CY1115877T1 - Συνθεσεις που περιλαμβανουν (s)-2-amino-1-(4-chlorophenyl)-1-[4-(1η-pyrazol-4-yl)-phenyl]-ethanol σαν παραγοντα τροποποιησης kinασων (kinases) πρωτεϊνης - Google Patents
Συνθεσεις που περιλαμβανουν (s)-2-amino-1-(4-chlorophenyl)-1-[4-(1η-pyrazol-4-yl)-phenyl]-ethanol σαν παραγοντα τροποποιησης kinασων (kinases) πρωτεϊνηςInfo
- Publication number
- CY1115877T1 CY1115877T1 CY20141100938T CY141100938T CY1115877T1 CY 1115877 T1 CY1115877 T1 CY 1115877T1 CY 20141100938 T CY20141100938 T CY 20141100938T CY 141100938 T CY141100938 T CY 141100938T CY 1115877 T1 CY1115877 T1 CY 1115877T1
- Authority
- CY
- Cyprus
- Prior art keywords
- phenyl
- chinese
- pyrazol
- ethanol
- amino
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- IIRWNGPLJQXWFJ-KRWDZBQOSA-N (1s)-2-amino-1-(4-chlorophenyl)-1-[4-(1h-pyrazol-4-yl)phenyl]ethanol Chemical compound C1([C@](O)(CN)C=2C=CC(=CC=2)C2=CNN=C2)=CC=C(Cl)C=C1 IIRWNGPLJQXWFJ-KRWDZBQOSA-N 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- IIRWNGPLJQXWFJ-QGZVFWFLSA-N (1r)-2-amino-1-(4-chlorophenyl)-1-[4-(1h-pyrazol-4-yl)phenyl]ethanol Chemical compound C1([C@@](O)(CN)C=2C=CC(=CC=2)C2=CNN=C2)=CC=C(Cl)C=C1 IIRWNGPLJQXWFJ-QGZVFWFLSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
- C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/08—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated
- C07C247/10—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89475207P | 2007-03-14 | 2007-03-14 | |
| GBGB0704932.3A GB0704932D0 (en) | 2007-03-14 | 2007-03-14 | Pharmaceutical compounds |
| EP08719025.2A EP2134339B1 (en) | 2007-03-14 | 2008-03-14 | Compositions comprising (s)-2-amino-1-(4-chlorophenyl)-1-[4-(1h-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1115877T1 true CY1115877T1 (el) | 2017-01-25 |
Family
ID=38008428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20141100938T CY1115877T1 (el) | 2007-03-14 | 2014-11-12 | Συνθεσεις που περιλαμβανουν (s)-2-amino-1-(4-chlorophenyl)-1-[4-(1η-pyrazol-4-yl)-phenyl]-ethanol σαν παραγοντα τροποποιησης kinασων (kinases) πρωτεϊνης |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20100113551A1 (enExample) |
| EP (2) | EP2433632A1 (enExample) |
| JP (2) | JP2010521446A (enExample) |
| KR (1) | KR20100014720A (enExample) |
| CN (1) | CN101686965B (enExample) |
| AU (1) | AU2008224657B2 (enExample) |
| BR (1) | BRPI0808802A2 (enExample) |
| CA (1) | CA2679878A1 (enExample) |
| CY (1) | CY1115877T1 (enExample) |
| DK (1) | DK2134339T3 (enExample) |
| ES (1) | ES2511817T3 (enExample) |
| GB (1) | GB0704932D0 (enExample) |
| HR (1) | HRP20141034T1 (enExample) |
| IL (1) | IL200822A (enExample) |
| MX (1) | MX2009009874A (enExample) |
| NZ (1) | NZ579341A (enExample) |
| PL (1) | PL2134339T3 (enExample) |
| PT (1) | PT2134339E (enExample) |
| RS (1) | RS53580B1 (enExample) |
| RU (1) | RU2527151C2 (enExample) |
| SI (1) | SI2134339T1 (enExample) |
