CY1113296T1 - Υβριδικο ανθρωπινο/τρωκτικου ιgg αντισωμα προς cd3 και μεθοδοι κατασκευης αυτου - Google Patents
Υβριδικο ανθρωπινο/τρωκτικου ιgg αντισωμα προς cd3 και μεθοδοι κατασκευης αυτουInfo
- Publication number
- CY1113296T1 CY1113296T1 CY20121100547T CY121100547T CY1113296T1 CY 1113296 T1 CY1113296 T1 CY 1113296T1 CY 20121100547 T CY20121100547 T CY 20121100547T CY 121100547 T CY121100547 T CY 121100547T CY 1113296 T1 CY1113296 T1 CY 1113296T1
- Authority
- CY
- Cyprus
- Prior art keywords
- ser
- asp
- pro
- rodent
- phe
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Παρέχεται ένα ΙgG αντίσωμα που έχει συνάφεια σύνδεσης για το σύμπλοκο αντιγόνου CD3, όπου στην βαριά άλυσο έχει πλαίσιο μεταβλητής περιοχής μαζί με τουλάχιστον μία CDR που επιλέγεται από τις αλληλουχίες αμινοξέος των SEQ ID Νο 2, 4 και 6 και αντίστοιχες διατηρητικώς τροποποιημένες παραλλαγές αυτών και η ελαφρά άλυσος έχει πλαίσιο μεταβλητής περιοχής μαζί με τουλάχιστον μια CDR που επιλέγεται από τις αλληλουχίες αμινοξέος των SΕQ ΙD Νο 8, 10 και 12 και αντίστοιχες διατηρητικώς τροποποιημένες παραλλαγές αυτών, που χαρακτηρίζονται από το ότι το πλαίσιο μεταβλητής περιοχής βαριάς αλύσου αντιστοιχεί στην αλληλουχία προς την ανθρώπινου τύπου αλληλουχία και το πλαίσιο μεταβλητής περιοχής ελαφράς αλύσου περιλαμβάνει ένα ή περισσότερα από τα ειδικά αμινοξέα χαρακτηριστικά της αλληλουχίας τύπου τρωκτικού. Το νέο αντίσωμα είναι ικανό να εκφράζεται από συστήματα έκφρασης κυττάρου θηλαστικού σε αυξημένες αποδόσεις.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9815909.8A GB9815909D0 (en) | 1998-07-21 | 1998-07-21 | Antibody preparation |
EP99934931A EP1098909B1 (en) | 1998-07-21 | 1999-07-21 | Hybrid human/rodent igg antibody to cd3, and methods of its construction |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113296T1 true CY1113296T1 (el) | 2016-04-13 |
Family
ID=10835937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100547T CY1113296T1 (el) | 1998-07-21 | 2012-06-15 | Υβριδικο ανθρωπινο/τρωκτικου ιgg αντισωμα προς cd3 και μεθοδοι κατασκευης αυτου |
Country Status (16)
Country | Link |
---|---|
US (4) | US20020131968A1 (el) |
EP (2) | EP2388275A3 (el) |
JP (1) | JP4629228B2 (el) |
KR (1) | KR100629017B1 (el) |
AT (1) | ATE551366T1 (el) |
AU (1) | AU766486B2 (el) |
CA (1) | CA2334047C (el) |
CY (1) | CY1113296T1 (el) |
DK (1) | DK1098909T3 (el) |
ES (1) | ES2384319T3 (el) |
GB (1) | GB9815909D0 (el) |
NZ (1) | NZ509074A (el) |
PT (1) | PT1098909E (el) |
RU (1) | RU2244720C2 (el) |
WO (1) | WO2000005268A1 (el) |
ZA (1) | ZA200100478B (el) |
Families Citing this family (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002062850A2 (en) * | 2001-02-02 | 2002-08-15 | Millennium Pharmaceuticals, Inc. | Hybrid antibodies and uses thereof |
GB2380127A (en) * | 2001-09-26 | 2003-04-02 | Isis Innovation | Treatment of chronic joint inflammation |
US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
EP1400534B1 (en) * | 2002-09-10 | 2015-10-28 | Affimed GmbH | Human CD3-specific antibody with immunosuppressive properties |
CA2528551A1 (en) * | 2003-06-13 | 2005-01-13 | Biogen Idec Ma Inc. | Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof |
AU2004266159A1 (en) | 2003-08-22 | 2005-03-03 | Biogen Idec Ma Inc. | Improved antibodies having altered effector function and methods for making the same |
