IL206197A0 - Crystalline modifications of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol - Google Patents
Crystalline modifications of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenolInfo
- Publication number
- IL206197A0 IL206197A0 IL206197A IL20619710A IL206197A0 IL 206197 A0 IL206197 A0 IL 206197A0 IL 206197 A IL206197 A IL 206197A IL 20619710 A IL20619710 A IL 20619710A IL 206197 A0 IL206197 A0 IL 206197A0
- Authority
- IL
- Israel
- Prior art keywords
- dimethylamino
- phenol
- propyl
- ethyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07023728 | 2007-12-07 | ||
| PCT/EP2008/010330 WO2009071310A1 (en) | 2007-12-07 | 2008-12-05 | Crystalline modifications of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl -propyl)-phenol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL206197A0 true IL206197A0 (en) | 2010-12-30 |
| IL206197A IL206197A (en) | 2015-03-31 |
Family
ID=39272207
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL206197A IL206197A (en) | 2007-12-07 | 2010-06-06 | Crystalline forms of the compound (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol, methods for their preparation, pharmaceutical compositions comprising the same and uses thereof for the preparation of compositions for treating pain |
| IL237478A IL237478A0 (en) | 2007-12-07 | 2015-03-01 | Crystalline modifications of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL237478A IL237478A0 (en) | 2007-12-07 | 2015-03-01 | Crystalline modifications of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8134032B2 (en) |
| EP (2) | EP2240431B1 (en) |
| CN (3) | CN104447360B (en) |
| CY (2) | CY1118976T1 (en) |
| DK (2) | DK2240431T3 (en) |
| ES (2) | ES2764451T3 (en) |
| HR (2) | HRP20170481T1 (en) |
| HU (2) | HUE031126T2 (en) |
| IL (2) | IL206197A (en) |
| LT (1) | LT2240431T (en) |
| PL (2) | PL3173400T3 (en) |
| PT (2) | PT3173400T (en) |
| SI (2) | SI3173400T1 (en) |
| WO (1) | WO2009071310A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100272815A1 (en) * | 2009-04-28 | 2010-10-28 | Actavis Group Ptc Ehf | Amorphous form of tapentadol hydrochloride |
| US8288592B2 (en) * | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
| US20130116333A1 (en) | 2010-05-05 | 2013-05-09 | Ratiopharm Gmbh | Solid tapentadol in non-crystalline form |
| WO2012051246A1 (en) | 2010-10-12 | 2012-04-19 | Ratiopharm Gmbh | Tapentadol hydrobromide and crystalline forms thereof |
| WO2013111161A2 (en) * | 2012-01-10 | 2013-08-01 | Msn Laboratories Limited | Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof |
| WO2014023652A1 (en) * | 2012-08-06 | 2014-02-13 | Ratiopharm Gmbh | Pharmaceutical formulation comprising tapentadol and cyclodextrin |
| EP2808319A1 (en) | 2013-05-31 | 2014-12-03 | Arevipharma GmbH | 3-[3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol resin complex |
| CZ307492B6 (en) | 2014-02-04 | 2018-10-17 | Zentiva, K.S. | A solid form of tapentadol maleate and a method of its preparation |
| GB2523089A (en) * | 2014-02-12 | 2015-08-19 | Azad Pharmaceutical Ingredients Ag | Stable polymorph form B of tapentadol hydrochloride |
| PL3653599T3 (en) | 2016-04-19 | 2023-03-20 | Ratiopharm Gmbh | Crystalline tapentadol phosphate |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1027666C (en) * | 1993-02-20 | 1995-02-15 | 袁晓辉 | High molecular polymer positive temperature coefficient thermistor material |
| DE4426245A1 (en) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-phenyl-3-dimethylamino-propane compounds with pharmacological activity |
