CY1118518T1 - Αναστολεις της κινασης p38 μαp - Google Patents
Αναστολεις της κινασης p38 μαpInfo
- Publication number
- CY1118518T1 CY1118518T1 CY20171100002T CY171100002T CY1118518T1 CY 1118518 T1 CY1118518 T1 CY 1118518T1 CY 20171100002 T CY20171100002 T CY 20171100002T CY 171100002 T CY171100002 T CY 171100002T CY 1118518 T1 CY1118518 T1 CY 1118518T1
- Authority
- CY
- Cyprus
- Prior art keywords
- optionally substituted
- hydrogen
- group
- radical
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0608855A GB0608855D0 (en) | 2006-05-04 | 2006-05-04 | Inhibitors of MAP kinase enzymes |
| GB0613914A GB0613914D0 (en) | 2006-07-13 | 2006-07-13 | Inhibitors of p38 map kinase |
| PCT/GB2007/001596 WO2007129040A1 (en) | 2006-05-04 | 2007-05-01 | p38 MAP KINASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118518T1 true CY1118518T1 (el) | 2017-07-12 |
Family
ID=38268953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100002T CY1118518T1 (el) | 2006-05-04 | 2017-01-02 | Αναστολεις της κινασης p38 μαp |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8044211B2 (https=) |
| EP (1) | EP2013175B9 (https=) |
| JP (1) | JP5340918B2 (https=) |
| KR (1) | KR101429780B1 (https=) |
| CN (1) | CN102942520B (https=) |
| AU (1) | AU2007246869B2 (https=) |
| BR (1) | BRPI0711310B8 (https=) |
| CA (1) | CA2650970C (https=) |
| CY (1) | CY1118518T1 (https=) |
| DK (1) | DK2013175T5 (https=) |
| ES (1) | ES2605727T3 (https=) |
| HU (1) | HUE033281T2 (https=) |
| NZ (1) | NZ573348A (https=) |
| PT (1) | PT2013175T (https=) |
| WO (1) | WO2007129040A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| WO2008053131A1 (en) * | 2006-10-30 | 2008-05-08 | Chroma Therapeutics Ltd. | Hydroxamates as inhibitors of histone deacetylase |
| JP5140154B2 (ja) | 2007-06-27 | 2013-02-06 | アストラゼネカ・アクチエボラーグ | ピラジノン誘導体および肺疾患の処置におけるそれらの使用 |
| US20100267774A1 (en) * | 2007-11-07 | 2010-10-21 | Chroma Therapeutics Ltd. | P38 map kinase inhibitors |
| GB0803747D0 (en) | 2008-02-29 | 2008-04-09 | Martin | Enzyme and receptor modulation |
| JP5555186B2 (ja) * | 2008-02-29 | 2014-07-23 | クロマ セラピューティクス リミテッド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| CN102099036B (zh) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
| AR073711A1 (es) | 2008-10-01 | 2010-11-24 | Astrazeneca Ab | Derivados de isoquinolina |
| GB0903480D0 (en) | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
| GB201211310D0 (en) | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| PL3222616T3 (pl) * | 2012-10-17 | 2019-12-31 | Macrophage Pharma Limited | N-[2-{4-[6-amino-5-(2,4-difluorobenzoilo)-2-oksopirydyn-1(2h)-ylo]-3,5-difluorofenylo}etylo)-L-alaninian tert-butylu lub jego sól, hydrat lub solwat |
| GB201306901D0 (en) * | 2013-04-16 | 2013-05-29 | Chroma Therapeutics Ltd | Combination |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| GB201713975D0 (en) | 2017-08-31 | 2017-10-18 | Macrophage Pharma Ltd | Medical use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1487794A1 (en) * | 2002-03-14 | 2004-12-22 | Bayer Aktiengesellschaft | Monocyclic aroylpyridinones as antiinflammatory agents |
| AU2006243000B2 (en) * | 2005-05-05 | 2011-05-26 | Macrophage Pharma Limited | Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase |
| JP5555186B2 (ja) * | 2008-02-29 | 2014-07-23 | クロマ セラピューティクス リミテッド | ｐ３８ＭＡＰキナーゼ阻害剤 |
-
2007
- 2007-05-01 EP EP07732629.6A patent/EP2013175B9/en not_active Not-in-force
- 2007-05-01 WO PCT/GB2007/001596 patent/WO2007129040A1/en not_active Ceased
- 2007-05-01 JP JP2009508455A patent/JP5340918B2/ja not_active Expired - Fee Related
- 2007-05-01 AU AU2007246869A patent/AU2007246869B2/en not_active Ceased
- 2007-05-01 BR BRPI0711310A patent/BRPI0711310B8/pt not_active IP Right Cessation
- 2007-05-01 ES ES07732629.6T patent/ES2605727T3/es active Active
- 2007-05-01 KR KR1020087029538A patent/KR101429780B1/ko not_active Expired - Fee Related
- 2007-05-01 CA CA2650970A patent/CA2650970C/en not_active Expired - Fee Related
- 2007-05-01 DK DK07732629.6T patent/DK2013175T5/da active
- 2007-05-01 NZ NZ573348A patent/NZ573348A/en not_active IP Right Cessation
- 2007-05-01 US US12/299,333 patent/US8044211B2/en not_active Expired - Fee Related
- 2007-05-01 HU HUE07732629A patent/HUE033281T2/en unknown
- 2007-05-01 PT PT77326296T patent/PT2013175T/pt unknown
- 2007-05-01 CN CN201210457450.4A patent/CN102942520B/zh not_active Expired - Fee Related
-
2017
- 2017-01-02 CY CY20171100002T patent/CY1118518T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2013175T (pt) | 2017-02-14 |
| CN102942520A (zh) | 2013-02-27 |
| DK2013175T3 (en) | 2017-02-20 |
| HUE033281T2 (en) | 2017-11-28 |
| KR20090014187A (ko) | 2009-02-06 |
| CN102942520B (zh) | 2015-03-04 |
| AU2007246869B2 (en) | 2012-10-18 |
| NZ573348A (en) | 2012-01-12 |
| ES2605727T3 (es) | 2017-03-16 |
| US20090099185A1 (en) | 2009-04-16 |
| WO2007129040A1 (en) | 2007-11-15 |
| CA2650970C (en) | 2014-09-16 |
| US8044211B2 (en) | 2011-10-25 |
| AU2007246869A1 (en) | 2007-11-15 |
| DK2013175T5 (da) | 2020-12-21 |
| BRPI0711310B8 (pt) | 2021-05-25 |
| EP2013175B9 (en) | 2020-11-11 |
| JP2009535385A (ja) | 2009-10-01 |
| JP5340918B2 (ja) | 2013-11-13 |
| CA2650970A1 (en) | 2007-11-15 |
| BRPI0711310A2 (pt) | 2011-12-06 |
| BRPI0711310B1 (pt) | 2020-12-15 |
| KR101429780B1 (ko) | 2014-08-18 |
| ES2605727T9 (es) | 2020-12-11 |
| EP2013175A1 (en) | 2009-01-14 |
| EP2013175B1 (en) | 2016-11-09 |
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