CY1111312T1 - Χρηση παλονοσετρονης για την αντιμετωπιση της μετεγχειρητικης ναυτιας καιτου εμετου - Google Patents
Χρηση παλονοσετρονης για την αντιμετωπιση της μετεγχειρητικης ναυτιας καιτου εμετουInfo
- Publication number
- CY1111312T1 CY1111312T1 CY20111100257T CY111100257T CY1111312T1 CY 1111312 T1 CY1111312 T1 CY 1111312T1 CY 20111100257 T CY20111100257 T CY 20111100257T CY 111100257 T CY111100257 T CY 111100257T CY 1111312 T1 CY1111312 T1 CY 1111312T1
- Authority
- CY
- Cyprus
- Prior art keywords
- palonosetron
- marine
- operative
- post
- vehicle
- Prior art date
Links
- CPZBLNMUGSZIPR-NVXWUHKLSA-N palonosetron Chemical compound C1N(CC2)CCC2[C@@H]1N1C(=O)C(C=CC=C2CCC3)=C2[C@H]3C1 CPZBLNMUGSZIPR-NVXWUHKLSA-N 0.000 title abstract 2
- 229960002131 palonosetron Drugs 0.000 title abstract 2
- 230000002980 postoperative effect Effects 0.000 title 1
- 208000031649 Postoperative Nausea and Vomiting Diseases 0.000 abstract 2
- 206010047700 Vomiting Diseases 0.000 abstract 2
- 230000008673 vomiting Effects 0.000 abstract 2
- 102000035037 5-HT3 receptors Human genes 0.000 abstract 1
- 108091005477 5-HT3 receptors Proteins 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44834203P | 2003-02-18 | 2003-02-18 | |
| EP04712041A EP1596862B1 (en) | 2003-02-18 | 2004-02-18 | Use of palonosetron for treating post-operative nausea and vomiting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111312T1 true CY1111312T1 (el) | 2015-08-05 |
Family
ID=32908576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111100257T CY1111312T1 (el) | 2003-02-18 | 2011-03-04 | Χρηση παλονοσετρονης για την αντιμετωπιση της μετεγχειρητικης ναυτιας καιτου εμετου |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20060074101A1 (https=) |
| EP (2) | EP1596862B1 (https=) |
| JP (1) | JP2006517944A (https=) |
| KR (1) | KR101113087B1 (https=) |
| CN (1) | CN1750822A (https=) |
| AT (1) | ATE490774T1 (https=) |
| AU (1) | AU2004212704B2 (https=) |
| BR (1) | BRPI0407549A (https=) |
| CA (1) | CA2515946C (https=) |
| CU (1) | CU23587B7 (https=) |
| CY (1) | CY1111312T1 (https=) |
| DE (1) | DE602004030424D1 (https=) |
| DK (1) | DK1596862T3 (https=) |
| EA (1) | EA013836B1 (https=) |
| EC (1) | ECSP055970A (https=) |
| ES (1) | ES2357769T3 (https=) |
| GE (1) | GEP20104908B (https=) |
| HR (1) | HRP20050709A2 (https=) |
| IS (1) | IS7983A (https=) |
| MX (1) | MXPA05008757A (https=) |
| MY (1) | MY143789A (https=) |
| NO (1) | NO20054296L (https=) |
| NZ (1) | NZ541862A (https=) |
| PL (1) | PL378122A1 (https=) |
| PT (1) | PT1596862E (https=) |
| SI (1) | SI1596862T1 (https=) |
| TW (1) | TWI355936B (https=) |
| UA (1) | UA96254C2 (https=) |
| UY (1) | UY28193A1 (https=) |
| WO (1) | WO2004073714A1 (https=) |
| ZA (1) | ZA200506580B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10393729T5 (de) * | 2002-11-15 | 2005-10-13 | Helsinn Healthcare S.A. | Verfahren zur Behandlung von Emesis |
| US8598219B2 (en) | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
| JO2735B1 (en) * | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formulations of palonosetron |
| CN101410094B (zh) * | 2006-01-27 | 2013-04-17 | 阿普塔利斯制药股份有限公司 | 包含弱碱性选择性5-羟色胺5-ht3阻断剂和有机酸的药物递送系统 |
| KR20140088230A (ko) * | 2006-01-27 | 2014-07-09 | 앱탈리스 파마테크, 인코포레이티드 | 약 염기성 약물과 유기산을 포함하는 약물 전달 시스템 |
| KR101441459B1 (ko) * | 2006-10-24 | 2014-09-18 | 헬신 헬쓰케어 에스.에이. | 안정성 및 생체이용률이 개선된 염산 팔로노세트론을 포함하는 연질 캡슐 |
| TWI429436B (zh) * | 2007-04-10 | 2014-03-11 | Helsinn Therapeutics Us Inc | 使用生長激素促泌素治療或預防嘔吐之方法 |
