CY1115352T1 - Μεθοδος παραγωγης ισοτοπου - Google Patents
Μεθοδος παραγωγης ισοτοπουInfo
- Publication number
- CY1115352T1 CY1115352T1 CY20141100445T CY141100445T CY1115352T1 CY 1115352 T1 CY1115352 T1 CY 1115352T1 CY 20141100445 T CY20141100445 T CY 20141100445T CY 141100445 T CY141100445 T CY 141100445T CY 1115352 T1 CY1115352 T1 CY 1115352T1
- Authority
- CY
- Cyprus
- Prior art keywords
- dga
- aqueous solution
- purity
- production
- radio
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0042—Technetium
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Radiation-Therapy Devices (AREA)
- Manufacture And Refinement Of Metals (AREA)
- Medicinal Preparation (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με μία μέθοδο για την παραγωγή 223Ra φαρμακευτικώς ανεκτής καθαρότητας η οποία περιλαμβάνει: i) την παρασκευή ενός μείγματος παραγωγής το οποίο περιλαμβάνει 227Ac, 227Th και 223Ra σε ένα πρώτο υδατικό διάλυμα το οποίο περιλαμβάνει ένα πρώτο ανόργανο οξύ˙ ii) την φόρτωση του εν λόγω μείγματος παραγωγής σε ένα DGA μέσο διαχωρισμού (π.χ., ρητίνη)˙ iii) την έκλουση του εν λόγω 223Ra από το εν λόγω DGA μέσο διαχωρισμού χρησιμοποιώντας ένα δεύτερο ανόργανο οξύ σε ένα δεύτερο υδατικό διάλυμα για να δώσει ένα εκλουόμενο 223Ra διάλυμα˙ και iv) την απογύμνωση του DGA μέσου διαχωρισμού από τα εν λόγω 227Ac και 227Th με ροή ενός τρίτου ανόργανου οξέος σε ένα τρίτο υδατικό διάλυμα μέσω του DGA μέσου διαχωρισμού σε μια αντίστροφη κατεύθυνση. Η εφεύρεση περαιτέρω σχετίζεται με υψηλής-καθαρότητας ράδιο-223 σχηματιζόμενο ή δυνάμενο να σχηματιστεί με μια τέτοια μέθοδο καθώς επίσης φαρμακευτικές συνθέσεις οι οποίες περιλαμβάνουν τέτοιο ράδιο-223 φαρμακευτικής καθαρότητας.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1007353.4A GB201007353D0 (en) | 2010-04-30 | 2010-04-30 | Method |
| EP11719187.4A EP2564397B1 (en) | 2010-04-30 | 2011-04-29 | Isotope production method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1115352T1 true CY1115352T1 (el) | 2017-01-04 |
Family
ID=42289983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20141100445T CY1115352T1 (el) | 2010-04-30 | 2014-06-18 | Μεθοδος παραγωγης ισοτοπου |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9056142B2 (el) |
| EP (2) | EP2564397B1 (el) |
| JP (1) | JP5969462B2 (el) |
| KR (1) | KR101886883B1 (el) |
| CN (1) | CN102985980B (el) |
| AU (1) | AU2011247362B2 (el) |
| BR (1) | BR112012027945B1 (el) |
| CA (1) | CA2797901C (el) |
| CY (1) | CY1115352T1 (el) |
| DK (1) | DK2564397T3 (el) |
| EA (1) | EA022226B1 (el) |
| ES (1) | ES2473266T3 (el) |
| GB (1) | GB201007353D0 (el) |
| HK (1) | HK1183557A1 (el) |
| IL (1) | IL222764A (el) |
| MX (1) | MX2012012669A (el) |
| NZ (1) | NZ603460A (el) |
| PL (1) | PL2564397T3 (el) |
| PT (1) | PT2564397E (el) |
| SG (1) | SG185106A1 (el) |
| WO (1) | WO2011134672A1 (el) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201002508D0 (en) | 2010-02-12 | 2010-03-31 | Algeta As | Product |
| WO2014095833A1 (en) | 2012-12-19 | 2014-06-26 | Bayer Pharma Aktiengesellschaft | Combination comprising radium-223 for the treatment of cancer |
