CY1117747T1 - Μεθοδος διαχωρισμου πυρηνωμενων κυτταρων που λαμβανονται απο μυελο οστου για σχηματισμο οστου - Google Patents
Μεθοδος διαχωρισμου πυρηνωμενων κυτταρων που λαμβανονται απο μυελο οστου για σχηματισμο οστουInfo
- Publication number
- CY1117747T1 CY1117747T1 CY20161100644T CY161100644T CY1117747T1 CY 1117747 T1 CY1117747 T1 CY 1117747T1 CY 20161100644 T CY20161100644 T CY 20161100644T CY 161100644 T CY161100644 T CY 161100644T CY 1117747 T1 CY1117747 T1 CY 1117747T1
- Authority
- CY
- Cyprus
- Prior art keywords
- bone
- bone marrow
- cells
- nucleated
- nucleated cells
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Materials For Medical Uses (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε μια μέθοδο για διαχωρισμό λαμβανομένων από μυελό οστού πυρηνωμένων κυττάρων για σχηματισμό οστού. Η μέθοδος περιλαμβάνει τα στάδια: έκπλυσης μυελού οστού• λύσης ερυθρών αιμοσφαιρίων στον μυελό οστού• εξουδετέρωσης του προϊόντος λύσης μυελού οστού• καθαρισμού των πυρηνωμένων κυττάρων από τον εξουδετερωμένο μυελό οστού και ανάμειξης των πυρηνωμένων κυττάρων με ρυθμιστικό συντήρησης για σχηματισμό οστού. Σύμφωνα προς την εφεύρεση, πυρηνωμένα κύτταρα που λαμβάνονται από μυελό οστού, τα οποία μπορεί να μεταμοσχεύονται εντός μιας θέσης που έχει ανάγκη σχηματισμού οστού ή θεραπείας ελαττώματος οστού, μπορεί να διαχωρίζονται με ταχύ και βολικό τρόπο. Ως αποτέλεσμα, σχηματισμός οστού σε ασθενείς έκτακτης ανάγκης ή σε ασθενείς οι οποίοι απαιτούν επανειλημμένες χειρουργικές επεμβάσεις, μπορεί να επιτυγχάνεται αποτελεσματικά με διαχωρισμό των πυρηνωμένων κυττάρων για σχηματισμό οστού σε χειρουργικές θέσεις με βολικό και ταχύ τρόπο και έγχυση των διαχωρισμένων κυττάρων εντός των ασθενών.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020060043936A KR100833793B1 (ko) | 2006-05-16 | 2006-05-16 | 골수 유래 골 생성용 유핵 세포 분리 방법 |
| PCT/KR2006/002434 WO2007132962A1 (en) | 2006-05-16 | 2006-06-23 | Separation method of nucleated cells derived from bone marrow for bone formation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117747T1 true CY1117747T1 (el) | 2017-05-17 |
Family
ID=38694041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100644T CY1117747T1 (el) | 2006-05-16 | 2016-07-07 | Μεθοδος διαχωρισμου πυρηνωμενων κυτταρων που λαμβανονται απο μυελο οστου για σχηματισμο οστου |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20090111087A1 (el) |
| EP (1) | EP2018419B1 (el) |
| JP (1) | JP2009537215A (el) |
| KR (1) | KR100833793B1 (el) |
| CN (1) | CN101432421A (el) |
| BR (1) | BRPI0621573A2 (el) |
| CY (1) | CY1117747T1 (el) |
| DK (1) | DK2018419T3 (el) |
| ES (1) | ES2585231T3 (el) |
| HR (1) | HRP20160966T1 (el) |
| HU (1) | HUE029896T2 (el) |
| PL (1) | PL2018419T3 (el) |
| PT (1) | PT2018419T (el) |
| RS (1) | RS54893B1 (el) |
| SG (2) | SG172595A1 (el) |
| SI (1) | SI2018419T1 (el) |
| WO (1) | WO2007132962A1 (el) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104774805A (zh) * | 2015-04-03 | 2015-07-15 | 银广悦 | 一种分离骨髓单个核细胞的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000503542A (ja) * | 1996-01-16 | 2000-03-28 | デピュイ オーソピーディック，インコーポレイテッド | 造血及び非造血組織からの前駆細胞の分離及び ｉｎ ｖｉｖｏ 骨及び軟骨再生におけるそれらの使用 |
| US5824084A (en) * | 1996-07-03 | 1998-10-20 | The Cleveland Clinic Foundation | Method of preparing a composite bone graft |
