CY1114192T1 - Λεντι-ιικος φορεας - Google Patents
Λεντι-ιικος φορεαςInfo
- Publication number
- CY1114192T1 CY1114192T1 CY20131100451T CY131100451T CY1114192T1 CY 1114192 T1 CY1114192 T1 CY 1114192T1 CY 20131100451 T CY20131100451 T CY 20131100451T CY 131100451 T CY131100451 T CY 131100451T CY 1114192 T1 CY1114192 T1 CY 1114192T1
- Authority
- CY
- Cyprus
- Prior art keywords
- lendi
- victory
- rev
- packaging
- upstream
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Ένα πολυκιστρονικό γονιδίωμα ρετροϊικού φορέα που περιέχει μία πρώτη αλληλουχία νουκλεϊκού οξέος, ανοδικά ενός εσωτερικού ρυθμιστικού στοιχείου, ώστε να αυξάνεται το επίπεδο του διαθέσιμου για πακετάρισμα γονιδιωματικού RNA με την απουσία του rev, ή ενός λειτουργικού ισοδύναμου αυτού.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0202403A GB0202403D0 (en) | 2002-02-01 | 2002-02-01 | Method |
GB0212768A GB0212768D0 (en) | 2002-05-31 | 2002-05-31 | Method |
EP03734767.1A EP1504108B1 (en) | 2002-02-01 | 2003-02-03 | Lentiviral vector |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114192T1 true CY1114192T1 (el) | 2016-08-31 |
Family
ID=27665368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100451T CY1114192T1 (el) | 2002-02-01 | 2013-06-06 | Λεντι-ιικος φορεας |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP2348119B1 (el) |
JP (2) | JP4598398B2 (el) |
AU (1) | AU2003238456A1 (el) |
CY (1) | CY1114192T1 (el) |
DK (2) | DK1504108T3 (el) |
ES (2) | ES2634424T3 (el) |
PT (1) | PT1504108E (el) |
SI (1) | SI1504108T1 (el) |
WO (1) | WO2003064665A2 (el) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2348119B1 (en) * | 2002-02-01 | 2017-04-26 | Oxford BioMedica (UK) Limited | Multicistronic lentiviral vector |
DK2002003T3 (en) | 2005-05-27 | 2016-03-21 | Ospedale San Raffaele Srl | Gene vector comprising miRNA |
WO2007014363A2 (en) * | 2005-07-27 | 2007-02-01 | Genentech, Inc. | Vectors for inducible expression of hairpin rna and use thereof |
US8765146B2 (en) | 2005-08-31 | 2014-07-01 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
GB0526210D0 (en) | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Vectors |
JP5559185B2 (ja) * | 2008-11-11 | 2014-07-23 | オックスフォード バイオメディカ(ユーケー)リミテッド | 方法 |
GB201118636D0 (en) | 2011-10-28 | 2011-12-07 | Oxford Biomedica Ltd | Nucleotide sequence |
GB201318804D0 (en) * | 2013-10-24 | 2013-12-11 | Adaptimmune Ltd | Vectors for transgene expression |
GB201322798D0 (en) | 2013-12-20 | 2014-02-05 | Oxford Biomedica Ltd | Production system |
RU2716991C2 (ru) | 2014-11-05 | 2020-03-17 | Вояджер Терапьютикс, Инк. | Полинуклеотиды aadc для лечения болезни паркинсона |
GB2540786A (en) * | 2015-07-28 | 2017-02-01 | Glaxosmithkline Ip Dev Ltd | Codon optimised tet repressor proteins |
EP3380620A1 (en) | 2015-11-23 | 2018-10-03 | Novartis AG | Optimized lentiviral transfer vectors and uses thereof |
FR3044017B1 (fr) | 2015-11-24 | 2019-05-03 | Glaxosmithkline Intellectual Property Development Limited | Procede de transfection transitoire pour la production retrovirale |
RU2752498C2 (ru) * | 2015-11-24 | 2021-07-28 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Стабильные клеточные линии для продуцирования ретровирусов |
CN110678197A (zh) | 2017-03-15 | 2020-01-10 | 牛津生物医学(英国)有限公司 | 方法 |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
