CY1117826T1 - Ενωσεις μορφiνανης - Google Patents
Ενωσεις μορφiνανηςInfo
- Publication number
- CY1117826T1 CY1117826T1 CY20161100624T CY161100624T CY1117826T1 CY 1117826 T1 CY1117826 T1 CY 1117826T1 CY 20161100624 T CY20161100624 T CY 20161100624T CY 161100624 T CY161100624 T CY 161100624T CY 1117826 T1 CY1117826 T1 CY 1117826T1
- Authority
- CY
- Cyprus
- Prior art keywords
- present disclosure
- diseases
- morfinanis
- units
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/493—Physical analysis of biological material of liquid biological material urine
Abstract
Η παρούσα αποκάλυψη αφορά καινούριες ενώσεις της μορφινάνης και παράγωγά τους, καθώς και φαρμακευτικά αποδεκτά άλατα, επιδιαλυτώματα και υδρίτες αυτών. Η παρούσα αποκάλυψη προβλέπει επίσης συνθέσεις αποτελούμενες από κάποια ένωση της παρούσας αποκάλυψης και τη χρήση τέτοιων συνθέσεων σε μεθόδους για την αντιμετώπιση νοσημάτων και παθήσεων οι οποίες είχαν επωφελώς αντιμετωπιστεί με τη χορήγηση κάποιου αγωνιστή υποδοχέα σ1, ο οποίος έχει επίσης και ενεργότητα ανταγωνιστή NMDA.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91513007P | 2007-05-01 | 2007-05-01 | |
US91666207P | 2007-05-08 | 2007-05-08 | |
US97604407P | 2007-09-28 | 2007-09-28 | |
EP11000764.8A EP2357183B1 (en) | 2007-05-01 | 2008-04-30 | Morphinan compounds |
EP08747238A EP2152709B1 (en) | 2007-05-01 | 2008-04-30 | Morphinan compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117826T1 true CY1117826T1 (el) | 2017-05-17 |
Family
ID=51894365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100624T CY1117826T1 (el) | 2007-05-01 | 2016-07-05 | Ενωσεις μορφiνανης |
Country Status (15)
Country | Link |
---|---|
US (6) | US9314440B2 (el) |
EP (5) | EP3093290B1 (el) |
BR (1) | BRPI0811478B8 (el) |
CA (3) | CA2945581C (el) |
CY (1) | CY1117826T1 (el) |
DK (4) | DK2522668T3 (el) |
ES (5) | ES2577477T3 (el) |
FI (1) | FI3825306T3 (el) |
HK (5) | HK1178154A1 (el) |
HR (5) | HRP20230745T3 (el) |
HU (3) | HUE063526T2 (el) |
LT (1) | LT3825306T (el) |
PL (3) | PL2792662T3 (el) |
PT (5) | PT2792662T (el) |
SI (2) | SI3825306T1 (el) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE063526T2 (hu) | 2007-05-01 | 2024-01-28 | Concert Pharmaceuticals Ind Inc | Morfinvegyületek |
MX341177B (es) * | 2007-05-01 | 2016-08-10 | Concert Pharmaceuticals Inc | Compuestos de morfina. |
WO2017020002A1 (en) * | 2015-07-30 | 2017-02-02 | Concert Pharmaceuticals, Inc. | Deuterated morphinan compounds for use in treating agitation |
CA2994153A1 (en) * | 2015-07-30 | 2017-02-02 | Concert Pharmaceuticals, Inc. | Deuterated morphinan compounds for use in treating agitation |
WO2017064876A1 (ja) | 2015-10-14 | 2017-04-20 | 学校法人 久留米大学 | グレリンを有効成分として含有するレット症候群(rtt)の予防・治療剤 |
EP3570842A1 (en) | 2017-01-19 | 2019-11-27 | Donald Danforth Plant Science Center | Morphinan n-demethylase isolated from themethylobacterium |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US38115A (en) | 1863-04-07 | Improvement in turning edges of plates or metal sheets | ||