| GB201314718D0 (en) * | 2013-08-16 | 2013-10-02 | Algeta As | Quantification method |
| JP6499657B2 (ja) | 2013-12-03 | 2019-04-10 | バイエル ファーマ アクチエンゲゼルシャフト | Ｐｉ３ｋ阻害剤の組み合わせ |
| EP3077003A1 (en) | 2013-12-03 | 2016-10-12 | Bayer Pharma Aktiengesellschaft | Combination of pi3k-inhibitors |
| WO2015137451A1 (ja) * | 2014-03-13 | 2015-09-17 | 株式会社クラレ | 重合体、吸着材、並びにその製造方法 |
| CN106415734B (zh) * | 2014-05-13 | 2019-02-15 | 保罗·谢勒学院 | 生产43Sc放射性核素及其放射性药物用于正电子发射断层显像 |
| WO2016083739A1 (fr) | 2014-11-26 | 2016-06-02 | Rhodia Operations | Composition de lanthane et d'actinium-227 |
| GB201600153D0 (en) * | 2016-01-05 | 2016-02-17 | Bayer As | Isotope preparation method |
| CZ306722B6 (cs) * | 2016-03-16 | 2017-05-24 | ÄŚeskĂ© vysokĂ© uÄŤenĂ technickĂ© v Praze | Způsob izolace Ac ze směsi radia, aktinia a thoria |
| CA3033734A1 (en) | 2016-08-16 | 2018-02-22 | Curium Us Llc | Chromatographic separation of mo-99 from w-187 |
| US10704123B2 (en) | 2016-08-22 | 2020-07-07 | Uchicago Argonne, Llc | Process for the separation and purification of medical isotopes |
| US10344355B2 (en) * | 2016-08-22 | 2019-07-09 | Uchicago Argonne, Llc | Process for the separation and purification of scandium medical isotopes |
| AR110995A1 (es) | 2017-02-24 | 2019-05-22 | Bayer Ag | Combinación de inhibidores de quinasa atr con sal de radio-223 |
| RU2752845C1 (ru) * | 2020-05-13 | 2021-08-11 | Акционерное Общество "Наука И Инновации" | Способ получения высокочистого радия-223 |
| CN114873626B (zh) * | 2021-12-31 | 2023-09-19 | 中国工程物理研究院核物理与化学研究所 | 一种176Yb2O3和160Gd2O3靶料回收方法 |
| CN115869658A (zh) * | 2022-12-29 | 2023-03-31 | 中国核动力研究设计院 | 用于制备Ra-223的分离系统及其分离方法、应用和制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4390517A (en) | 1979-12-19 | 1983-06-28 | New England Nuclear Corporation | Method, composition and kit for stabilizing radiolabeled compounds |
| US5809394A (en) * | 1996-12-13 | 1998-09-15 | Battelle Memorial Institute | Methods of separating short half-life radionuclides from a mixture of radionuclides |
| JP3832961B2 (ja) * | 1998-03-10 | 2006-10-11 | ユニチカ株式会社 | ラジウム吸着剤の再生方法 |
| NO310544B1 (no) * | 1999-01-04 | 2001-07-23 | Algeta As | Opparbeidelse og anvendelse av radium-223 til fremstilling av preparat samt kit til behandling av kalsifisert vev for palliasjon, benkreft-terapi og/eller overflatebehandling av ben |
| JP4380875B2 (ja) * | 2000-02-29 | 2009-12-09 | 株式会社東芝 | 液体処理装置 |
| JP2001318087A (ja) * | 2000-05-11 | 2001-11-16 | Kawasaki Steel Corp | 液体クロマトグラフィー用カラム及びその使用方法 |
| JP4495453B2 (ja) * | 2001-06-22 | 2010-07-07 | ピージー リサーチ ファンデーション，インコーポレーテッド | 自動放射性核種分離システム |
| US7087206B2 (en) * | 2002-04-12 | 2006-08-08 | Pg Research Foundation | Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine |
| JP4740545B2 (ja) * | 2002-04-12 | 2011-08-03 | ピージー リサーチ ファンデーション インコーポレイテッド | 不純物を含まない所望の娘放射性核種の溶液の製造方法 |
| US7157022B2 (en) * | 2002-09-30 | 2007-01-02 | .Pg Research Foundation, Inc. | Multivalent metal ion extraction using diglycolamide-coated particles |
| US20070009409A1 (en) | 2005-07-11 | 2007-01-11 | Hariprasad Gali | 212Bi or 213Bi Generator from supported parent isotope |
| EP2796575B8 (en) * | 2006-09-08 | 2020-04-01 | Actinium Pharmaceuticals, Inc. | Method for the purification of radium from different sources |
| GB201007354D0 (en) * | 2010-04-30 | 2010-06-16 | Algeta Asa | Method |
-
2010
- 2010-04-30 GB GBGB1007353.4A patent/GB201007353D0/en not_active Ceased
-
2011
- 2011-04-29 MX MX2012012669A patent/MX2012012669A/es active IP Right Grant
- 2011-04-29 WO PCT/EP2011/002156 patent/WO2011134672A1/en active Application Filing
- 2011-04-29 SG SG2012080354A patent/SG185106A1/en unknown
- 2011-04-29 BR BR112012027945-9A patent/BR112012027945B1/pt active IP Right Grant
- 2011-04-29 ES ES11719187.4T patent/ES2473266T3/es active Active
- 2011-04-29 EP EP11719187.4A patent/EP2564397B1/en active Active
- 2011-04-29 EP EP14155426.1A patent/EP2733705A1/en not_active Withdrawn
- 2011-04-29 CN CN201180032430.6A patent/CN102985980B/zh active Active
- 2011-04-29 NZ NZ603460A patent/NZ603460A/en unknown
- 2011-04-29 JP JP2013506544A patent/JP5969462B2/ja active Active
- 2011-04-29 PT PT117191874T patent/PT2564397E/pt unknown
- 2011-04-29 DK DK11719187.4T patent/DK2564397T3/da active
- 2011-04-29 AU AU2011247362A patent/AU2011247362B2/en active Active
- 2011-04-29 CA CA2797901A patent/CA2797901C/en active Active
- 2011-04-29 KR KR1020127031313A patent/KR101886883B1/ko active IP Right Grant
- 2011-04-29 PL PL11719187T patent/PL2564397T3/pl unknown
- 2011-04-29 US US13/695,355 patent/US9056142B2/en active Active
- 2011-04-29 EA EA201291061A patent/EA022226B1/ru not_active IP Right Cessation
-
2012
- 2012-10-30 IL IL222764A patent/IL222764A/en active IP Right Grant
-
2013
- 2013-09-23 HK HK13110818.4A patent/HK1183557A1/xx unknown
-
2014
- 2014-06-18 CY CY20141100445T patent/CY1115352T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2564397E (pt) | 2014-06-25 |
| CA2797901C (en) | 2019-02-26 |
| JP2013533459A (ja) | 2013-08-22 |
| IL222764A (en) | 2016-07-31 |
| CN102985980A (zh) | 2013-03-20 |
| US20130095031A1 (en) | 2013-04-18 |
| CN102985980B (zh) | 2015-08-12 |
| IL222764A0 (en) | 2012-12-31 |
| EP2564397A1 (en) | 2013-03-06 |
| US9056142B2 (en) | 2015-06-16 |
| BR112012027945B1 (pt) | 2022-07-26 |
| CA2797901A1 (en) | 2011-11-03 |
| EA201291061A1 (ru) | 2013-05-30 |
| KR20130111930A (ko) | 2013-10-11 |
| ES2473266T3 (es) | 2014-07-04 |
| EP2564397B1 (en) | 2014-03-19 |
| JP5969462B2 (ja) | 2016-08-17 |
| BR112012027945A2 (el) | 2017-08-15 |
| MX2012012669A (es) | 2013-03-08 |
| NZ603460A (en) | 2014-09-26 |
| SG185106A1 (en) | 2012-12-28 |
| EP2733705A1 (en) | 2014-05-21 |
| EA022226B1 (ru) | 2015-11-30 |
| WO2011134672A1 (en) | 2011-11-03 |
| DK2564397T3 (da) | 2014-06-23 |
| KR101886883B1 (ko) | 2018-08-08 |
| AU2011247362B2 (en) | 2014-11-27 |
| PL2564397T3 (pl) | 2014-10-31 |
| GB201007353D0 (en) | 2010-06-16 |
| HK1183557A1 (en) | 2013-12-27 |
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