BRPI0816289A2 - identificando moléculas que modulam interações proteína-proteína usando repórteres ativados por protease - Google Patents

identificando moléculas que modulam interações proteína-proteína usando repórteres ativados por protease

Info

Publication number
BRPI0816289A2
BRPI0816289A2 BRPI0816289A BRPI0816289A BRPI0816289A2 BR PI0816289 A2 BRPI0816289 A2 BR PI0816289A2 BR PI0816289 A BRPI0816289 A BR PI0816289A BR PI0816289 A BRPI0816289 A BR PI0816289A BR PI0816289 A2 BRPI0816289 A2 BR PI0816289A2
Authority
BR
Brazil
Prior art keywords
protein
protease
identifying molecules
modulate
reporters
Prior art date
Application number
BRPI0816289A
Other languages
English (en)
Inventor
Haifeng Eishingdrelo
Jidong Cai
Paul S Wright
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0816289A2 publication Critical patent/BRPI0816289A2/pt
Publication of BRPI0816289A8 publication Critical patent/BRPI0816289A8/pt
Publication of BRPI0816289B1 publication Critical patent/BRPI0816289B1/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0816289A 2007-09-04 2008-08-28 método para identificar um composto que module uma interação proteína-proteína entre uma primeira proteína e uma segunda proteína e sistema de ensaio BRPI0816289B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96975607P 2007-09-04 2007-09-04
US8498708P 2008-07-30 2008-07-30
PCT/US2008/074543 WO2009032716A1 (en) 2007-09-04 2008-08-28 Identifying molecules that modulate protein- protein interactions using protease activated reporters

Publications (3)

Publication Number Publication Date
BRPI0816289A2 true BRPI0816289A2 (pt) 2016-11-01
BRPI0816289A8 BRPI0816289A8 (pt) 2018-05-08
BRPI0816289B1 BRPI0816289B1 (pt) 2019-01-15

Family

ID=40029329

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0816289A BRPI0816289B1 (pt) 2007-09-04 2008-08-28 método para identificar um composto que module uma interação proteína-proteína entre uma primeira proteína e uma segunda proteína e sistema de ensaio

Country Status (22)

Country Link
US (2) US8574865B2 (pt)
EP (1) EP2191275B1 (pt)
JP (1) JP5618829B2 (pt)
KR (1) KR101636306B1 (pt)
CN (1) CN102187225B (pt)
AU (1) AU2008296501B2 (pt)
BR (1) BRPI0816289B1 (pt)
CA (1) CA2698362C (pt)
CL (1) CL2008002602A1 (pt)
CY (1) CY1113816T1 (pt)
DK (1) DK2191275T3 (pt)
ES (1) ES2393642T3 (pt)
HK (1) HK1162664A1 (pt)
IL (1) IL204260A (pt)
MX (1) MX2010002399A (pt)
MY (1) MY155343A (pt)
PL (1) PL2191275T3 (pt)
PT (1) PT2191275E (pt)
RU (1) RU2476891C2 (pt)
TW (1) TWI425094B (pt)
UY (1) UY31323A1 (pt)
WO (1) WO2009032716A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2191275T3 (da) * 2007-09-04 2012-11-26 Sanofi Sa Identificering af molekyler, der modulerer protein-protein-interaktioner, ved anvendelse af proteaseaseaktiverede reportere
EP3004375A4 (en) * 2013-06-06 2017-05-10 Agency For Science, Technology And Research Protease-responsive peptide biosensors and methods for analyte detection
EP3068880A4 (en) 2013-11-11 2017-06-14 University Hospitals Cleveland Medical Center Targeted treatment of anerobic cancer
CA2965872C (en) 2014-11-25 2022-02-22 Ventana Medical Systems, Inc. Proximity assays using chemical ligation and hapten transfer
US10422003B2 (en) * 2015-03-23 2019-09-24 The Regents Of The University Of California Methods for detection of RNase activity
RU2639539C2 (ru) * 2015-12-29 2017-12-21 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Репортерная система на основе лентивирусных репортерных конструкций для изучения белок-белковых взаимодействий
US20180301048A1 (en) * 2017-04-12 2018-10-18 Age Of Learning, Inc. Remote live tutoring platform
US20210247384A1 (en) * 2018-07-30 2021-08-12 Montana Molecular, Llc Biosensors for detecting arrestin signaling
WO2020123376A1 (en) * 2018-12-10 2020-06-18 Yale University Microbiota metabolites that shape host physiology
CN114450310A (zh) * 2019-10-15 2022-05-06 瑞士苏黎世联邦理工学院 用于检测胞内或囊内生物分子相互作用的人工跨膜蛋白

