CY1118975T1 - Παραγωγο μεταστινης και χρηση αυτου - Google Patents
Παραγωγο μεταστινης και χρηση αυτουInfo
- Publication number
- CY1118975T1 CY1118975T1 CY20171100265T CY171100265T CY1118975T1 CY 1118975 T1 CY1118975 T1 CY 1118975T1 CY 20171100265 T CY20171100265 T CY 20171100265T CY 171100265 T CY171100265 T CY 171100265T CY 1118975 T1 CY1118975 T1 CY 1118975T1
- Authority
- CY
- Cyprus
- Prior art keywords
- metastatin
- cancer
- derivative
- inhibitory effect
- secretion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Αποκαλύπτεται ένα σταθερό παράγωγο μεταστίνης που έχει εξαιρετικές βιολογικές δραστικότητες (π.χ., ανασταλτική δραστικότητα καρκινικής μετάστασης, ανασταλτική δραστικότητα πολλαπλασιασμού του καρκίνου, δραστικότητα προώθησης έκκρισης γοναδοτροπίνης, δραστικότητα προώθησης έκκρισης ορμονών του φύλου). Ένα παράγωγο μεταστίνης που παράγεται με υποκατάσταση ενός συστατικού αμινοξέος σε μεταστίνη μπορεί να βελτιωθεί σε σταθερότητα στο αίμα και μπορεί να έχει μια εξαιρετική ανασταλτική δραστικότητα καρκινικής μετάστασης, μια εξαιρετική ανασταλτική δραστικότητα πολλαπλασιασμού του καρκίνου, μια εξαιρετική ανασταλτική δραστικότητα έκκρισης γοναδοτροπίνης, μια εξαιρετική ανασταλτική δραστικότητα έκκρισης ορμονών του φύλου και τα παρόμοια με την πρόσδεση του παραγώγου μεταστίνης σε πολυαιθυλενογλυκόλη.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008196598 | 2008-07-30 | ||
PCT/JP2009/063533 WO2010013762A1 (ja) | 2008-07-30 | 2009-07-29 | メタスチン誘導体およびその用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118975T1 true CY1118975T1 (el) | 2018-01-10 |
Family
ID=41610461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100265T CY1118975T1 (el) | 2008-07-30 | 2017-02-28 | Παραγωγο μεταστινης και χρηση αυτου |
Country Status (13)
Country | Link |
---|---|
US (1) | US20110212890A1 (el) |
EP (2) | EP3210998A1 (el) |
JP (1) | JP5698977B2 (el) |
CY (1) | CY1118975T1 (el) |
DK (1) | DK2314609T3 (el) |
ES (1) | ES2617657T3 (el) |
HR (1) | HRP20170319T1 (el) |
HU (1) | HUE030900T2 (el) |
LT (1) | LT2314609T (el) |
PL (1) | PL2314609T3 (el) |
PT (1) | PT2314609T (el) |
SI (1) | SI2314609T1 (el) |
WO (1) | WO2010013762A1 (el) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8592379B2 (en) * | 2008-04-30 | 2013-11-26 | Kyoto University | Metastin derivative and use thereof |
JP5455661B2 (ja) | 2009-01-29 | 2014-03-26 | ギガフォトン株式会社 | 極端紫外光源装置 |
WO2013017631A1 (en) | 2011-08-04 | 2013-02-07 | Msd Oss B.V. | Kisspeptide-pentasaccharide conjugates |
EP3518952A1 (en) | 2016-09-30 | 2019-08-07 | Myovant Sciences GmbH | Methods of treating female infertility |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE50892B1 (en) | 1980-02-11 | 1986-08-06 | Novo Industri As | Process for preparing insulin esters |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
JP4486187B2 (ja) | 1998-10-27 | 2010-06-23 | 武田薬品工業株式会社 | 新規g蛋白質共役型レセプター蛋白質、そのdnaおよびそのリガンド |
US6638906B1 (en) * | 1999-12-13 | 2003-10-28 | Nobex Corporation | Amphiphilic polymers and polypeptide conjugates comprising same |
CN1411509A (zh) * | 1999-12-17 | 2003-04-16 | 武田药品工业株式会社 | Kiss-1肽的制造方法 |
WO2001075104A1 (fr) | 2000-03-30 | 2001-10-11 | Takeda Chemical Industries, Ltd. | Nouvelle proteine, adn codant pour celle-ci, et son procede de production |
WO2002085399A1 (en) | 2001-04-20 | 2002-10-31 | Takeda Chemical Industries, Ltd. | Peptide-containing preparations |
EP1428835B1 (en) * | 2001-09-19 | 2007-04-18 | Takeda Pharmaceutical Company Limited | Antibody against metastin and use of the same in the diagnosis of pregnancy |
US20050176091A1 (en) * | 2002-01-11 | 2005-08-11 | Takao Yamada | Process for producing kiss-1 peptide |
