CY1120201T1 - Ενωσεις, συνθεσεις και μεθοδοι με χρηση ανταγωνιστων σελεκτινης ε για κινητοποιηση αιμοποιητικων κυτταρων - Google Patents

Ενωσεις, συνθεσεις και μεθοδοι με χρηση ανταγωνιστων σελεκτινης ε για κινητοποιηση αιμοποιητικων κυτταρων

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Publication number
CY1120201T1
CY1120201T1 CY20181100478T CY181100478T CY1120201T1 CY 1120201 T1 CY1120201 T1 CY 1120201T1 CY 20181100478 T CY20181100478 T CY 20181100478T CY 181100478 T CY181100478 T CY 181100478T CY 1120201 T1 CY1120201 T1 CY 1120201T1
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Cyprus
Prior art keywords
cells
methods
celltic
unions
compositions
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Application number
CY20181100478T
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English (en)
Inventor
John L. Magnani
Original Assignee
Glycomimetics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomimetics, Inc. filed Critical Glycomimetics, Inc.
Publication of CY1120201T1 publication Critical patent/CY1120201T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Στο παρόν παρέχονται μέθοδοι για χρήση ανταγωνιστών σελεκτίνης Ε για την κινητοποίηση κυττάρων, όπως αιμοποιητικά κύτταρα, αιμοποιητικά αρχέγονα και προγονικά κύτταρα, λευκοκύτταρα και κακοήθη κύτταρα και αιμοποιητικά ογκικά κύτταρα από τον μυελό των οστών. Πιο συγκεκριμένα, παρέχονται μέθοδοι χρήσης ανταγωνιστών σελεκτίνης Ε, συμπεριλαμβανομένων, για παράδειγμα, γλυκομιμητικών ενώσεων, αντισωμάτων, απταμερών και πεπτιδίων για την κινητοποίηση κυττάρων από τον μυελό των οστών στο περιφερειακό αγγειακό σύστημα και τους ιστούς.
CY20181100478T 2012-12-07 2018-05-07 Ενωσεις, συνθεσεις και μεθοδοι με χρηση ανταγωνιστων σελεκτινης ε για κινητοποιηση αιμοποιητικων κυτταρων CY1120201T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261734924P 2012-12-07 2012-12-07
US201361784206P 2013-03-14 2013-03-14
PCT/US2013/073258 WO2014089269A1 (en) 2012-12-07 2013-12-05 Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells

Publications (1)

Publication Number Publication Date
CY1120201T1 true CY1120201T1 (el) 2018-12-12

Family

ID=49841843

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100478T CY1120201T1 (el) 2012-12-07 2018-05-07 Ενωσεις, συνθεσεις και μεθοδοι με χρηση ανταγωνιστων σελεκτινης ε για κινητοποιηση αιμοποιητικων κυτταρων

Country Status (15)

Country Link
US (1) US9867841B2 (el)
EP (1) EP2928476B1 (el)
JP (2) JP6392773B2 (el)
CN (1) CN104837492B (el)
AU (1) AU2013355238B2 (el)
CA (1) CA2891514C (el)
CY (1) CY1120201T1 (el)
DK (1) DK2928476T3 (el)
ES (1) ES2668045T3 (el)
HU (1) HUE038423T2 (el)
LT (1) LT2928476T (el)
PL (1) PL2928476T3 (el)
PT (1) PT2928476T (el)
SI (1) SI2928476T1 (el)
WO (1) WO2014089269A1 (el)

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AU2012358150B2 (en) * 2011-12-22 2017-07-20 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
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CN105524927A (zh) * 2016-02-28 2016-04-27 汪晓明 一种用于造血干细胞分离的适配子及其试剂盒
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
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JP7069136B2 (ja) 2016-10-07 2022-05-17 グリコミメティクス， インコーポレイテッド 極めて強力な多量体ｅ－セレクチンアンタゴニスト
US11197877B2 (en) 2017-03-15 2021-12-14 Glycomimetics. Inc. Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
US11712446B2 (en) 2017-11-30 2023-08-01 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
EP3732186A1 (en) * 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
CN111867601A (zh) 2018-03-05 2020-10-30 糖模拟物有限公司 用于治疗急性髓系白血病及相关病症的方法
EP3893936A2 (en) * 2018-12-10 2021-10-20 GlycoMimetics, Inc. Methods of treating hiv and aids and the elimination of latent reservoirs of hiv infection using selectin, galectin, and siglec antagonists
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
EP4017863A1 (en) 2019-08-20 2022-06-29 GlycoMimetics, Inc. Process for preparing an e-selectin inhibitor intermediate
US20240140976A1 (en) * 2021-02-18 2024-05-02 Glycomimetics, Inc. Process for preparing an e-selectin inhibitor intermediate

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