ATE446300T1 - Antiarrhythmische vorläuferverbindungen, syntheseverfahren und verwendungsverfahren - Google Patents

Antiarrhythmische vorläuferverbindungen, syntheseverfahren und verwendungsverfahren

Info

Publication number
ATE446300T1
ATE446300T1 AT06787500T AT06787500T ATE446300T1 AT E446300 T1 ATE446300 T1 AT E446300T1 AT 06787500 T AT06787500 T AT 06787500T AT 06787500 T AT06787500 T AT 06787500T AT E446300 T1 ATE446300 T1 AT E446300T1
Authority
AT
Austria
Prior art keywords
methods
antiarrhythmic
synthesis
compounds
precursor compounds
Prior art date
Application number
AT06787500T
Other languages
English (en)
Inventor
Pascal Druzgala
Jien-Heh Tien
Art Cooper
Cyrus Becker
Original Assignee
Aryx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aryx Therapeutics Inc filed Critical Aryx Therapeutics Inc
Application granted granted Critical
Publication of ATE446300T1 publication Critical patent/ATE446300T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Steroid Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
AT06787500T 2005-07-15 2006-07-14 Antiarrhythmische vorläuferverbindungen, syntheseverfahren und verwendungsverfahren ATE446300T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69978005P 2005-07-15 2005-07-15
PCT/US2006/027599 WO2007011835A2 (en) 2005-07-15 2006-07-14 Antiarrhythmic precursor compounds, methods of synthesis and methods of use

Publications (1)

Publication Number Publication Date
ATE446300T1 true ATE446300T1 (de) 2009-11-15

Family

ID=37492022

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06787500T ATE446300T1 (de) 2005-07-15 2006-07-14 Antiarrhythmische vorläuferverbindungen, syntheseverfahren und verwendungsverfahren

Country Status (20)

Country Link
US (1) US7498449B2 (de)
EP (2) EP1904502B1 (de)
JP (1) JP2009501723A (de)
KR (1) KR20080040645A (de)
CN (1) CN101248079A (de)
AT (1) ATE446300T1 (de)
AU (1) AU2006270086B2 (de)
BR (1) BRPI0613047A8 (de)
CA (1) CA2612599C (de)
CY (1) CY1109613T1 (de)
DE (1) DE602006009940D1 (de)
DK (1) DK1904502T3 (de)
ES (1) ES2334712T3 (de)
IL (1) IL187917A (de)
MX (1) MX2008000497A (de)
NO (1) NO341172B1 (de)
PT (1) PT1904502E (de)
RU (1) RU2422447C2 (de)
WO (1) WO2007011835A2 (de)
ZA (1) ZA200710688B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110136779A1 (en) * 2009-11-23 2011-06-09 Milner Peter G Methods for stroke reduction in atrial fibrillation patients
US9549912B2 (en) 2009-11-23 2017-01-24 Armetheon, Inc. Methods for treating atrial fibrillation
US9890132B2 (en) 2013-08-25 2018-02-13 Council Of Scientific & Industrial Research Process for the preparation of anti-inflammatory aroylbenzofuran compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248401A (en) 1966-04-26 Diethylaminoe hoxybenzoyl benzofurans
FR2550091B1 (fr) 1983-08-02 1986-05-23 Sanofi Sa Composition pharmaceutique ou veterinaire destinee a combattre des troubles ischemiques cardiaques contenant un derive du benzofuranne
US5175187A (en) 1989-03-06 1992-12-29 Soorianarain Baligadoo Synergistic compositions for the treatment of coronary insufficiency and methods of use thereof
WO1990007329A1 (en) 1989-01-06 1990-07-12 The Regents Of The University Of California Selection method for pharmacologically active compounds
US4962095A (en) 1989-02-15 1990-10-09 E. R. Squibb & Sons, Inc. Method of reducing pre-and post-ischemic myocardial arrhythmias and fibrillation
US4931464A (en) 1989-02-15 1990-06-05 E. R. Squibb & Sons, Inc. Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation
FR2653431B1 (fr) * 1989-10-23 1994-05-27 Sanofi Sa Procede de preparation de derives de benzoyl-3 benzofuranne.
JP2853404B2 (ja) * 1990-10-05 1999-02-03 味の素株式会社 抗不整脈薬
SE9101509D0 (sv) 1991-05-17 1991-05-17 Karobio Ab Receptor ligands
US6316487B1 (en) * 1993-06-16 2001-11-13 Aryx Therapeutics Compounds for treatment of cardiac arrhythmia synthesis, and methods of use
US5364880A (en) 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
ATE369351T1 (de) 1999-10-15 2007-08-15 Aryx Therapeutics Enantiomere verbindungen zur behandlung von herzrythmusstörungen und verfahren zu ihrer anwendung
US6683195B2 (en) 1999-10-15 2004-01-27 Aryx Therapeutics Enantiomeric compounds for treatment of cardiac arrhythmias and methods of use
US6362223B1 (en) * 1999-10-15 2002-03-26 Aryx Therapeutics Enantiomeric compounds for treatment of cardiac arrhythmias and methods of use
NL1015686C2 (nl) 2000-07-12 2002-01-15 Dsm Nv Werkwijze voor het met laserbestraling irreversibel aanbrengen van een voor het naakte oog onzichtbare markering op een polymeer vormdeel.
EP1451169A1 (de) 2001-12-10 2004-09-01 ARYx Therapeutics Neue verbindungen für die behandlung von herzarrythmien, ihre synthese und ihre verwendung

Also Published As

Publication number Publication date
RU2422447C2 (ru) 2011-06-27
US20070060640A1 (en) 2007-03-15
KR20080040645A (ko) 2008-05-08
EP1904502B1 (de) 2009-10-21
IL187917A (en) 2015-04-30
RU2008105757A (ru) 2009-08-20
NO341172B1 (no) 2017-09-04
US7498449B2 (en) 2009-03-03
DE602006009940D1 (de) 2009-12-03
EP2145881A1 (de) 2010-01-20
CA2612599A1 (en) 2007-01-25
BRPI0613047A8 (pt) 2018-01-02
DK1904502T3 (da) 2009-12-07
ES2334712T3 (es) 2010-03-15
CN101248079A (zh) 2008-08-20
EP1904502A2 (de) 2008-04-02
BRPI0613047A2 (pt) 2010-12-14
WO2007011835A2 (en) 2007-01-25
MX2008000497A (es) 2008-04-17
ZA200710688B (en) 2009-09-30
NO20080828L (no) 2008-02-15
JP2009501723A (ja) 2009-01-22
WO2007011835A3 (en) 2007-03-29
IL187917A0 (en) 2008-03-20
AU2006270086B2 (en) 2012-12-13
CA2612599C (en) 2015-01-06
CY1109613T1 (el) 2014-08-13
AU2006270086A1 (en) 2007-01-25
PT1904502E (pt) 2009-12-15

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