CY1117482T1 - Παραγωγα πλευρομουτιλινης για τη θεραπεια ασθενειων που προκαλουνται απο μικροβια - Google Patents

Παραγωγα πλευρομουτιλινης για τη θεραπεια ασθενειων που προκαλουνται απο μικροβια

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Publication number
CY1117482T1
CY1117482T1 CY20111101198T CY111101198T CY1117482T1 CY 1117482 T1 CY1117482 T1 CY 1117482T1 CY 20111101198 T CY20111101198 T CY 20111101198T CY 111101198 T CY111101198 T CY 111101198T CY 1117482 T1 CY1117482 T1 CY 1117482T1
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CY
Cyprus
Prior art keywords
plyromutiline
products
treatment
alkyl
cycloalkyl
Prior art date
Application number
CY20111101198T
Other languages
English (en)
Inventor
Rosemarie Mang
Werner Heilmayer
Rudolf Badegruber
Dirk Strickmann
Rodger Novak
Mathias Ferencic
Atchyuta Rama Chandra Murty Bulusu
Original Assignee
Nabriva Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38668870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117482(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nabriva Therapeutics Ag filed Critical Nabriva Therapeutics Ag
Publication of CY1117482T1 publication Critical patent/CY1117482T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/95—Spiro compounds containing "not free" spiro atoms
    • C07C2603/98—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members
    • C07C2603/99—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members containing eight-membered rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Ένωση του τύπου (Ι) όπου το n είναι 0 έως 4, το m είναι 0 ή 1 υπό την προϋπόθεση ότι το άτομο θείου και το R3 είναι σε γειτονική τοποθεσία (εάν m = 0 τότε το R3 είναι στην τοποθεσία 2' και εάν m = 1 τότε το R3 είναι επί της τοποθεσίας 1'), το R είναι αιθύλ ή βινύλ, το R1 είναι υδρογόνο ή (C1-6)αλκύλ, το R2 είναι υδρογόνο ή - (C3-6)κυκλοαλκύλ ή - μη υποκατεστημένο (C1-6)αλκύλ ή (C1-6)αλκύλ υποκατεστημένο με ένα ή περισσότερα από υδρόξυ, κατά προτίμηση ένα ή δύο, μεθόξυ, αλογόνο, (C3-6)κυκλοαλκύλ ή τα R1 και R2 μαζί με το άτομο αζώτου προς το οποίο συνδέονται σχηματίζουν 5-μελή έως 7-μελή ετεροκυκλικό δακτύλιο που περιέχει τουλάχιστον 1 άτομο αζώτου ή 1 άζωτο και 1 επιπρόσθετο ετεροάτομο π.χ. που επιλέγεται από Ν ή Ο ή το R1 είναι υδρόξυ και το R2 είναι φορμύλ, το R3 είναι ΟΗ, ΟR4, άτομο αλογόνου ή υπό την προϋπόθεση ότι το R3 συνδέεται προς 2' το R3 αντιπροσωπεύει -Ο-(CΗ2)p-Ο- με p είναι 2 ή 3, το R4 είναι μη υποκατεστημένο (C1-6)αλκύλ ή (C3-6)κυκλοαλκύλ.
CY20111101198T 2007-03-20 2011-12-02 Παραγωγα πλευρομουτιλινης για τη θεραπεια ασθενειων που προκαλουνται απο μικροβια CY1117482T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07450053A EP1972618A1 (en) 2007-03-20 2007-03-20 Pleuromutilin derivatives for the treatment of diseases mediated by microbes
EP08714294A EP2137143B1 (en) 2007-03-20 2008-03-19 Pleuromutilin derivatives for the treatment of diseases mediated by microbes

Publications (1)

Publication Number Publication Date
CY1117482T1 true CY1117482T1 (el) 2017-04-26

Family

ID=38668870

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20111101198T CY1117482T1 (el) 2007-03-20 2011-12-02 Παραγωγα πλευρομουτιλινης για τη θεραπεια ασθενειων που προκαλουνται απο μικροβια
CY2020032C CY2020032I1 (el) 2007-03-20 2020-09-16 Παραγωγα πλευρομουτιλινης για τη θεραπεια ασθενειων που προκαλουνται απο μικροβια

Family Applications After (1)

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CY2020032C CY2020032I1 (el) 2007-03-20 2020-09-16 Παραγωγα πλευρομουτιλινης για τη θεραπεια ασθενειων που προκαλουνται απο μικροβια

Country Status (32)

Country Link
US (12) US20090118366A1 (el)
EP (3) EP1972618A1 (el)
JP (2) JP5479114B2 (el)
KR (1) KR101478593B1 (el)
CN (2) CN104211624B (el)
AT (1) ATE523486T1 (el)
AU (1) AU2008229609B2 (el)
BR (1) BRPI0809023B8 (el)
CA (1) CA2678795C (el)
CY (2) CY1117482T1 (el)
DK (2) DK2380874T3 (el)
EA (1) EA018707B1 (el)
ES (2) ES2375503T3 (el)
FI (1) FIC20200038I1 (el)
HK (1) HK1140185A1 (el)
HR (1) HRP20110869T1 (el)
HU (1) HUS2100001I1 (el)
IL (1) IL200440A (el)
LT (1) LTPA2020531I1 (el)
MA (1) MA31314B1 (el)
MY (1) MY148916A (el)
NL (1) NL301086I2 (el)
NO (1) NO2021002I1 (el)
NZ (1) NZ579011A (el)
PL (1) PL2137143T3 (el)
PT (2) PT2380874T (el)
SI (1) SI2137143T1 (el)
TN (1) TN2009000347A1 (el)
TW (1) TWI406657B (el)
UA (1) UA97836C2 (el)
WO (1) WO2008113089A1 (el)
ZA (1) ZA200905590B (el)

