06 | 2016-04-06 | Single-arm type i and type ii receptor fusion proteins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124247T1 true CY1124247T1 (el) | 2022-07-22 |
Family
ID=57015654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100341T CY1124247T1 (el) | 2015-04-06 | 2021-04-20 | Πρωτεϊνες συγχωνευσης υποδοχεα ενος βραχιονα τυπου ι και τυπου ii και χρηση αυτων |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10358476B2 (el) |
| EP (2) | EP3865505A1 (el) |
| JP (2) | JP6810702B2 (el) |
| KR (1) | KR20170141215A (el) |
| CN (3) | CN113683709A (el) |
| AU (2) | AU2016246602B2 (el) |
| CA (1) | CA2981793A1 (el) |
| CY (1) | CY1124247T1 (el) |
| DK (1) | DK3280727T3 (el) |
| ES (1) | ES2864850T3 (el) |
| HK (1) | HK1252958A1 (el) |
| HR (1) | HRP20210411T1 (el) |
| HU (1) | HUE054180T2 (el) |
| LT (1) | LT3280727T (el) |
| MA (1) | MA53883A (el) |
| MD (1) | MD3280727T2 (el) |
| PL (1) | PL3280727T3 (el) |
| PT (1) | PT3280727T (el) |
| RS (1) | RS61728B1 (el) |
| SI (1) | SI3280727T1 (el) |
| WO (1) | WO2016164501A1 (el) |
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| LT3280727T (lt) | 2015-04-06 | 2021-04-12 | Acceleron Pharma Inc. | Vienos atšakos i tipo ir ii tipo receptorių sulieti baltymai ir jų naudojimas |
| CN114736307A (zh) | 2015-04-06 | 2022-07-12 | 阿塞勒隆制药公司 | TGF-β超家族I型和II型受体异多聚体及其用途 |
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| EP3522912A4 (en) | 2016-10-05 | 2020-10-14 | Acceleron Pharma Inc. | HETEROMULTIMERS OF TYPE I AND TYPE II RECEIVERS OF THE TGF-BETA SUPERFAMILY AND THEIR USES |
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| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
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