CY1120301T1 - Φαρμακευτικες συνθεσεις που περιεχουν δεξκετοπροφαινη και τραμαδολη - Google Patents
Φαρμακευτικες συνθεσεις που περιεχουν δεξκετοπροφαινη και τραμαδοληInfo
- Publication number
- CY1120301T1 CY1120301T1 CY20181100578T CY181100578T CY1120301T1 CY 1120301 T1 CY1120301 T1 CY 1120301T1 CY 20181100578 T CY20181100578 T CY 20181100578T CY 181100578 T CY181100578 T CY 181100578T CY 1120301 T1 CY1120301 T1 CY 1120301T1
- Authority
- CY
- Cyprus
- Prior art keywords
- organic
- group
- tramadol
- acid
- malic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Περιγράφεται μία φαρμακευτική σύνθεση ως μία στερεή μορφή δοσολογίας η οποία χορηγείται από του στόματος, η οποία περιλαμβάνει: i) έναν συνδυασμό δύο φαρμακολογικά δραστικών συστατικών, άλατος δεξκετοπροφαίνης με μία οργανική ή ανόργανη βάση και άλατος τραμαδόλης με ένα οργανικό ή ανόργανο οξύ, όπου: - η οργανική ή ανόργανη βάση επιλέγεται από την ομάδα: τρομεταμόλη, τριμεθυλαμίνη, διμεθυλαμίνη, αιθυλαμίνη, τριαιθυλαμίνη, διαιθυλαμίνη, L-λυσίνη, L-αργινίνη, διαιθανολαμίνη, υδροξείδιο του νατρίου, υδροξείδιο του ασβεστίου - το οργανικό ή ανόργανο οξύ επιλέγεται από την ομάδα: υδροχλωρικό, υδροβρωμικό, φωσφορικό, θειικό, μεθανοσουλφονικό, βενζολοσουλφονικό, τολουολοσουλφονικό, οξικό, προπιονικό, μηλικό, μηλεϊνικό, ηλεκτρικό, κιτρικό, L-τρυγικό, γαλακτικό, μηλονικό, ασπαρτικό, γλουταμικό• ii) μικροκρυσταλλική κυτταρίνη ως ένα υλικό πλήρωσης• iii) ένα συνδετικό μέσο το οποίο επιλέγεται από την ομάδα: άμυλο αραβοσίτου, προζελατινοποιημένο άμυλο αραβοσίτου, υπρομελλόζη, ή μείγματα αυτών• iv) φαρμακευτικά αποδεκτά έκδοχα.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000210A ITMI20130210A1 (it) | 2013-02-14 | 2013-02-14 | Composizioni farmaceutiche contenenti dexketoprofene e tramadolo |
| PCT/EP2014/052342 WO2014124862A1 (en) | 2013-02-14 | 2014-02-06 | Pharmaceutical compositions containing dexketoprofen and tramadol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120301T1 true CY1120301T1 (el) | 2019-07-10 |
Family
ID=47953547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100578T CY1120301T1 (el) | 2013-02-14 | 2018-05-30 | Φαρμακευτικες συνθεσεις που περιεχουν δεξκετοπροφαινη και τραμαδολη |
Country Status (45)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022023211A1 (en) | 2020-07-31 | 2022-02-03 | Krka, D.D., Novo Mesto | Formulation containing dexketoprofen and tramadol and method for making the same |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU661723B2 (en) | 1991-10-30 | 1995-08-03 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
| US5516803A (en) * | 1991-10-30 | 1996-05-14 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
| US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| ES2058024B1 (es) | 1992-11-10 | 1995-05-01 | Menarini Lab | Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico. |
| DE19530575A1 (de) | 1995-08-19 | 1997-02-20 | Gruenenthal Gmbh | Schnell zerfallende Arzneiform von Tramadol oder einem Tramadolsalz |
| PT1058538E (pt) * | 1998-03-06 | 2002-11-29 | Eurand Int | Comprimidos de desintegracao rapida |
| EP1739072A1 (en) | 2005-06-15 | 2007-01-03 | Laboratorios Menarini S.A. | Polymorphic forms of dexketoprofen trometamol, preparation and pharmaceutical compositions thereof |
| BRPI0612802A2 (pt) | 2005-07-07 | 2010-11-30 | Farnam Co Inc | composições farmacêuticas de liberação sustentada para medicamentos extremamente hidrossolúveis |
| ITMI20060983A1 (it) * | 2006-05-18 | 2007-11-19 | Formevet S P A | Composizioni farmaceutiche veterinarie per il trattamento del dolore e dell'inifiamazione |
| BRPI0700133A (pt) * | 2007-01-29 | 2008-09-16 | Incrementha P D & I Pesquisa D | composição farmacêutica compreendendo tramadol e cetoprofeno em combinação |
