BRPI0816289B1 - método para identificar um composto que module uma interação proteína-proteína entre uma primeira proteína e uma segunda proteína e sistema de ensaio - Google Patents
método para identificar um composto que module uma interação proteína-proteína entre uma primeira proteína e uma segunda proteína e sistema de ensaio Download PDFInfo
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- Endocrinology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2008/074543 WO2009032716A1 (en) | 2007-09-04 | 2008-08-28 | Identifying molecules that modulate protein- protein interactions using protease activated reporters |
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| BRPI0816289A2 BRPI0816289A2 (pt) | 2016-11-01 |
| BRPI0816289A8 BRPI0816289A8 (pt) | 2018-05-08 |
| BRPI0816289B1 true BRPI0816289B1 (pt) | 2019-01-15 |
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| WO2009032716A1 (en) * | 2007-09-04 | 2009-03-12 | Sanofi-Aventis | Identifying molecules that modulate protein- protein interactions using protease activated reporters |
| WO2014196932A1 (en) * | 2013-06-06 | 2014-12-11 | Agency For Science, Technology And Research | Protease-responsive peptide biosensors and methods for analyte detection |
| CA2930001A1 (en) | 2013-11-11 | 2015-05-14 | University Hospitals Cleveland Medical Center | Targeted treatment of anerobic cancer |
| CN107003323B (zh) | 2014-11-25 | 2019-06-04 | 文塔纳医疗系统公司 | 使用化学连接和半抗原转移的邻近测定法 |
| WO2016153880A2 (en) * | 2015-03-23 | 2016-09-29 | The Regents Of The University Of California | Methods for detection of rnase activity |
| RU2639539C2 (ru) * | 2015-12-29 | 2017-12-21 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Репортерная система на основе лентивирусных репортерных конструкций для изучения белок-белковых взаимодействий |
| US20180301048A1 (en) * | 2017-04-12 | 2018-10-18 | Age Of Learning, Inc. | Remote live tutoring platform |
| WO2020028381A1 (en) * | 2018-07-30 | 2020-02-06 | Montana Molecular, Llc | Biosensors for detecting arrestin signaling |
| JP2022513606A (ja) * | 2018-12-10 | 2022-02-09 | イエール ユニバーシティ | 宿主の生理機能を形成する微生物叢代謝産物 |
| JP2022551820A (ja) * | 2019-10-15 | 2022-12-14 | エフ．ホフマン－ラ ロシュ アーゲー | 細胞内または小胞内生体分子相互作用を検出するための人工膜貫通タンパク質 |
| WO2022259904A1 (ja) * | 2021-06-07 | 2022-12-15 | 国立研究開発法人理化学研究所 | プロテアーゼ活性測定用の融合タンパク質基質 |
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| US5891646A (en) | 1997-06-05 | 1999-04-06 | Duke University | Methods of assaying receptor activity and constructs useful in such methods |
| US7128915B2 (en) | 1997-09-18 | 2006-10-31 | Research Development Foundation | Membrane virus host range mutations and their uses as vaccine substrates |
| US6884870B2 (en) | 1998-03-20 | 2005-04-26 | California Institute Of Technology | Fusion proteins for identifying proteases, protease target sites and regulators of protease activity in living cells |
| US20030157553A1 (en) | 2000-03-03 | 2003-08-21 | Gabriel Berstein | Methods of assaying for G protein-coupled receptor ligands and modulators |
| EP1205191A1 (en) | 2000-11-13 | 2002-05-15 | Centre National De La Recherche Scientifique | Targeted modification of intracellular compounds |
| EP1353182A3 (en) | 2002-04-12 | 2004-02-04 | Smithkline Beecham Corporation | Method of predicting cell-based assay results using binding profiles |
| US20070224615A1 (en) * | 2003-07-09 | 2007-09-27 | Invitrogen Corporation | Methods for assaying protein-protein interactions |
| JP4734498B2 (ja) * | 2003-07-09 | 2011-07-27 | ライフ テクノロジーズ コーポレイション | タンパク質−タンパク質相互作用を解析する方法 |
| US7524925B2 (en) | 2004-11-18 | 2009-04-28 | Washington State University | Protein interaction reporter agents and methods for using same |
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| EP3508570B1 (en) * | 2010-05-11 | 2020-07-22 | Promega Corporation | Mutant protease biosensors with enhanced detection characteristics |
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