CY1109613T1 - Προδρομες αντιαρρυθμικες ενωσεις, μεθοδοι συνθεσης και μεθοδοι χρησης - Google Patents

Προδρομες αντιαρρυθμικες ενωσεις, μεθοδοι συνθεσης και μεθοδοι χρησης

Info

Publication number
CY1109613T1
CY1109613T1 CY20091101190T CY091101190T CY1109613T1 CY 1109613 T1 CY1109613 T1 CY 1109613T1 CY 20091101190 T CY20091101190 T CY 20091101190T CY 091101190 T CY091101190 T CY 091101190T CY 1109613 T1 CY1109613 T1 CY 1109613T1
Authority
CY
Cyprus
Prior art keywords
methods
prevention
unions
regulatory
composition
Prior art date
Application number
CY20091101190T
Other languages
English (en)
Inventor
Pascal Druzgala
Jien-Heh J Tien
Art Cooper
Cyrus Becker
Original Assignee
Aryx Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aryx Therapeutics, Inc. filed Critical Aryx Therapeutics, Inc.
Publication of CY1109613T1 publication Critical patent/CY1109613T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Steroid Compounds (AREA)

Abstract

Η εφεύρεση περιλαμβάνει ενώσεις του Τύπου 1: όπου, το R1 είναι ανεξαρτήτως Η ή αλογόνο, το R2 είναι, για παράδειγμα, Η ή -R10-NR11R12 και όπου το R10 είναι C1-C6 αλκυλ και τα R11 και R12 είναι ανεξαρτήτως Η, C1-C4 αλκυλ και υδρίτες, διαλυτώματα, άλατα και ταυτομερή αυτών. Η εφεύρεση περαιτέρω περιλαμβάνει μεθόδους για την παρασκευή ενώσεων της εφεύρεσης και μεθόδους για την παρασκευή ενώσεων χρήσιμων στη θεραπεία ή πρόληψη καρδιακής αρρυθμίας από τις ενώσεις της εφεύρεσης.
CY20091101190T 2005-07-15 2009-11-12 Προδρομες αντιαρρυθμικες ενωσεις, μεθοδοι συνθεσης και μεθοδοι χρησης CY1109613T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69978005P 2005-07-15 2005-07-15
EP06787500A EP1904502B1 (en) 2005-07-15 2006-07-14 Antiarrhythmic precursor compounds, methods of synthesis and methods of use

Publications (1)

Publication Number Publication Date
CY1109613T1 true CY1109613T1 (el) 2014-08-13

Family

ID=37492022

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101190T CY1109613T1 (el) 2005-07-15 2009-11-12 Προδρομες αντιαρρυθμικες ενωσεις, μεθοδοι συνθεσης και μεθοδοι χρησης

Country Status (20)

Country Link
US (1) US7498449B2 (el)
EP (2) EP1904502B1 (el)
JP (1) JP2009501723A (el)
KR (1) KR20080040645A (el)
CN (1) CN101248079A (el)
AT (1) ATE446300T1 (el)
AU (1) AU2006270086B2 (el)
BR (1) BRPI0613047A8 (el)
CA (1) CA2612599C (el)
CY (1) CY1109613T1 (el)
DE (1) DE602006009940D1 (el)
DK (1) DK1904502T3 (el)
ES (1) ES2334712T3 (el)
IL (1) IL187917A (el)
MX (1) MX2008000497A (el)
NO (1) NO341172B1 (el)
PT (1) PT1904502E (el)
RU (1) RU2422447C2 (el)
WO (1) WO2007011835A2 (el)
ZA (1) ZA200710688B (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110136779A1 (en) * 2009-11-23 2011-06-09 Milner Peter G Methods for stroke reduction in atrial fibrillation patients
US9549912B2 (en) 2009-11-23 2017-01-24 Armetheon, Inc. Methods for treating atrial fibrillation
WO2015029062A1 (en) 2013-08-25 2015-03-05 Council Of Scientific And Industrial Rsearch A process for the preparation of anti-inflammatory aroylbenzofuran compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248401A (en) * 1966-04-26 Diethylaminoe hoxybenzoyl benzofurans
FR2550091B1 (fr) * 1983-08-02 1986-05-23 Sanofi Sa Composition pharmaceutique ou veterinaire destinee a combattre des troubles ischemiques cardiaques contenant un derive du benzofuranne
US5175187A (en) * 1989-03-06 1992-12-29 Soorianarain Baligadoo Synergistic compositions for the treatment of coronary insufficiency and methods of use thereof
WO1990007330A1 (en) 1989-01-06 1990-07-12 The Regents Of The University Of California Selection method for specific useful pharmaceutical compounds
US4962095A (en) * 1989-02-15 1990-10-09 E. R. Squibb & Sons, Inc. Method of reducing pre-and post-ischemic myocardial arrhythmias and fibrillation
US4931464A (en) 1989-02-15 1990-06-05 E. R. Squibb & Sons, Inc. Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation
FR2653431B1 (fr) 1989-10-23 1994-05-27 Sanofi Sa Procede de preparation de derives de benzoyl-3 benzofuranne.
JP2853404B2 (ja) 1990-10-05 1999-02-03 味の素株式会社 抗不整脈薬
SE9101509D0 (sv) 1991-05-17 1991-05-17 Karobio Ab Receptor ligands
US6316487B1 (en) * 1993-06-16 2001-11-13 Aryx Therapeutics Compounds for treatment of cardiac arrhythmia synthesis, and methods of use
US5364880A (en) 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
US6683195B2 (en) * 1999-10-15 2004-01-27 Aryx Therapeutics Enantiomeric compounds for treatment of cardiac arrhythmias and methods of use
US6372783B1 (en) 1999-10-15 2002-04-16 Aryx Therapeutics Enantiomeric compounds for treatment of cardiac arrhythmias and methods of use
DK1222180T3 (da) 1999-10-15 2007-12-27 Aryx Therapeutics Enantiomere forbindelser til behandling af hjertearytmier og fremgangsmåde til anvendelse
NL1015686C2 (nl) 2000-07-12 2002-01-15 Dsm Nv Werkwijze voor het met laserbestraling irreversibel aanbrengen van een voor het naakte oog onzichtbare markering op een polymeer vormdeel.
CA2469730A1 (en) 2001-12-10 2003-06-19 Aryx Therapeutics Novel methods for treatment of cardiac arrhythmia, synthesis, and methods of use

Also Published As

Publication number Publication date
EP1904502A2 (en) 2008-04-02
ATE446300T1 (de) 2009-11-15
NO341172B1 (no) 2017-09-04
BRPI0613047A2 (pt) 2010-12-14
CA2612599C (en) 2015-01-06
PT1904502E (pt) 2009-12-15
EP1904502B1 (en) 2009-10-21
AU2006270086A1 (en) 2007-01-25
DE602006009940D1 (de) 2009-12-03
CA2612599A1 (en) 2007-01-25
MX2008000497A (es) 2008-04-17
BRPI0613047A8 (pt) 2018-01-02
DK1904502T3 (da) 2009-12-07
ES2334712T3 (es) 2010-03-15
WO2007011835A3 (en) 2007-03-29
US7498449B2 (en) 2009-03-03
CN101248079A (zh) 2008-08-20
ZA200710688B (en) 2009-09-30
RU2008105757A (ru) 2009-08-20
NO20080828L (no) 2008-02-15
RU2422447C2 (ru) 2011-06-27
EP2145881A1 (en) 2010-01-20
WO2007011835A2 (en) 2007-01-25
JP2009501723A (ja) 2009-01-22
IL187917A0 (en) 2008-03-20
US20070060640A1 (en) 2007-03-15
IL187917A (en) 2015-04-30
KR20080040645A (ko) 2008-05-08
AU2006270086B2 (en) 2012-12-13

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