CY1114409T1 - Μορια αναγνωρισης για την αγωγη και ανιχνευση νεοπλασιων - Google Patents
Μορια αναγνωρισης για την αγωγη και ανιχνευση νεοπλασιωνInfo
- Publication number
- CY1114409T1 CY1114409T1 CY20131100804T CY131100804T CY1114409T1 CY 1114409 T1 CY1114409 T1 CY 1114409T1 CY 20131100804 T CY20131100804 T CY 20131100804T CY 131100804 T CY131100804 T CY 131100804T CY 1114409 T1 CY1114409 T1 CY 1114409T1
- Authority
- CY
- Cyprus
- Prior art keywords
- tyr
- asn
- gly
- ala
- sequences
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Finger-Pressure Massage (AREA)
Abstract
Η εφεύρεση αναφέρεται σε μόρια αναγνώρισης τα οποία στρέφονται προς νεοπλασίες, σε φαρμακευτικές συνθέσεις που περιλαμβάνουν τα μόρια αναγνώρισης, σε μεθόδους για την παραγωγή των μορίων αναγνώρισης και στην χρήση των μορίων αναγνώρισης για τη διάγνωση και θεραπεία νεοπλασιακών παθήσεων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10303664A DE10303664A1 (de) | 2003-01-23 | 2003-01-23 | Erkennungsmoleküle zur Behandlung und Detektion von Tumoren |
EP08171923.9A EP2053063B1 (de) | 2003-01-23 | 2004-01-23 | Erkennungsmoleküle zur Behandlung und Detektion von Tumoren |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114409T1 true CY1114409T1 (el) | 2016-08-31 |
Family
ID=32695061
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100431T CY1108965T1 (el) | 2003-01-23 | 2009-04-13 | Μορια αναγνωρισης για την αγωγη και ανιχνευση νεοπλασιων |
CY20131100804T CY1114409T1 (el) | 2003-01-23 | 2013-09-17 | Μορια αναγνωρισης για την αγωγη και ανιχνευση νεοπλασιων |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100431T CY1108965T1 (el) | 2003-01-23 | 2009-04-13 | Μορια αναγνωρισης για την αγωγη και ανιχνευση νεοπλασιων |
Country Status (10)
Country | Link |
---|---|
US (2) | US8779102B2 (el) |
EP (2) | EP2053063B1 (el) |
AT (1) | ATE421537T1 (el) |
CY (2) | CY1108965T1 (el) |
DE (2) | DE10303664A1 (el) |
DK (2) | DK2053063T3 (el) |
ES (2) | ES2427832T3 (el) |
PT (2) | PT1585770E (el) |
SI (2) | SI2053063T1 (el) |
WO (1) | WO2004065423A2 (el) |
Families Citing this family (70)
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US8968730B2 (en) | 2002-08-14 | 2015-03-03 | Macrogenics Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8946387B2 (en) | 2002-08-14 | 2015-02-03 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
DE10256900A1 (de) | 2002-11-29 | 2004-06-24 | Nemod Immuntherapie Ag | Tumorspezifische Erkennungsmoleküle |
US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
ES2897506T3 (es) | 2003-01-09 | 2022-03-01 | Macrogenics Inc | Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de utilización de los mismos |
DE10303664A1 (de) * | 2003-01-23 | 2004-08-12 | Nemod Immuntherapie Ag | Erkennungsmoleküle zur Behandlung und Detektion von Tumoren |
MXPA06012601A (es) | 2004-05-10 | 2007-05-10 | Macrogenics Inc | Anticuerpos especificos de fcy riib humanizados y metodos de uso de los mismos. |
AU2006208226A1 (en) * | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
US11254748B2 (en) | 2005-04-15 | 2022-02-22 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US9296816B2 (en) | 2005-04-15 | 2016-03-29 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
GB2437727B (en) * | 2006-05-04 | 2011-04-20 | Univ Open | Aptamers directed to MUC1 |
HUE030269T2 (en) | 2006-06-26 | 2017-04-28 | Macrogenics Inc | FC RIIB-specific antibodies and methods for their use |
EP2032159B1 (en) | 2006-06-26 | 2015-01-07 | MacroGenics, Inc. | Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof |
WO2008007941A1 (en) * | 2006-07-10 | 2008-01-17 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Gainac specific binding molecules and uses thereof |
US8337852B2 (en) * | 2006-08-22 | 2012-12-25 | G2 Inflammation Pty Ltd | Anti-C5aR antibodies with improved properties |
ES2620261T3 (es) | 2006-09-10 | 2017-06-28 | Glycotope Gmbh | Uso de células humanas de origen leucémico mieloide para expresión de anticuerpos |
US8652466B2 (en) | 2006-12-08 | 2014-02-18 | Macrogenics, Inc. | Methods for the treatment of disease using immunoglobulins having Fc regions with altered affinities for FcγRactivating and FcγRinhibiting |
US8795667B2 (en) | 2007-12-19 | 2014-08-05 | Macrogenics, Inc. | Compositions for the prevention and treatment of smallpox |
AU2008343855B2 (en) | 2007-12-21 | 2013-08-15 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
US8669349B2 (en) | 2008-04-02 | 2014-03-11 | Macrogenics, Inc. | BCR-complex-specific antibodies and methods of using same |
JP5555223B2 (ja) | 2008-04-02 | 2014-07-23 | マクロジェニクス,インコーポレーテッド | HER2/neu特異的抗体およびその使用方法 |
US20100082438A1 (en) * | 2008-10-01 | 2010-04-01 | Ronnie Jack Garmon | Methods and systems for customer performance scoring |
JP5773352B2 (ja) * | 2008-10-28 | 2015-09-02 | 塩野義製薬株式会社 | 抗muc1抗体 |
EP2281844A1 (en) * | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
KR20150089096A (ko) * | 2009-08-17 | 2015-08-04 | 트라콘 파마수티칼즈, 인코포레이티드 | 항엔도글린 항체 및 항vegf 제제를 사용한 암 치료를 위한 병용 요법 |
US8221753B2 (en) * | 2009-09-30 | 2012-07-17 | Tracon Pharmaceuticals, Inc. | Endoglin antibodies |
ES2672121T3 (es) | 2009-10-07 | 2018-06-12 | Macrogenics, Inc. | Polipéptidos que contienen región Fc que presentan una función efectora mejorada debido a alteraciones del grado de fucosilación, y métodos para su uso |
US8518405B2 (en) * | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
PH12018501083A1 (en) | 2010-03-04 | 2019-02-18 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
US8802091B2 (en) | 2010-03-04 | 2014-08-12 | Macrogenics, Inc. | Antibodies reactive with B7-H3 and uses thereof |
US8883977B2 (en) | 2010-04-28 | 2014-11-11 | Shionogi & Co., Ltd. | MUC1 antibody |
AU2011286024B2 (en) | 2010-08-02 | 2014-08-07 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
PT2603528T (pt) | 2010-08-10 | 2016-12-01 | Glycotope Gmbh | Anticorpos glicosilados em fab |
US9845362B2 (en) | 2010-10-08 | 2017-12-19 | The University Of North Carolina At Charlotte | Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same |
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US9587032B2 (en) * | 2013-06-12 | 2017-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | IgE antibodies for the inhibition of tumor metastasis |
UA116479C2 (uk) | 2013-08-09 | 2018-03-26 | Макродженікс, Інк. | БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ |
US11384149B2 (en) | 2013-08-09 | 2022-07-12 | Macrogenics, Inc. | Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof |
EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
EP2840091A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof |
CA2921999C (en) | 2013-09-13 | 2023-03-21 | Genentech, Inc. | Methods and compositions comprising an anti-il13 antibody and residual hamster phospholipase b-like 2 |
WO2015038884A2 (en) | 2013-09-13 | 2015-03-19 | Genentech, Inc. | Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products |
EP3150634B1 (en) | 2014-04-28 | 2020-04-22 | Medicinal Chemistry Pharmaceuticals Co., Ltd. | Anti-muc1 antibody or antigen-binding fragment thereof, and uses thereof |
WO2016026143A1 (en) | 2014-08-22 | 2016-02-25 | Huiru Wang | Saccharide-based biomarkers and therapeutics |