DK1673398T3 (da) | 2003-10-16 | 2011-04-18 | Micromet Ag | Multispecifikke, deimmuniserede CD3-bindere |
AU2005287406B2 (en) | 2004-07-26 | 2011-08-18 | Biogen Ma Inc. | Anti-CD154 antibodies |
JP2009539841A (ja) * | 2006-06-06 | 2009-11-19 | トラークス,インコーポレイテッド | 自己免疫疾患の治療における抗cd3抗体の投与 |
WO2008013918A2 (en) * | 2006-07-26 | 2008-01-31 | Myelin Repair Foundation, Inc. | Cell cycle regulation and differentiation |
US20090239235A1 (en) * | 2006-09-20 | 2009-09-24 | Demaria Christine | Facs- and Reporter Protein-Based System for High Throughput Development of Therapeutic Proteins |
US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
US9056905B2 (en) * | 2007-05-21 | 2015-06-16 | Alderbio Holdings Llc | Antibodies to TNF-α and use thereof |
SI2164514T1 (sl) * | 2007-05-21 | 2017-04-26 | Alderbio Holdings Llc | Protitelesa proti IL-6 in njihova uporaba |
US7906117B2 (en) * | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
KR101667319B1 (ko) | 2008-08-05 | 2016-10-18 | 도레이 카부시키가이샤 | 암의 치료 및 예방용 의약 조성물 |
JP5644110B2 (ja) | 2008-08-05 | 2014-12-24 | 東レ株式会社 | 癌の検出方法 |
US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US9452227B2 (en) * | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
WO2011066378A2 (en) | 2009-11-24 | 2011-06-03 | Alder Biopharmaceuticals, Inc. | Antagonists of il-6 to prevent or treat thrombosis |
US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
WO2012016227A2 (en) | 2010-07-29 | 2012-02-02 | Xencor, Inc. | Antibodies with modified isoelectric points |
CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
US9249217B2 (en) | 2010-12-03 | 2016-02-02 | Secretary, DHHS | Bispecific EGFRvIII x CD3 antibody engaging molecules |
BR112014002616B1 (pt) | 2011-08-04 | 2022-01-18 | Toray Industries, Inc | Método para detectar câncer pancreático |
KR101968499B1 (ko) * | 2011-08-04 | 2019-04-12 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
MX354049B (es) * | 2011-12-21 | 2018-02-09 | Hoffmann La Roche | Método rápido para la clonación y expresión de segmentos génicos de regiones variables de anticuerpos cognados. |
PL2818483T3 (pl) | 2012-02-21 | 2018-01-31 | Toray Industries | Kompozycja lecznicza do leczenia i/lub zapobiegania nowotworowi |
CA2915412A1 (en) | 2012-06-14 | 2013-12-19 | Therapix Biosciences Ltd. | Humanized antibodies to cluster of differentiation 3 (cd3) |
CN104471404B (zh) | 2012-07-19 | 2017-03-01 | 东丽株式会社 | 癌的检测方法 |
KR102056654B1 (ko) | 2012-07-19 | 2019-12-17 | 도레이 카부시키가이샤 | 암의 검출 방법 |
US9645151B2 (en) | 2012-08-17 | 2017-05-09 | California Institute Of Technology | Targeting phosphofructokinase and its glycosylation form for cancer |
EP3620473A1 (en) | 2013-01-14 | 2020-03-11 | Xencor, Inc. | Novel heterodimeric proteins |
US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
AU2014207549B2 (en) | 2013-01-15 | 2018-12-06 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
CA2906927C (en) | 2013-03-15 | 2021-07-13 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
CN105722859B (zh) | 2013-07-25 | 2021-05-07 | 西托姆克斯治疗公司 | 多特异性抗体、多特异性可活化抗体及其使用方法 |
US9770461B2 (en) | 2013-08-02 | 2017-09-26 | California Institute Of Technology | Tailored glycopolymers as anticoagulant heparin mimetics |
