CY1117810T1 - Πολυμορφα ενος ανταγωνιστη υποδοχεα mglur5 - Google Patents
Πολυμορφα ενος ανταγωνιστη υποδοχεα mglur5Info
- Publication number
- CY1117810T1 CY1117810T1 CY20161100705T CY161100705T CY1117810T1 CY 1117810 T1 CY1117810 T1 CY 1117810T1 CY 20161100705 T CY20161100705 T CY 20161100705T CY 161100705 T CY161100705 T CY 161100705T CY 1117810 T1 CY1117810 T1 CY 1117810T1
- Authority
- CY
- Cyprus
- Prior art keywords
- mglur5
- receptor
- multiplicator
- treatment
- present
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με μονοθειικά και ημιθειικά άλατα της 2-χλωρο-4-[1-(4-φθορο-φαινυλο)-2,5-διμεθυλο-1Η-ιμιδαζολ-4-υλοαιθυνυλο]-πυριδίνης, με κρυσταλλικές και άμορφες μορφές αυτών και με τη χρήση τους σε φαρμακευτικές τυποποιήσεις. Οι ενώσεις της παρούσας εφεύρεσης είναι δραστικές στον υποδοχέα mGluR5, για τη θεραπευτική αντιμετώπιση παθήσεων που σχετίζονται με αυτόν τον υποδοχέα, όπως οξειών και/ή χρόνιων νευρολογικών διαταραχών, συγκεκριμένα του άγχους, ή για τη θεραπευτική αντιμετώπιση του χρόνιου και οξέος πόνου, την προστασία έναντι ηπατικής βλάβης, της ανεπάρκειας που προκαλείται είτε από φάρμακο είτε από πάθηση, της ακράτειας ούρων, της παχυσαρκίας, του συνδρόμου εύθραυστου Χ ή του αυτισμού.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87639806P | 2006-12-21 | 2006-12-21 | |
PCT/EP2007/063721 WO2008074697A1 (en) | 2006-12-21 | 2007-12-11 | Polymorphs of a mglur5 receptor antagonist |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117810T1 true CY1117810T1 (el) | 2017-05-17 |
Family
ID=39186951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100705T CY1117810T1 (el) | 2006-12-21 | 2016-07-19 | Πολυμορφα ενος ανταγωνιστη υποδοχεα mglur5 |
Country Status (33)
Country | Link |
---|---|
US (2) | US8063076B2 (el) |
EP (1) | EP2125779B1 (el) |
JP (1) | JP5405311B2 (el) |
KR (1) | KR101148580B1 (el) |
CN (1) | CN101568531B (el) |
AR (1) | AR064654A1 (el) |
AU (1) | AU2007336369B2 (el) |
BR (1) | BRPI0720954A2 (el) |
CA (1) | CA2673444C (el) |
CL (1) | CL2007003695A1 (el) |
CO (1) | CO6210731A2 (el) |
CY (1) | CY1117810T1 (el) |
DK (1) | DK2125779T3 (el) |
EC (1) | ECSP099431A (el) |
ES (1) | ES2577391T3 (el) |
HR (1) | HRP20160950T1 (el) |
HU (1) | HUE029324T2 (el) |
IL (1) | IL199181A (el) |
MA (1) | MA31008B1 (el) |
MX (1) | MX2009006694A (el) |
MY (1) | MY148217A (el) |
NO (1) | NO342451B1 (el) |
NZ (1) | NZ577440A (el) |
PE (1) | PE20081484A1 (el) |
PL (1) | PL2125779T3 (el) |
PT (1) | PT2125779T (el) |
RS (1) | RS54853B1 (el) |
RU (1) | RU2460728C2 (el) |
SI (1) | SI2125779T1 (el) |
TW (1) | TWI347320B (el) |
UA (1) | UA96970C2 (el) |
WO (1) | WO2008074697A1 (el) |
ZA (1) | ZA200904289B (el) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2125779B1 (en) | 2006-12-21 | 2016-04-27 | F. Hoffmann-La Roche AG | Polymorphs of a mglur5 receptor antagonist |
US20120039999A1 (en) * | 2010-08-11 | 2012-02-16 | Ashish Chatterji | Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists |
WO2012127393A1 (en) | 2011-03-18 | 2012-09-27 | Novartis Ag | COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE |
EP2837631A1 (en) * | 2013-08-14 | 2015-02-18 | Merck & Cie | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
GB201317022D0 (en) * | 2013-09-25 | 2013-11-06 | Addex Pharmaceuticals Sa | Polymorphs |
US10548985B2 (en) | 2014-01-10 | 2020-02-04 | Birdie Biopharmaceuticals, Inc. | Compounds and compositions for treating EGFR expressing tumors |
CN106943597A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技(北京)有限公司 | 用于治疗肿瘤的抗-egfr组合 |
CN108794467A (zh) | 2017-04-27 | 2018-11-13 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
CN116056701A (zh) * | 2020-06-05 | 2023-05-02 | 诺埃玛制药公司 | 治疗结节硬化复合症的方法 |
CN115989024A (zh) * | 2020-07-30 | 2023-04-18 | 诺埃玛制药公司 | 治疗三叉神经痛的方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3303199A (en) * | 1963-07-15 | 1967-02-07 | Geigy Chem Corp | Certain imidazolone derivatives and process for making same |
US3341548A (en) * | 1964-04-29 | 1967-09-12 | Hoffmann La Roche | Nitroimidazoles and their preparation |
DE2035905A1 (de) | 1970-07-20 | 1972-02-03 | Chemische Fabrik Stockhausen & Cie.,4150Krefeld | Imidazolverbindungen und deren Herstellungsverfahren |
