CO6231040A2 - Moleculas y metodos para modular la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) - Google Patents

Moleculas y metodos para modular la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)

Info

Publication number
CO6231040A2
CO6231040A2 CO09112535A CO09112535A CO6231040A2 CO 6231040 A2 CO6231040 A2 CO 6231040A2 CO 09112535 A CO09112535 A CO 09112535A CO 09112535 A CO09112535 A CO 09112535A CO 6231040 A2 CO6231040 A2 CO 6231040A2
Authority
CO
Colombia
Prior art keywords
seq
amino acids
pcsk9
antigen binding
subtilisin
Prior art date
Application number
CO09112535A
Other languages
English (en)
Inventor
Dmitri Mikhailov
David Langdon Yowe
Tony Fleming
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO6231040A2 publication Critical patent/CO6231040A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

1.- Una molécula de enlace de polipéptido de pro-proteína convertasa-subtilisina/quexina tipo 9 aislada (PCSK9), la cual comprende una porción de enlace de antígeno de un anticuerpo que se enlaza específicamente con una PCSK9, en donde la porción de enlace de antígeno se enlaza con un epítopo dentro del dominio catalítico de la PCSK9 humana (SEQ ID NO:1), dentro o traslapándose con uno de los siguientes: (a) aminoácidos 166-177 de la SEQ ID NO:1; (b) aminoácidos 187-202 de la SEQ ID NO:1; (c) aminoácidos 206-219 de la SEQ ID NO:1; (d) aminoácidos 231-246 de la SEQ ID NO:1; (e) aminoácidos 277-283 de la SEQ ID NO:1; (f) aminoácidos 336-349 de la SEQ ID NO:1; (g) aminoácidos 368-383 de la SEQ ID NO:1; o (h) aminoácidos 426-439 de la SEQ ID NO:1. 2.- Una molécula de enlace de PCSK9 aislada, la cual comprende una porción de enlace de antígeno de un anticuerpo que se enlaza específicamente con una PCSK9, en donde la porción de enlace de antígeno se enlaza con un epítopo dentro del dominio rico en cisteína de la PCSK9 humana, dentro o traslapándose con uno de los siguientes: (a) aminoácidos 443-500 de la SEQ ID NO: 1; (b) aminoácidos 557-590 de la SEQ ID NO: 1; o (c) aminoácidos 636-678 de la SEQ ID NO: 1. 3.- Una molécula de enlace de PCSK9 aislada, la cual comprende una porción de enlace de antígeno de un anticuerpo que se enlaza específicamente con una PCSK9, en donde la porción de enlace de antígeno se enlaza con un epítopo dentro del pro-dominio de la PCSK9 humana dentro o traslapándose con los aminoácidos 89-134 de la SEQ ID NO:1.
CO09112535A 2007-04-13 2009-10-09 Moleculas y metodos para modular la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) CO6231040A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91165407P 2007-04-13 2007-04-13

Publications (1)

Publication Number Publication Date
CO6231040A2 true CO6231040A2 (es) 2010-12-20

Family

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Family Applications (1)

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CO09112535A CO6231040A2 (es) 2007-04-13 2009-10-09 Moleculas y metodos para modular la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)

Country Status (21)

Country Link
US (1) US20100233177A1 (es)
EP (1) EP2137218A2 (es)
JP (1) JP2010523135A (es)
KR (1) KR20100019440A (es)
CN (1) CN101679527A (es)
AR (1) AR066042A1 (es)
AU (1) AU2008237940A1 (es)
BR (1) BRPI0810551A2 (es)
CA (1) CA2681428A1 (es)
CO (1) CO6231040A2 (es)
EA (1) EA200901376A1 (es)
EC (1) ECSP099688A (es)
GT (1) GT200900264A (es)
IL (1) IL201194A0 (es)
MA (1) MA31304B1 (es)
MX (1) MX2009010957A (es)
PE (1) PE20090145A1 (es)
TN (1) TN2009000410A1 (es)
TW (1) TW200906439A (es)
WO (1) WO2008125623A2 (es)
ZA (1) ZA200906489B (es)

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