GB713146A (en) | 1951-10-18 | 1954-08-04 | Roche Products Ltd | Anti-cough agents comprising (ú½)-3-hydroxy-n-methyl-morphinane ethers and process for the manufacture thereof |
US4316888A (en) | 1980-04-15 | 1982-02-23 | Nelson Research & Development Co. | Method and composition of reducing pain |
US4446140A (en) | 1981-12-10 | 1984-05-01 | Nelson Research & Development Company | Method and composition for treating mouth pain |
JPS6089474A (ja) | 1983-10-20 | 1985-05-20 | Toyo Pharma- Kk | モルフイナン誘導体,その製造方法,及び該化合物を含有する抗腫瘍剤 |
US4694010A (en) | 1985-08-16 | 1987-09-15 | New York University | Anticonvulsant compositions and method |
US4898860A (en) | 1985-08-16 | 1990-02-06 | New York University | Anticonvulsant composition and method |
US4994467A (en) | 1989-05-31 | 1991-02-19 | Zimmerman Andrew W | Treating autism and other developmental disorders in children with NMDA receptor antagonists |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5366980A (en) | 1991-06-17 | 1994-11-22 | Smith Richard A | Use of dextromethorphan and an oxidase inhibitor to treat dermatitis |
US5166207A (en) | 1991-06-17 | 1992-11-24 | Neurotherapeutics, Inc. | Method for enhancing the systemic delivery of dextromethorphan for the treatment of neurological disorders |
US5350756A (en) | 1991-06-17 | 1994-09-27 | Smith Richard A | Use of a cytochrome oxidase inhibitor to increase the cough-suppressing activity of dextromorphan |
US5336980A (en) | 1992-12-10 | 1994-08-09 | Leopold Kostal Gmbh & Co. | Apparatus and method for controlling a windshield wiping system |
US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
KR20040068613A (ko) | 1994-03-25 | 2004-07-31 | 이소테크니카 인코포레이티드 | 중수소화된 화합물 이를 포함하는 고혈압 치료용 조성물 |
USRE38115E1 (en) | 1994-09-22 | 2003-05-06 | Center For Neurologic Study | Dextromethorphan and an oxidase inhibitor for treating intractable conditions |
US5605911A (en) | 1995-01-31 | 1997-02-25 | Washington University | Use of alpha-2 adrenergic drugs to prevent adverse effects of NMDA receptor hypofunction (NRH) |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US6197830B1 (en) | 1995-09-22 | 2001-03-06 | Bruce M. Frome | Method for achieving relief from sympathetically mediated pain |
AUPN605795A0 (en) | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
CH690817A5 (de) | 1996-09-03 | 2001-01-31 | Flachsmann Ag Emil | Verfahren zur Herstellung eines stabilen, homogenen, von Folgeprodukten freien oder nahezu freien Extraktes. |
US6187782B1 (en) | 1997-03-27 | 2001-02-13 | Toray Industries, Inc. | Morphinane derivatives and medicinal use thereof |
US6884429B2 (en) | 1997-09-05 | 2005-04-26 | Isotechnika International Inc. | Medical devices incorporating deuterated rapamycin for controlled delivery thereof |
EP1051163A2 (en) | 1998-01-29 | 2000-11-15 | Sepracor, Inc. | Methods and compositions for aiding in smoking cessation and for treating pain and other disorders using optically pure (-)-bupropion |
US6110973A (en) | 1998-01-29 | 2000-08-29 | Sepracor | Methods for treating obesity and weight gain using optically pure (-)-bupropion |