US10227370B2 (en) | 2013-08-02 | 2019-03-12 | California Institute Of Technology | Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity |
TR201819812T4 (tr) | 2013-08-09 | 2019-01-21 | Toray Industries | Kanserin Tedavisi Ve/Veya Önlenmesi Amacına Yönelik Farmasötik Bileşim |
ME03666B (me) | 2014-03-28 | 2020-10-20 | Xencor Inc | Bispecifična antitela koja se vezuju za cd38 i cd3 |
WO2016014974A2 (en) | 2014-07-25 | 2016-01-28 | Cytomx Therapeutics, Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
EP3223845B1 (en) | 2014-11-26 | 2021-05-19 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cd20 |
KR20170084327A (ko) | 2014-11-26 | 2017-07-19 | 젠코어 인코포레이티드 | Cd3 및 cd38에 결합하는 이형이량체 항체 |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
WO2016105450A2 (en) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
WO2016141387A1 (en) | 2015-03-05 | 2016-09-09 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
JP7058219B2 (ja) | 2015-12-07 | 2022-04-21 | ゼンコア インコーポレイテッド | Cd3及びpsmaに結合するヘテロ二量体抗体 |
CA3007646A1 (en) * | 2015-12-09 | 2017-06-15 | Bioatla, Llc | Humanized anti-cd73 antibodies |
RU2022104399A (ru) | 2016-06-14 | 2022-05-05 | Ксенкор, Инк. | Биспецифические антитела-ингибиторы контрольных точек |
CN109475603B (zh) | 2016-06-20 | 2023-06-13 | 科马布有限公司 | 抗pd-l1抗体 |
US10316088B2 (en) | 2016-06-28 | 2019-06-11 | Xencor, Inc. | Heterodimeric antibodies that bind somatostatin receptor 2 |
US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
KR102562519B1 (ko) | 2016-10-14 | 2023-08-02 | 젠코어 인코포레이티드 | IL-15/IL-15Rα FC-융합 단백질 및 PD-1 항체 단편을 포함하는 이중특이성 이종이량체 융합 단백질 |
CA3065328C (en) | 2017-06-21 | 2023-08-15 | Gilead Sciences, Inc. | Multispecific antibodies that target hiv gp120 and cd3 |
MA49517A (fr) | 2017-06-30 | 2020-05-06 | Xencor Inc | Protéines de fusion fc hétérodimères ciblées contenant il-15/il-15ra et domaines de liaison à l'antigène |
BR122021015266B1 (pt) | 2017-08-03 | 2023-01-24 | Amgen Inc. | Conjugado compreendendo muteína de il-21 e anticorpo anti-pd, kit e composição farmacêutica |
ES2928576T3 (es) | 2017-09-08 | 2022-11-21 | Amgen Inc | Inhibidores de KRAS G12C y métodos de uso de los mismos |
US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
KR20200085828A (ko) | 2017-11-08 | 2020-07-15 | 젠코어 인코포레이티드 | 신규의 항-pd-1 서열을 사용한 이중특이적 및 단일특이적 항체 |
MX2020006322A (es) | 2017-12-19 | 2020-09-18 | Xencor Inc | Proteinas de fusion il-2 fc modificadas. |
JP2019122373A (ja) | 2018-01-12 | 2019-07-25 | アムジエン・インコーポレーテツド | 抗pd−1抗体及び治療方法 |
AU2019247415A1 (en) | 2018-04-04 | 2020-10-22 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
CN112437777A (zh) | 2018-04-18 | 2021-03-02 | Xencor股份有限公司 | 包含IL-15/IL-15RA Fc融合蛋白和TIM-3抗原结合结构域的靶向TIM-3的异源二聚体融合蛋白 |
WO2019204665A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof |
WO2020025596A1 (en) | 2018-07-31 | 2020-02-06 | Amgen Research (Munich) Gmbh | Dosing regimen for bcma-cd3 bispecific antibodies |
BR112021002032A2 (pt) | 2018-08-03 | 2021-07-20 | Amgen Research (Munich) Gmbh | construtos de anticorpos para cldn18.2 e cd3 |
UY38393A (es) | 2018-09-28 | 2020-03-31 | Amgen Inc | Anticuerpos contra bcma soluble |
CA3115096A1 (en) | 2018-10-03 | 2020-04-09 | Xencor, Inc. | Il-12 heterodimeric fc-fusion proteins |
EP3864049A1 (en) | 2018-10-11 | 2021-08-18 | Inhibrx, Inc. | Pd-1 single domain antibodies and therapeutic compositions thereof |
WO2020076992A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | 5t4 single domain antibodies and therapeutic compositions thereof |
TW202028246A (zh) | 2018-10-11 | 2020-08-01 | 美商英伊布里克斯公司 | B7h3單域抗體及其治療性組合物 |
JP2022504822A (ja) | 2018-10-11 | 2022-01-13 | インヒブルクス インコーポレイテッド | Dll3シングルドメイン抗体およびその治療用組成物 |
KR20210087472A (ko) | 2018-11-01 | 2021-07-12 | 산동 뉴 타임 파마슈티칼 코., 리미티드. | 이중 특이성 항체 및 그 용도 |
US11472890B2 (en) | 2019-03-01 | 2022-10-18 | Xencor, Inc. | Heterodimeric antibodies that bind ENPP3 and CD3 |
WO2021006199A1 (ja) | 2019-07-05 | 2021-01-14 | 小野薬品工業株式会社 | Pd-1/cd3二重特異性タンパク質による血液がん治療 |
EP3819007A1 (en) | 2019-11-11 | 2021-05-12 | Amgen Research (Munich) GmbH | Dosing regimen for anti-bcma agents |
EP4093771A1 (en) | 2020-01-22 | 2022-11-30 | Amgen Research (Munich) GmbH | Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof |
IL298046A (en) | 2020-05-11 | 2023-01-01 | Janssen Biotech Inc | Treatment methods for multiple myeloma |
US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
US20220017636A1 (en) | 2020-05-19 | 2022-01-20 | Amgen Inc. | Mageb2 binding constructs |
EP4200332A1 (en) | 2020-08-19 | 2023-06-28 | Xencor, Inc. | Anti-cd28 and/or anti-b7h3 compositions |
BR112023008629A2 (pt) | 2020-11-06 | 2023-10-03 | Amgen Inc | Construtos de polipeptídeos que se ligam seletivamente a cldn6 e cd3 |
US20230406887A1 (en) | 2020-11-06 | 2023-12-21 | Amegen Inc. | Antigen binding domain with reduced clipping rate |
WO2022103781A1 (en) | 2020-11-10 | 2022-05-19 | Amgen Inc. | Methods for administering a bcma x cd3 binding molecule |
CA3212665A1 (en) | 2021-03-09 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
WO2022192586A1 (en) | 2021-03-10 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and gpc3 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
US4361539A (en) | 1980-05-05 | 1982-11-30 | Instrumentation Laboratory Inc. | Analysis system |
US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
GB8318575D0 (en) | 1983-07-08 | 1983-08-10 | Cobbold S P | Antibody preparations |
GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
GB9021679D0 (en) | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
US5968509A (en) * | 1990-10-05 | 1999-10-19 | Btp International Limited | Antibodies with binding affinity for the CD3 antigen |
CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
GB9206422D0 (en) * | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
GB2421689B (en) | 2002-08-05 | 2007-03-07 | Caretek Medical Ltd | Drug delivery system |
-
1998
- 1998-07-21 GB GBGB9815909.8A patent/GB9815909D0/en not_active Ceased
-
1999
- 1999-07-21 DK DK99934931.9T patent/DK1098909T3/da active
- 1999-07-21 JP JP2000561224A patent/JP4629228B2/ja not_active Expired - Fee Related
- 1999-07-21 EP EP10184932A patent/EP2388275A3/en not_active Withdrawn
- 1999-07-21 AU AU50552/99A patent/AU766486B2/en not_active Ceased
- 1999-07-21 PT PT99934931T patent/PT1098909E/pt unknown
- 1999-07-21 KR KR1020017000915A patent/KR100629017B1/ko not_active IP Right Cessation
- 1999-07-21 WO PCT/GB1999/002380 patent/WO2000005268A1/en active IP Right Grant
- 1999-07-21 ES ES99934931T patent/ES2384319T3/es not_active Expired - Lifetime
- 1999-07-21 CA CA2334047A patent/CA2334047C/en not_active Expired - Fee Related
