HK1071895A1 - Processes for resolving piperidyl acetamide stereoisomers - Google Patents

Processes for resolving piperidyl acetamide stereoisomers

Info

Publication number
HK1071895A1
HK1071895A1 HK05104796.3A HK05104796A HK1071895A1 HK 1071895 A1 HK1071895 A1 HK 1071895A1 HK 05104796 A HK05104796 A HK 05104796A HK 1071895 A1 HK1071895 A1 HK 1071895A1
Authority
HK
Hong Kong
Prior art keywords
stereoisomers
resolving
processes
threo
piperidyl acetamide
Prior art date
Application number
HK05104796.3A
Other languages
English (en)
Inventor
Vikram Khetani
Yalin Luo
Sowmianarayanan Ramaswamy
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of HK1071895A1 publication Critical patent/HK1071895A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
HK05104796.3A 1997-05-22 2005-06-08 Processes for resolving piperidyl acetamide stereoisomers HK1071895A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/861,988 US5936091A (en) 1997-05-22 1997-05-22 Processes and intermediates for resolving piperidyl acetamide stereoisomers

Publications (1)

Publication Number Publication Date
HK1071895A1 true HK1071895A1 (en) 2005-08-05

Family

ID=25337317

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05104796.3A HK1071895A1 (en) 1997-05-22 2005-06-08 Processes for resolving piperidyl acetamide stereoisomers

Country Status (13)

Country Link
US (1) US5936091A (xx)
EP (2) EP0983238B1 (xx)
JP (1) JP4439595B2 (xx)
AT (2) ATE273952T1 (xx)
AU (1) AU735353B2 (xx)
CA (1) CA2291170C (xx)
CY (1) CY1113023T1 (xx)
DE (1) DE69825746T2 (xx)
DK (2) DK0983238T3 (xx)
ES (2) ES2226131T3 (xx)
HK (1) HK1071895A1 (xx)
PT (2) PT983238E (xx)
WO (1) WO1998052921A1 (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
US6395752B1 (en) * 1999-03-04 2002-05-28 Pharmaquest Limited Method of treating depression using 1-threo-methylphenidate
US6127385A (en) * 1999-03-04 2000-10-03 Pharmaquest Limited Method of treating depression using l-threo-methylphenidate
US20020187192A1 (en) * 2001-04-30 2002-12-12 Yatindra Joshi Pharmaceutical composition which reduces or eliminates drug abuse potential
US6638533B2 (en) 2002-01-03 2003-10-28 George Krsek Pulse dosage formulations of methylphenidate and method to prepare same
CH712083B1 (de) * 2003-02-05 2017-07-31 Siegfried Ag Verfahren zur Herstellung von d-threo-2-Phenyl-2-piperidin-2-yl-essigsäureestern.
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
CA2591247A1 (en) * 2004-12-09 2006-06-15 Celgene Corporation Treatment of patients suffering from a disease having a family history or diagnosis of tics or tourette's syndrome with d-threo methylphenidate
CN101786982A (zh) * 2010-03-30 2010-07-28 华东师范大学 一种合成2-吡啶基苯乙腈的方法
JP5886869B2 (ja) 2010-12-17 2016-03-16 ローズ テクノロジーズ メチルフェニデート塩酸塩の低温合成
US9233924B2 (en) 2014-03-11 2016-01-12 Ampac Fine Chemicals Llc Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof
WO2018015971A1 (en) 2016-07-18 2018-01-25 Harman Finochem Limited An improved process for the preparation of dexmethyl phenidate hydrochloride
CN115322141B (zh) * 2022-09-01 2024-04-16 凯特立斯（深圳）科技有限公司 一种不对称氢化制备手性哌甲酯类化合物的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2507631A (en) * 1944-01-19 1950-05-16 Ciba Pharm Prod Inc Pyridine and piperidine compounds and process of making same
US2957880A (en) * 1953-12-23 1960-10-25 Ciba Pharm Prod Inc Process for the conversion of stereoisomers

Also Published As

Publication number Publication date
EP1506961A2 (en) 2005-02-16
JP2002515066A (ja) 2002-05-21
PT983238E (pt) 2004-10-29
ES2226131T3 (es) 2005-03-16
AU735353B2 (en) 2001-07-05
EP0983238B1 (en) 2004-08-18
EP1506961A3 (en) 2007-01-03
DE69825746T2 (de) 2005-08-18
US5936091A (en) 1999-08-10
EP0983238A4 (en) 2001-08-08
CA2291170A1 (en) 1998-11-26
DK1506961T3 (da) 2012-05-21
ES2381361T3 (es) 2012-05-25
CA2291170C (en) 2008-09-16
CY1113023T1 (el) 2016-04-13
EP1506961B1 (en) 2012-02-22
AU7495598A (en) 1998-12-11
PT1506961E (pt) 2012-05-07
DK0983238T3 (da) 2004-11-29
WO1998052921A1 (en) 1998-11-26
ATE273952T1 (de) 2004-09-15
DE69825746D1 (de) 2004-09-23
ATE546429T1 (de) 2012-03-15
JP4439595B2 (ja) 2010-03-24
EP0983238A1 (en) 2000-03-08

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20180517