AR074843A1 - Dihidropiridona -amidas como moduladores de p2x7 - Google Patents
Dihidropiridona -amidas como moduladores de p2x7Info
- Publication number
- AR074843A1 AR074843A1 ARP090105035A ARP090105035A AR074843A1 AR 074843 A1 AR074843 A1 AR 074843A1 AR P090105035 A ARP090105035 A AR P090105035A AR P090105035 A ARP090105035 A AR P090105035A AR 074843 A1 AR074843 A1 AR 074843A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- optionally substituted
- dihydropiridone
- amidas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen los compuestos para el tratamiento de enfermedades asociadas con el receptor purinérgico de P2X7. Reivindicación 1: Un compuesto de la fórmula o sales farmacéuticamente aceptables del mismo, en la que: m es el número 0 ó 1; n es el número 0 ó 1; R1 es heteroarilo opcionalmente sustituido; R2 es: arilo opcionalmente sustituido; heteroarilo opcionalmente sustituido; cicloalquilo C3-6; o alquilo C1-6; R3 es: hidrógeno; alquilo C1-6; alquilcarbonilalquilo; o alcoxicarbonilalquilo; R4 y R5 con Independencia entre si son: hidrógeno; o alquilo C1-6; y Ra es hidrogeno; alquilo C1-6; hidroxi -alquilo C1-6; (alcoxi C1-6)-alquilo C1-6.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20348208P | 2008-12-23 | 2008-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR074843A1 true AR074843A1 (es) | 2011-02-16 |
Family
ID=41664810
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090105035A AR074843A1 (es) | 2008-12-23 | 2009-12-22 | Dihidropiridona -amidas como moduladores de p2x7 |
Country Status (14)
Country | Link |
---|---|
US (1) | US8372865B2 (es) |
EP (1) | EP2385939A1 (es) |
JP (1) | JP5478637B2 (es) |
KR (1) | KR101381074B1 (es) |
CN (1) | CN102264723B (es) |
AR (1) | AR074843A1 (es) |
AU (1) | AU2009331659B2 (es) |
BR (1) | BRPI0923498A2 (es) |
CA (1) | CA2745864A1 (es) |
IL (1) | IL213417A0 (es) |
MX (1) | MX2011006232A (es) |
SG (1) | SG172336A1 (es) |
TW (1) | TW201028396A (es) |
WO (1) | WO2010072597A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5819846B2 (ja) * | 2009-12-08 | 2015-11-24 | バンダービルト ユニバーシティ | 静脈摘出および自家移植のための改善された方法および組成物 |
US9988373B2 (en) | 2013-12-26 | 2018-06-05 | Shionogi & Co., Ltd. | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same |
MY187540A (en) | 2014-08-01 | 2021-09-28 | Nuevolution As | Compounds active towards bromodomains |
EP3957627B1 (en) | 2015-04-24 | 2024-06-19 | Shionogi & Co., Ltd | 6-membered heterocyclic derivative and pharmaceutical composition comprising same |
MX2018009870A (es) | 2016-02-15 | 2018-11-29 | Cemm Forschungszentrum Fuer Molekulare Medizin Gmbh | Inhibidores de taf1 para la terapia del cancer. |
WO2018074390A1 (ja) | 2016-10-17 | 2018-04-26 | 塩野義製薬株式会社 | 二環性含窒素複素環誘導体およびそれらを含有する医薬組成物 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU653734B2 (en) * | 1990-06-19 | 1994-10-13 | Meiji Seika Kabushiki Kaisha | Substituted 4-biphenylmethoxypyridine derivatives |
CZ403592A3 (en) | 1992-02-20 | 1993-12-15 | Hoechst Ag | Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use |
DE4206045A1 (de) | 1992-02-27 | 1993-09-02 | Bayer Ag | Sulfonylbenzyl substituierte pyridone |
DE4215587A1 (de) | 1992-05-12 | 1993-11-18 | Bayer Ag | Sulfonylbenzyl-substituierte Benzo- und Pyridopyridone |
SE9704544D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
KR20010034442A (ko) | 1998-01-27 | 2001-04-25 | 아벤티스 파마슈티칼즈 프로덕츠 인코포레이티드 | 치환된 옥소아자헤테로사이클릴 인자 Xa 억제제 |
IL152848A0 (en) | 2000-06-12 | 2003-06-24 | Eisai Co Ltd | 1,2-dihydropyridine derivatives, pharmaceutical compositions containing the same and methods for the production thereof |
GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
JP2005170790A (ja) | 2002-01-09 | 2005-06-30 | Ajinomoto Co Inc | N−アルキルスルフォニル置換アミド誘導体 |
WO2005082890A1 (en) * | 2004-02-20 | 2005-09-09 | Smithkline Beecham Corporation | Novel compounds |
SA05260265A (ar) | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
FR2878528B1 (fr) | 2004-11-29 | 2008-05-16 | Aventis Pharma Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation |
US20060270709A1 (en) | 2005-04-04 | 2006-11-30 | Eisai Co. Ltd. | Dihydropyridine compounds and compositions for headaches |
AU2006234627C1 (en) | 2005-04-08 | 2009-11-26 | Eisai R & D Management Co., Ltd. | Therapeutic agent for dyskinesia |
WO2007035428A1 (en) | 2005-09-15 | 2007-03-29 | Bristol-Myers Squibb Company | Met kinase inhibitors |