CA1174673A (en) * | 1981-02-27 | 1984-09-18 | Walter Hunkeler | Imidazodiazepines |
EP0079312A3 (de) * | 1981-11-11 | 1984-04-25 | Ciba-Geigy Ag | Heterocyclische Acetylenverbindungen |
US4711962A (en) * | 1984-10-18 | 1987-12-08 | Stauffer Chemical Company | Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles |
WO1991000277A1 (en) | 1989-06-30 | 1991-01-10 | E.I. Du Pont De Nemours And Company | Substituted imidazoles |
TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
NZ502463A (en) | 1997-08-14 | 2002-05-31 | F | 1-Phenyl vinyl substituted imidazole, triazole or tetrazole derivatives useful for controlling or preventing acute or chronic neurological disorders |
AU780009B2 (en) | 1999-08-31 | 2005-02-24 | Merck Sharp & Dohme Corp. | Heterocyclic compounds and methods of use thereof |
DK1303495T3 (da) | 2000-07-24 | 2010-09-20 | Krenitsky Pharmaceuticals Inc | Substituerede 5-alkylnylpyrimidiner med neurotrofisk aktivitet |
WO2002046166A1 (en) | 2000-12-04 | 2002-06-13 | F. Hoffmann-La Roche Ag | Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists |
US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
US20040259917A1 (en) * | 2001-12-19 | 2004-12-23 | Cosford Nicholas D.P. | Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5 |
TWI292318B (en) | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
US7091222B2 (en) | 2003-07-03 | 2006-08-15 | Hoffmann-La Roche Inc. | Imidazole derivatives |
US7452909B2 (en) | 2003-09-04 | 2008-11-18 | Hoffman-La Roche Inc. | Imidazole derivatives |
CN1960984B (zh) * | 2004-06-01 | 2010-05-12 | 弗·哈夫曼-拉罗切有限公司 | 作为mglu5受体拮抗剂的吡啶-4-基-乙炔基-咪唑和吡唑 |
EP2125779B1 (en) | 2006-12-21 | 2016-04-27 | F. Hoffmann-La Roche AG | Polymorphs of a mglur5 receptor antagonist |
-
2007
- 2007-12-11 EP EP07857408.4A patent/EP2125779B1/en active Active
- 2007-12-11 HU HUE07857408A patent/HUE029324T2/en unknown
- 2007-12-11 BR BRPI0720954-1A patent/BRPI0720954A2/pt not_active Application Discontinuation
- 2007-12-11 MX MX2009006694A patent/MX2009006694A/es active IP Right Grant
- 2007-12-11 ES ES07857408.4T patent/ES2577391T3/es active Active
- 2007-12-11 DK DK07857408.4T patent/DK2125779T3/en active
- 2007-12-11 JP JP2009541986A patent/JP5405311B2/ja active Active
- 2007-12-11 CA CA2673444A patent/CA2673444C/en active Active
- 2007-12-11 RS RS20160461A patent/RS54853B1/sr unknown
- 2007-12-11 MY MYPI20092393A patent/MY148217A/en unknown
- 2007-12-11 KR KR1020097012810A patent/KR101148580B1/ko active IP Right Grant
- 2007-12-11 SI SI200731792A patent/SI2125779T1/sl unknown
- 2007-12-11 CN CN2007800475969A patent/CN101568531B/zh active Active
- 2007-12-11 NZ NZ577440A patent/NZ577440A/en unknown
- 2007-12-11 UA UAA200907474A patent/UA96970C2/ru unknown
- 2007-12-11 RU RU2009123135/04A patent/RU2460728C2/ru active
- 2007-12-11 PL PL07857408.4T patent/PL2125779T3/pl unknown
- 2007-12-11 PT PT78574084T patent/PT2125779T/pt unknown
- 2007-12-11 AU AU2007336369A patent/AU2007336369B2/en active Active
- 2007-12-11 WO PCT/EP2007/063721 patent/WO2008074697A1/en active Application Filing
- 2007-12-14 PE PE2007001802A patent/PE20081484A1/es not_active Application Discontinuation
- 2007-12-17 US US11/957,515 patent/US8063076B2/en active Active
- 2007-12-19 CL CL200703695A patent/CL2007003695A1/es unknown
- 2007-12-19 TW TW096148786A patent/TWI347320B/zh active
- 2007-12-21 AR ARP070105822A patent/AR064654A1/es not_active Application Discontinuation
-
2009
- 2009-06-04 IL IL199181A patent/IL199181A/en active IP Right Grant
- 2009-06-05 CO CO09058653A patent/CO6210731A2/es not_active Application Discontinuation
- 2009-06-15 EC EC2009009431A patent/ECSP099431A/es unknown
- 2009-06-17 MA MA32012A patent/MA31008B1/fr unknown
- 2009-06-18 ZA ZA200904289A patent/ZA200904289B/xx unknown
- 2009-06-19 NO NO20092357A patent/NO342451B1/no unknown
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2011
- 2011-10-14 US US13/273,266 patent/US8329912B2/en active Active
-
2016
- 2016-07-19 CY CY20161100705T patent/CY1117810T1/el unknown
- 2016-07-26 HR HRP20160950TT patent/HRP20160950T1/hr unknown
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