| US20090155363A1 (en) * | 2007-12-14 | 2009-06-18 | Todd Maibach | Methods for oral administration of active drugs |
| EP2286814B1 (en) | 2008-05-15 | 2013-10-16 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal preparation containing palonosetron |
| EP2364138A2 (en) * | 2008-12-08 | 2011-09-14 | Teva Pharmaceutical Industries Ltd. | Palonosetron formulation |
| DK2432467T3 (en) | 2009-05-20 | 2018-04-16 | Inst Nat Sante Rech Med | SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS FOR USE IN TREATMENT OF VESTIBULAR DAMAGE LESSONS |
| ES2432618T3 (es) * | 2009-05-20 | 2013-12-04 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular |
| US20110003005A1 (en) * | 2009-07-06 | 2011-01-06 | Gopi Venkatesh | Methods of Treating PDNV and PONV with Extended Release Ondansetron Compositions |
| CN102781939A (zh) | 2009-11-13 | 2012-11-14 | 赫尔辛医疗股份公司 | 帕洛诺司琼代谢物 |
| ES2623503T3 (es) | 2009-11-18 | 2017-07-11 | Helsinn Healthcare Sa | Composiciones para tratar náuseas y vómitos mediados centralmente |
| EP2722045B1 (en) | 2009-11-18 | 2016-07-06 | Helsinn Healthcare SA | Compositions for treating centrally mediated nausea and vomiting |
| KR101368587B1 (ko) * | 2010-12-27 | 2014-03-05 | 주식회사 삼양바이오팜 | 오심 또는 구토 방지용 조성물 |
| WO2014004126A1 (en) | 2012-06-26 | 2014-01-03 | Fleming C Andrew | Treating postoperative nausea and vomiting |
| CN105934247A (zh) | 2013-12-23 | 2016-09-07 | 株式会社三养生物制药 | 包含帕洛诺司琼的药物组合物 |
| MX384045B (es) | 2016-04-14 | 2025-03-14 | Sensorion | (+)-azasetrón para su uso en el tratamiento de trastornos del oído. |
| JP6768404B2 (ja) * | 2016-08-12 | 2020-10-14 | 武田テバファーマ株式会社 | パロノセトロン又はその薬学的に許容される塩を含む医薬組成物 |
| JP6705348B2 (ja) * | 2016-09-23 | 2020-06-03 | ニプロ株式会社 | 液体製剤、及び、パロノセトロンの安定性を向上する方法 |
| GB201618425D0 (en) * | 2016-11-01 | 2016-12-14 | Acacia Pharma Ltd | method |
| KR101802183B1 (ko) * | 2016-11-16 | 2017-11-28 | 주식회사 유영제약 | 팔로노세트론을 활성성분으로 함유하는 약제학적 조성물 |
| GB201702250D0 (en) | 2017-02-10 | 2017-03-29 | Acacia Pharma Ltd | Method |
| HRP20230471T1 (hr) | 2018-01-12 | 2023-07-21 | Orion Corporation | Palonsetron kapi za oči za liječenje ili prevenciju mučnine i povraćanja |
| CN108703960A (zh) * | 2018-07-25 | 2018-10-26 | 无锡鑫连鑫生物医药科技有限公司 | 一种帕洛诺司琼缓释微球及其制备方法和使用方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695578A (en) | 1984-01-25 | 1987-09-22 | Glaxo Group Limited | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances |
| US4937247A (en) | 1985-04-27 | 1990-06-26 | Beecham Group P.L.C. | 1-acyl indazoles |
| DE3650772T2 (de) | 1985-04-27 | 2003-04-03 | F. Hoffmann-La Roche Ag, Basel | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
| US5240954A (en) | 1985-06-25 | 1993-08-31 | Glaxo Group Limited | Medicaments |
| GB8516083D0 (en) | 1985-06-25 | 1985-07-31 | Glaxo Group Ltd | Heterocyclic compounds |
| US5578628A (en) | 1985-06-25 | 1996-11-26 | Glaxo Group Limited | Medicaments for the treatment of nausea and vomiting |
| US4906755A (en) | 1986-11-03 | 1990-03-06 | Merrell Dow Pharmaceuticals Inc. | Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds |
| US4707484A (en) | 1986-11-25 | 1987-11-17 | Hoffmann-La Roche Inc. | Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives |
| US5011846A (en) | 1988-02-23 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof |
| US5344658A (en) * | 1989-06-28 | 1994-09-06 | Glaxo Group Limited | Process and composition using ondansetron |
| GB8914804D0 (en) * | 1989-06-28 | 1989-08-16 | Glaxo Group Ltd | Process |
