BRPI0808802A2 - composição, composto, uso de uma composição ou composto, métodos para a profilaxia ou tratamento de um estado de doença ou condição, para o tratamento de uma doença ou condição, para o alívio ou redução da incidência de uma doença ou condição, para a inibição da proteína quinase, para a modulação de um processo celular, para o diagnóstico e tratamento de um estado de doença ou condição, para a modulação da proteína quinase b e/ou proteína quinase a e para a preparação de uma composição ou composto, e, processo para a preparação de um compposto. - Google Patents

composição, composto, uso de uma composição ou composto, métodos para a profilaxia ou tratamento de um estado de doença ou condição, para o tratamento de uma doença ou condição, para o alívio ou redução da incidência de uma doença ou condição, para a inibição da proteína quinase, para a modulação de um processo celular, para o diagnóstico e tratamento de um estado de doença ou condição, para a modulação da proteína quinase b e/ou proteína quinase a e para a preparação de uma composição ou composto, e, processo para a preparação de um compposto.

Info

Publication number
BRPI0808802A2
BRPI0808802A2 BRPI0808802A BRPI0808802A BRPI0808802A2 BR PI0808802 A2 BRPI0808802 A2 BR PI0808802A2 BR PI0808802 A BRPI0808802 A BR PI0808802A BR PI0808802 A BRPI0808802 A BR PI0808802A BR PI0808802 A2 BRPI0808802 A2 BR PI0808802A2
Authority
BR
Brazil
Prior art keywords
compound
condition
disease
composition
protein kinase
Prior art date
Application number
BRPI0808802A
Other languages
English (en)
Portuguese (pt)
Inventor
Charles Rees David
Merriom Grimshaw Kyla
Frederickson Martyn
John Woodhead Steven
Original Assignee
Astex Therapeutics Ltd
Cancer Res Tech Ltd
The Inst Of Cancer Research: Royal Cancer Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Ltd, Cancer Res Tech Ltd, The Inst Of Cancer Research: Royal Cancer Hospital filed Critical Astex Therapeutics Ltd
Publication of BRPI0808802A2 publication Critical patent/BRPI0808802A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/08—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated
    • C07C247/10—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI0808802A 2007-03-14 2008-03-14 composição, composto, uso de uma composição ou composto, métodos para a profilaxia ou tratamento de um estado de doença ou condição, para o tratamento de uma doença ou condição, para o alívio ou redução da incidência de uma doença ou condição, para a inibição da proteína quinase, para a modulação de um processo celular, para o diagnóstico e tratamento de um estado de doença ou condição, para a modulação da proteína quinase b e/ou proteína quinase a e para a preparação de uma composição ou composto, e, processo para a preparação de um compposto. BRPI0808802A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89475207P 2007-03-14 2007-03-14
GBGB0704932.3A GB0704932D0 (en) 2007-03-14 2007-03-14 Pharmaceutical compounds
PCT/GB2008/050180 WO2008110846A2 (en) 2007-03-14 2008-03-14 Compositions comprising (s)-2-amino-1-(4-chlorophenyl)-1-[4-(1h-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases

Publications (1)

Publication Number Publication Date
BRPI0808802A2 true BRPI0808802A2 (pt) 2017-05-02

Family

ID=38008428

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0808802A BRPI0808802A2 (pt) 2007-03-14 2008-03-14 composição, composto, uso de uma composição ou composto, métodos para a profilaxia ou tratamento de um estado de doença ou condição, para o tratamento de uma doença ou condição, para o alívio ou redução da incidência de uma doença ou condição, para a inibição da proteína quinase, para a modulação de um processo celular, para o diagnóstico e tratamento de um estado de doença ou condição, para a modulação da proteína quinase b e/ou proteína quinase a e para a preparação de uma composição ou composto, e, processo para a preparação de um compposto.

Country Status (23)

Country Link
US (2) US20100113551A1 (enExample)
EP (2) EP2134339B1 (enExample)
JP (2) JP2010521446A (enExample)
KR (1) KR20100014720A (enExample)
CN (1) CN101686965B (enExample)
AU (1) AU2008224657B2 (enExample)
BR (1) BRPI0808802A2 (enExample)
CA (1) CA2679878A1 (enExample)
CY (1) CY1115877T1 (enExample)
DK (1) DK2134339T3 (enExample)
ES (1) ES2511817T3 (enExample)
GB (1) GB0704932D0 (enExample)
HR (1) HRP20141034T1 (enExample)
IL (1) IL200822A (enExample)
MX (1) MX2009009874A (enExample)
NZ (1) NZ579341A (enExample)
PL (1) PL2134339T3 (enExample)
PT (1) PT2134339E (enExample)
RS (1) RS53580B1 (enExample)
RU (1) RU2527151C2 (enExample)
SI (1) SI2134339T1 (enExample)
WO (1) WO2008110846A2 (enExample)
ZA (1) ZA200906303B (enExample)

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Also Published As

Publication number Publication date
EP2134339B1 (en) 2014-09-17
WO2008110846A2 (en) 2008-09-18
EP2134339A2 (en) 2009-12-23
CN101686965A (zh) 2010-03-31
AU2008224657A1 (en) 2008-09-18
RU2527151C2 (ru) 2014-08-27
ES2511817T3 (es) 2014-10-23
JP2015028033A (ja) 2015-02-12
US20110269808A1 (en) 2011-11-03
RS53580B1 (sr) 2015-02-27
IL200822A0 (en) 2010-05-17
RU2009137779A (ru) 2011-05-10
HK1133828A1 (en) 2010-04-09
JP2010521446A (ja) 2010-06-24
IL200822A (en) 2016-09-29
US20100113551A1 (en) 2010-05-06
AU2008224657B2 (en) 2014-06-26
CN101686965B (zh) 2014-09-17
MX2009009874A (es) 2009-09-24
ZA200906303B (en) 2015-08-26
WO2008110846A3 (en) 2009-03-05
GB0704932D0 (en) 2007-04-25
DK2134339T3 (da) 2014-11-03
PT2134339E (pt) 2014-11-03
KR20100014720A (ko) 2010-02-10
CA2679878A1 (en) 2008-09-18
PL2134339T3 (pl) 2015-04-30
EP2433632A1 (en) 2012-03-28
HRP20141034T1 (hr) 2014-12-19
NZ579341A (en) 2012-08-31
US8497294B2 (en) 2013-07-30
SI2134339T1 (sl) 2014-12-31
CY1115877T1 (el) 2017-01-25

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