CY1114500T1 - Γεφυρωμενα παραγωγα σπειρο[2.4]επτανιου ως αγωνιστες υποδοχεων alx kai/ή fprl2 - Google Patents

Γεφυρωμενα παραγωγα σπειρο[2.4]επτανιου ως αγωνιστες υποδοχεων alx kai/ή fprl2

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Publication number
CY1114500T1
CY1114500T1 CY20131100903T CY131100903T CY1114500T1 CY 1114500 T1 CY1114500 T1 CY 1114500T1 CY 20131100903 T CY20131100903 T CY 20131100903T CY 131100903 T CY131100903 T CY 131100903T CY 1114500 T1 CY1114500 T1 CY 1114500T1
Authority
CY
Cyprus
Prior art keywords
alx
bridged
spiral
eptaniou
fprl2
Prior art date
Application number
CY20131100903T
Other languages
English (en)
Inventor
Daniel Bur
Olivier Corminboeuf
Sylvaine Cren
Corinna Grisostomi
Xavier Leroy
Sylvia Richard-Bildstein
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of CY1114500T1 publication Critical patent/CY1114500T1/el

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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Abstract

Η παρούσα εφεύρεση αναφέρεται σε γεφυρωμένα παράγωγα σπείρο[2.4] επτανίου του χημικού τύπου (Ι), όπου τα W, Υ, Ζ, R1 και R2 είναι όπως ορίστηκαν στη περιγραφή, στη παρασκευή τους και στη χρήση τους ως φαρμακευτικώς δραστικές ενώσεις και συγκεκριμένα στη χρήση τους ως αγωνιστές υποδοχέων ΑLΧ και/ή FΡRL2.
CY20131100903T 2009-05-18 2013-10-16 Γεφυρωμενα παραγωγα σπειρο[2.4]επτανιου ως αγωνιστες υποδοχεων alx kai/ή fprl2 CY1114500T1 (el)

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EP10723342.1A EP2432760B1 (en) 2009-05-18 2010-05-17 Bridged spiro [2.4] heptane derivatives as alx receptor and/or fprl2 agonists

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EP2225231B1 (en) 2007-12-18 2011-08-17 Actelion Pharmaceuticals Ltd. Aminotriazole derivatives as alx agonists
SG175363A1 (en) 2009-06-09 2011-12-29 Actelion Pharmaceuticals Ltd Fluorinated aminotriazole derivatives
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