| AU769903B2 (en) * | 1999-05-28 | 2004-02-05 | Stemcell Technologies Canada Inc. | Method for separating cells using immunorosettes |
| JP3929283B2 (ja) * | 2000-11-08 | 2007-06-13 | シスメックス株式会社 | 骨髄有核細胞の分類計数方法 |
| US7049093B2 (en) * | 2000-11-08 | 2006-05-23 | Sysmex Corporation | Method of classifying and counting nucleated bone marrow cells |
| US6723131B2 (en) * | 2001-02-28 | 2004-04-20 | The Cleveland Clinic Foundation | Composite bone marrow graft material with method and kit |
| EP1412740B1 (en) * | 2001-07-27 | 2015-07-08 | Beckman Coulter, Inc. | Method for measurement of nucleated red blood cells |
| EP1451304A4 (en) * | 2001-11-07 | 2006-09-20 | Bioview Ltd | KITS AND METHODS FOR PREPARING CELLULAR SAMPLES OPTIMIZED FOR DUAL COLORING |
| KR20030085257A (ko) * | 2002-04-29 | 2003-11-05 | 주식회사 셀론텍 | 유핵세포 분리용 혈액백 및 이를 이용한 유핵세포 분리방법 |
| JP4087161B2 (ja) * | 2002-06-21 | 2008-05-21 | シスメックス株式会社 | リンパ球サブセットの異常を検出する方法 |
| US20060154309A1 (en) * | 2002-11-08 | 2006-07-13 | Hiroshi Takahashi | Method of examining cancer cells and reagent therefor |
| JP2006055106A (ja) * | 2004-08-23 | 2006-03-02 | National Institute Of Advanced Industrial & Technology | ヒト血清培地を用いるヒト骨髄由来間葉系幹細胞培養法 |
-
2006
- 2006-05-16 KR KR1020060043936A patent/KR100833793B1/ko active IP Right Grant
- 2006-06-23 EP EP06769014.9A patent/EP2018419B1/en active Active
- 2006-06-23 CN CNA200680054424XA patent/CN101432421A/zh active Pending
- 2006-06-23 PL PL06769014.9T patent/PL2018419T3/pl unknown
- 2006-06-23 SI SI200632077A patent/SI2018419T1/sl unknown
- 2006-06-23 JP JP2009510876A patent/JP2009537215A/ja active Pending
- 2006-06-23 PT PT67690149T patent/PT2018419T/pt unknown
- 2006-06-23 RS RS20160463A patent/RS54893B1/sr unknown
- 2006-06-23 HU HUE06769014A patent/HUE029896T2/en unknown
- 2006-06-23 ES ES06769014.9T patent/ES2585231T3/es active Active
- 2006-06-23 BR BRPI0621573-4A patent/BRPI0621573A2/pt not_active Application Discontinuation
- 2006-06-23 SG SG2011035201A patent/SG172595A1/en unknown
- 2006-06-23 SG SG10201407593RA patent/SG10201407593RA/en unknown
- 2006-06-23 WO PCT/KR2006/002434 patent/WO2007132962A1/en active Application Filing
- 2006-06-23 DK DK06769014.9T patent/DK2018419T3/en active
- 2006-06-23 US US12/226,472 patent/US20090111087A1/en not_active Abandoned
-
2016
- 2016-07-07 CY CY20161100644T patent/CY1117747T1/el unknown
- 2016-07-28 HR HRP20160966TT patent/HRP20160966T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2018419T (pt) | 2016-07-14 |
| KR100833793B1 (ko) | 2008-05-29 |
| CN101432421A (zh) | 2009-05-13 |
| SG10201407593RA (en) | 2014-12-30 |
| KR20070111073A (ko) | 2007-11-21 |
| PL2018419T3 (pl) | 2016-11-30 |
| HRP20160966T1 (hr) | 2016-11-18 |
| BRPI0621573A2 (pt) | 2011-12-13 |
| SG172595A1 (en) | 2011-07-28 |
| ES2585231T3 (es) | 2016-10-04 |
| DK2018419T3 (en) | 2016-08-15 |
| HUE029896T2 (en) | 2017-04-28 |
| JP2009537215A (ja) | 2009-10-29 |
| WO2007132962A1 (en) | 2007-11-22 |
| EP2018419A4 (en) | 2010-07-14 |
| US20090111087A1 (en) | 2009-04-30 |
| EP2018419A1 (en) | 2009-01-28 |
| RS54893B1 (sr) | 2016-10-31 |
| EP2018419B1 (en) | 2016-05-04 |
| SI2018419T1 (sl) | 2016-08-31 |
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