| WO (1) | WO2008110846A2 (enExample) |
| ZA (1) | ZA200906303B (enExample) |
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| MXPA06007326A (es) | 2003-12-23 | 2007-01-26 | Astex Therapeutics Ltd | Derivados de pirazol como moduladores de proteina cinasa. |
| US8343953B2 (en) | 2005-06-22 | 2013-01-01 | Astex Therapeutics Limited | Pharmaceutical compounds |
| JP5345842B2 (ja) | 2005-06-23 | 2013-11-20 | アステックス・セラピューティクス・リミテッド | プロテインキナーゼモジュレーターとしてのピラゾール誘導体を含む医薬組み合わせ |
| GB0704932D0 (en) | 2007-03-14 | 2007-04-25 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| JOP20190231A1 (ar) * | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
| CN106456631A (zh) * | 2014-03-06 | 2017-02-22 | 南加利福尼亚大学 | 利用短期饥饿方案结合激酶抑制剂来增强传统化学药物功效和可行性并逆转激酶在正常细胞和组织中的副作用 |
| RU2657832C1 (ru) * | 2017-06-07 | 2018-06-15 | федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет" | Антидиабетическое средство |
| EP3424533A1 (en) * | 2017-07-05 | 2019-01-09 | Nh Theraguix | Methods for treating tumors |
| US10696638B2 (en) | 2017-12-26 | 2020-06-30 | Industrial Technology Research Institute | Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same |
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| CN111707830B (zh) * | 2020-07-16 | 2023-08-15 | 首都医科大学附属北京朝阳医院 | Rock激酶活性在辅助诊断肺损害中的应用 |
| WO2025017499A1 (en) | 2023-07-17 | 2025-01-23 | Graviton Bioscience Bv | Formulations and uses of rock2 inhibitors for als |
| WO2025069008A1 (en) | 2023-09-28 | 2025-04-03 | Graviton Bioscience Bv | Therapy for treating type 1 diabetes using rock2 and dyrk1 inhibitors |
| WO2025069009A1 (en) | 2023-09-29 | 2025-04-03 | Graviton Bioscience Bv | Rock2 inhibitors in the treatment of obesity |
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| WO2006136823A1 (en) | 2005-06-21 | 2006-12-28 | Astex Therapeutics Limited | Heterocyclic containing amines as kinase b inhibitors |
| JP2008543919A (ja) | 2005-06-21 | 2008-12-04 | アステックス・セラピューティクス・リミテッド | 医薬化合物 |
| AR054485A1 (es) * | 2005-06-21 | 2007-06-27 | Cancer Rec Tech Ltd | ARIL-ALQUILAMINAS Y HETEROARIL-ALQUILAMINAS COMO INHIBIDORES DE PROTEINA QUINASA A Y B, UN PROCESO PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN Y SU USO EN LA FABRICACIoN DE MEDICAMENTOS PARA EL TRATAMIENTO O PROFILAXIS DE ENFERMEDADES ORIGINADAS EN EL CRECIMIENTO ANORMAL DE LA |
| US8343953B2 (en) | 2005-06-22 | 2013-01-01 | Astex Therapeutics Limited | Pharmaceutical compounds |
| JP5345842B2 (ja) * | 2005-06-23 | 2013-11-20 | アステックス・セラピューティクス・リミテッド | プロテインキナーゼモジュレーターとしてのピラゾール誘導体を含む医薬組み合わせ |
| GB0704932D0 (en) | 2007-03-14 | 2007-04-25 | Astex Therapeutics Ltd | Pharmaceutical compounds |
-
2007
- 2007-03-14 GB GBGB0704932.3A patent/GB0704932D0/en not_active Ceased
-
2008
- 2008-03-14 HR HRP20141034AT patent/HRP20141034T1/hr unknown
- 2008-03-14 JP JP2009553222A patent/JP2010521446A/ja active Pending
