CY1111046T1 - Πολυμορφα τετομιλαστης - Google Patents

Πολυμορφα τετομιλαστης

Info

Publication number
CY1111046T1
CY1111046T1 CY20101100965T CY101100965T CY1111046T1 CY 1111046 T1 CY1111046 T1 CY 1111046T1 CY 20101100965 T CY20101100965 T CY 20101100965T CY 101100965 T CY101100965 T CY 101100965T CY 1111046 T1 CY1111046 T1 CY 1111046T1
Authority
CY
Cyprus
Prior art keywords
ray powder
powder diffraction
diffraction spectrum
crystal
tetomilast
Prior art date
Application number
CY20101100965T
Other languages
English (en)
Inventor
Satoshi Aoki
Kenji Nakaya
Masahiro Sota
Masashi Ishigami
Original Assignee
Otsuka Pharmaceutical Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38069222&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1111046(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co., Ltd filed Critical Otsuka Pharmaceutical Co., Ltd
Publication of CY1111046T1 publication Critical patent/CY1111046T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
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  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει κρύσταλλο τετομιλάστης που παράγεται ευκόλως βιομηχανικά σε μεγάλο όγκο. (1) κρύσταλλο ένυδρου τετομιλάστης που έχει φάσμα περίθλασης σκόνης ακτινών Χ που ουσιαστικά είναι ίδιο όπως το φάσμα περίθλασης σκόνης ακτίνων Χ που δείχνεται στο Σχήμα, (2) κρύσταλλο ανύδρου τετομιλάστης τύπου Α που έχει φάσμα περίθλασης σκόνης ακτίνων Χ που ουσιαστικά είναι το ίδιο όπως το φάσμα περίθλασης σκόνης ακτίνων Χ που δείχνεται στο Σχήμα 4, (3) κρύσταλλο ανύδρου τετομιλάστης τύπου C που έχει φάσμα περίθλασης σκόνης ακτίνων Χ που ουσιαστικά είναι το ίδιο όπως το φάσμα περίθλασης σκόνης ακτίνων Χ που δείχνεται στο Σχήμα 8, (4) κρύσταλλο διαλυτώματος ακετονιτριλίου τετομιλάστης που έχει φάσμα περίθλασης σκόνης ακτίνων Χ που ουσιαστικά είναι το ίδιο όπως φάσμα περίθλασης σκόνης ακτίνων Χ που δείχνεται στο Σχήμα 10 και (5) μείγμα που συνίσταται από τον ανωτέρω κρύσταλλο ανύδρου τετομιλάστης τύπου Α και κρύσταλλο ανύδρου τετομιλάστης τύπου Β. Αυτοί οι κρύσταλλοι είναι σταθεροί στην θερμότητα και την υγρασία και επίσης είναι εξαιρετικοί όσον αφορά την ιδιότητα αποσάθρωσης και την ιδιότητα διαλυτοποίησης δισκίων. Συνεπώς, αυτοί οι κρύσταλλοι κατά προτίμηση χρησιμοποιούνται ως φαρμακευτικές συνθέσεις.
CY20101100965T 2006-03-17 2010-10-25 Πολυμορφα τετομιλαστης CY1111046T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006075307 2006-03-17
EP07739373A EP1999128B1 (en) 2006-03-17 2007-03-15 Tetomilast polymorphs

Publications (1)

Publication Number Publication Date
CY1111046T1 true CY1111046T1 (el) 2015-06-11

Family

ID=38069222

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20101100965T CY1111046T1 (el) 2006-03-17 2010-10-25 Πολυμορφα τετομιλαστης
CY20121100994T CY1113262T1 (el) 2006-03-17 2012-10-23 Πολυμορφα τετομιλαστης
CY20121100996T CY1113263T1 (el) 2006-03-17 2012-10-23 Πολυμορφο τετομιλαστης

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY20121100994T CY1113262T1 (el) 2006-03-17 2012-10-23 Πολυμορφα τετομιλαστης
CY20121100996T CY1113263T1 (el) 2006-03-17 2012-10-23 Πολυμορφο τετομιλαστης

Country Status (27)

Country Link
US (4) US8501949B2 (el)
EP (4) EP1999128B1 (el)
JP (2) JP4182363B2 (el)
KR (6) KR101252994B1 (el)
CN (4) CN101365697B (el)
AR (1) AR059911A1 (el)
AT (1) ATE476433T1 (el)
AU (1) AU2007239906B2 (el)
BR (1) BRPI0706224A2 (el)
CA (4) CA2725649C (el)
CY (3) CY1111046T1 (el)
DE (1) DE602007008212D1 (el)
DK (3) DK2206711T3 (el)
ES (3) ES2348630T3 (el)
HK (3) HK1159080A1 (el)
IL (4) IL192237A (el)
MY (2) MY143808A (el)
NO (1) NO20083000L (el)
PH (1) PH12015502374A1 (el)
PL (3) PL1999128T3 (el)
PT (3) PT1999128E (el)
RU (2) RU2408597C2 (el)
SG (4) SG10201408225VA (el)
SI (3) SI2311832T1 (el)
TW (1) TWI394753B (el)
WO (1) WO2007119496A1 (el)
ZA (2) ZA200805235B (el)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109790197A (zh) 2016-10-06 2019-05-21 协和发酵生化株式会社 胞苷二磷酸胆碱的晶体及其制造方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3282731B2 (ja) * 1990-06-15 2002-05-20 メルク エンド カムパニー インコーポレーテッド 結晶の構造および大きさを改良する結晶化方法
DE69133471T2 (de) * 1990-11-30 2006-05-11 Otsuka Pharmaceutical Co., Ltd. Azolderivate und ihre Verwendung als Inhibitoren von Superoxidradikalen
JP4300373B2 (ja) 1996-09-30 2009-07-22 大塚製薬株式会社 サイトカイン産生抑制剤及び接着抑制剤
MY128323A (en) * 1996-09-30 2007-01-31 Otsuka Pharma Co Ltd Thiazole derivatives for inhibition of cytokine production and of cell adhesion
US6221153B1 (en) * 1998-06-09 2001-04-24 Trevor Percival Castor Method for producing large crystals of complex molecules
SA99191255B1 (ar) * 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
JP4336913B2 (ja) 1999-02-12 2009-09-30 大塚製薬株式会社 アミド誘導体の製造方法
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
WO2003009844A1 (en) * 2001-07-24 2003-02-06 Otsuka Pharmaceutical Co., Ltd. Use of thiazole deirvatives for the manufacture of a medicament for the treatment of chronic obstructive pulmonary disease
JP3713577B2 (ja) 2001-07-24 2005-11-09 大塚製薬株式会社 慢性閉塞性肺疾患治療薬
AR033485A1 (es) * 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
PT1613598E (pt) * 2003-12-16 2012-01-13 Teva Pharma Métodos para preparar formas cristalinas de aripiprazol

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CA2634100A1 (en) 2007-10-25
EP2206711A2 (en) 2010-07-14
NO20083000L (no) 2008-09-30
RU2408597C2 (ru) 2011-01-10
EP1999128A1 (en) 2008-12-10
AU2007239906B2 (en) 2010-07-29
CA2725810A1 (en) 2007-10-25
IL192237A0 (en) 2009-02-11
EP2206711B1 (en) 2012-08-22
EP2311832A1 (en) 2011-04-20
KR20110135427A (ko) 2011-12-16
ZA200805235B (en) 2010-07-28
CN101365697B (zh) 2011-11-23
TWI394753B (zh) 2013-05-01
CN101365697A (zh) 2009-02-11
ES2390957T3 (es) 2012-11-20
KR20110087350A (ko) 2011-08-02
IL214253A (en) 2014-01-30
EP2206711A3 (en) 2010-10-13
CN102174045A (zh) 2011-09-07
RU2009147223A (ru) 2011-06-27
HK1124062A1 (en) 2009-07-03
EP1999128B1 (en) 2010-08-04
CY1113263T1 (el) 2016-04-13
US8993601B2 (en) 2015-03-31
JP2007277235A (ja) 2007-10-25
CA2725698A1 (en) 2007-10-25
SI2206711T1 (sl) 2012-12-31
PT1999128E (pt) 2011-01-20
TW200813041A (en) 2008-03-16
ATE476433T1 (de) 2010-08-15
ES2390926T3 (es) 2012-11-19
CN102174044B (zh) 2014-02-26
AU2007239906A1 (en) 2007-10-25
JP5197196B2 (ja) 2013-05-15
KR20080077260A (ko) 2008-08-21
IL192237A (en) 2013-06-27
PL2311832T3 (pl) 2013-01-31
CA2725649C (en) 2013-05-14
SG172708A1 (en) 2011-07-28
KR101118943B1 (ko) 2012-02-27
EP2311832B1 (en) 2012-08-22
IL214252A0 (en) 2011-08-31
HK1159080A1 (en) 2012-07-27
US20150352095A1 (en) 2015-12-10
SI1999128T1 (sl) 2010-12-31
AR059911A1 (es) 2008-05-07
PL2206711T3 (pl) 2013-01-31
SG10201408225VA (en) 2015-01-29
BRPI0706224A2 (pt) 2011-03-22
US9145404B2 (en) 2015-09-29
RU2008127324A (ru) 2010-01-10
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JP2008285498A (ja) 2008-11-27
MY143808A (en) 2011-07-15
CA2725649A1 (en) 2007-10-25
PT2206711E (pt) 2012-08-31
EP2311833A1 (en) 2011-04-20
US8501949B2 (en) 2013-08-06
RU2441002C2 (ru) 2012-01-27
US20100222590A1 (en) 2010-09-02
JP4182363B2 (ja) 2008-11-19
US20140113937A1 (en) 2014-04-24
PT2311832E (pt) 2012-08-30
CN102174044A (zh) 2011-09-07
KR101482374B1 (ko) 2015-01-14
CY1113262T1 (el) 2016-04-13
WO2007119496A1 (en) 2007-10-25
CN102174046B (zh) 2013-12-25
CA2725810C (en) 2013-01-22
KR101083611B1 (ko) 2011-11-16
KR20130003041A (ko) 2013-01-08
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DK2311832T3 (da) 2012-10-08
PL1999128T3 (pl) 2010-12-31
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MY151343A (en) 2014-05-15
KR101168630B1 (ko) 2012-07-30
PH12015502374A1 (en) 2017-03-22
HK1159079A1 (en) 2012-07-27
DK1999128T3 (da) 2010-11-08
SI2311832T1 (sl) 2012-12-31
ZA201001687B (en) 2010-11-24
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ES2348630T3 (es) 2010-12-10
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