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EP1972618A1 (en) 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
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EP2433926A1 (en) 2010-09-09 2012-03-28 Nabriva Therapeutics AG Pleuromutilin derivatives for use in the treatment of diseases mediated by microbes
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CN103265487A (zh) * 2013-06-05 2013-08-28 北京理工大学 截短侧耳素扩环衍生物及其制备方法和用途
CN104803911B (zh) * 2014-01-23 2018-01-05 中国科学院上海药物研究所 一类截短侧耳素化合物、其药物组合物、合成方法与用途
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EP3310331B1 (en) 2015-06-17 2020-10-14 Nabriva Therapeutics GMBH Injectable pharmaceutical formulations of lefamulin
KR102664563B1 (ko) 2015-06-18 2024-05-09 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 에스테트롤 성분을 함유하는 구강분해성 투여 단위
SI3310333T1 (sl) 2015-06-18 2020-08-31 Estetra Sprl Orodisperzibilna enota odmerka, ki vsebuje komponento estetrola
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
CN111170911A (zh) * 2019-09-29 2020-05-19 安帝康（无锡）生物科技有限公司 用于治疗细菌感染性疾病的截短侧耳素类化合物
CN111170893B (zh) * 2020-01-19 2022-04-26 郑州依米花手性药物研究有限公司 Lefamulin的中间体化合物及其在Lefamulin制备中的应用
WO2021209596A1 (en) 2020-04-17 2021-10-21 Nabriva Therapeutics GmbH Therapeutic use of pleuromutilins
CN115443131A (zh) * 2020-04-17 2022-12-06 纳布里瓦治疗有限责任公司 截短侧耳素类化合物的治疗用途
WO2021209173A1 (en) 2020-04-17 2021-10-21 Nabriva Therapeutics GmbH Novel therapeutic use of pleuromutilins
WO2023152115A1 (en) 2022-02-09 2023-08-17 Nabriva Therapeutics GmbH Lefamulin and its derivatives for use in the treatment of a spiral shaped bacteria
EP4338732A1 (en) 2022-09-16 2024-03-20 Nabriva Therapeutics GMBH Lefamulin and its derivatives for use in the treatment of tularemia

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EP1972618A1 (en) 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes

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US20090118366A1 (en) 2009-05-07
LTPA2020531I1 (lt) 2020-11-10
KR101478593B1 (ko) 2015-01-02
HRP20110869T1 (hr) 2011-12-31
EP2380874A2 (en) 2011-10-26
JP2014159416A (ja) 2014-09-04
US20130040954A1 (en) 2013-02-14
ES2620459T3 (es) 2017-06-28
US20200030335A1 (en) 2020-01-30
SI2137143T1 (sl) 2012-01-31
CN104211624A (zh) 2014-12-17
IL200440A (en) 2013-09-30
US20170266194A1 (en) 2017-09-21
JP5479114B2 (ja) 2014-04-23
US20210113571A1 (en) 2021-04-22
US20220218713A1 (en) 2022-07-14
TWI406657B (zh) 2013-09-01
US8071643B2 (en) 2011-12-06
EP2137143A1 (en) 2009-12-30
US20120029072A1 (en) 2012-02-02
TN2009000347A1 (fr) 2010-12-31
DK2137143T3 (da) 2012-01-02
HUS2100001I1 (hu) 2021-03-01
CN104211624B (zh) 2017-12-15
BRPI0809023B1 (pt) 2020-12-01
PL2137143T3 (pl) 2012-02-29
CA2678795A1 (en) 2008-09-25
EP1972618A1 (en) 2008-09-24
IL200440A0 (en) 2010-04-29
EA200970868A1 (ru) 2010-02-26
JP5893651B2 (ja) 2016-03-23
EP2137143B1 (en) 2011-09-07
CN101668738A (zh) 2010-03-10
NL301086I2 (nl) 2021-01-28
WO2008113089A1 (en) 2008-09-25
EA018707B1 (ru) 2013-10-30
TW200904402A (en) 2009-02-01
CY2020032I2 (el) 2020-11-25
DK2380874T3 (en) 2017-03-27
NO2021002I1 (no) 2021-01-15
FIC20200038I1 (fi) 2020-10-01
MY148916A (en) 2013-06-14
CA2678795C (en) 2014-11-18
JP2010522143A (ja) 2010-07-01
KR20090123882A (ko) 2009-12-02
HK1140185A1 (en) 2010-10-08
US20100035987A1 (en) 2010-02-11
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US8153689B2 (en) 2012-04-10
PT2380874T (pt) 2017-04-03
US20200281933A1 (en) 2020-09-10
ES2375503T3 (es) 2012-03-01
UA97836C2 (ru) 2012-03-26
US20180303842A1 (en) 2018-10-25
BRPI0809023B8 (pt) 2021-05-25
BRPI0809023A2 (pt) 2014-09-23
US20140256731A1 (en) 2014-09-11
ZA200905590B (en) 2010-10-27
US20190175603A1 (en) 2019-06-13
MA31314B1 (fr) 2010-04-01
PT2137143E (pt) 2011-12-22
EP2380874A3 (en) 2011-12-07
AU2008229609B2 (en) 2012-03-29
AU2008229609A1 (en) 2008-09-25
CY2020032I1 (el) 2020-11-25
EP2380874B1 (en) 2016-12-28
ATE523486T1 (de) 2011-09-15
CN101668738B (zh) 2014-10-15

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