SI1874807T1 - Fuzijski proteini, ki obsegajo ne-citotoksično proteazo, ciljajoč del, proteazno mesto cepitve in translokacijsko domeno - Google Patents

Fuzijski proteini, ki obsegajo ne-citotoksično proteazo, ciljajoč del, proteazno mesto cepitve in translokacijsko domeno

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Publication number
SI1874807T1
SI1874807T1 SI200531795T SI200531795T SI1874807T1 SI 1874807 T1 SI1874807 T1 SI 1874807T1 SI 200531795 T SI200531795 T SI 200531795T SI 200531795 T SI200531795 T SI 200531795T SI 1874807 T1 SI1874807 T1 SI 1874807T1
Authority
SI
Slovenia
Prior art keywords
protease
fusion proteins
cleavage site
targeting moiety
translocation domain
Prior art date
Application number
SI200531795T
Other languages
English (en)
Inventor
Keith Health Protection Agency FOSTER
John Health Protection Agency CHADDOCK
Philip Health Protection Agency MARKS
Patrick Health Protection Agency STANCOMBE
Lyndsey Interdisciplinary Biomedical Research Centre DUROSE
Original Assignee
Syntaxin Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntaxin Limited filed Critical Syntaxin Limited
Publication of SI1874807T1 publication Critical patent/SI1874807T1/sl

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
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SI200531795T 2004-12-01 2005-12-01 Fuzijski proteini, ki obsegajo ne-citotoksično proteazo, ciljajoč del, proteazno mesto cepitve in translokacijsko domeno SI1874807T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0426397.6A GB0426397D0 (en) 2004-12-01 2004-12-01 Fusion proteins
EP05818352.6A EP1874807B1 (en) 2004-12-01 2005-12-01 Fusion proteins comprising a non-cytotoxic protease, a targeting moiety, a protease cleavage site and a translocation domain
PCT/GB2005/004606 WO2006059113A2 (en) 2004-12-01 2005-12-01 Fusion proteins comprising a non-cytotoxic protease, a targeting moiety, a protease cleavage site and a translocation domain

Publications (1)

Publication Number Publication Date
SI1874807T1 true SI1874807T1 (sl) 2013-12-31

Family

ID=34043887

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200531795T SI1874807T1 (sl) 2004-12-01 2005-12-01 Fuzijski proteini, ki obsegajo ne-citotoksično proteazo, ciljajoč del, proteazno mesto cepitve in translokacijsko domeno

Country Status (15)

Country Link
US (4) US8124074B2 (sl)
EP (1) EP1874807B1 (sl)
JP (1) JP5438901B2 (sl)
CN (1) CN101098885B (sl)
AU (1) AU2005311106B2 (sl)
BR (1) BRPI0515760A (sl)
CA (1) CA2593707C (sl)
CY (1) CY1114839T1 (sl)
DK (1) DK1874807T3 (sl)
ES (1) ES2431841T3 (sl)
GB (1) GB0426397D0 (sl)
PL (1) PL1874807T3 (sl)
PT (1) PT1874807E (sl)
SI (1) SI1874807T1 (sl)
WO (1) WO2006059113A2 (sl)

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CA2593707A1 (en) 2006-06-08
WO2006059113A3 (en) 2006-09-28
ES2431841T3 (es) 2013-11-28
AU2005311106A1 (en) 2006-06-08
AU2005311106B2 (en) 2011-05-26
US20080064092A1 (en) 2008-03-13
US8124074B2 (en) 2012-02-28
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US20130115682A1 (en) 2013-05-09
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EP1874807B1 (en) 2013-09-25
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EP1874807A2 (en) 2008-01-09
US8124405B2 (en) 2012-02-28
PT1874807E (pt) 2013-10-09
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US20120149084A1 (en) 2012-06-14
US8372615B2 (en) 2013-02-12
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US8956847B2 (en) 2015-02-17
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