ES2951857T3 (es) | 2017-12-22 | 2023-10-25 | Oxford Biomedica Ltd | Vector retroviral |
EP3836956A4 (en) * | 2018-08-16 | 2022-05-18 | Spacecraft Seven, LLC | METHODS FOR PRODUCING VIRAL VECTORS |
WO2020106621A1 (en) * | 2018-11-19 | 2020-05-28 | Board Of Regents, The University Of Texas System | A modular, polycistronic vector for car and tcr transduction |
CA3133188A1 (en) | 2019-03-10 | 2020-09-17 | Oxford Biomedica (Uk) Limited | Gene therapy compositions and methods for treating parkinson's disease |
EP4058067A1 (en) | 2019-11-12 | 2022-09-21 | Oxford BioMedica (UK) Limited | Production system |
US20240052366A1 (en) | 2020-02-13 | 2024-02-15 | Oxford Biomedica (Uk) Limited | Production of Lentiviral Vectors |
EP4118217A1 (en) | 2020-03-13 | 2023-01-18 | Oxford BioMedica (UK) Limited | Lentiviral vectors |
AU2021264465A1 (en) | 2020-04-27 | 2022-12-15 | University Of Iowa Research Foundation | Compositions and methods for the treatment of cystic fibrosis |
GB202007199D0 (en) | 2020-05-15 | 2020-07-01 | Oxford Biomedica Ltd | Viral vector production |
IL300219A (en) * | 2020-08-03 | 2023-03-01 | Prevail Therapeutics Inc | Parkin-encoding AAV vectors and uses thereof |
GB202017725D0 (en) | 2020-11-10 | 2020-12-23 | Oxford Biomedica Ltd | Method |
GB202114530D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Retroviral vectors |
GB202114529D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral vectors |
GB202114532D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral Vectors |
GB202114528D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral vectors |
GB202114534D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Novel viral regulatory elements |
GB202117844D0 (en) | 2021-12-09 | 2022-01-26 | Oxford Biomedica Ltd | Purification method |
GB202211935D0 (en) | 2022-08-16 | 2022-09-28 | Oxford Biomedica Ltd | envelope proteins |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6075190A (en) | 1989-06-30 | 1991-01-17 | Regents Of The University Of California, The | Retrovirus detection |
EP1285967A3 (en) | 1990-09-21 | 2005-03-02 | Chiron Corporation | Human retroviral packaging cell line |
DE4228458A1 (de) * | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronische Expressionseinheiten und deren Verwendung |
US5834256A (en) | 1993-06-11 | 1998-11-10 | Cell Genesys, Inc. | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells |
EP0758397B1 (en) | 1994-04-29 | 2005-06-22 | Baxter Healthcare S.A. | Recombinant poxviruses with foreign polynucleotides in essential regions |
WO1996009400A1 (en) | 1994-09-19 | 1996-03-28 | Systemix, Inc. | Methods for genetically modifying hematopoietic stem cells |
AU716045B2 (en) | 1994-11-28 | 2000-02-17 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
GB9510272D0 (en) | 1995-05-22 | 1995-07-19 | Isis Innovation | Retroviral vectors |
WO1997014809A2 (en) * | 1995-10-16 | 1997-04-24 | Dana-Farber Cancer Institute | Novel expression vectors and methods of use |
WO1997017457A2 (en) | 1995-11-08 | 1997-05-15 | Whitehead Institute For Biomedical Research | Stable packaging cell line producing pseudotyped retroviruses |
US6133027A (en) | 1996-08-07 | 2000-10-17 | City Of Hope | Inducible expression system |
US5739018A (en) | 1996-08-07 | 1998-04-14 | The Regents Of The University Of California | Packaging cell lines for pseudotyped retroviral vectors |
