CY1110168T1 - Παραγωγα των τρικυκλικων ν-ετεροαρυλο-καρβοξαμιδιων που περιεχουν ενα μοτιβο βενζιμιδαζολης, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη - Google Patents
Παραγωγα των τρικυκλικων ν-ετεροαρυλο-καρβοξαμιδιων που περιεχουν ενα μοτιβο βενζιμιδαζολης, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικηInfo
- Publication number
- CY1110168T1 CY1110168T1 CY20101100609T CY101100609T CY1110168T1 CY 1110168 T1 CY1110168 T1 CY 1110168T1 CY 20101100609 T CY20101100609 T CY 20101100609T CY 101100609 T CY101100609 T CY 101100609T CY 1110168 T1 CY1110168 T1 CY 1110168T1
- Authority
- CY
- Cyprus
- Prior art keywords
- denotes
- benzimidazole
- motif
- tricyclic
- heteroaryl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Diabetes (AREA)
- Reproductive Health (AREA)
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- Oncology (AREA)
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Abstract
Η εφεύρεση αφορά τα παράγωγα των τρικυκλικών N-ετεροαρυλο- καρβοξαμίδιων που περιέχουν ένα μοτίβο βενζιμιδαζόλης, γενικού τύπου (I) όπου το Α δηλώνει, με τον σύνδεσμο C-N του μοτίβου βενζιμιδαζόλης με το οποίο έχει τηχθεί, έναν μονοκυκλικό ετερόκυκλο ή έναν μονοκυκλικό ετερόκυκλο με 4 έως 7 κρίκους, που περιέχει από ένα έως τρία ετεροάτομα που επιλέγονται ανάμεσα από Ο, S ή Ν, συμπεριλαμβανομένου του ατόμου του αζώτου του μοτίβου βενζιμιδαζόλης. Το Ρ δηλώνει έναν δικυκλικό ετερόκυκλο ή δικυκλικό ετεροαρύλιο με 8-, 9-, 10 ή 11 κρίκους, που περιέχει από 1 έως 6 ετεροάτομα τα οποία επιλέγονται ανάμεσα από τα Ν, Ο και S. To Ri δηλώνει από ένα έως τέσσερα άτομα ή ομάδες, πανομοιότυπα ή διαφορετικά, το Υ δηλώνει ένα άτομο οξυγόνου ή θείου, το R2 δηλώνει ένα άτομο υδρογόνου, ένα άτομο αλογόνου, μια ομάδα C1C6-αλκυλίου, C3-C7- κυκλοαλκυλίου, C3C7-κυκλοαλκυλο-C1C3-αλκυλένιου, C1C6-φλουοροαλκυλίου ή C1C6-αλκοξέος, To R3 δηλώνει από ένα έως τρία άτομα ή ομάδες, πανομοιότυπα ή διαφορετικά, στην κατάσταση της βάσης ή του άλατος προσθήκης σε οξύ, καθώς και στην κατάσταση του ένυδρου στοιχείου ή του διαλύτη. Η εφεύρεση αφορά επίσης μια διαδικασία παρασκευής των ενώσεων και της εφαρμογής στη θεραπευτική.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0601007A FR2897061B1 (fr) | 2006-02-03 | 2006-02-03 | Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique. |
EP07730900A EP1987010B1 (fr) | 2006-02-03 | 2007-02-01 | Dérivés de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur préparation et leur application en thérapeutique |
Publications (1)
Publication Number | Publication Date |
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CY1110168T1 true CY1110168T1 (el) | 2015-01-14 |
Family
ID=36954977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100609T CY1110168T1 (el) | 2006-02-03 | 2010-07-01 | Παραγωγα των τρικυκλικων ν-ετεροαρυλο-καρβοξαμιδιων που περιεχουν ενα μοτιβο βενζιμιδαζολης, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη |
Country Status (33)
Country | Link |
---|---|
US (2) | US8143248B2 (el) |
EP (1) | EP1987010B1 (el) |
JP (1) | JP5136938B2 (el) |
KR (1) | KR20080090495A (el) |
CN (1) | CN101379041B (el) |
AR (1) | AR059279A1 (el) |
AT (1) | ATE463484T1 (el) |
AU (1) | AU2007211399B2 (el) |
BR (1) | BRPI0710480A2 (el) |
CA (1) | CA2637333C (el) |
CY (1) | CY1110168T1 (el) |
DE (1) | DE602007005779D1 (el) |
DK (1) | DK1987010T3 (el) |
DO (1) | DOP2007000022A (el) |
EA (1) | EA014450B1 (el) |
ES (1) | ES2344087T3 (el) |
FR (1) | FR2897061B1 (el) |
HK (1) | HK1129670A1 (el) |
HR (1) | HRP20100327T1 (el) |
