CY1119364T1 - Φαρμακοτεχνικες μορφες(ζ)-2-κυανο-3-υδροξυ-βουτ-2-ενοϊκο οξυ-(4'-τριφθορομεθυλοφαινυλο)-αμιδιου με βελτιωμενη σταθεροτητα - Google Patents
Φαρμακοτεχνικες μορφες(ζ)-2-κυανο-3-υδροξυ-βουτ-2-ενοϊκο οξυ-(4'-τριφθορομεθυλοφαινυλο)-αμιδιου με βελτιωμενη σταθεροτηταInfo
- Publication number
- CY1119364T1 CY1119364T1 CY20171100710T CY171100710T CY1119364T1 CY 1119364 T1 CY1119364 T1 CY 1119364T1 CY 20171100710 T CY20171100710 T CY 20171100710T CY 171100710 T CY171100710 T CY 171100710T CY 1119364 T1 CY1119364 T1 CY 1119364T1
- Authority
- CY
- Cyprus
- Prior art keywords
- amide
- enoic acid
- triffluoromethylphenyl
- kyano
- hydroxy
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
- UTNUDOFZCWSZMS-YFHOEESVSA-N teriflunomide Chemical compound C\C(O)=C(/C#N)C(=O)NC1=CC=C(C(F)(F)F)C=C1 UTNUDOFZCWSZMS-YFHOEESVSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/44—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
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- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η εφεύρεση αναφέρεται σε στερεές φαρμακευτικές συνθέσεις που περιέχουν (Ζ)-2-κυανο-3-υδροξυ-βουτ-2-ενοϊκό οξύ-(4'-τριφθορομεθυλοφαινυλο)-αμίδιο, καθώς επίσης σε μια διαδικασία για την παρασκευή των ιδίων, σε μεθόδους χρήσης τέτοιων συνθέσεων για τη θεραπεία υποκειμένων που υποφέρουν από αυτοάνοσες νόσους, συγκεκριμένα συστηματικό ερυθηματώδη λύκο ή χρόνια ασθένεια μοσχεύματος έναντι ξενιστή, πολλαπλή σκλήρυνση ή ρευματοειδή αρθρίτιδα.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09290716 | 2009-09-18 | ||
| US36338210P | 2010-07-12 | 2010-07-12 | |
| EP10752585.9A EP2477611B1 (en) | 2009-09-18 | 2010-09-14 | (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluormethylphenyl)-amide tablet formulations with improved stability |
| PCT/EP2010/063439 WO2011032929A1 (en) | 2009-09-18 | 2010-09-14 | (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluormethylphenyl)-amide tablet formulations with improved stability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119364T1 true CY1119364T1 (el) | 2018-02-14 |
Family
ID=41510564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100710T CY1119364T1 (el) | 2009-09-18 | 2017-07-04 | Φαρμακοτεχνικες μορφες(ζ)-2-κυανο-3-υδροξυ-βουτ-2-ενοϊκο οξυ-(4'-τριφθορομεθυλοφαινυλο)-αμιδιου με βελτιωμενη σταθεροτητα |
Country Status (40)
| Country | Link |
|---|---|
| US (5) | US20120172427A1 (el) |
| EP (1) | EP2477611B1 (el) |
| JP (1) | JP2013505213A (el) |
| KR (1) | KR101547880B1 (el) |
| CN (4) | CN102596184B (el) |
| AR (1) | AR078383A1 (el) |
| AU (2) | AU2010297357B2 (el) |
| BR (1) | BR112012006184B1 (el) |
| CA (1) | CA2772275A1 (el) |
| CL (1) | CL2015000047A1 (el) |
| CO (1) | CO6511244A2 (el) |
| CR (2) | CR20170078A (el) |
| CY (1) | CY1119364T1 (el) |
| DK (1) | DK2477611T3 (el) |
| DO (1) | DOP2012000070A (el) |
| ES (1) | ES2625731T3 (el) |
| GT (1) | GT201200075A (el) |
| HK (2) | HK1206245A1 (el) |
| HN (1) | HN2012000576A (el) |
| HR (1) | HRP20170904T1 (el) |
| HU (1) | HUE032963T2 (el) |
| IL (3) | IL218492A (el) |
| JO (1) | JO3327B1 (el) |
| LT (1) | LT2477611T (el) |
| MA (1) | MA33585B1 (el) |
| ME (1) | ME02765B (el) |
| MX (1) | MX336663B (el) |
| MY (1) | MY155613A (el) |
| NZ (2) | NZ598744A (el) |
| PE (2) | PE20152031A1 (el) |
| PL (1) | PL2477611T3 (el) |
| PT (1) | PT2477611T (el) |
| RS (1) | RS56074B1 (el) |
| RU (2) | RU2012115459A (el) |
| SI (1) | SI2477611T1 (el) |
| TN (1) | TN2012000061A1 (el) |
| TW (2) | TWI522130B (el) |
| UA (2) | UA115979C2 (el) |
| UY (1) | UY32889A (el) |