US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
CZ137399A3 (cs) | 1996-10-17 | 1999-07-14 | Oxford Biomedica (Uk) Limited | Retrovirový produkční systém pro produkci replikačně defektivních vektorovýh partikulí |
GB9621680D0 (en) | 1996-10-17 | 1996-12-11 | Oxford Biomedica Ltd | Lentiviral vectors |
WO1999032646A1 (en) * | 1997-12-22 | 1999-07-01 | Oxford Biomedica (Uk) Limited | Equine infectious anaemia virus (eiav) based |
GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
GB9720465D0 (en) | 1997-09-25 | 1997-11-26 | Oxford Biomedica Ltd | Dual-virus vectors |
WO1999040930A1 (en) | 1998-02-12 | 1999-08-19 | Center For Blood Research, Inc. | Specific inhibitors of nfat activation by calcineurin and their use in treating immune-related diseases |
GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
CA2322664A1 (en) | 1998-03-06 | 1999-09-10 | Oxford Biomedica (Uk) Limited | Enhanced prodrug activation |
CN1325653C (zh) | 1998-05-22 | 2007-07-11 | 牛津生物医学(英国)有限公司 | 逆转录病毒传递系统 |
DE69839970D1 (de) | 1998-11-10 | 2008-10-16 | Univ Rochester | Methoden zu herstellung von genbanken |
EP1160323A1 (en) | 1998-11-18 | 2001-12-05 | Oxford Biomedica (UK) Limited | 5T4 tumour-associated antigen for use in tumour immunotherapy |
GB9912965D0 (en) | 1999-06-03 | 1999-08-04 | Oxford Biomedica Ltd | In vivo selection method |
GB0009760D0 (en) * | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
GB0024550D0 (el) * | 2000-10-06 | 2000-11-22 | Oxford Biomedica Ltd | |
EP2348119B1 (en) * | 2002-02-01 | 2017-04-26 | Oxford BioMedica (UK) Limited | Multicistronic lentiviral vector |
-
2003
- 2003-02-03 EP EP10012190.4A patent/EP2348119B1/en not_active Expired - Lifetime
- 2003-02-03 ES ES10012190.4T patent/ES2634424T3/es not_active Expired - Lifetime
- 2003-02-03 DK DK03734767.1T patent/DK1504108T3/da active
- 2003-02-03 ES ES03734767T patent/ES2411981T3/es not_active Expired - Lifetime
- 2003-02-03 WO PCT/GB2003/000418 patent/WO2003064665A2/en active Application Filing
- 2003-02-03 DK DK10012190.4T patent/DK2348119T3/en active
- 2003-02-03 AU AU2003238456A patent/AU2003238456A1/en not_active Abandoned
- 2003-02-03 EP EP03734767.1A patent/EP1504108B1/en not_active Expired - Lifetime
- 2003-02-03 JP JP2003564256A patent/JP4598398B2/ja not_active Expired - Lifetime
- 2003-02-03 PT PT37347671T patent/PT1504108E/pt unknown
- 2003-02-03 SI SI200332266T patent/SI1504108T1/sl unknown
-
2010
- 2010-06-25 JP JP2010144625A patent/JP5601898B2/ja not_active Expired - Lifetime
-
2013
- 2013-06-06 CY CY20131100451T patent/CY1114192T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK1504108T3 (da) | 2013-06-10 |
ES2411981T3 (es) | 2013-07-09 |
EP2348119A3 (en) | 2011-11-02 |
AU2003238456A1 (en) | 2003-09-02 |
JP2005515783A (ja) | 2005-06-02 |
EP1504108B1 (en) | 2013-04-17 |
WO2003064665A2 (en) | 2003-08-07 |
SI1504108T1 (sl) | 2013-07-31 |
WO2003064665A3 (en) | 2004-12-02 |
EP2348119B1 (en) | 2017-04-26 |
EP1504108A2 (en) | 2005-02-09 |
DK2348119T3 (en) | 2017-08-21 |
JP4598398B2 (ja) | 2010-12-15 |
EP2348119A2 (en) | 2011-07-27 |
JP2010263904A (ja) | 2010-11-25 |
PT1504108E (pt) | 2013-06-12 |
ES2634424T3 (es) | 2017-09-27 |
JP5601898B2 (ja) | 2014-10-08 |
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