CY1121106T1 - Συζευγματα λιπαρων οξεων της κουετιαπινης, διαδικασια παρασκευης και χρησης της - Google Patents
Συζευγματα λιπαρων οξεων της κουετιαπινης, διαδικασια παρασκευης και χρησης τηςInfo
- Publication number
- CY1121106T1 CY1121106T1 CY191100028T CY191100028T CY1121106T1 CY 1121106 T1 CY1121106 T1 CY 1121106T1 CY 191100028 T CY191100028 T CY 191100028T CY 191100028 T CY191100028 T CY 191100028T CY 1121106 T1 CY1121106 T1 CY 1121106T1
- Authority
- CY
- Cyprus
- Prior art keywords
- quetiapine
- production
- product
- fatty acid
- acid conjugates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα τεχνολογία παρέχει μια νέα κατηγορία προφαρμάκων της κουετιαπίνης που μπορούν να συντεθούν με χημική σύζευξη λιπαρών οξέων στην κουετιαπίνη. Παρέχονται επίσης φαρμακευτικές συνθέσεις και μέθοδοι σύνθεσης συζευγμάτων της παρούσας τεχνολογίας. Επιπλέον, παρέχονται μέθοδοι θεραπείας των ασθενών με τις συνθέσεις της παρούσας τεχνολογίας.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31297710P | 2010-03-11 | 2010-03-11 | |
PCT/US2011/027658 WO2011112657A1 (en) | 2010-03-11 | 2011-03-09 | Fatty acid conjugates of quetiapine, process for making and using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121106T1 true CY1121106T1 (el) | 2019-12-11 |
Family
ID=44560214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY191100028T CY1121106T1 (el) | 2010-03-11 | 2019-01-14 | Συζευγματα λιπαρων οξεων της κουετιαπινης, διαδικασια παρασκευης και χρησης της |
Country Status (14)
Country | Link |
---|---|
US (7) | US20110223207A1 (el) |
EP (2) | EP2544536B1 (el) |
CY (1) | CY1121106T1 (el) |
DK (1) | DK2544536T3 (el) |
ES (1) | ES2705233T3 (el) |
HR (1) | HRP20190057T1 (el) |
HU (1) | HUE042945T2 (el) |
LT (1) | LT2544536T (el) |
PL (1) | PL2544536T3 (el) |
PT (1) | PT2544536T (el) |
RS (1) | RS58335B1 (el) |
SI (1) | SI2544536T1 (el) |
TR (1) | TR201900067T4 (el) |
WO (1) | WO2011112657A1 (el) |
Families Citing this family (30)
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US9061250B2 (en) * | 2009-06-26 | 2015-06-23 | Bl Technologies, Inc. | Non-braided, textile-reinforced hollow fiber membrane |
CA2889457C (en) | 2009-12-31 | 2016-06-28 | Kempharm, Inc. | Amino acid conjugates of quetiapine, process for making and using the same |
CN103097008B (zh) | 2010-09-15 | 2015-12-09 | Bl科技公司 | 围绕可溶芯体制造纱增强式中空纤维膜的方法 |
CN103747788A (zh) * | 2011-05-13 | 2014-04-23 | 马尼托巴大学 | 用喹硫平或其类似物治疗暴露于uv辐射的皮肤 |
US9321014B2 (en) * | 2011-12-16 | 2016-04-26 | Bl Technologies, Inc. | Hollow fiber membrane with compatible reinforcements |
US9643129B2 (en) | 2011-12-22 | 2017-05-09 | Bl Technologies, Inc. | Non-braided, textile-reinforced hollow fiber membrane |
US9022229B2 (en) | 2012-03-09 | 2015-05-05 | General Electric Company | Composite membrane with compatible support filaments |
US8999454B2 (en) | 2012-03-22 | 2015-04-07 | General Electric Company | Device and process for producing a reinforced hollow fibre membrane |
JP6286429B2 (ja) | 2012-08-21 | 2018-02-28 | ヤンセン ファーマシューティカ エヌ.ベー. | パリペリドンのハプテン |
JP2015529199A (ja) | 2012-08-21 | 2015-10-05 | オルソ−クリニカル ダイアグノスティクス,インコーポレイティド | パリペリドンハプテンに対する抗体及びその使用 |
ES2926662T3 (es) | 2012-08-21 | 2022-10-27 | Janssen Pharmaceutica Nv | Anticuerpos contra haptenos de risperidona y uso de los mismos |
