CY1117096T1 - Ετεροκυκλικες ενωσεις ως προσδετες η3 υποδοχεα ισταμινης - Google Patents

Ετεροκυκλικες ενωσεις ως προσδετες η3 υποδοχεα ισταμινης

Info

Publication number
CY1117096T1
CY1117096T1 CY20151101205T CY151101205T CY1117096T1 CY 1117096 T1 CY1117096 T1 CY 1117096T1 CY 20151101205 T CY20151101205 T CY 20151101205T CY 151101205 T CY151101205 T CY 151101205T CY 1117096 T1 CY1117096 T1 CY 1117096T1
Authority
CY
Cyprus
Prior art keywords
heterocyclic compounds
histamine receptors
compounds
formula
pharmaceutically acceptable
Prior art date
Application number
CY20151101205T
Other languages
English (en)
Inventor
Ramakrishna Nirogi
Anil Karbhari Shinde
Ramasastri Kambhampati
Rambabu Namala
Adi Reddy Dwarampudi
Laxman Kota
Murlimohan Gampa
Padmavathi Kodru
Taraka Naga Vinaykumar Tiriveedhi
Vishwottam Nagaraj Kandikere
Nageshwara Rao Muddana
Ramanatha Shrikantha Saralaya
Pradeep Jayarajan
Dhanalakshmi Shanmuganathan
Ishtiyaque Ahmad
Venkateswarlu Jasti
Original Assignee
Suven Life Sciences Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Limited filed Critical Suven Life Sciences Limited
Publication of CY1117096T1 publication Critical patent/CY1117096T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεση αφορά ετεροκυκλικές ενώσεις του τύπου (I) και τα φαρμακευτικά αποδεκτά άλατα αυτών και συνθέσεις οι οποίες περιέχουν αυτά. Η παρούσα εφεύρεση αφορά επίσης μια μέθοδο για την παρασκευή των ανωτέρω αναφερομένων νέων ενώσεων και των φαρμακευτικά αποδεκτών αλάτων αυτών. Οι ενώσεις του τύπου (I) είναι χρήσιμες στην αγωγή διαφόρων παθήσεων οι οποίες σχετίζονται με τους υποδοχείς της ισταμίνης Η, παραδείγματος χάριν γνωστικών διαταραχών, διαταραχών του ύπνου, της παχυσαρκίας και του πόνου.
CY20151101205T 2010-09-02 2015-12-30 Ετεροκυκλικες ενωσεις ως προσδετες η3 υποδοχεα ισταμινης CY1117096T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2551CH2010 2010-09-02
EP10803396.0A EP2611444B1 (en) 2010-09-02 2010-11-15 Heterocyclyl compounds as histamine h3 receptor ligands

Publications (1)

Publication Number Publication Date
CY1117096T1 true CY1117096T1 (el) 2017-04-05

Family

ID=43608695

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151101205T CY1117096T1 (el) 2010-09-02 2015-12-30 Ετεροκυκλικες ενωσεις ως προσδετες η3 υποδοχεα ισταμινης

Country Status (27)