| PL166267B1 (pl) | 1989-11-28 | 1995-04-28 | Syntex Inc | Sposób wytwarzania nowych zwiazków trójpierscieniowych PL PL PL PL |
| US5189041A (en) | 1990-11-16 | 1993-02-23 | Syntex (U.S.A.) Inc. | Tricyclic 5-ht3 receptor antagonists |
| US5137893A (en) | 1991-03-07 | 1992-08-11 | G. D. Searle & Co. | Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof |
| US5491148A (en) | 1991-04-26 | 1996-02-13 | Syntex (U.S.A.) Inc. | Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists |
| US5272137A (en) * | 1992-02-14 | 1993-12-21 | Mcneil-Pfc, Inc. | Aqueous pharmaceutical suspension for pharmaceutical actives |
| GB9305593D0 (en) | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Pharmaceuticals |
| US5492914A (en) | 1994-07-28 | 1996-02-20 | Syntex (U.S.A.) Inc. | 2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]is[2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof |
| GB9423588D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| GB9423511D0 (en) | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| GB9625589D0 (en) * | 1996-12-10 | 1997-01-29 | Boots Co Plc | Therapeutic agents |
| US20030095926A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract |
| US6294548B1 (en) | 1998-05-04 | 2001-09-25 | Hoffmann-La Roche Inc. | Multidose vial formulations for administering endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride |
| AU4551499A (en) * | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Multivalent agonists, partial agonists, inverse agonists and antagonists of the 5-HT3 receptors |
| BR9914799A (pt) * | 1998-10-27 | 2001-07-10 | Alcon Lab Inc | Sistema conservante para composições farmacêuticas administráveis topicamente contendo um sabão de ácido graxo/aminoácido |
| US6196963B1 (en) * | 1999-03-02 | 2001-03-06 | Medtronic Ave, Inc. | Brachytherapy device assembly and method of use |
| WO2003100091A1 (en) * | 2002-05-24 | 2003-12-04 | Epidauros Biotechnologie Ag | Means and methods for improved treatment using 'setrones' |
| DE10393729T5 (de) * | 2002-11-15 | 2005-10-13 | Helsinn Healthcare S.A. | Verfahren zur Behandlung von Emesis |
| JO2735B1 (en) * | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formulations of palonosetron |
| US8598219B2 (en) * | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
-
2004
- 2004-02-17 MY MYPI20040515A patent/MY143789A/en unknown
- 2004-02-17 TW TW093103716A patent/TWI355936B/zh not_active IP Right Cessation
- 2004-02-18 AT AT04712041T patent/ATE490774T1/de active
- 2004-02-18 PT PT04712041T patent/PT1596862E/pt unknown
- 2004-02-18 ES ES04712041T patent/ES2357769T3/es not_active Expired - Lifetime
- 2004-02-18 JP JP2006501881A patent/JP2006517944A/ja active Pending
- 2004-02-18 DK DK04712041.5T patent/DK1596862T3/da active
- 2004-02-18 EA EA200501318A patent/EA013836B1/ru not_active IP Right Cessation
- 2004-02-18 BR BRPI0407549-8A patent/BRPI0407549A/pt not_active Application Discontinuation
- 2004-02-18 GE GEAP20048984A patent/GEP20104908B/en unknown
- 2004-02-18 DE DE602004030424T patent/DE602004030424D1/de not_active Expired - Lifetime
- 2004-02-18 MX MXPA05008757A patent/MXPA05008757A/es active IP Right Grant
- 2004-02-18 WO PCT/EP2004/001558 patent/WO2004073714A1/en not_active Ceased
- 2004-02-18 CA CA002515946A patent/CA2515946C/en not_active Expired - Fee Related
- 2004-02-18 CN CNA2004800045134A patent/CN1750822A/zh active Pending
- 2004-02-18 UA UAA200508834A patent/UA96254C2/uk unknown
- 2004-02-18 SI SI200431601T patent/SI1596862T1/sl unknown
- 2004-02-18 NZ NZ541862A patent/NZ541862A/en not_active IP Right Cessation
- 2004-02-18 KR KR1020057014589A patent/KR101113087B1/ko not_active Ceased
- 2004-02-18 AU AU2004212704A patent/AU2004212704B2/en not_active Expired
- 2004-02-18 HR HR20050709A patent/HRP20050709A2/xx not_active Application Discontinuation
- 2004-02-18 PL PL378122A patent/PL378122A1/pl not_active Application Discontinuation
- 2004-02-18 UY UY28193A patent/UY28193A1/es not_active Application Discontinuation
- 2004-02-18 EP EP04712041A patent/EP1596862B1/en not_active Revoked
- 2004-02-18 EP EP10177400A patent/EP2258367A3/en not_active Withdrawn
-
2005
- 2005-08-10 US US11/201,035 patent/US20060074101A1/en not_active Abandoned
- 2005-08-15 IS IS7983A patent/IS7983A/is unknown
- 2005-08-17 ZA ZA200506580A patent/ZA200506580B/en unknown
- 2005-08-17 CU CU20050158A patent/CU23587B7/es active IP Right Grant
- 2005-08-18 EC EC2005005970A patent/ECSP055970A/es unknown
- 2005-09-16 NO NO20054296A patent/NO20054296L/no unknown
-
2011
- 2011-03-04 CY CY20111100257T patent/CY1111312T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1111312T1 (el) | Χρηση παλονοσετρονης για την αντιμετωπιση της μετεγχειρητικης ναυτιας καιτου εμετου | |
| CY1120170T1 (el) | Χρησιμοποιηση αμισουλπριδης για τη θεραπεια επαγομενης απο οπιοειδη ναυτιας και εμετου | |
| AU2003272285A8 (en) | Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine h4 receptor ligands | |
| WO2004098494A3 (en) | Compounds, compositions, and methods | |
| WO2007018998A3 (en) | Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators | |
| BRPI0409367A (pt) | derivados de piperidina inibidores de renina | |
| BRPI0414599A (pt) | pirrol-indóis substituìdos | |
| ATE393764T1 (de) | Polymorphe formen von valsartan | |
| CY1110170T1 (el) | Ν-καρβαμοϋλμεθυλ-4(-r)-φαινυλ-2-πυρρολιδινονη, μεθοδος παρασκευης της και φαρμακευτικη χρηση αυτης | |
| WO2009155054A3 (en) | 5-ht3 receptor modulators, methods of making, and use thereof | |
| EA201490268A1 (ru) | Производные циклопропиламида, направленно действующие на гистаминовый н3-рецептор | |
| IL180551A0 (en) | Use of substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines in the treatment of nausea and vomiting | |
| TN2009000091A1 (en) | Nitrogen containing substituted heterocycles as platelet adp receptor inhibitors | |
| SE0102858D0 (sv) | N-type calcium channel antagonists for the treatment of pain | |
| BR0313588A (pt) | Métodos para o tratamento da demência com base em apo e genótipo | |
| EA200700146A1 (ru) | Кристаллизированный полиэтилентерефталат, содержащий кремний, и способ его получения | |
| DE50307717D1 (de) | Opiod-rezeptor-antagonisten in transdermalen systemen mit buprenorphin | |
| BRPI0519466B8 (pt) | dispersão sólida estável de um derivado de alcalóide de vinca e processo para a fabricação do mesmo | |
| WO2004058353A3 (en) | Therapeutic use of selective noradrenaline reuptake inhibitors | |
| BRPI0510407A (pt) | derivados de 3-amino-2-fenilpirrolidina | |
| TW200619281A (en) | Method for preparation of polyolefin nanocomposite | |
| ECSP055917A (es) | Derivados de diazepanes útiles como inhibidores de lfa | |
| UY29620A1 (es) | Polimorfos de hidrocodona | |
| SE0102857D0 (sv) | N-type calcium channel antagonists for the treatment of pain | |
| WO2005041875A3 (en) | Dopamine-, norepinephrine- and serotonin- transporter- selective heterocyclic compounds and their therapeutic applications |