ES2691092T3 (es) | 2012-08-21 | 2018-11-23 | Janssen Pharmaceutica Nv | Anticuerpos contra la risperidona y uso de los mismos |
PL2888286T3 (pl) * | 2012-08-21 | 2018-07-31 | Janssen Pharmaceutica Nv | Przeciwciała skierowane przeciwko haptenom kwetiapinowym i ich zastosowanie |
PT2888590T (pt) | 2012-08-21 | 2020-09-11 | Janssen Pharmaceutica Nv | Anticorpos para olanzapina e utilização destes |
EP3354751B1 (en) | 2012-08-21 | 2019-10-02 | Janssen Pharmaceutica NV | Antibodies to aripiprazole and use thereof |
WO2014031656A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to olanzapine haptens and use thereof |
ES2822907T3 (es) * | 2012-08-21 | 2021-05-05 | Janssen Pharmaceutica Nv | Haptenos de quetiapina para su uso en inmunoensayos |
CN108640996A (zh) | 2012-08-21 | 2018-10-12 | 詹森药业有限公司 | 帕潘立酮的抗体及其用途 |
US9504682B2 (en) | 2012-08-21 | 2016-11-29 | Janssen Pharmaceutica Nv | Haptens of aripiprazole |
PL2888269T3 (pl) | 2012-08-21 | 2019-06-28 | Janssen Pharmaceutica Nv | Hapteny olanzapiny |
AU2013305907B2 (en) | 2012-08-21 | 2018-01-18 | Saladax Biomedical Inc. | Antibodies to quetiapine and use thereof |
PL2888263T3 (pl) | 2012-08-21 | 2018-10-31 | Janssen Pharmaceutica Nv | Hapteny rysperydonu i paliperydonu |
CN104736567B (zh) | 2012-08-21 | 2019-09-03 | 詹森药业有限公司 | 阿立哌唑半抗原的抗体及其用途 |
US9227362B2 (en) | 2012-08-23 | 2016-01-05 | General Electric Company | Braid welding |
WO2014057439A2 (en) * | 2012-10-13 | 2014-04-17 | Mahesh Kandula | Compositions and methods for the treatment of neurological diseases and its associated complications |
EA201591137A1 (ru) | 2013-03-15 | 2016-02-29 | Селджен Авиломикс Рисерч, Инк. | Ингибиторы mk2 и их применения |
MA44067A (fr) | 2015-12-17 | 2018-10-24 | Janssen Pharmaceutica Nv | Anticorps dirigés contre la quétiapine et utilisation associée |
EP3390449A1 (en) | 2015-12-17 | 2018-10-24 | Janssen Pharmaceutica N.V. | Antibodies to risperidone and use thereof |
CN109689598A (zh) * | 2016-07-27 | 2019-04-26 | 陶氏环球技术有限责任公司 | 可交联的表面活性剂 |
WO2018045094A1 (en) * | 2016-08-31 | 2018-03-08 | The Board Of Trustees Of The Leland Stanford Junior University | Ladderane lipid compounds and liposomes and methods of preparing and using the same |
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US4064138A (en) | 1975-11-12 | 1977-12-20 | General Mills, Inc. | Amino acid derivatives |
GB8607684D0 (en) * | 1986-03-27 | 1986-04-30 | Ici America Inc | Thiazepine compounds |
DE69125750D1 (de) * | 1990-05-21 | 1997-05-28 | Abbott Lab | Fettsäure-Oberflächenaktives-Lungenprotein Konjate |
DE69320378T2 (de) | 1992-01-21 | 1999-04-29 | Macrochem Corp | Iontophoretische verbesserte Verabreichung von Medikamenten |
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US7393920B2 (en) * | 2003-06-23 | 2008-07-01 | Cem Corporation | Microwave-assisted peptide synthesis |
WO2005002586A1 (en) | 2003-07-02 | 2005-01-13 | Astrazeneca Ab | Metabolite of quetiapine |
WO2005002587A1 (en) | 2003-07-02 | 2005-01-13 | Astrazeneca Ab | Quetiapine metabolite with antipsychotic activity |
JP2007509155A (ja) * | 2003-10-21 | 2007-04-12 | アルファーマ インコーポレイテッド | クエチアピンを含有する薬剤 |