- 1999-07-21 AT AT99934931T patent/ATE551366T1/de active
- 1999-07-21 EP EP99934931A patent/EP1098909B1/en not_active Expired - Lifetime
- 1999-07-21 NZ NZ509074A patent/NZ509074A/en not_active IP Right Cessation
- 1999-07-21 RU RU2001104893/13A patent/RU2244720C2/ru not_active IP Right Cessation
-
2000
- 2000-12-15 US US09/736,371 patent/US20020131968A1/en not_active Abandoned
-
2001
- 2001-01-17 ZA ZA200100478A patent/ZA200100478B/en unknown
-
2003
- 2003-06-18 US US10/463,442 patent/US7994289B2/en not_active Expired - Fee Related
-
2006
- 2006-10-16 US US11/581,008 patent/US7993641B2/en not_active Expired - Fee Related
-
2011
- 2011-06-17 US US13/162,755 patent/US20110282037A1/en not_active Abandoned
-
2012
- 2012-06-15 CY CY20121100547T patent/CY1113296T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US7993641B2 (en) | 2011-08-09 |
EP2388275A2 (en) | 2011-11-23 |
DK1098909T3 (da) | 2012-06-25 |
NZ509074A (en) | 2003-09-26 |
GB9815909D0 (en) | 1998-09-16 |
AU5055299A (en) | 2000-02-14 |
KR20010082010A (ko) | 2001-08-29 |
KR100629017B1 (ko) | 2006-09-26 |
RU2244720C2 (ru) | 2005-01-20 |
US20110282037A1 (en) | 2011-11-17 |
CA2334047A1 (en) | 2000-02-03 |
JP4629228B2 (ja) | 2011-02-09 |
US20040006216A1 (en) | 2004-01-08 |
US20070092516A1 (en) | 2007-04-26 |
ZA200100478B (en) | 2001-07-30 |
EP2388275A3 (en) | 2013-04-03 |
US20020131968A1 (en) | 2002-09-19 |
JP2002521022A (ja) | 2002-07-16 |
WO2000005268A1 (en) | 2000-02-03 |
EP1098909B1 (en) | 2012-03-28 |
EP1098909A1 (en) | 2001-05-16 |
AU766486B2 (en) | 2003-10-16 |
US7994289B2 (en) | 2011-08-09 |
ATE551366T1 (de) | 2012-04-15 |
ES2384319T3 (es) | 2012-07-03 |
PT1098909E (pt) | 2012-06-25 |
CA2334047C (en) | 2015-11-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1113296T1 (el) | Υβριδικο ανθρωπινο/τρωκτικου ιgg αντισωμα προς cd3 και μεθοδοι κατασκευης αυτου | |
CY1124289T1 (el) | Ανοσοσυζευμα που περιλαμβανει εξανθρωποποιημενα αντισωματα rs7 | |
GB2246781A (en) | CD3 specific recombinant antibody | |
DE69638355D1 (de) | Anti-CD3-Antikörper zur Verwendung zur Induzierung von Immunsuppression | |
PE20050925A1 (es) | Anticuerpo recombinante humanizado anti-interleuquina 10 | |
TW222279B (el) | ||
PL406852A1 (pl) | Preparat zawierający ludzkie przeciwciała do leczenia zaburzeń związanych z TNF-α | |
SG196688A1 (en) | Therapeutic human anti-il-1r1 monoclonal antibody | |
EA200100698A1 (ru) | Моноклональные антитела человека к ctla-4 | |
NZ593068A (en) | IL-18 antibody | |
WO1996023071A3 (en) | MONOCLONAL ANTIBODIES SPECIFIC FOR DIFFERENT EPITOPES OF HUMAN gp39 AND METHODS FOR THEIR USE IN DIAGNOSIS AND THERAPY | |
GEP20074222B (en) | Antibodies to cd40 | |
MA29374B1 (fr) | Anticorps anti-ccr5 et leurs utilisations | |
NZ611387A (en) | Selected antibodies binding to anionic phospholipids and aminophospholipids and their use in treatment | |
WO2005094446A3 (en) | Anti-myostatin antibodies | |
UY27242A1 (es) | Anticuerpos recombinantes asociados a gangliosidos. su uso en el diasnostico y tratamiento de tumores | |
PE20020871A1 (es) | Moleculas de enlace terapeuticas | |
AR046094A1 (es) | Anticuerpos completamente humanos contra 4-1bb humano | |
DK0576439T3 (da) | Monoklonalt antistof mod LPS-kerne | |
RU2011128702A (ru) | Средства для лечения пузырчатки, содержащие антитела против лиганда fas |