| WO (1) | WO2011032929A1 (el) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2012115459A (ru) * | 2009-09-18 | 2013-10-27 | Санофи | Таблетируюмый препарат (4'-трифторметилфенил)амида (z)-2-циано-3-гидрокси-бут-2-еноевой кислоты с улучшенной устойчивостью |
| RU2493845C1 (ru) * | 2012-06-07 | 2013-09-27 | Общество с ограниченной ответственностью "ВАЛЕНТА ИНТЕЛЛЕКТ" | Композиция для лечения рассеянного склероза (варианты) |
| AU2014352920A1 (en) * | 2013-11-22 | 2016-06-23 | Genzyme Corporation | Novel methods for treating neurodegenerative diseases |
| CN103656657A (zh) * | 2013-12-18 | 2014-03-26 | 北京科源创欣科技有限公司 | 特立氟胺药物组合物及制备方法 |
| AU2015238301B2 (en) | 2014-03-26 | 2020-06-25 | Astex Therapeutics Ltd | Combinations |
| US20160058730A1 (en) * | 2014-08-29 | 2016-03-03 | Cadila Healthcare Limited | Pharmaceutical compositions of teriflunomide |
| WO2016079687A1 (en) * | 2014-11-18 | 2016-05-26 | Lupin Limited | Oral pharmaceutical composition of teriflunomide |
| JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
| US20180147148A1 (en) | 2015-05-23 | 2018-05-31 | Ftf Pharma Private Limited | Pharmaceutical composition of teriflunomide |
| JP6917375B2 (ja) * | 2015-09-01 | 2021-08-11 | ザ・ブロード・インスティテュート・インコーポレイテッド | 血液がんの治療または予防に有用な化合物および方法 |
| WO2017037645A1 (en) * | 2015-09-02 | 2017-03-09 | Leiutis Pharmaceuticals Pvt Ltd | Stable pharmaceutical formulations of teriflunomide |
| WO2017056104A1 (en) * | 2015-09-28 | 2017-04-06 | Natco Pharma Limited | Stable pharmaceutical compositions of teriflunomide |
| WO2017125841A1 (en) * | 2016-01-20 | 2017-07-27 | Emcure Pharmaceuticals Limited | Pharmaceutical compositions of teriflunomide |
| JOP20190207A1 (ar) * | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
| US20220265612A1 (en) * | 2019-07-17 | 2022-08-25 | Cytokinetics, Inc. | Cardiac sarcomere inhibitor oral formulations |
| WO2022085015A1 (en) * | 2020-10-24 | 2022-04-28 | V-Ensure Pharma Technologies Private Limited | A solid oral composition of teriflunomide |
| GR1010137B (el) | 2020-12-15 | 2021-12-07 | Φαρματεν Α.Β.Ε.Ε., | Στερεη φαρμακοτεχνικη μορφη αμεσης αποδεσμευσης περιεχουσα τεριφλουνομιδη και μεθοδος παρασκευης αυτης |
| TR202022336A2 (tr) * | 2020-12-30 | 2022-07-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | A film coated tablet comprising teriflunomide |
| WO2024112298A1 (en) * | 2022-11-25 | 2024-05-30 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | A tablet comprising teriflunomide |
| EP4382097A1 (en) | 2022-11-25 | 2024-06-12 | Sanovel Ilac Sanayi Ve Ticaret A.S. | A tablet comprising teriflunomide |
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| TWI275029B (en) * | 2005-11-18 | 2007-03-01 | Hon Hai Prec Ind Co Ltd | An embedded system and method for processing data thereof |
| JP2009524658A (ja) | 2006-01-24 | 2009-07-02 | テバ ファーマシューティカル インダストリーズ リミティド | レベチラセタム製剤、及びそれらの製造方法 |
| DE102006017896A1 (de) * | 2006-04-13 | 2007-10-25 | Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg | Leflunomid enthaltende pharmazeutische Zusammensetzungen |
| EP1990048A3 (en) | 2007-05-08 | 2009-05-06 | Ulrike Wiebelitz | Therapy of benign prostatic hyperplasia (bph) |
| RU2012115459A (ru) * | 2009-09-18 | 2013-10-27 | Санофи | Таблетируюмый препарат (4'-трифторметилфенил)амида (z)-2-циано-3-гидрокси-бут-2-еноевой кислоты с улучшенной устойчивостью |
| EP2762135A1 (en) * | 2013-02-04 | 2014-08-06 | Sanofi | Methods for reducing the risk of an adverse teriflunomide and rosuvastatin interaction in multiple sclerosis patients |
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