| WO2008150324A1 (en) * | 2007-03-26 | 2008-12-11 | Theraquest Biosciences, Inc. | Subanalgesic doses of drug combinations |
| EP2177215A1 (en) * | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| ES2356762B1 (es) * | 2009-09-04 | 2011-11-24 | Farmalider S.A. | Composicion farmaceutica de ibuprofeno, tramadol y un aminoacido basico, procedimiento para su preparacion y utilizacion de la misma. |
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2013
- 2013-02-14 IT IT000210A patent/ITMI20130210A1/it unknown
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2014
- 2014-02-06 PE PE2015001736A patent/PE20151430A1/es not_active Application Discontinuation
- 2014-02-06 WO PCT/EP2014/052342 patent/WO2014124862A1/en active Application Filing
- 2014-02-06 BR BR112015018952-0A patent/BR112015018952B1/pt active IP Right Grant
- 2014-02-06 EA EA201591319A patent/EA029709B1/ru active Protection Beyond IP Right Term
- 2014-02-06 JP JP2015557377A patent/JP6297068B2/ja active Active
- 2014-02-06 NZ NZ710967A patent/NZ710967A/en unknown
- 2014-02-06 US US14/767,424 patent/US9949940B2/en active Active
- 2014-02-06 PL PL14705987T patent/PL2956129T3/pl unknown
- 2014-02-06 CU CUP2015000081A patent/CU24310B1/xx unknown
- 2014-02-06 SG SG11201506291UA patent/SG11201506291UA/en unknown
- 2014-02-06 AU AU2014218110A patent/AU2014218110B2/en active Active
- 2014-02-06 PT PT147059877T patent/PT2956129T/pt unknown
- 2014-02-06 EP EP14705987.7A patent/EP2956129B1/en active Active
- 2014-02-06 MA MA38335A patent/MA38335B1/fr unknown
- 2014-02-06 HU HUE14705987A patent/HUE038417T2/hu unknown
- 2014-02-06 TR TR2018/10114T patent/TR201810114T4/tr unknown
- 2014-02-06 UA UAA201508027A patent/UA115684C2/uk unknown
- 2014-02-06 MX MX2015010431A patent/MX353897B/es active IP Right Grant
- 2014-02-06 ES ES14705987.7T patent/ES2672986T3/es active Active
- 2014-02-06 GE GEAP201413908A patent/GEP201706649B/en unknown
- 2014-02-06 KR KR1020157021833A patent/KR102262408B1/ko active IP Right Grant
- 2014-02-06 MY MYPI2015002021A patent/MY173102A/en unknown
- 2014-02-06 DK DK14705987.7T patent/DK2956129T3/en active
- 2014-02-06 RS RS20180618A patent/RS57271B1/sr unknown
- 2014-02-06 LT LTEP14705987.7T patent/LT2956129T/lt unknown
- 2014-02-06 CA CA2900979A patent/CA2900979C/en active Active
- 2014-02-06 CN CN201480008502.7A patent/CN105007907B/zh active Active
- 2014-02-06 AP AP2015008616A patent/AP2015008616A0/xx unknown
- 2014-02-06 NO NO14705987A patent/NO2956129T3/no unknown
- 2014-02-06 SI SI201430739T patent/SI2956129T1/en unknown
- 2014-02-13 TW TW103104694A patent/TWI642430B/zh active
- 2014-02-13 AR ARP140100462A patent/AR094783A1/es not_active Application Discontinuation
- 2014-02-13 UY UY0001035324A patent/UY35324A/es active IP Right Grant
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2015
- 2015-08-11 SA SA515360877A patent/SA515360877B1/ar unknown
- 2015-08-11 EC ECIEPI201534660A patent/ECSP15034660A/es unknown
- 2015-08-12 CR CR20150411A patent/CR20150411A/es unknown
- 2015-08-12 TN TN2015000345A patent/TN2015000345A1/en unknown
- 2015-08-12 IL IL24051415A patent/IL240514B/en active IP Right Grant
- 2015-08-12 PH PH12015501766A patent/PH12015501766A1/en unknown
- 2015-08-12 CL CL2015002251A patent/CL2015002251A1/es unknown
- 2015-08-12 NI NI201500105A patent/NI201500105A/es unknown
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2016
- 2016-04-25 HK HK16104703.2A patent/HK1216840A1/zh unknown
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2018
- 2018-05-30 CY CY20181100578T patent/CY1120301T1/el unknown
- 2018-06-27 HR HRP20180974TT patent/HRP20180974T1/hr unknown
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