RU2476891C2 - Идентификация молекул, модулирующих белок-белковое взаимодействие - Google Patents

Идентификация молекул, модулирующих белок-белковое взаимодействие Download PDF

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RU2476891C2
RU2476891C2 RU2010112854/15A RU2010112854A RU2476891C2 RU 2476891 C2 RU2476891 C2 RU 2476891C2 RU 2010112854/15 A RU2010112854/15 A RU 2010112854/15A RU 2010112854 A RU2010112854 A RU 2010112854A RU 2476891 C2 RU2476891 C2 RU 2476891C2
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protein
reporter
receptor
protease
activating
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RU2010112854/15A
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English (en)
Russian (ru)
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RU2010112854A (ru
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Цзидун ЦАЙ
Пол С. РАЙТ
Пол УЭЙССЕНСИ
Хайфенг АЙСХИНГДРЕЛО
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Санофи-Авентис
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2010112854/15A 2007-09-04 2008-08-28 Идентификация молекул, модулирующих белок-белковое взаимодействие RU2476891C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US96975607P 2007-09-04 2007-09-04
US60/969,756 2007-09-04
US8498708P 2008-07-30 2008-07-30
US61/084,987 2008-07-30
PCT/US2008/074543 WO2009032716A1 (en) 2007-09-04 2008-08-28 Identifying molecules that modulate protein- protein interactions using protease activated reporters

Publications (2)

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RU2010112854A RU2010112854A (ru) 2011-10-10
RU2476891C2 true RU2476891C2 (ru) 2013-02-27

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RU2010112854/15A RU2476891C2 (ru) 2007-09-04 2008-08-28 Идентификация молекул, модулирующих белок-белковое взаимодействие

Country Status (21)

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US (2) US8574865B2 (https=)
EP (1) EP2191275B1 (https=)
JP (1) JP5618829B2 (https=)
KR (1) KR101636306B1 (https=)
CN (1) CN102187225B (https=)
AU (1) AU2008296501B2 (https=)
BR (1) BRPI0816289B1 (https=)
CA (1) CA2698362C (https=)
CL (1) CL2008002602A1 (https=)
CY (1) CY1113816T1 (https=)
DK (1) DK2191275T3 (https=)
ES (1) ES2393642T3 (https=)
IL (1) IL204260A (https=)
MX (1) MX2010002399A (https=)
MY (1) MY155343A (https=)
PL (1) PL2191275T3 (https=)
PT (1) PT2191275E (https=)
RU (1) RU2476891C2 (https=)
TW (1) TWI425094B (https=)
UY (1) UY31323A1 (https=)
WO (1) WO2009032716A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2639539C2 (ru) * 2015-12-29 2017-12-21 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Репортерная система на основе лентивирусных репортерных конструкций для изучения белок-белковых взаимодействий

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WO2009032716A1 (en) * 2007-09-04 2009-03-12 Sanofi-Aventis Identifying molecules that modulate protein- protein interactions using protease activated reporters
WO2014196932A1 (en) * 2013-06-06 2014-12-11 Agency For Science, Technology And Research Protease-responsive peptide biosensors and methods for analyte detection
CA2930001A1 (en) 2013-11-11 2015-05-14 University Hospitals Cleveland Medical Center Targeted treatment of anerobic cancer
CN107003323B (zh) 2014-11-25 2019-06-04 文塔纳医疗系统公司 使用化学连接和半抗原转移的邻近测定法
WO2016153880A2 (en) * 2015-03-23 2016-09-29 The Regents Of The University Of California Methods for detection of rnase activity
US20180301048A1 (en) * 2017-04-12 2018-10-18 Age Of Learning, Inc. Remote live tutoring platform
WO2020028381A1 (en) * 2018-07-30 2020-02-06 Montana Molecular, Llc Biosensors for detecting arrestin signaling
JP2022513606A (ja) * 2018-12-10 2022-02-09 イエール ユニバーシティ 宿主の生理機能を形成する微生物叢代謝産物
JP2022551820A (ja) * 2019-10-15 2022-12-14 エフ.ホフマン-ラ ロシュ アーゲー 細胞内または小胞内生体分子相互作用を検出するための人工膜貫通タンパク質
WO2022259904A1 (ja) * 2021-06-07 2022-12-15 国立研究開発法人理化学研究所 プロテアーゼ活性測定用の融合タンパク質基質

