CY1113198T1 - Μεθοδος καθαρισμου της μοξιδεκτινης μεσω κρυσταλλωσης - Google Patents

Μεθοδος καθαρισμου της μοξιδεκτινης μεσω κρυσταλλωσης

Info

Publication number
CY1113198T1
CY1113198T1 CY20121100701T CY121100701T CY1113198T1 CY 1113198 T1 CY1113198 T1 CY 1113198T1 CY 20121100701 T CY20121100701 T CY 20121100701T CY 121100701 T CY121100701 T CY 121100701T CY 1113198 T1 CY1113198 T1 CY 1113198T1
Authority
CY
Cyprus
Prior art keywords
moxidexine
crystallation
cleaning
moxidectin
macrolide
Prior art date
Application number
CY20121100701T
Other languages
English (en)
Inventor
Isidoro Hector Sorokin
Raimonda Paola Di
Chin-Liang Chou
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of CY1113198T1 publication Critical patent/CY1113198T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Οι μέθοδοι για τον καθαρισμό της μακρολίδης μοξιδεκτίνης καταλήγουν σε υψηλότερα επίπεδα καθαρότητας από ό,τι θα μπορούσαν συχνά να ληφθούν διαφορετικά. Η κρυσταλλική μοξιδεκτίνη στη συνέχεια χρησιμοποιείται σε ευρεία ποικιλία φαρμακευτικών και κτηνιατρικών εφαρμογών, συμπεριλαμβανομένης της πρόληψης, θεραπείας και ελέγχου παρασίτων σε φυτά, ζώα και ανθρώπους.
CY20121100701T 2003-08-07 2012-08-06 Μεθοδος καθαρισμου της μοξιδεκτινης μεσω κρυσταλλωσης CY1113198T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49331703P 2003-08-07 2003-08-07
EP04254592A EP1505069B1 (en) 2003-08-07 2004-07-30 A method of purifying moxidectin through crystallization

Publications (1)

Publication Number Publication Date
CY1113198T1 true CY1113198T1 (el) 2016-04-13

Family

ID=33552111

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100701T CY1113198T1 (el) 2003-08-07 2012-08-06 Μεθοδος καθαρισμου της μοξιδεκτινης μεσω κρυσταλλωσης

Country Status (12)

Country Link
US (2) US7348417B2 (el)
EP (1) EP1505069B1 (el)
JP (1) JP4653979B2 (el)
KR (1) KR101123018B1 (el)
CN (1) CN100439375C (el)
CY (1) CY1113198T1 (el)
DK (1) DK1505069T3 (el)
ES (1) ES2387390T3 (el)
PL (1) PL1505069T3 (el)
PT (1) PT1505069E (el)
SI (1) SI1505069T1 (el)
TW (1) TWI343254B (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8426460B2 (en) 2008-12-04 2013-04-23 Merial Limited Dimeric avermectin and milbemycin derivatives
US8980896B2 (en) 2009-12-17 2015-03-17 Merial, Inc. Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
DK3351546T5 (da) 2011-12-02 2024-08-12 Boehringer Ingelheim Vetmedica Gmbh Langtidsvirkende injicerbare moxidectinformuleringer
PE20151726A1 (es) 2013-04-12 2015-11-18 Zoetis Services Llc Formulaciones veterinarias estables de combinacion de lactonas macrociclicas e imidazotiazoles
CN103601735B (zh) * 2013-11-08 2015-12-09 大连九信生物化工科技有限公司 一种提纯莫西克汀的方法
KR101484481B1 (ko) * 2014-08-07 2015-01-20 주식회사 다림바이오텍 Pde-5 저해제를 포함하는 설하분무제의 제조방법 및 이에 의하여 제조된 설하분무용 조성물
CN105001232A (zh) * 2015-07-08 2015-10-28 安徽省皖北药业股份有限公司 一种莫昔克丁的提纯方法
CN105646521B (zh) * 2016-03-28 2018-10-02 河北圣雪大成制药有限责任公司 一种莫西克汀的结晶方法
CN107383053B (zh) * 2017-07-25 2019-11-05 宁夏泰瑞制药股份有限公司 一种莫西菌素粗品的纯化方法
KR102412089B1 (ko) * 2021-09-13 2022-06-22 주식회사 세라수 Dmts의 정제방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317030A (en) * 1984-06-05 1994-05-31 American Cyanamid Company Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
US5169956A (en) * 1984-06-05 1992-12-08 American Cyanamid Company Macrolide antibiotic compounds
US5106994A (en) * 1984-06-05 1992-04-21 American Cyanamid Company Agents and method of production thereof
US5198464A (en) * 1984-06-05 1993-03-30 American Cyanamid Company Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
CA1296329C (en) * 1986-06-06 1992-02-25 Derek R. Sutherland Macrolide compounds
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
US4988824A (en) * 1989-09-11 1991-01-29 Maulding Donald R Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds
US5478951A (en) * 1994-06-22 1995-12-26 American Cyanamid Company Method for the purification of 23-E isomers of 23-imino derivatives of LL-F28249 compounds

Also Published As

Publication number Publication date
TWI343254B (en) 2011-06-11
ES2387390T3 (es) 2012-09-21
KR20050016205A (ko) 2005-02-21
US20050033041A1 (en) 2005-02-10
US7348417B2 (en) 2008-03-25
JP2005053916A (ja) 2005-03-03
JP4653979B2 (ja) 2011-03-16
SI1505069T1 (sl) 2012-08-31
EP1505069A1 (en) 2005-02-09
DK1505069T3 (da) 2012-07-23
US20080119543A1 (en) 2008-05-22
PT1505069E (pt) 2012-08-07
PL1505069T3 (pl) 2012-12-31
TW200509903A (en) 2005-03-16
CN1626536A (zh) 2005-06-15
CN100439375C (zh) 2008-12-03
US7645863B2 (en) 2010-01-12
EP1505069B1 (en) 2012-07-04
KR101123018B1 (ko) 2012-03-15

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