CY1120622T1 - Μεθοδοι και συνθεσεις για επαγωγη μιας ανοσιακης αποκρισης ως προς egfrviii - Google Patents
Μεθοδοι και συνθεσεις για επαγωγη μιας ανοσιακης αποκρισης ως προς egfrviiiInfo
- Publication number
- CY1120622T1 CY1120622T1 CY181100893T CY181100893T CY1120622T1 CY 1120622 T1 CY1120622 T1 CY 1120622T1 CY 181100893 T CY181100893 T CY 181100893T CY 181100893 T CY181100893 T CY 181100893T CY 1120622 T1 CY1120622 T1 CY 1120622T1
- Authority
- CY
- Cyprus
- Prior art keywords
- egfrviii
- methods
- indication
- compositions
- immune response
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001104—Epidermal growth factor receptors [EGFR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41485010P | 2010-11-17 | 2010-11-17 | |
| PCT/US2011/061164 WO2012068360A1 (en) | 2010-11-17 | 2011-11-17 | Methods and compositions for inducing an immune response to egfrviii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120622T1 true CY1120622T1 (el) | 2019-12-11 |
Family
ID=46084412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY181100893T CY1120622T1 (el) | 2010-11-17 | 2018-08-27 | Μεθοδοι και συνθεσεις για επαγωγη μιας ανοσιακης αποκρισης ως προς egfrviii |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9200057B2 (OSRAM) |
| EP (1) | EP2640842B1 (OSRAM) |
| JP (1) | JP5998370B2 (OSRAM) |
| CN (1) | CN103415620B (OSRAM) |
| CA (1) | CA2818353A1 (OSRAM) |
| CY (1) | CY1120622T1 (OSRAM) |
| DK (1) | DK2640842T3 (OSRAM) |
| ES (1) | ES2684684T3 (OSRAM) |
| HR (1) | HRP20181343T1 (OSRAM) |
| HU (1) | HUE039747T2 (OSRAM) |
| LT (1) | LT2640842T (OSRAM) |
| PL (1) | PL2640842T3 (OSRAM) |
| PT (1) | PT2640842T (OSRAM) |
| RS (1) | RS57630B1 (OSRAM) |
| SI (1) | SI2640842T1 (OSRAM) |
| SM (1) | SMT201800444T1 (OSRAM) |
| WO (1) | WO2012068360A1 (OSRAM) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| CN103429606A (zh) | 2010-10-01 | 2013-12-04 | 现代治疗公司 | 设计核酸及其使用方法 |
| SI2640842T1 (sl) * | 2010-11-17 | 2018-09-28 | Aduro Biotech, Inc. | Postopki in sestavki za induciranje imunskega odziva na EGFRvIII |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| KR20190099538A (ko) | 2011-10-03 | 2019-08-27 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도 |
| EP4144378A1 (en) | 2011-12-16 | 2023-03-08 | ModernaTX, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| AU2013243954A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| SG11201407875UA (en) | 2012-06-08 | 2014-12-30 | Aduro Biotech | Compostions and methods for cancer immunotherapy |
| US9511129B2 (en) | 2012-11-06 | 2016-12-06 | Aduro Biotech, Inc. | Facultatively attenuated bacterial species and methods of preparation and use thereof |
| DK2922554T3 (en) | 2012-11-26 | 2022-05-23 | Modernatx Inc | Terminalt modificeret rna |
| AU2013358892B2 (en) | 2012-12-13 | 2018-06-21 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| MX2015008329A (es) | 2012-12-27 | 2016-03-01 | Aduro Biotech Inc | Compañeros de fusion de peptido, señal que facilita la expresion listeral de secuencias antigenicas y metodos de preparacion y uso de los mismos. |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| JP2016518140A (ja) | 2013-05-03 | 2016-06-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | I型インターフェロンの環状ジヌクレオチド誘導法 |
| DK2996473T3 (da) | 2013-05-18 | 2019-11-04 | Aduro Biotech Inc | Sammensætninger og fremgangsmåder til aktivering af "stimulator af interferon-gen"-afhængig signalering |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| BR112016007255A2 (pt) | 2013-10-03 | 2017-09-12 | Moderna Therapeutics Inc | polinucleotídeos que codificam receptor de lipoproteína de baixa densidade |
| US10258679B2 (en) * | 2014-04-24 | 2019-04-16 | Advaxis, Inc. | Recombinant Listeria vaccine strains and methods of producing the same |