Country Link
US (1) US8912179B2 (el)
EP (1) EP2611444B1 (el)
JP (1) JP5650329B2 (el)
KR (1) KR101538239B1 (el)
CN (1) CN103079566B (el)
AU (1) AU2010360038B2 (el)
BR (1) BR112013005084A2 (el)
CA (1) CA2812970C (el)
CY (1) CY1117096T1 (el)
DK (1) DK2611444T3 (el)
EA (1) EA022746B1 (el)
ES (1) ES2558531T3 (el)
HK (1) HK1180955A1 (el)
HR (1) HRP20151380T1 (el)
HU (1) HUE028435T2 (el)
IL (1) IL224652A (el)
ME (1) ME02320B (el)
MX (1) MX354852B (el)
NZ (1) NZ607658A (el)
PL (1) PL2611444T3 (el)
PT (1) PT2611444E (el)
RS (1) RS54514B1 (el)
SG (1) SG188212A1 (el)
SI (1) SI2611444T1 (el)
SM (1) SMT201600012B (el)
WO (1) WO2012029070A1 (el)
ZA (1) ZA201301143B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201408423XA (en) * 2012-08-23 2015-01-29 Suven Life Sciences Ltd ACRYLAMIDE COMPOUNDS AS HISTAMINE H<sb>3</sb> RECEPTOR LIGANDS
CN104530088A (zh) * 2014-12-08 2015-04-22 苏州施亚生物科技有限公司 2-氨基-6,7-二氢-5H-噻唑并[5,4-b]吡啶-4-羧酸叔丁酯及其衍生物,以及它们的合成方法
EP3378477A1 (en) * 2017-03-21 2018-09-26 BIOPROJET Pharma New therapeutical use of h3-ligands
CU20200037A7 (es) 2017-11-02 2021-03-11 Aicuris Gmbh & Co Kg Derivados de indol-2-carboxamidas sustituidos con amino-tiazol activos contra el virus de la hepatitis b (vhb)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH23995A (en) 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4695575A (en) 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
JP2005502623A (ja) 2001-07-02 2005-01-27 ノボ　ノルディスク　アクティーゼルスカブ 置換ピペラジンおよびジアゼパン
AU2003265886A1 (en) 2002-09-06 2004-03-29 Janssen Pharmaceutica N.V. (1H-Benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine H4-receptor antagonists for the treatment of inflammatory and allergic disorders
KR20070036149A (ko) * 2004-07-16 2007-04-02 얀센 파마슈티카 엔.브이. 이량체 피페리딘 유도체
JP2008506670A (ja) * 2004-07-16 2008-03-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 二量体ピペリジン誘導体
US20080161289A1 (en) * 2005-03-14 2008-07-03 Glaxo Group Limited Fused Thiazole Derivatives Having Affinity for the Histamine H3 Receptor
AU2007229492B2 (en) * 2006-03-28 2011-11-03 High Point Pharmaceuticals, Llc Benzothiazoles having histamine H3 receptor activity
US20100009969A1 (en) * 2006-07-27 2010-01-14 Ucb Pharma, S.A. Fused Oxazoles & Thiazoles As Histamine H3- Receptor Ligands
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US20080146559A1 (en) * 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
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WO2010026113A1 (en) 2008-09-03 2010-03-11 Evotec Neurosciences Gmbh Acyl- and sufonyl tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists

Also Published As

Publication number Publication date
IL224652A (en) 2016-05-31
PT2611444E (pt) 2016-02-04
MX2013001988A (es) 2013-05-09
NZ607658A (en) 2014-02-28
BR112013005084A2 (pt) 2020-08-25
SMT201600012B (it) 2016-02-25
HRP20151380T1 (hr) 2016-01-15
HK1180955A1 (en) 2013-11-01
RS54514B1 (en) 2016-06-30
JP5650329B2 (ja) 2015-01-07
US8912179B2 (en) 2014-12-16
AU2010360038A1 (en) 2013-04-04
HUE028435T2 (en) 2016-12-28
KR101538239B1 (ko) 2015-07-20
CN103079566B (zh) 2015-06-17
MX354852B (es) 2018-03-22
SG188212A1 (en) 2013-04-30
EP2611444B1 (en) 2015-10-14
CA2812970C (en) 2015-01-13
CN103079566A (zh) 2013-05-01
ZA201301143B (en) 2013-10-30
ME02320B (me) 2016-06-20
CA2812970A1 (en) 2012-03-08
JP2013536834A (ja) 2013-09-26
SI2611444T1 (sl) 2016-04-29
EP2611444A1 (en) 2013-07-10
WO2012029070A1 (en) 2012-03-08
EA022746B1 (ru) 2016-02-29
AU2010360038B2 (en) 2014-05-15
EA201390327A1 (ru) 2013-08-30
PL2611444T3 (pl) 2016-03-31
DK2611444T3 (en) 2016-01-11
US20140148440A1 (en) 2014-05-29
KR20130042605A (ko) 2013-04-26
ES2558531T3 (es) 2016-02-05

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