US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
GB2355191A (en) | 1999-10-12 | 2001-04-18 | Laxdale Ltd | Combination formulations for fatigue, head injury and strokes |
GB9925962D0 (en) | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
DE60001623T2 (de) | 1999-12-03 | 2003-12-18 | Pfizer Prod Inc | Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
US6362226B2 (en) | 1999-12-08 | 2002-03-26 | Vanderbilt University | Modulation of in vivo glutamine and glycine levels in the treatment of autism |
US20050129783A1 (en) | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
US6780871B2 (en) | 2001-01-29 | 2004-08-24 | Albany Medical College | Methods and compositions for treating addiction disorders |
US20040087479A1 (en) | 2001-04-30 | 2004-05-06 | Sosnowski Robert E. | Composition and method for reducing the risk or progression of cardiovascular, glaucoma, tardive dyskinesia and other diseases |
US6583152B2 (en) | 2001-04-30 | 2003-06-24 | Dexgen Pharmaceuticals, Inc. | Composition for reducing the risk or progression of cardiovascular diseases |
JP4101661B2 (ja) | 2001-05-03 | 2008-06-18 | エフ.ホフマン−ラ ロシュ アーゲー | 非晶質メシル酸ネルフィナビルの製薬剤形 |
CA2446904A1 (en) | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
UA77234C2 (en) | 2001-12-05 | 2006-11-15 | Wyeth Corp | Monohydrate of venlafaxine hydrochloride and methods for its preparation (variants) |
MXPA04011327A (es) | 2002-05-17 | 2005-08-15 | Jenken Biosciences Inc | Opioides y compuestos similares a opioides y usos de los mismos. |
TWI326214B (en) | 2002-07-17 | 2010-06-21 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
DE102004009445A1 (de) | 2004-02-27 | 2005-09-29 | Chemetall Gmbh | Verfahren zur Herstellung von Alkyllithiumverbindungen und Aryllithiumverbindungen durch Reaktionsverfolgung mittels IR-Spektroskopie |
CA2576232C (en) | 2004-05-14 | 2009-10-27 | Green Cross Corp. | Neuroprotective properties of dextrorotatory morphinans |
JP2008514706A (ja) | 2004-09-29 | 2008-05-08 | コーディス・コーポレイション | 安定非晶質ラパマイシン様化合物の薬学的投与形態 |
US20070191411A1 (en) | 2004-10-07 | 2007-08-16 | Smith Richard A | Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor |
US7114547B2 (en) | 2005-01-11 | 2006-10-03 | Sullivan Michael R | Casting ring |
AU2006274037B2 (en) | 2005-07-26 | 2012-04-26 | Takeda Gmbh | Isotopically substituted pantoprazole |
JP5301991B2 (ja) | 2005-07-29 | 2013-09-25 | コンサート ファーマシューティカルズ インコーポレイテッド | 新規なベンゾ[d][1,3]−ジオキソール誘導体 |
CN101309917B (zh) | 2005-10-06 | 2013-09-11 | 奥斯拜客斯制药有限公司 | 具有增强治疗性质的胃h+,k+-atp酶氘代抑制剂 |
US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
AU2007285845A1 (en) | 2006-08-16 | 2008-02-21 | Auspex Pharmaceuticals, Inc. | Preparation and utility of opioid analgesics |
WO2008030382A1 (en) | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
WO2008097924A2 (en) | 2007-02-05 | 2008-08-14 | Avanir Pharmaceuticals | Pharmaceutical compositions comprising dextromethorphan analogs for the treatment of neurological disorders |
HUE063526T2 (hu) | 2007-05-01 | 2024-01-28 | Concert Pharmaceuticals Ind Inc | Morfinvegyületek |
CN102964302B (zh) | 2007-05-01 | 2015-10-21 | 康塞特医药品公司 | 吗啡烷化合物 |
PL3248978T3 (pl) | 2008-09-19 | 2019-12-31 | Concert Pharmaceuticals Inc. | Zdeuterowane związki morfinanu |
US20120083487A1 (en) | 2008-10-30 | 2012-04-05 | Amanda Thomas | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurolgical diseases, intractable and chronic pain and brain injury |
JP6525419B2 (ja) | 2015-01-15 | 2019-06-05 | 株式会社半導体エネルギー研究所 | 二次電池 |
-
2008
- 2008-04-30 HU HUE20200633A patent/HUE063526T2/hu unknown
- 2008-04-30 PL PL14173190.1T patent/PL2792662T3/pl unknown
- 2008-04-30 SI SI200832212T patent/SI3825306T1/sl unknown
- 2008-04-30 CA CA2945581A patent/CA2945581C/en active Active
- 2008-04-30 ES ES14173190.1T patent/ES2577477T3/es active Active
- 2008-04-30 HU HUE11000764A patent/HUE025569T2/en unknown
- 2008-04-30 SI SI200831620A patent/SI2792662T1/sl unknown
- 2008-04-30 ES ES12176544.0T patent/ES2536984T3/es active Active
- 2008-04-30 BR BRPI0811478A patent/BRPI0811478B8/pt active IP Right Grant
- 2008-04-30 EP EP16163718.6A patent/EP3093290B1/en active Active
- 2008-04-30 FI FIEP20200633.4T patent/FI3825306T3/fi active
- 2008-04-30 PT PT141731901T patent/PT2792662T/pt unknown
- 2008-04-30 EP EP14173190.1A patent/EP2792662B1/en active Active
- 2008-04-30 HU HUE14173190A patent/HUE029782T2/en unknown
- 2008-04-30 CA CA3208128A patent/CA3208128A1/en active Pending
- 2008-04-30 DK DK12176544.0T patent/DK2522668T3/en active
- 2008-04-30 CA CA3056205A patent/CA3056205C/en active Active
- 2008-04-30 DK DK20200633.4T patent/DK3825306T3/da active
- 2008-04-30 ES ES12176476.5T patent/ES2523286T3/es active Active
- 2008-04-30 PT PT121765440T patent/PT2522668E/pt unknown
- 2008-04-30 PT PT121764765T patent/PT2522667E/pt unknown
- 2008-04-30 EP EP20200633.4A patent/EP3825306B8/en active Active
- 2008-04-30 HR HRP20230745TT patent/HRP20230745T3/hr unknown
- 2008-04-30 PT PT110007648T patent/PT2357183E/pt unknown
- 2008-04-30 PT PT202006334T patent/PT3825306T/pt unknown
- 2008-04-30 PL PL20200633.4T patent/PL3825306T3/pl unknown
- 2008-04-30 DK DK11000764.8T patent/DK2357183T3/en active
- 2008-04-30 LT LTEP20200633.4T patent/LT3825306T/lt unknown
- 2008-04-30 EP EP17206213.5A patent/EP3357923B1/en active Active
- 2008-04-30 EP EP11000764.8A patent/EP2357183B1/en active Active
- 2008-04-30 ES ES11000764.8T patent/ES2545617T3/es active Active
- 2008-04-30 DK DK14173190.1T patent/DK2792662T3/da active
- 2008-04-30 ES ES20200633T patent/ES2951028T3/es active Active
- 2008-04-30 PL PL11000764T patent/PL2357183T3/pl unknown
-
2010
- 2010-07-22 HK HK13105154.6A patent/HK1178154A1/xx unknown
- 2010-07-22 HK HK11109620.6A patent/HK1155442A1/xx unknown
- 2010-07-22 HK HK13105601.5A patent/HK1178889A1/xx unknown
- 2010-07-22 HK HK15101294.4A patent/HK1201058A1/zh unknown
-
2014
- 2014-07-17 US US14/334,227 patent/US9314440B2/en active Active
- 2014-09-22 HR HRP20140903AT patent/HRP20140903T1/hr unknown
-
2015
- 2015-07-24 HR HRP20150809TT patent/HRP20150809T1/hr unknown
- 2015-08-10 HR HRP20150848TT patent/HRP20150848T1/hr unknown
-
2016
- 2016-03-11 US US15/068,404 patent/US9868976B2/en active Active
- 2016-05-16 HR HRP20160521TT patent/HRP20160521T8/hr unknown
- 2016-07-05 CY CY20161100624T patent/CY1117826T1/el unknown
-
2017
- 2017-05-02 HK HK19101064.8A patent/HK1259133A1/zh unknown
- 2017-12-12 US US15/839,387 patent/US20180327809A1/en not_active Abandoned
-
2020
- 2020-12-14 US US17/120,880 patent/US11473123B2/en active Active
-
2022
- 2022-09-12 US US17/942,555 patent/US20240093265A1/en active Pending
-
2023
- 2023-04-25 US US18/306,710 patent/US20240117407A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1117826T1 (el) | Ενωσεις μορφiνανης | |
ATE546449T1 (de) | Morphinanverbindungen | |
CY1118721T1 (el) | Παραγωγα 2,3 διϋδρο-1η-ινδεν-1-υλ-2,7-διαζασπειρο[3.6]εννεανιου και η χρηση αυτων ως ανταγωνιστες ή αντιστροφοι αγωνιστες του υποδοχεα γκρελινης | |
CY1109860T1 (el) | Παραγοντες υποδοχεα ισταμινης η3, παρασκευη και θεραπευτικες χρησεις | |
EA201690033A3 (ru) | Морфинановые соединения | |
EA201001724A1 (ru) | Производные изоксазола и их применение в качестве потенциирующих средств для метаботропных глутаматных рецепторов | |
CY1117584T1 (el) | Παραγωγα 1-βενζυλ-3-υδροξυμεθυλινδαζολης και η χρηση τους στη θεραπευτικη αντιμετωπιση νοσων που βασιζονται στην εκφραση των mcp-1, cx3cr1 | |
CY1115262T1 (el) | Ανταγωνιστες trpv1 και χρησεις αυτων | |
DK1856090T3 (da) | Substituerede thiophen-derivater som glucagon-receptorantagonister, fremstilling og terapeutiske anvendelser | |
EA200970341A1 (ru) | Пиразолиновые соединения в качестве антагонистов минералокортикоидных рецепторов | |
EA200700365A1 (ru) | Производные индол-2-карбоксамидина как антагонисты nmda рецептора | |
ATE466842T1 (de) | 3-substituierte pyridinderivate als h3- antagonisten | |
EP2328414A4 (en) | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES | |
MX2010006230A (es) | Derivados de arilamida substituidos con triazol y su uso como antagonistas de receptor purinergico p2x3 y/o p2x2/3. | |
CY1118314T1 (el) | Συνδυασμοι αγωνιστων υποδοχεα σεροτονινης για την αγωγη κινητικων διαταραχων | |
CY1113504T1 (el) | Παραγωγο προπανο-1,3-διονης ή αλας αυτου | |
ATE399156T1 (de) | Neue indol- oder benzimidazol-derivate | |
ATE496918T1 (de) | Als a2b-adenosinrezeptorantagonisten geeignete 5- phenyl-6-pyridin-4-yl-1,3-dihydro-2h-imidazoä4, - büpyridin-2-onderivate | |
CY1124301T1 (el) | Ενωσεις ινδαζολης για χρηση σε κακωσεις του τενοντα ή/και των συνδεσμων | |
CY1109694T1 (el) | Παραγωγα πυρρολιδινης ως ανταγωνιστες υποδοχεα η3 ισταμινης | |
NO20055207L (no) | Oralt farmasoytisk preparat for protonpumpeantagonister | |
CO6300937A2 (es) | Derivados de 3-carboxipropil-aminotetralina y compuestos relacionados como antagonistas de receptores opioides mu | |
BRPI0906632A2 (pt) | Imidazolinil metil aril sulfonamidas | |
CY1115153T1 (el) | Μεθοδοι για την αγωγη δερματολογικων διαταραχων | |
EA201000720A1 (ru) | 4,4-дизамещённые пиперидины как ингибиторы ренина |