CY1113816T1 - Μορια ταυτοποιησης τα οποια ρυθμιζουν τις αλληλεπιδρασεις πρωτεϊνης-πρωτεϊνης με τη χρηση ανταποκριτων που ενεργοποιουνται με μια πρωτεαση - Google Patents
Μορια ταυτοποιησης τα οποια ρυθμιζουν τις αλληλεπιδρασεις πρωτεϊνης-πρωτεϊνης με τη χρηση ανταποκριτων που ενεργοποιουνται με μια πρωτεασηInfo
- Publication number
- CY1113816T1 CY1113816T1 CY20121101062T CY121101062T CY1113816T1 CY 1113816 T1 CY1113816 T1 CY 1113816T1 CY 20121101062 T CY20121101062 T CY 20121101062T CY 121101062 T CY121101062 T CY 121101062T CY 1113816 T1 CY1113816 T1 CY 1113816T1
- Authority
- CY
- Cyprus
- Prior art keywords
- protein
- responders
- acting
- regulate
- identification molecules
- Prior art date
Links
- 230000004850 protein–protein interaction Effects 0.000 title abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 238000010998 test method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96975607P | 2007-09-04 | 2007-09-04 | |
| US8498708P | 2008-07-30 | 2008-07-30 | |
| EP20080829659 EP2191275B1 (en) | 2007-09-04 | 2008-08-28 | Identifying molecules that modulate protein- protein interactions using protease activated reporters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113816T1 true CY1113816T1 (el) | 2016-07-27 |
Family
ID=40029329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121101062T CY1113816T1 (el) | 2007-09-04 | 2012-11-08 | Μορια ταυτοποιησης τα οποια ρυθμιζουν τις αλληλεπιδρασεις πρωτεϊνης-πρωτεϊνης με τη χρηση ανταποκριτων που ενεργοποιουνται με μια πρωτεαση |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8574865B2 (https=) |
| EP (1) | EP2191275B1 (https=) |
| JP (1) | JP5618829B2 (https=) |
| KR (1) | KR101636306B1 (https=) |
| CN (1) | CN102187225B (https=) |
| AU (1) | AU2008296501B2 (https=) |
| BR (1) | BRPI0816289B1 (https=) |
| CA (1) | CA2698362C (https=) |
| CL (1) | CL2008002602A1 (https=) |
| CY (1) | CY1113816T1 (https=) |
| DK (1) | DK2191275T3 (https=) |
| ES (1) | ES2393642T3 (https=) |
| IL (1) | IL204260A (https=) |
| MX (1) | MX2010002399A (https=) |
| MY (1) | MY155343A (https=) |
| PL (1) | PL2191275T3 (https=) |
| PT (1) | PT2191275E (https=) |
| RU (1) | RU2476891C2 (https=) |
| TW (1) | TWI425094B (https=) |
| UY (1) | UY31323A1 (https=) |
| WO (1) | WO2009032716A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009032716A1 (en) * | 2007-09-04 | 2009-03-12 | Sanofi-Aventis | Identifying molecules that modulate protein- protein interactions using protease activated reporters |
| WO2014196932A1 (en) * | 2013-06-06 | 2014-12-11 | Agency For Science, Technology And Research | Protease-responsive peptide biosensors and methods for analyte detection |
| CA2930001A1 (en) | 2013-11-11 | 2015-05-14 | University Hospitals Cleveland Medical Center | Targeted treatment of anerobic cancer |
| CN107003323B (zh) | 2014-11-25 | 2019-06-04 | 文塔纳医疗系统公司 | 使用化学连接和半抗原转移的邻近测定法 |
| WO2016153880A2 (en) * | 2015-03-23 | 2016-09-29 | The Regents Of The University Of California | Methods for detection of rnase activity |
| RU2639539C2 (ru) * | 2015-12-29 | 2017-12-21 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Репортерная система на основе лентивирусных репортерных конструкций для изучения белок-белковых взаимодействий |
| US20180301048A1 (en) * | 2017-04-12 | 2018-10-18 | Age Of Learning, Inc. | Remote live tutoring platform |
| WO2020028381A1 (en) * | 2018-07-30 | 2020-02-06 | Montana Molecular, Llc | Biosensors for detecting arrestin signaling |
| JP2022513606A (ja) * | 2018-12-10 | 2022-02-09 | イエール ユニバーシティ | 宿主の生理機能を形成する微生物叢代謝産物 |