| WO2016061115A1 (en) | 2014-10-13 | 2016-04-21 | Providence Health & Services-Oregon D/B/A Providence Portland Medical Center | Bacterial vaccines deficient in the 2-c-methyl-d-erythritol-4-phosphate pathway and methods of preparation and use thereof |
| JP2017532328A (ja) * | 2014-10-14 | 2017-11-02 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 癌治療用の併用療法 |
| US10688166B2 (en) | 2014-11-03 | 2020-06-23 | Cerus Corporation | Compositions and methods for improved car-T cell therapies |
| PE20171448A1 (es) | 2015-03-10 | 2017-10-02 | Aduro Biotech Inc | Composiciones y metodos para activar la senalizacion dependiente del estimulador del gen de interferon |
| AU2016247887A1 (en) * | 2015-04-13 | 2017-11-02 | Aduro Biotech, Inc. | Epidermal growth factor receptor variant III-mesothelin fusions and methods of using the same |
| MA44378A (fr) * | 2015-04-13 | 2019-01-23 | Aduro Biotech Inc | Protéines de fusion immunogènes pour le traitement du cancer |
| US10455265B2 (en) * | 2015-04-27 | 2019-10-22 | Ericsson Ab | Program and device class entitlements in a media platform |
| JP2018515588A (ja) * | 2015-05-26 | 2018-06-14 | アドバクシス, インコーポレイテッド | 個別化送達ベクターに基づく免疫療法とその使用 |
| MA42263A (fr) * | 2015-06-24 | 2021-03-31 | Advaxis Inc | Dispositif de fabrication et procédé pour immunothérapie fondée sur un vecteur d'administration personnalisé |
| MX2018007204A (es) | 2015-12-16 | 2018-12-11 | Gritstone Oncology Inc | Identificacion, fabricacion y uso de neoantigeno. |
| NL2017267B1 (en) | 2016-07-29 | 2018-02-01 | Aduro Biotech Holdings Europe B V | Anti-pd-1 antibodies |
| WO2018026717A1 (en) * | 2016-08-01 | 2018-02-08 | Aduro Biotech, Inc. | Protein expression enhancer sequences and use thereof |
| NL2017270B1 (en) | 2016-08-02 | 2018-02-09 | Aduro Biotech Holdings Europe B V | New anti-hCTLA-4 antibodies |
| AU2018348165B2 (en) | 2017-10-10 | 2025-09-04 | Seattle Project Corp. | Neoantigen identification using hotspots |
| US11885815B2 (en) | 2017-11-22 | 2024-01-30 | Gritstone Bio, Inc. | Reducing junction epitope presentation for neoantigens |
| WO2021014398A1 (en) * | 2019-07-23 | 2021-01-28 | University Of Rijeka Faculty Of Medicine | Integrated human cytomegalovirus / glioblastoma vaccine |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830702A (en) | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
| US5571702A (en) | 1991-03-29 | 1996-11-05 | Genentech, Inc. | Amplification method for detection of human PF4A receptors |
| IT1262895B (it) | 1992-03-02 | 1996-07-22 | Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. | |
| US6379943B1 (en) | 1999-03-05 | 2002-04-30 | Merck & Co., Inc. | High-efficiency Cre/loxp based system for construction of adenovirus vectors |
| US5709999A (en) * | 1994-08-12 | 1998-01-20 | Myriad Genetics Inc. | Linked breast and ovarian cancer susceptibility gene |
| US7794729B2 (en) * | 1994-11-08 | 2010-09-14 | The Trustees Of The University Of Pennsylvania | Methods and compositions for immunotherapy of cancer |
| US6051237A (en) | 1994-11-08 | 2000-04-18 | The Trustees Of The University Of Pennsylvania | Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector |
| ATE262586T1 (de) * | 1994-11-28 | 2004-04-15 | Univ Jefferson | Fusion junction typ iii mutant egf rezeptor peptid-tumorvakzin |
| US5888530A (en) | 1995-07-21 | 1999-03-30 | The General Hospital Corporation | Method of enhancing delivery of a pharmaceutical formulation |
| US6099848A (en) | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| WO2002097044A2 (en) * | 2001-05-25 | 2002-12-05 | Thomas Jefferson University | Alternative splice forms of proteins as basis for multiple therapeutic modalities |