US11554181B2 (en) | 2014-09-05 | 2023-01-17 | The University Of North Carolina At Charlotte | Tumor specific antibody conjugates and uses therefor |
AU2015323860B2 (en) | 2014-09-29 | 2021-05-27 | Duke University | Bispecific molecules comprising an HIV-1 envelope targeting arm |
CA2966905A1 (en) | 2014-11-12 | 2016-05-19 | Tracon Pharmaceuticals, Inc. | Anti-endoglin antibodies and uses thereof |
US9926375B2 (en) | 2014-11-12 | 2018-03-27 | Tracon Pharmaceuticals, Inc. | Anti-endoglin antibodies and uses thereof |
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CN109152798B (zh) | 2015-12-02 | 2022-10-21 | 斯特库比股份有限公司 | 特异于糖基化的pd-1的抗体及其使用方法 |
WO2017139975A1 (en) | 2016-02-19 | 2017-08-24 | Huiru Wang | Antibodies against n-acetylglucosamine and n-acetyl-galactosamine |
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TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類CEACAM5抗體Fab片段 |
US11161911B2 (en) | 2017-10-23 | 2021-11-02 | Go Therapeutics, Inc. | Anti-glyco-MUC1 antibodies and their uses |
EP3700936A4 (en) * | 2017-10-24 | 2021-05-26 | Go Therapeutics, Inc. | ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES |
BR112020015202A2 (pt) | 2018-03-01 | 2020-12-29 | Glycotope Gmbh | Construções de proteínas de fusão compreendendo um anticorpo anti-muc1 e il-15 |
US20210221910A1 (en) | 2018-05-18 | 2021-07-22 | Glycotope Gmbh | Anti-muc1 antibody |
KR102463078B1 (ko) * | 2022-01-24 | 2022-11-03 | 싸이런테라퓨틱스 주식회사 | Muc-1에 특이적으로 결합하는 항체 및 이의 용도 |
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-
2003
- 2003-01-23 DE DE10303664A patent/DE10303664A1/de not_active Withdrawn
-
2004
- 2004-01-23 PT PT04704545T patent/PT1585770E/pt unknown
- 2004-01-23 DK DK08171923.9T patent/DK2053063T3/da active
- 2004-01-23 AT AT04704545T patent/ATE421537T1/de active
- 2004-01-23 DE DE502004008910T patent/DE502004008910D1/de not_active Expired - Lifetime
- 2004-01-23 DK DK04704545T patent/DK1585770T3/da active
- 2004-01-23 SI SI200432082T patent/SI2053063T1/sl unknown
- 2004-01-23 EP EP08171923.9A patent/EP2053063B1/de not_active Expired - Lifetime
- 2004-01-23 WO PCT/DE2004/000132 patent/WO2004065423A2/de active Application Filing
- 2004-01-23 US US10/540,479 patent/US8779102B2/en active Active
- 2004-01-23 PT PT81719239T patent/PT2053063E/pt unknown
- 2004-01-23 ES ES08171923T patent/ES2427832T3/es not_active Expired - Lifetime
- 2004-01-23 SI SI200431041T patent/SI1585770T1/sl unknown
- 2004-01-23 EP EP04704545A patent/EP1585770B1/de not_active Expired - Lifetime
- 2004-01-23 ES ES04704545T patent/ES2321298T3/es not_active Expired - Lifetime
-
2009
- 2009-04-13 CY CY20091100431T patent/CY1108965T1/el unknown
-
2013
- 2013-09-17 CY CY20131100804T patent/CY1114409T1/el unknown
-
2014
- 2014-06-26 US US14/316,389 patent/US9845361B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PT2053063E (pt) | 2013-09-24 |
SI2053063T1 (sl) | 2013-10-30 |
ES2321298T3 (es) | 2009-06-04 |
WO2004065423A3 (de) | 2004-11-25 |
WO2004065423A2 (de) | 2004-08-05 |
EP2053063A1 (de) | 2009-04-29 |
US9845361B2 (en) | 2017-12-19 |
PT1585770E (pt) | 2009-03-18 |
SI1585770T1 (sl) | 2009-06-30 |
CY1108965T1 (el) | 2014-07-02 |
ES2427832T3 (es) | 2013-11-04 |
US20150005474A1 (en) | 2015-01-01 |
DK1585770T3 (da) | 2009-05-04 |
US8779102B2 (en) | 2014-07-15 |
EP1585770A2 (de) | 2005-10-19 |
DE502004008910D1 (de) | 2009-03-12 |
DE10303664A1 (de) | 2004-08-12 |
DK2053063T3 (da) | 2013-09-30 |
ATE421537T1 (de) | 2009-02-15 |
EP1585770B1 (de) | 2009-01-21 |
US20060292643A1 (en) | 2006-12-28 |
EP2053063B1 (de) | 2013-06-19 |
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