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US6528271B1 (en) * 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US7128915B2 (en) * 1997-09-18 2006-10-31 Research Development Foundation Membrane virus host range mutations and their uses as vaccine substrates
US6884870B2 (en) * 1998-03-20 2005-04-26 California Institute Of Technology Fusion proteins for identifying proteases, protease target sites and regulators of protease activity in living cells
US20030157553A1 (en) * 2000-03-03 2003-08-21 Gabriel Berstein Methods of assaying for G protein-coupled receptor ligands and modulators
EP1205191A1 (en) * 2000-11-13 2002-05-15 Centre National De La Recherche Scientifique Targeted modification of intracellular compounds
EP1353182A3 (en) * 2002-04-12 2004-02-04 Smithkline Beecham Corporation Method of predicting cell-based assay results using binding profiles
US20070224615A1 (en) * 2003-07-09 2007-09-27 Invitrogen Corporation Methods for assaying protein-protein interactions
CN1894581B (zh) * 2003-07-09 2012-02-01 生命技术公司 检测蛋白-蛋白相互作用的方法
US7524925B2 (en) * 2004-11-18 2009-04-28 Washington State University Protein interaction reporter agents and methods for using same
DK2191275T3 (da) * 2007-09-04 2012-11-26 Sanofi Sa Identificering af molekyler, der modulerer protein-protein-interaktioner, ved anvendelse af proteaseaseaktiverede reportere
EP3508570B1 (en) * 2010-05-11 2020-07-22 Promega Corporation Mutant protease biosensors with enhanced detection characteristics

Also Published As

Publication number Publication date
PL2191275T3 (pl) 2013-01-31
BRPI0816289A8 (pt) 2018-05-08
WO2009032716A8 (en) 2011-02-17
CL2008002602A1 (es) 2009-06-05
KR101636306B1 (ko) 2016-07-05
US20140162289A1 (en) 2014-06-12
PT2191275E (pt) 2012-11-16
CA2698362C (en) 2013-03-26
JP2010537669A (ja) 2010-12-09
RU2476891C2 (ru) 2013-02-27
UY31323A1 (es) 2009-04-30
CN102187225A (zh) 2011-09-14
TWI425094B (zh) 2014-02-01
KR20100058526A (ko) 2010-06-03
WO2009032716A1 (en) 2009-03-12
TW200925281A (en) 2009-06-16
CN102187225B (zh) 2015-08-05
US9023610B2 (en) 2015-05-05
AU2008296501A1 (en) 2009-03-12
ES2393642T3 (es) 2012-12-26
JP5618829B2 (ja) 2014-11-05
HK1162664A1 (zh) 2012-08-31
EP2191275B1 (en) 2012-08-08
MX2010002399A (es) 2010-03-25
US8574865B2 (en) 2013-11-05
IL204260A (en) 2013-12-31
RU2010112854A (ru) 2011-10-10
CY1113816T1 (el) 2016-07-27
MY155343A (en) 2015-10-15
DK2191275T3 (da) 2012-11-26
CA2698362A1 (en) 2009-03-12
BRPI0816289B1 (pt) 2019-01-15
AU2008296501B2 (en) 2014-07-03
EP2191275A1 (en) 2010-06-02
US20100311096A1 (en) 2010-12-09

Similar Documents

Publication Publication Date Title
BRPI0816289A2 (pt) identificando moléculas que modulam interações proteína-proteína usando repórteres ativados por protease
DE102007013391A8 (de) Zeitinformationsquelle
DK1888645T3 (da) Anti-CD 16-bindende molekyler
IS2320B (is) Tæki til flokkunar á hlutum
DE602006007941D1 (de) Dichtungsanordnung
DE602006015768D1 (de) Teilchenstrahlgerät mit Ozon-Quelle
DE602007001170D1 (de) Projektionsanzeigegerät
DE602008006139D1 (de) Lichtquelle
FI20065725A0 (fi) Suoriteohjeinformaation generointi
AT504987A3 (de) System zur alarmierung von einsatzkräften
DK2029372T3 (da) Sikkerhedsindretning til en fortrolig oplysning
DE602007013231D1 (de) Abstimmbarer elektrooptischer modulator
FI20070582A0 (fi) Tiivistysjärjestelmä
DK1885319T3 (da) Indretning til ødelæggelse af neoplasier
SI2191275T1 (sl) Identificiranje molekul, ki modulirajo interakcije protein-protein, ob uporabi proteazno aktiviranih reporterjev
DE112007002885A5 (de) Dichtungseinrichtung
DK2081952T3 (da) Peptider
DE602007000612D1 (de) Projektor
ES1064302Y (es) Panel para expositores con fondo intercambiable
ES1062392Y (es) Embalaje expositor
ATE556423T1 (de) Ionenquellen
ITRM20060109U1 (it) Capo di abbigliamento
UA13518S (uk) Вивіска
UA15896S (uk) Рекламний матеріал
UA13951S (uk) Рекламний матеріал

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/01/2019, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2789 DE 18-06-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.