| JP2022551820A (ja) * | 2019-10-15 | 2022-12-14 | エフ．ホフマン－ラ ロシュ アーゲー | 細胞内または小胞内生体分子相互作用を検出するための人工膜貫通タンパク質 |
| WO2022259904A1 (ja) * | 2021-06-07 | 2022-12-15 | 国立研究開発法人理化学研究所 | プロテアーゼ活性測定用の融合タンパク質基質 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6528271B1 (en) | 1997-06-05 | 2003-03-04 | Duke University | Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia |
| US5891646A (en) | 1997-06-05 | 1999-04-06 | Duke University | Methods of assaying receptor activity and constructs useful in such methods |
| US7128915B2 (en) | 1997-09-18 | 2006-10-31 | Research Development Foundation | Membrane virus host range mutations and their uses as vaccine substrates |
| US6884870B2 (en) | 1998-03-20 | 2005-04-26 | California Institute Of Technology | Fusion proteins for identifying proteases, protease target sites and regulators of protease activity in living cells |
| US20030157553A1 (en) | 2000-03-03 | 2003-08-21 | Gabriel Berstein | Methods of assaying for G protein-coupled receptor ligands and modulators |
| EP1205191A1 (en) | 2000-11-13 | 2002-05-15 | Centre National De La Recherche Scientifique | Targeted modification of intracellular compounds |
| EP1353182A3 (en) | 2002-04-12 | 2004-02-04 | Smithkline Beecham Corporation | Method of predicting cell-based assay results using binding profiles |
| US20070224615A1 (en) * | 2003-07-09 | 2007-09-27 | Invitrogen Corporation | Methods for assaying protein-protein interactions |
| JP4734498B2 (ja) * | 2003-07-09 | 2011-07-27 | ライフ テクノロジーズ コーポレイション | タンパク質−タンパク質相互作用を解析する方法 |
| US7524925B2 (en) | 2004-11-18 | 2009-04-28 | Washington State University | Protein interaction reporter agents and methods for using same |
| WO2009032716A1 (en) * | 2007-09-04 | 2009-03-12 | Sanofi-Aventis | Identifying molecules that modulate protein- protein interactions using protease activated reporters |
| EP3508570B1 (en) * | 2010-05-11 | 2020-07-22 | Promega Corporation | Mutant protease biosensors with enhanced detection characteristics |
-
2008
- 2008-08-28 WO PCT/US2008/074543 patent/WO2009032716A1/en not_active Ceased
- 2008-08-28 CA CA 2698362 patent/CA2698362C/en not_active Expired - Fee Related
- 2008-08-28 BR BRPI0816289A patent/BRPI0816289B1/pt not_active IP Right Cessation
- 2008-08-28 JP JP2010524099A patent/JP5618829B2/ja not_active Expired - Fee Related
- 2008-08-28 PT PT08829659T patent/PT2191275E/pt unknown
- 2008-08-28 EP EP20080829659 patent/EP2191275B1/en active Active
- 2008-08-28 CN CN200880110461.7A patent/CN102187225B/zh active Active
- 2008-08-28 ES ES08829659T patent/ES2393642T3/es active Active
- 2008-08-28 AU AU2008296501A patent/AU2008296501B2/en active Active
- 2008-08-28 DK DK08829659T patent/DK2191275T3/da active
- 2008-08-28 RU RU2010112854/15A patent/RU2476891C2/ru not_active IP Right Cessation
- 2008-08-28 MX MX2010002399A patent/MX2010002399A/es active IP Right Grant
- 2008-08-28 MY MYPI2010000555A patent/MY155343A/en unknown
- 2008-08-28 US US12/676,284 patent/US8574865B2/en active Active
- 2008-08-28 KR KR1020107004803A patent/KR101636306B1/ko not_active Expired - Fee Related
- 2008-08-28 PL PL08829659T patent/PL2191275T3/pl unknown
- 2008-09-02 CL CL2008002602A patent/CL2008002602A1/es unknown
- 2008-09-04 TW TW97133835A patent/TWI425094B/zh not_active IP Right Cessation
- 2008-09-04 UY UY31323A patent/UY31323A1/es not_active Application Discontinuation
-
2010
- 2010-03-02 IL IL204260A patent/IL204260A/en not_active IP Right Cessation
-
2012
- 2012-11-08 CY CY20121101062T patent/CY1113816T1/el unknown
-
2013
- 2013-10-02 US US14/044,250 patent/US9023610B2/en active Active
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