WO2004035089A1 (ja) * | 2002-10-09 | 2004-04-29 | Kyowa Hakko Kogyo Co., Ltd. | ホルモン依存性癌の治療剤 |
JP4804714B2 (ja) * | 2002-12-26 | 2011-11-02 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
US20060241051A1 (en) * | 2002-12-26 | 2006-10-26 | Chieko Kitada | Metastin derivatives and use thereof |
US6800611B2 (en) | 2003-01-06 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Metastin derivatives and their use |
US7754220B2 (en) * | 2003-03-12 | 2010-07-13 | Takeda Pharmaceutical Company Limited | Methods of inhibiting secretion of follicle-stimulating hormone and testosterone |
EP1750513A4 (en) * | 2004-04-23 | 2009-07-22 | Serono Lab | USE OF GPCR54 LIGANDS FOR THE TREATMENT OF INFERTILITY |
AR049938A1 (es) | 2004-06-25 | 2006-09-13 | Takeda Pharmaceutical | Derivados de metastina y utilizacion de los mismos |
WO2007084211A2 (en) * | 2005-11-11 | 2007-07-26 | The General Hospital Corporation | Use of gpr54 ligands for treatment of reproductive disorders, proliferative disorders, and for contraception |
US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
US8404643B2 (en) * | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
US20090099334A1 (en) * | 2005-12-22 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
AR058584A1 (es) * | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
EP1999143B1 (en) * | 2006-03-20 | 2011-07-13 | Merck Sharp & Dohme Corp. | Neuromedin u receptor agonists and uses thereof |
AU2007231553B2 (en) * | 2006-03-28 | 2012-10-25 | Molecular Discovery Systems | Agent for the treatment of hormone-dependent disorders and uses thereof |
JP5279021B2 (ja) | 2006-04-26 | 2013-09-04 | 国立大学法人京都大学 | Gpr54アゴニスト活性を有する新規化合物 |
JO3048B1 (ar) | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
JP4906476B2 (ja) | 2006-11-06 | 2012-03-28 | 株式会社ブリヂストン | タイヤ加硫モールドの洗浄方法 |
JP2009058102A (ja) | 2007-09-03 | 2009-03-19 | Akebono Brake Ind Co Ltd | パッドクリップ及び多板ディスクブレーキ |
WO2009044918A1 (ja) * | 2007-10-05 | 2009-04-09 | Takeda Pharmaceutical Company Limited | ニューロメジンu誘導体 |
-
2009
- 2009-07-29 WO PCT/JP2009/063533 patent/WO2010013762A1/ja active Application Filing
- 2009-07-29 EP EP16196765.8A patent/EP3210998A1/en not_active Withdrawn
- 2009-07-29 US US13/056,297 patent/US20110212890A1/en not_active Abandoned
- 2009-07-29 LT LTEP09803004.2T patent/LT2314609T/lt unknown
- 2009-07-29 PL PL09803004T patent/PL2314609T3/pl unknown
- 2009-07-29 EP EP09803004.2A patent/EP2314609B1/en active Active
- 2009-07-29 DK DK09803004.2T patent/DK2314609T3/en active
- 2009-07-29 HU HUE09803004A patent/HUE030900T2/en unknown
- 2009-07-29 JP JP2010522744A patent/JP5698977B2/ja active Active
- 2009-07-29 SI SI200931623A patent/SI2314609T1/sl unknown
- 2009-07-29 ES ES09803004.2T patent/ES2617657T3/es active Active
- 2009-07-29 PT PT98030042T patent/PT2314609T/pt unknown
-
2017
- 2017-02-27 HR HRP20170319TT patent/HRP20170319T1/hr unknown
- 2017-02-28 CY CY20171100265T patent/CY1118975T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
LT2314609T (lt) | 2017-04-10 |
PL2314609T3 (pl) | 2017-07-31 |
EP3210998A1 (en) | 2017-08-30 |
HRP20170319T1 (hr) | 2017-05-05 |
EP2314609B1 (en) | 2016-11-30 |
EP2314609A4 (en) | 2013-01-16 |
ES2617657T3 (es) | 2017-06-19 |
DK2314609T3 (en) | 2017-03-13 |
US20110212890A1 (en) | 2011-09-01 |
SI2314609T1 (sl) | 2017-05-31 |
WO2010013762A1 (ja) | 2010-02-04 |
JP5698977B2 (ja) | 2015-04-08 |
JPWO2010013762A1 (ja) | 2012-01-12 |
EP2314609A1 (en) | 2011-04-27 |
HUE030900T2 (en) | 2017-06-28 |
PT2314609T (pt) | 2017-03-06 |
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