| EP1513924A4 (en) | 2002-05-29 | 2008-05-21 | Univ California | ATTENUATED LISTERIA SPP. AND METHOD OF USE THEREOF |
| AU2003259109A1 (en) | 2002-07-12 | 2004-02-02 | The Johns Hopkins University | Mesothelin vaccines and model systems |
| KR101192652B1 (ko) | 2003-02-06 | 2012-10-19 | 앤저 테라퓨틱스 인코퍼레이티드 | 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법 |
| US7833775B2 (en) | 2003-02-06 | 2010-11-16 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
| US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| MX2008005640A (es) * | 2005-11-02 | 2008-12-09 | Univ Duke | Quimioterapia e inmunoterapia concurrentes. |
| JP5347135B2 (ja) * | 2006-03-01 | 2013-11-20 | アドゥロ バイオテック | 遺伝子工学操作されたlisteriaおよびその使用方法 |
| WO2007117371A2 (en) | 2006-03-01 | 2007-10-18 | Anza Therapeutics, Inc. | Engineered listeria and methods of use thereof |
| US8900816B2 (en) * | 2007-07-19 | 2014-12-02 | Duke University | Assay for anti-EGFRvIII antibodies |
| EP2283112B1 (en) | 2008-05-19 | 2016-10-12 | Aduro Biotech | Compositions comprising prfa*mutant listeria and methods of use thereof |
| AU2009273949A1 (en) * | 2008-07-24 | 2010-01-28 | Aduro Biotech | Compositions and methods for the treatment of hepatitis C |
| TWI543767B (zh) * | 2008-08-19 | 2016-08-01 | 腫瘤療法 科學股份有限公司 | Hig2與urlc10抗原決定位胜肽以及含此胜肽之疫苗 |
| SI2640842T1 (sl) * | 2010-11-17 | 2018-09-28 | Aduro Biotech, Inc. | Postopki in sestavki za induciranje imunskega odziva na EGFRvIII |
-
2011
- 2011-11-17 SI SI201131548T patent/SI2640842T1/sl unknown
- 2011-11-17 RS RS20180979A patent/RS57630B1/sr unknown
- 2011-11-17 WO PCT/US2011/061164 patent/WO2012068360A1/en not_active Ceased
- 2011-11-17 HU HUE11841347A patent/HUE039747T2/hu unknown
- 2011-11-17 ES ES11841347.5T patent/ES2684684T3/es active Active
- 2011-11-17 EP EP11841347.5A patent/EP2640842B1/en active Active
- 2011-11-17 DK DK11841347.5T patent/DK2640842T3/en active
- 2011-11-17 SM SM20180444T patent/SMT201800444T1/it unknown
- 2011-11-17 HR HRP20181343TT patent/HRP20181343T1/hr unknown
- 2011-11-17 US US13/988,076 patent/US9200057B2/en not_active Expired - Fee Related
- 2011-11-17 PL PL11841347T patent/PL2640842T3/pl unknown
- 2011-11-17 JP JP2013540008A patent/JP5998370B2/ja not_active Expired - Fee Related
- 2011-11-17 LT LTEP11841347.5T patent/LT2640842T/lt unknown
- 2011-11-17 CA CA2818353A patent/CA2818353A1/en not_active Abandoned
- 2011-11-17 CN CN201180062129.XA patent/CN103415620B/zh not_active Expired - Fee Related
- 2011-11-17 PT PT11841347T patent/PT2640842T/pt unknown
-
2015
- 2015-11-25 US US14/952,470 patent/US9775891B2/en not_active Expired - Fee Related
-
2017
- 2017-10-02 US US15/722,908 patent/US20180021420A1/en not_active Abandoned
-
2018
- 2018-08-27 CY CY181100893T patent/CY1120622T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103415620B (zh) | 2016-10-12 |
| SI2640842T1 (sl) | 2018-09-28 |
| US20140037662A1 (en) | 2014-02-06 |
| US20160074491A1 (en) | 2016-03-17 |
| LT2640842T (lt) | 2018-09-10 |
| PL2640842T3 (pl) | 2018-11-30 |
| US20180021420A1 (en) | 2018-01-25 |
| RS57630B1 (sr) | 2018-11-30 |
| EP2640842A1 (en) | 2013-09-25 |
| CA2818353A1 (en) | 2012-05-24 |
| EP2640842B1 (en) | 2018-05-30 |
| US9200057B2 (en) | 2015-12-01 |
| HRP20181343T1 (hr) | 2018-10-19 |
| US9775891B2 (en) | 2017-10-03 |
| JP2014504851A (ja) | 2014-02-27 |
| DK2640842T3 (en) | 2018-08-13 |
| EP2640842A4 (en) | 2014-04-09 |
| JP5998370B2 (ja) | 2016-09-28 |
| HUE039747T2 (hu) | 2019-02-28 |
| CN103415620A (zh) | 2013-11-27 |
| ES2684684T3 (es) | 2018-10-04 |
| WO2012068360A1 (en) | 2012-05-24 |
| SMT201800444T1 (it) | 2018-09-13 |
| PT2640842T (pt) | 2018-10-12 |
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