CY1118106T1 - Επιλεκτικοι ανταγωνιστες η4-υποδοχεα ισταμινης για τη θεραπεια των διαταραχων του αιθουσαιου συστηματος - Google Patents

Επιλεκτικοι ανταγωνιστες η4-υποδοχεα ισταμινης για τη θεραπεια των διαταραχων του αιθουσαιου συστηματος

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Publication number
CY1118106T1
CY1118106T1 CY20161101030T CY161101030T CY1118106T1 CY 1118106 T1 CY1118106 T1 CY 1118106T1 CY 20161101030 T CY20161101030 T CY 20161101030T CY 161101030 T CY161101030 T CY 161101030T CY 1118106 T1 CY1118106 T1 CY 1118106T1
Authority
CY
Cyprus
Prior art keywords
treatment
eythesian
histamin
competitors
receptors
Prior art date
Application number
CY20161101030T
Other languages
English (en)
Inventor
Gilles Desmadryl
Christian Chabbert
Original Assignee
Inserm - Institut National De La Santé Et De La Recherche Médicale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inserm - Institut National De La Santé Et De La Recherche Médicale filed Critical Inserm - Institut National De La Santé Et De La Recherche Médicale
Publication of CY1118106T1 publication Critical patent/CY1118106T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση αναφέρεται στους ανταγωνιστές Η4-υποδοχέα ισταμίνης ή στους αναστολείς της έκφρασης γονιδίου του Η4-υποδοχέα ισταμίνης για τη θεραπεία και / ή την πρόληψη των διαταραχών του αιθουσαίου συστήματος.
CY20161101030T 2008-12-24 2016-10-13 Επιλεκτικοι ανταγωνιστες η4-υποδοχεα ισταμινης για τη θεραπεια των διαταραχων του αιθουσαιου συστηματος CY1118106T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20080306013 EP2201982A1 (en) 2008-12-24 2008-12-24 Histamine H4 receptor antagonists for the treatment of vestibular disorders
PCT/EP2009/067897 WO2010072829A1 (en) 2008-12-24 2009-12-23 Selective histamine h4 receptor antagonists for the treatment of vestibular disorders.
EP09798938.8A EP2382013B1 (en) 2008-12-24 2009-12-23 Selective histamine h4 receptor antagonists for the treatment of vestibular disorders.

Publications (1)

Publication Number Publication Date
CY1118106T1 true CY1118106T1 (el) 2017-06-28

Family

ID=40466853

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161101030T CY1118106T1 (el) 2008-12-24 2016-10-13 Επιλεκτικοι ανταγωνιστες η4-υποδοχεα ισταμινης για τη θεραπεια των διαταραχων του αιθουσαιου συστηματος

Country Status (20)

Country Link
US (2) US9526725B2 (el)
EP (3) EP2201982A1 (el)
JP (2) JP5814126B2 (el)
KR (1) KR101749285B1 (el)
CN (2) CN107050030A (el)
CA (1) CA2748159C (el)
CY (1) CY1118106T1 (el)
DK (1) DK2382013T3 (el)
ES (1) ES2597834T3 (el)
HK (1) HK1163571A1 (el)
HR (1) HRP20161290T1 (el)
HU (1) HUE031645T2 (el)
IL (1) IL213540A (el)
LT (1) LT2382013T (el)
PL (1) PL2382013T3 (el)
PT (1) PT2382013T (el)
RU (1) RU2589846C2 (el)
SI (1) SI2382013T1 (el)
SM (1) SMT201600368B (el)
WO (1) WO2010072829A1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9688989B2 (en) * 2012-06-08 2017-06-27 Sensorion H4 receptor inhibitors for treating tinnitus
CN105017385B (zh) * 2015-07-02 2018-08-03 吉林大学 基于模拟人组胺受体4（hr4）表位的疫苗及其构建方法
JP7274473B2 (ja) 2017-10-17 2023-05-16 パラウ ファルマ，エス．エル．ユー． ４－アミノピリミジン化合物の合成

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Also Published As

Publication number Publication date
US20170056397A1 (en) 2017-03-02
RU2012101595A (ru) 2013-07-27
CA2748159A1 (en) 2010-07-01
EP2382013A1 (en) 2011-11-02
CA2748159C (en) 2017-06-27
HRP20161290T1 (hr) 2016-11-18
PL2382013T3 (pl) 2017-01-31
DK2382013T3 (en) 2016-11-14
KR101749285B1 (ko) 2017-06-20
IL213540A0 (en) 2011-07-31
ES2597834T3 (es) 2017-01-23
US10195195B2 (en) 2019-02-05
EP2201982A1 (en) 2010-06-30
LT2382013T (lt) 2016-10-25
JP2016041694A (ja) 2016-03-31
EP2382013B1 (en) 2016-07-13
WO2010072829A1 (en) 2010-07-01
IL213540A (en) 2015-10-29
EP3130376A1 (en) 2017-02-15
RU2589846C2 (ru) 2016-07-10
HK1163571A1 (zh) 2012-09-14
CN102325566A (zh) 2012-01-18
KR20110117661A (ko) 2011-10-27
US9526725B2 (en) 2016-12-27
PT2382013T (pt) 2016-10-25
SI2382013T1 (sl) 2017-02-28
JP5814126B2 (ja) 2015-11-17
CN107050030A (zh) 2017-08-18
HUE031645T2 (en) 2017-07-28
SMT201600368B (it) 2016-11-10
US20120039913A1 (en) 2012-02-16
JP2012513968A (ja) 2012-06-21

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