CY1113023T1 - Μεθοδοι δια διαχωρισμον εις τα οπτικα ισομερη στερeοϊσομερων πιπεριδυλ-ακεταμιδiου - Google Patents

Μεθοδοι δια διαχωρισμον εις τα οπτικα ισομερη στερeοϊσομερων πιπεριδυλ-ακεταμιδiου

Info

Publication number
CY1113023T1
CY1113023T1 CY20121100457T CY121100457T CY1113023T1 CY 1113023 T1 CY1113023 T1 CY 1113023T1 CY 20121100457 T CY20121100457 T CY 20121100457T CY 121100457 T CY121100457 T CY 121100457T CY 1113023 T1 CY1113023 T1 CY 1113023T1
Authority
CY
Cyprus
Prior art keywords
acetamidi
piperidyl
separation
methods
optical isomer
Prior art date
Application number
CY20121100457T
Other languages
English (en)
Inventor
Vikram Khetani
Yalin Luo
Sowmianarayanan Ramaswamy
Original Assignee
Celgene Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corporation filed Critical Celgene Corporation
Publication of CY1113023T1 publication Critical patent/CY1113023T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει μια συνθετική διαδικασία η οποία περιλαμβάνει τα στάδια: της παροχής d, l-threo στερεοϊσομερών πιπεριδυλ-ακεταμιδίου τα οποία έχουν τους τύπους:
CY20121100457T 1997-05-22 2012-05-18 Μεθοδοι δια διαχωρισμον εις τα οπτικα ισομερη στερeοϊσομερων πιπεριδυλ-ακεταμιδiου CY1113023T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/861,988 US5936091A (en) 1997-05-22 1997-05-22 Processes and intermediates for resolving piperidyl acetamide stereoisomers
EP04076158A EP1506961B1 (en) 1997-05-22 1998-05-18 Processes for resolving piperidyl acetamide stereoisomers

Publications (1)

Publication Number Publication Date
CY1113023T1 true CY1113023T1 (el) 2016-04-13

Family

ID=25337317

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100457T CY1113023T1 (el) 1997-05-22 2012-05-18 Μεθοδοι δια διαχωρισμον εις τα οπτικα ισομερη στερeοϊσομερων πιπεριδυλ-ακεταμιδiου

Country Status (13)

Country Link
US (1) US5936091A (el)
EP (2) EP0983238B1 (el)
JP (1) JP4439595B2 (el)
AT (2) ATE273952T1 (el)
AU (1) AU735353B2 (el)
CA (1) CA2291170C (el)
CY (1) CY1113023T1 (el)
DE (1) DE69825746T2 (el)
DK (2) DK0983238T3 (el)
ES (2) ES2226131T3 (el)
HK (1) HK1071895A1 (el)
PT (2) PT983238E (el)
WO (1) WO1998052921A1 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
US6395752B1 (en) * 1999-03-04 2002-05-28 Pharmaquest Limited Method of treating depression using 1-threo-methylphenidate
US6127385A (en) * 1999-03-04 2000-10-03 Pharmaquest Limited Method of treating depression using l-threo-methylphenidate
US20020187192A1 (en) * 2001-04-30 2002-12-12 Yatindra Joshi Pharmaceutical composition which reduces or eliminates drug abuse potential
US6638533B2 (en) 2002-01-03 2003-10-28 George Krsek Pulse dosage formulations of methylphenidate and method to prepare same
CH712083B1 (de) * 2003-02-05 2017-07-31 Siegfried Ag Verfahren zur Herstellung von d-threo-2-Phenyl-2-piperidin-2-yl-essigsäureestern.
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
CA2591247A1 (en) * 2004-12-09 2006-06-15 Celgene Corporation Treatment of patients suffering from a disease having a family history or diagnosis of tics or tourette's syndrome with d-threo methylphenidate
CN101786982A (zh) * 2010-03-30 2010-07-28 华东师范大学 一种合成2-吡啶基苯乙腈的方法
JP5886869B2 (ja) 2010-12-17 2016-03-16 ローズ テクノロジーズ メチルフェニデート塩酸塩の低温合成
US9233924B2 (en) 2014-03-11 2016-01-12 Ampac Fine Chemicals Llc Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof
WO2018015971A1 (en) 2016-07-18 2018-01-25 Harman Finochem Limited An improved process for the preparation of dexmethyl phenidate hydrochloride
CN115322141B (zh) * 2022-09-01 2024-04-16 凯特立斯（深圳）科技有限公司 一种不对称氢化制备手性哌甲酯类化合物的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2507631A (en) * 1944-01-19 1950-05-16 Ciba Pharm Prod Inc Pyridine and piperidine compounds and process of making same
US2957880A (en) * 1953-12-23 1960-10-25 Ciba Pharm Prod Inc Process for the conversion of stereoisomers

Also Published As

Publication number Publication date
EP1506961A2 (en) 2005-02-16
JP2002515066A (ja) 2002-05-21
PT983238E (pt) 2004-10-29
ES2226131T3 (es) 2005-03-16
AU735353B2 (en) 2001-07-05
EP0983238B1 (en) 2004-08-18
EP1506961A3 (en) 2007-01-03
HK1071895A1 (en) 2005-08-05
DE69825746T2 (de) 2005-08-18
US5936091A (en) 1999-08-10
EP0983238A4 (en) 2001-08-08
CA2291170A1 (en) 1998-11-26
DK1506961T3 (da) 2012-05-21
ES2381361T3 (es) 2012-05-25
CA2291170C (en) 2008-09-16
EP1506961B1 (en) 2012-02-22
AU7495598A (en) 1998-12-11
PT1506961E (pt) 2012-05-07
DK0983238T3 (da) 2004-11-29
WO1998052921A1 (en) 1998-11-26
ATE273952T1 (de) 2004-09-15
DE69825746D1 (de) 2004-09-23
ATE546429T1 (de) 2012-03-15
JP4439595B2 (ja) 2010-03-24
EP0983238A1 (en) 2000-03-08

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