IL (1) | IL192648A (el) |
JO (1) | JO2602B1 (el) |
MA (1) | MA30229B1 (el) |
NO (1) | NO20083520L (el) |
NZ (1) | NZ569669A (el) |
PE (1) | PE20071325A1 (el) |
PL (1) | PL1987010T3 (el) |
PT (1) | PT1987010E (el) |
RS (1) | RS51366B (el) |
SI (1) | SI1987010T1 (el) |
TW (1) | TWI401256B (el) |
UY (1) | UY30130A1 (el) |
WO (1) | WO2007088277A1 (el) |
ZA (1) | ZA200806139B (el) |
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FR2888848B1 (fr) * | 2005-07-22 | 2007-09-28 | Sanofi Aventis Sa | Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
FR2911605B1 (fr) | 2007-01-19 | 2009-04-17 | Sanofi Aventis Sa | Derives de pyrrolopyridine-2-carbowamides, leur preparation et leur application en therapeutique |
FR2911604B1 (fr) * | 2007-01-19 | 2009-04-17 | Sanofi Aventis Sa | Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
FR2919610B1 (fr) * | 2007-08-02 | 2009-10-16 | Sanofi Aventis Sa | Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique |
FR2926556B1 (fr) | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
FR2926554B1 (fr) | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
FR2926555B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
FR2926553B1 (fr) * | 2008-01-23 | 2010-02-19 | Sanofi Aventis | Derives d'indole-2-carboxamides et d'azaindole-2- carboxamides substitues par un groupe silanyle, leur preparation et leur application en therapeutique |
WO2009108551A2 (en) * | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
WO2010005528A2 (en) * | 2008-06-30 | 2010-01-14 | Ironwood Pharmaceuticals Incorporated | Pyrrolopyridine carboxylic acid derivatives |
US20100113472A1 (en) * | 2008-11-03 | 2010-05-06 | Chemocentryx, Inc. | Compounds for the treatment of osteoporosis and cancers |
CN102388043A (zh) * | 2009-02-11 | 2012-03-21 | 桑诺维恩药品公司 | 组胺h3反相激动剂和拮抗剂及其使用方法 |
JP2013504581A (ja) * | 2009-09-11 | 2013-02-07 | スノヴィオン ファーマシューティカルズ インコーポレイテッド | ヒスタミンh3インバースアゴニストおよびアンタゴニストとその使用方法 |
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MX354820B (es) * | 2012-03-16 | 2018-03-21 | Vitae Pharmaceuticals Inc | Moduladores del receptor x del higado. |
BR112014031731B1 (pt) | 2012-06-18 | 2022-12-06 | Dart Neuroscience (Cayman) Ltd | Composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e respectivos usos |
US10683293B2 (en) | 2014-08-04 | 2020-06-16 | Nuevolution A/S | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
US10513694B2 (en) | 2015-06-25 | 2019-12-24 | Promega Corporation | Thienopyrrole compounds and uses thereof |
AU2017336074A1 (en) * | 2016-09-30 | 2019-03-28 | Epizyme, Inc. | Substituted fused bi- or tri- heterocyclic compounds as ehmt2 inhibitors |
EP3562823B1 (en) | 2016-12-28 | 2023-02-08 | Promega Corporation | Functionalized nanoluc inhibitors |
JP2020517618A (ja) | 2017-04-21 | 2020-06-18 | エピザイム,インコーポレイティド | Ehmt2阻害剤との併用療法 |
CN109761974B (zh) * | 2019-01-21 | 2021-05-14 | 河南大学 | 1,2,3,4-四氢-9H-吡啶并[3,4-b]吲哚类TRPV1拮抗剂及其应用 |
JP2021098692A (ja) | 2019-12-20 | 2021-07-01 | ヌエヴォリューション・アクティーゼルスカブNuevolution A/S | 核内受容体に対して活性の化合物 |
EP4126875A1 (en) | 2020-03-31 | 2023-02-08 | Nuevolution A/S | Compounds active towards nuclear receptors |
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DE102004021716A1 (de) * | 2004-04-30 | 2005-12-01 | Grünenthal GmbH | Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen |
EP2314585B1 (en) * | 2004-07-15 | 2012-09-12 | Japan Tobacco, Inc. | Condensed benzamide compounds as inhibitors of vanilloid receptor subtype 1 (VR1) activity |
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