WO2008104472A1 (en) | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | 2, 4 -diaminopyrimidine derivatives and their use as p2x antagonists or as prodrugs thereof |
GB0705882D0 (en) * | 2007-03-27 | 2007-05-02 | Glaxo Group Ltd | Novel compounds |
WO2008116845A1 (en) * | 2007-03-28 | 2008-10-02 | Glaxo Group Limited | Piperidinone carboxamide derivatives as p2x7 modulators |
JP2010522710A (ja) * | 2007-03-29 | 2010-07-08 | グラクソ グループ リミテッド | P2x7調節因子としてのオキサゾリジンおよびモルホリンカルボキサミド誘導体 |
EP2150535A2 (en) * | 2007-04-11 | 2010-02-10 | Glaxo Group Limited | Pyrazole derivatives as p2x7 modulators |
SG172785A1 (en) * | 2008-12-23 | 2011-08-29 | Hoffmann La Roche | Dihydropyridone amides as p2x7 modulators |
-
2009
- 2009-12-14 SG SG2011045945A patent/SG172336A1/en unknown
- 2009-12-14 KR KR1020117014366A patent/KR101381074B1/ko not_active IP Right Cessation
- 2009-12-14 CN CN200980152176.6A patent/CN102264723B/zh not_active Expired - Fee Related
- 2009-12-14 CA CA2745864A patent/CA2745864A1/en not_active Abandoned
- 2009-12-14 EP EP09775181A patent/EP2385939A1/en not_active Withdrawn
- 2009-12-14 MX MX2011006232A patent/MX2011006232A/es active IP Right Grant
- 2009-12-14 AU AU2009331659A patent/AU2009331659B2/en not_active Ceased
- 2009-12-14 BR BRPI0923498A patent/BRPI0923498A2/pt not_active IP Right Cessation
- 2009-12-14 WO PCT/EP2009/067026 patent/WO2010072597A1/en active Application Filing
- 2009-12-14 JP JP2011542760A patent/JP5478637B2/ja not_active Expired - Fee Related
- 2009-12-15 US US12/637,984 patent/US8372865B2/en not_active Expired - Fee Related
- 2009-12-21 TW TW098143978A patent/TW201028396A/zh unknown
- 2009-12-22 AR ARP090105035A patent/AR074843A1/es unknown
-
2011
- 2011-06-06 IL IL213417A patent/IL213417A0/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN102264723B (zh) | 2014-12-10 |
AU2009331659A1 (en) | 2011-06-23 |
CN102264723A (zh) | 2011-11-30 |
EP2385939A1 (en) | 2011-11-16 |
AU2009331659B2 (en) | 2015-09-03 |
SG172336A1 (en) | 2011-07-28 |
IL213417A0 (en) | 2011-07-31 |
JP2012513433A (ja) | 2012-06-14 |
TW201028396A (en) | 2010-08-01 |
KR20110086768A (ko) | 2011-07-29 |
KR101381074B1 (ko) | 2014-04-11 |
MX2011006232A (es) | 2011-06-24 |
US20100160373A1 (en) | 2010-06-24 |
WO2010072597A1 (en) | 2010-07-01 |
JP5478637B2 (ja) | 2014-04-23 |
BRPI0923498A2 (pt) | 2019-09-24 |
CA2745864A1 (en) | 2010-07-01 |
US8372865B2 (en) | 2013-02-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP088773A (es) | Derivados de amida y su aplicación para el tratamiento de enfermedades relacionadas con proteína-g | |
PE20121695A1 (es) | 5-alquinil-pirimidinas | |
AR085960A1 (es) | 1,3-oxazinas como inhibidores de la bace1 y/o de la bace2 | |
AR082154A1 (es) | DERIVADOS DE PIRAZOLO[1,5-a]PIRIMIDINA COMO MODULADORES DE IRAK4 | |
UY32483A (es) | Nuevos compuestos de bencimidazol para el tratamiento del virus sincicial respiratorio | |
AR074817A1 (es) | Dihidropiridona-amidas como moduladores de p2x7 | |
UY32543A (es) | Análogos de isoxazol-3(2h)-ona como agentes terapéuticos | |
CY1117085T1 (el) | C7-φθορο υποκατεστημενες ενωσεις τετρακυκλινης | |
ECSP13012611A (es) | Derivados de pirazol-aminopirimidina como moduladores de la lrrk2 | |
UY30498A1 (es) | Nueva clase de compuestos de benzimidazolilo, sus sales, composiciones farmacéuticas conteniéndolos y aplicaciones | |
AR074843A1 (es) | Dihidropiridona -amidas como moduladores de p2x7 | |
CR20110059A (es) | Compuestos organicos | |
TN2009000199A1 (en) | Heteromonocyclic compound and use thereof | |
ECSP12012293A (es) | Ciertas amino-pirimidinas, composicioines de las mismas y métodos para el uso de los mismos | |
CR11861A (es) | Compuestos organicos | |
CR11150A (es) | Compuestos de bencimidazol | |
ECSP066375A (es) | Forma cristalina gamma de clorhidrato de ivabradina, su procedimiento de preparación y composiciones farmacéuticas que la contienen | |
UY31803A (es) | Compuesto cristalino | |
UY33817A (es) | ?nuevas oxindolpirimidinas bencílicas?. | |
AR074818A1 (es) | Dihidropiridona-amidas como moduladores de p2x7 | |
CU23761B7 (es) | Nuevos derivados de diosmetina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
BR112012029647A2 (pt) | novos derivados de pirimidinas | |
ECSP14013296A (es) | Derivados de etinilo | |
PE20141000A1 (es) | Ureas asimetricas y usos medicos de las mismas | |
ECSP109961A (es) | Derivados de indol-2-ona disustituidos en 3, su preparación y su aplicación en terapéutica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |