CY1114839T1 - Πρωτεϊνες συγχωνευσεως περιλαμβανουσες μια μη κυτταροτοξικη πρωτεαση, μια ομαδα στοχευσεως, μια θεση αποκοπης πρωτεασης και εναν τομεα μετατοπισεως - Google Patents

Πρωτεϊνες συγχωνευσεως περιλαμβανουσες μια μη κυτταροτοξικη πρωτεαση, μια ομαδα στοχευσεως, μια θεση αποκοπης πρωτεασης και εναν τομεα μετατοπισεως

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Publication number
CY1114839T1
CY1114839T1 CY20131101088T CY131101088T CY1114839T1 CY 1114839 T1 CY1114839 T1 CY 1114839T1 CY 20131101088 T CY20131101088 T CY 20131101088T CY 131101088 T CY131101088 T CY 131101088T CY 1114839 T1 CY1114839 T1 CY 1114839T1
Authority
CY
Cyprus
Prior art keywords
protease
target cell
site
targeting group
principles
Prior art date
Application number
CY20131101088T
Other languages
Greek (el)
English (en)
Inventor
Keith Foster
John Chaddock
Philip Marks
Patrick Stancombe
Lyndsey Durose
Original Assignee
Syntaxin Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntaxin Limited filed Critical Syntaxin Limited
Publication of CY1114839T1 publication Critical patent/CY1114839T1/el

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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CY20131101088T 2004-12-01 2013-12-03 Πρωτεϊνες συγχωνευσεως περιλαμβανουσες μια μη κυτταροτοξικη πρωτεαση, μια ομαδα στοχευσεως, μια θεση αποκοπης πρωτεασης και εναν τομεα μετατοπισεως CY1114839T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0426397.6A GB0426397D0 (en) 2004-12-01 2004-12-01 Fusion proteins
EP05818352.6A EP1874807B1 (fr) 2004-12-01 2005-12-01 Proteines de fusion comprenant une protease non-cytotoxique, une partie de ciblage, un site de clivage de protease et un domaine de translocation

Publications (1)

Publication Number Publication Date
CY1114839T1 true CY1114839T1 (el) 2016-12-14

Family

ID=34043887

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131101088T CY1114839T1 (el) 2004-12-01 2013-12-03 Πρωτεϊνες συγχωνευσεως περιλαμβανουσες μια μη κυτταροτοξικη πρωτεαση, μια ομαδα στοχευσεως, μια θεση αποκοπης πρωτεασης και εναν τομεα μετατοπισεως

Country Status (15)

Country Link
US (4) US8124074B2 (fr)
EP (1) EP1874807B1 (fr)
JP (1) JP5438901B2 (fr)
CN (1) CN101098885B (fr)
AU (1) AU2005311106B2 (fr)
BR (1) BRPI0515760A (fr)
CA (1) CA2593707C (fr)
CY (1) CY1114839T1 (fr)
DK (1) DK1874807T3 (fr)
ES (1) ES2431841T3 (fr)
GB (1) GB0426397D0 (fr)
PL (1) PL1874807T3 (fr)
PT (1) PT1874807E (fr)
SI (1) SI1874807T1 (fr)
WO (1) WO2006059113A2 (fr)

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EP1784420B1 (fr) 2004-09-01 2008-12-03 Allergan, Inc. Toxines clostridiales degradables
US8399400B2 (en) 2004-12-01 2013-03-19 Syntaxin, Ltd. Fusion proteins
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GB0426394D0 (en) 2004-12-01 2005-01-05 Health Prot Agency Fusion proteins
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US8603779B2 (en) 2004-12-01 2013-12-10 Syntaxin, Ltd. Non-cytotoxic protein conjugates
WO2006099590A2 (fr) 2005-03-15 2006-09-21 Allergan, Inc. Toxines de clostridiose modifiees presentant des capacites de ciblage modifiees pour des cellules cibles de toxine de clostridiose
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BRPI0618753A2 (pt) * 2005-11-17 2011-09-13 Revance Therapeutics Inc composição para liberação transdérmica de toxina botulìnica e método de administração
GB0610867D0 (en) 2006-06-01 2006-07-12 Syntaxin Ltd Treatment of pain
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JP5826635B2 (ja) 2009-03-13 2015-12-02 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 免疫系調節エンドペプチターゼ活性アッセイ
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US20080064092A1 (en) 2008-03-13
ES2431841T3 (es) 2013-11-28
CN101098885B (zh) 2016-04-27
CA2593707C (fr) 2015-01-20
CN101098885A (zh) 2008-01-02
EP1874807A2 (fr) 2008-01-09
BRPI0515760A (pt) 2008-07-29
US20120149084A1 (en) 2012-06-14
EP1874807B1 (fr) 2013-09-25
GB0426397D0 (en) 2005-01-05
WO2006059113A2 (fr) 2006-06-08
US8956847B2 (en) 2015-02-17
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WO2006059113A3 (fr) 2006-09-28
US20130115682A1 (en) 2013-05-09
DK1874807T3 (da) 2013-12-09
AU2005311106B2 (en) 2011-05-26
US8124074B2 (en) 2012-02-28
US20090004174A1 (en) 2009-01-01
US8372615B2 (en) 2013-02-12
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