- 2008-03-14 EP EP11194939A patent/EP2433632A1/en not_active Withdrawn
- 2008-03-14 MX MX2009009874A patent/MX2009009874A/es active IP Right Grant
- 2008-03-14 US US12/531,013 patent/US20100113551A1/en not_active Abandoned
- 2008-03-14 CN CN200880015813.0A patent/CN101686965B/zh not_active Expired - Fee Related
- 2008-03-14 BR BRPI0808802A patent/BRPI0808802A2/pt not_active IP Right Cessation
- 2008-03-14 WO PCT/GB2008/050180 patent/WO2008110846A2/en not_active Ceased
- 2008-03-14 SI SI200831312T patent/SI2134339T1/sl unknown
- 2008-03-14 AU AU2008224657A patent/AU2008224657B2/en not_active Ceased
- 2008-03-14 DK DK08719025.2T patent/DK2134339T3/da active
- 2008-03-14 CA CA002679878A patent/CA2679878A1/en not_active Abandoned
- 2008-03-14 KR KR1020097020516A patent/KR20100014720A/ko not_active Ceased
- 2008-03-14 EP EP08719025.2A patent/EP2134339B1/en active Active
- 2008-03-14 PL PL08719025T patent/PL2134339T3/pl unknown
- 2008-03-14 RU RU2009137779/04A patent/RU2527151C2/ru not_active IP Right Cessation
- 2008-03-14 NZ NZ579341A patent/NZ579341A/xx not_active IP Right Cessation
- 2008-03-14 PT PT87190252T patent/PT2134339E/pt unknown
- 2008-03-14 RS RSP20140587 patent/RS53580B1/sr unknown
- 2008-03-14 ES ES08719025.2T patent/ES2511817T3/es active Active
-
2009
- 2009-09-08 IL IL200822A patent/IL200822A/en not_active IP Right Cessation
- 2009-09-10 ZA ZA2009/06303A patent/ZA200906303B/en unknown
-
2011
- 2011-07-11 US US13/180,127 patent/US8497294B2/en not_active Expired - Fee Related
-
2014
- 2014-08-25 JP JP2014170885A patent/JP2015028033A/ja active Pending
- 2014-11-12 CY CY20141100938T patent/CY1115877T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200906303B (en) | 2015-08-26 |
| NZ579341A (en) | 2012-08-31 |
| CN101686965B (zh) | 2014-09-17 |
| CA2679878A1 (en) | 2008-09-18 |
| WO2008110846A2 (en) | 2008-09-18 |
| AU2008224657A1 (en) | 2008-09-18 |
| MX2009009874A (es) | 2009-09-24 |
| HRP20141034T1 (hr) | 2014-12-19 |
| BRPI0808802A2 (pt) | 2017-05-02 |
| RS53580B1 (sr) | 2015-02-27 |
| SI2134339T1 (sl) | 2014-12-31 |
| RU2009137779A (ru) | 2011-05-10 |
| EP2433632A1 (en) | 2012-03-28 |
| ES2511817T3 (es) | 2014-10-23 |
| KR20100014720A (ko) | 2010-02-10 |
| PT2134339E (pt) | 2014-11-03 |
| PL2134339T3 (pl) | 2015-04-30 |
| EP2134339B1 (en) | 2014-09-17 |
| GB0704932D0 (en) | 2007-04-25 |
| CN101686965A (zh) | 2010-03-31 |
| WO2008110846A3 (en) | 2009-03-05 |
| US20110269808A1 (en) | 2011-11-03 |
| JP2010521446A (ja) | 2010-06-24 |
| US20100113551A1 (en) | 2010-05-06 |
| RU2527151C2 (ru) | 2014-08-27 |
| AU2008224657B2 (en) | 2014-06-26 |
| IL200822A0 (en) | 2010-05-17 |
| DK2134339T3 (da) | 2014-11-03 |
| JP2015028033A (ja) | 2015-02-12 |
| EP2134339A2 (en) | 2009-12-23 |
| IL200822A (en) | 2016-09-29 |
| US8497294B2 (en) | 2013-07-30 |
| HK1133828A1 (en) | 2010-04-09 |
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