US20050171088A1 (en) * | 2004-01-30 | 2005-08-04 | Astrazeneca Ab | Treatment of psychoses with dibenzothiazepine antipsychotic |
CA2596023A1 (en) * | 2005-01-27 | 2006-11-09 | Ocean Nutrition Canada Ltd. | Fatty acid-benzenediol derivatives and methods of making and using thereof |
WO2007004236A2 (en) | 2005-07-04 | 2007-01-11 | Ramu Krishnan | Improved drug or pharmaceutical compounds and a preparation thereof |
WO2007092638A1 (en) | 2006-02-09 | 2007-08-16 | University Of Virginia Patent Foundation | Bicyclic sphingosine 1-phosphate analogs |
WO2008050341A2 (en) | 2006-10-25 | 2008-05-02 | Ramot At Tel-Aviv University Ltd | Novel psychotropic agents having glutamate nmda activity |
CN101616585A (zh) | 2006-12-20 | 2009-12-30 | 阿斯利康(瑞典)有限公司 | 化合物及其用途 |
CA2889457C (en) | 2009-12-31 | 2016-06-28 | Kempharm, Inc. | Amino acid conjugates of quetiapine, process for making and using the same |
-
2011
- 2011-03-09 PL PL11753975T patent/PL2544536T3/pl unknown
- 2011-03-09 RS RS20190019A patent/RS58335B1/sr unknown
- 2011-03-09 HU HUE11753975A patent/HUE042945T2/hu unknown
- 2011-03-09 WO PCT/US2011/027658 patent/WO2011112657A1/en active Application Filing
- 2011-03-09 TR TR2019/00067T patent/TR201900067T4/tr unknown
- 2011-03-09 DK DK11753975.9T patent/DK2544536T3/en active
- 2011-03-09 SI SI201131642T patent/SI2544536T1/sl unknown
- 2011-03-09 US US13/043,764 patent/US20110223207A1/en not_active Abandoned
- 2011-03-09 PT PT11753975T patent/PT2544536T/pt unknown
- 2011-03-09 LT LTEP11753975.9T patent/LT2544536T/lt unknown
- 2011-03-09 EP EP11753975.9A patent/EP2544536B1/en active Active
- 2011-03-09 ES ES11753975T patent/ES2705233T3/es active Active
- 2011-03-09 US US13/581,496 patent/US8900604B2/en active Active
- 2011-03-09 EP EP18209307.0A patent/EP3476218A1/en not_active Withdrawn
-
2013
- 2013-02-19 US US13/770,462 patent/US20130158007A1/en not_active Abandoned
-
2014
- 2014-10-28 US US14/525,836 patent/US9511149B2/en active Active
-
2016
- 2016-11-01 US US15/340,533 patent/US20170042906A1/en not_active Abandoned
-
2017
- 2017-05-15 US US15/595,358 patent/US9890150B2/en active Active
- 2017-05-15 US US15/595,336 patent/US9889198B2/en active Active
-
2019
- 2019-01-09 HR HRP20190057TT patent/HRP20190057T1/hr unknown
- 2019-01-14 CY CY191100028T patent/CY1121106T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20130158007A1 (en) | 2013-06-20 |
ES2705233T3 (es) | 2019-03-22 |
US20130045247A1 (en) | 2013-02-21 |
US20150044261A1 (en) | 2015-02-12 |
EP2544536A4 (en) | 2013-08-14 |
WO2011112657A1 (en) | 2011-09-15 |
PT2544536T (pt) | 2019-01-23 |
US20170246301A1 (en) | 2017-08-31 |
DK2544536T3 (en) | 2019-02-04 |
PL2544536T3 (pl) | 2019-05-31 |
TR201900067T4 (tr) | 2019-02-21 |
US20170247368A1 (en) | 2017-08-31 |
HRP20190057T1 (hr) | 2019-03-22 |
LT2544536T (lt) | 2019-02-25 |
EP3476218A1 (en) | 2019-05-01 |
HUE042945T2 (hu) | 2019-07-29 |
US8900604B2 (en) | 2014-12-02 |
EP2544536A1 (en) | 2013-01-16 |
US9889198B2 (en) | 2018-02-13 |
US20110223207A1 (en) | 2011-09-15 |
US9511149B2 (en) | 2016-12-06 |
SI2544536T1 (sl) | 2019-03-29 |
RS58335B1 (sr) | 2019-03-29 |
US9890150B2 (en) | 2018-02-13 |
EP2544536B1 (en) | 2018-12-12 |
US20170042906A1 (en) | 2017-02-16 |
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