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US20050100934A1 (en) * 2003-07-09 2005-05-12 Lee Kevin J. Method for assaying protein-protein interaction
US20060115871A1 (en) * 2004-11-18 2006-06-01 Washington State University Protein interaction reporter agents and methods for using same

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US20030157553A1 (en) 2000-03-03 2003-08-21 Gabriel Berstein Methods of assaying for G protein-coupled receptor ligands and modulators
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US20070224615A1 (en) * 2003-07-09 2007-09-27 Invitrogen Corporation Methods for assaying protein-protein interactions
WO2009032716A1 (en) * 2007-09-04 2009-03-12 Sanofi-Aventis Identifying molecules that modulate protein- protein interactions using protease activated reporters
EP3508570B1 (en) * 2010-05-11 2020-07-22 Promega Corporation Mutant protease biosensors with enhanced detection characteristics

Patent Citations (2)

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US20050100934A1 (en) * 2003-07-09 2005-05-12 Lee Kevin J. Method for assaying protein-protein interaction
US20060115871A1 (en) * 2004-11-18 2006-06-01 Washington State University Protein interaction reporter agents and methods for using same

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IGOR STAGLJAR et al., A genetic system based on split-ubiquitin for the analysis of interactions between membrane proteins in vivo, Proc. Natl. Acad. Sci. USA April 1998, Vol.95, pp.5187-5192. MICHAEL C. WEHR et al., Monitoring regulated protein-protein interactions using split TEV, Nature Methods. Vol.3, no.12, 2006 pp.985-93. *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2639539C2 (ru) * 2015-12-29 2017-12-21 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Репортерная система на основе лентивирусных репортерных конструкций для изучения белок-белковых взаимодействий

Also Published As

Publication number Publication date
WO2009032716A1 (en) 2009-03-12
US20100311096A1 (en) 2010-12-09
PL2191275T3 (pl) 2013-01-31
JP5618829B2 (ja) 2014-11-05
CY1113816T1 (el) 2016-07-27
DK2191275T3 (da) 2012-11-26
MY155343A (en) 2015-10-15
CL2008002602A1 (es) 2009-06-05
AU2008296501B2 (en) 2014-07-03
JP2010537669A (ja) 2010-12-09
BRPI0816289A2 (pt) 2016-11-01
CN102187225A (zh) 2011-09-14
US8574865B2 (en) 2013-11-05
IL204260A (en) 2013-12-31
KR20100058526A (ko) 2010-06-03
TW200925281A (en) 2009-06-16
KR101636306B1 (ko) 2016-07-05
CA2698362C (en) 2013-03-26
AU2008296501A1 (en) 2009-03-12
HK1162664A1 (zh) 2012-08-31
UY31323A1 (es) 2009-04-30
MX2010002399A (es) 2010-03-25
PT2191275E (pt) 2012-11-16
TWI425094B (zh) 2014-02-01
US20140162289A1 (en) 2014-06-12
RU2010112854A (ru) 2011-10-10
EP2191275B1 (en) 2012-08-08
CN102187225B (zh) 2015-08-05
ES2393642T3 (es) 2012-12-26
EP2191275A1 (en) 2010-06-02
BRPI0816289B1 (pt) 2019-01-15
BRPI0816289A8 (pt) 2018-05-08
WO2009032716A8 (en) 2011-02-17
CA2698362A1 (en) 2009-03-12
US9023610B2 (en) 2015-05-05

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Effective date: 20180829