| PE20030527A1 (en) * | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | DELAYED-RELEASE PHARMACEUTICAL FORMULATION CONTAINING 3- (3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL) PHENOL OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME AND ORAL TABLETS CONTAINING IT |
| DE10326097A1 (en) * | 2003-06-06 | 2005-01-05 | Grünenthal GmbH | Process for the preparation of dimethyl (3-aryl-butyl) -amine compounds |
| ATE368639T1 (en) * | 2004-06-28 | 2007-08-15 | Gruenenthal Gmbh | CRYSTALLINE FORMS OF (-)-(1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYLPROPYL)-PHENOL HYDROCHLORIDE |
| DE102005034974A1 (en) * | 2005-07-22 | 2007-04-19 | Grünenthal GmbH | Salt of dimethylaminomethyl-phenyl-cyclohexane and its crystalline forms |
| US20070254960A1 (en) * | 2006-04-28 | 2007-11-01 | Gruenenthal Gmbh | Pharmaceutical combination |
-
2008
- 2008-12-05 SI SI200832101T patent/SI3173400T1/en unknown
- 2008-12-05 US US12/329,111 patent/US8134032B2/en active Active
- 2008-12-05 EP EP08857298.7A patent/EP2240431B1/en active Active
- 2008-12-05 PT PT162038483T patent/PT3173400T/en unknown
- 2008-12-05 HU HUE08857298A patent/HUE031126T2/en unknown
- 2008-12-05 PL PL16203848T patent/PL3173400T3/en unknown
- 2008-12-05 WO PCT/EP2008/010330 patent/WO2009071310A1/en active Application Filing
- 2008-12-05 DK DK08857298.7T patent/DK2240431T3/en active
- 2008-12-05 CN CN201410468436.3A patent/CN104447360B/en active Active
- 2008-12-05 LT LTEP08857298.7T patent/LT2240431T/en unknown
- 2008-12-05 PT PT88572987T patent/PT2240431T/en unknown
- 2008-12-05 SI SI200831791A patent/SI2240431T1/en unknown
- 2008-12-05 DK DK16203848T patent/DK3173400T3/en active
- 2008-12-05 PL PL08857298T patent/PL2240431T3/en unknown
- 2008-12-05 HU HUE16203848A patent/HUE047275T2/en unknown
- 2008-12-05 ES ES16203848T patent/ES2764451T3/en active Active
- 2008-12-05 CN CN201410468681.4A patent/CN104447361B/en active Active
- 2008-12-05 CN CN200880126383.XA patent/CN101939287B/en active Active
- 2008-12-05 ES ES08857298.7T patent/ES2623413T3/en active Active
- 2008-12-05 EP EP16203848.3A patent/EP3173400B1/en active Active
-
2010
- 2010-06-06 IL IL206197A patent/IL206197A/en active IP Right Grant
-
2015
- 2015-03-01 IL IL237478A patent/IL237478A0/en unknown
-
2017
- 2017-03-21 HR HRP20170481TT patent/HRP20170481T1/en unknown
- 2017-04-07 CY CY20171100414T patent/CY1118976T1/en unknown
-
2019
- 2019-12-04 CY CY20191101278T patent/CY1122416T1/en unknown
-
2020
- 2020-01-16 HR HRP20200067TT patent/HRP20200067T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2240431A1 (en) | 2010-10-20 |
| US8134032B2 (en) | 2012-03-13 |
| DK2240431T3 (en) | 2017-04-10 |
| HRP20170481T1 (en) | 2017-05-19 |
| CN104447361B (en) | 2017-04-12 |
| IL206197A (en) | 2015-03-31 |
| EP2240431B1 (en) | 2017-01-25 |
| PL2240431T3 (en) | 2017-07-31 |
| PL3173400T3 (en) | 2020-05-18 |
| CY1118976T1 (en) | 2018-01-10 |
| EP3173400A1 (en) | 2017-05-31 |
| PT3173400T (en) | 2019-12-13 |
| CN104447360A (en) | 2015-03-25 |
| CN104447360B (en) | 2017-04-12 |
| SI3173400T1 (en) | 2020-01-31 |
| EP3173400B1 (en) | 2019-11-06 |
| ES2623413T3 (en) | 2017-07-11 |
| CY1122416T1 (en) | 2021-01-27 |
| HRP20200067T1 (en) | 2020-04-03 |
| PT2240431T (en) | 2017-05-03 |
| HUE047275T2 (en) | 2020-04-28 |
| CN101939287B (en) | 2014-10-22 |
| WO2009071310A1 (en) | 2009-06-11 |
| DK3173400T3 (en) | 2019-11-25 |
| LT2240431T (en) | 2017-04-10 |
| US20090149534A1 (en) | 2009-06-11 |
| ES2764451T3 (en) | 2020-06-03 |
| IL237478A0 (en) | 2015-04-30 |
| CN101939287A (en) | 2011-01-05 |
| SI2240431T1 (en) | 2017-05-31 |
| HUE031126T2 (en) | 2017-07-28 |
| CN104447361A (en) | 2015-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |