CY1108692T1 - Μεθοδος θεραπειας μιας κακοηθειας σε ενα υποκειμενο και φαρμακευτικη συνθεση για χρηση σεαυτη - Google Patents

Μεθοδος θεραπειας μιας κακοηθειας σε ενα υποκειμενο και φαρμακευτικη συνθεση για χρηση σεαυτη

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Publication number
CY1108692T1
CY1108692T1 CY20091100019T CY091100019T CY1108692T1 CY 1108692 T1 CY1108692 T1 CY 1108692T1 CY 20091100019 T CY20091100019 T CY 20091100019T CY 091100019 T CY091100019 T CY 091100019T CY 1108692 T1 CY1108692 T1 CY 1108692T1
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Cyprus
Prior art keywords
mistake
subject
treatment
pharmaceutical composition
virus
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Application number
CY20091100019T
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English (en)
Inventor
Darren R Shafren
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Viralytics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Viralytics Limited filed Critical Viralytics Limited
Publication of CY1108692T1 publication Critical patent/CY1108692T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32333—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32371—Demonstrated in vivo effect

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)

Abstract

Αποκαλύπτεται μέθοδος θανάτωσης μη κανονικών κυττάρων, όπως κακοηθών κυττάρων που συμπεριλαμβάνουν κύτταρα μελανώματος, χρησιμοποιώντας έναν ιό που αναγνωρίζει τουλάχιστον ένα από ένα μόριο προσκόλλησης κυττάρου και μία ρυθμιστική πρωτεΐνη συμπληρώματος. Ο ιός μπορεί να είναι ένα μέλος της οικογένειας Picornaviridae. Οι ιοί ομάδας Coxsackie Α έχουν βρεθεί ότι είναι ιδιαιτέρως κατάλληλοι. Το μόριο προσκόλλησης κυττάρου επιθυμητά είναι ένα μέλος της υπεροικογένειας ανοσοσφαιρίνης (lg). Τυπικά, η ρυθμιστική πρωτεΐνη συμπληρώματος θα είναι DAF.
CY20091100019T 1999-11-25 2009-01-12 Μεθοδος θεραπειας μιας κακοηθειας σε ενα υποκειμενο και φαρμακευτικη συνθεση για χρηση σεαυτη CY1108692T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPQ4256A AUPQ425699A0 (en) 1999-11-25 1999-11-25 A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
EP00979268A EP1235590B1 (en) 1999-11-25 2000-11-27 A method of treating a malignancy in a subject and a pharmaceutical composition for use in same

Publications (1)

Publication Number Publication Date
CY1108692T1 true CY1108692T1 (el) 2014-04-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100019T CY1108692T1 (el) 1999-11-25 2009-01-12 Μεθοδος θεραπειας μιας κακοηθειας σε ενα υποκειμενο και φαρμακευτικη συνθεση για χρηση σεαυτη

Country Status (12)

Country Link
US (5) US7361354B1 (el)
EP (2) EP2016952B1 (el)
JP (2) JP5085825B2 (el)
AT (1) ATE411814T1 (el)
AU (1) AUPQ425699A0 (el)
CA (1) CA2422429C (el)
CY (1) CY1108692T1 (el)
DE (1) DE60040616D1 (el)
DK (1) DK1235590T3 (el)
ES (2) ES2316394T3 (el)
PT (1) PT1235590E (el)
WO (1) WO2001037866A1 (el)

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Also Published As

Publication number Publication date
AUPQ425699A0 (en) 1999-12-23
CA2422429A1 (en) 2001-05-31
US7361354B1 (en) 2008-04-22
EP1235590A1 (en) 2002-09-04
PT1235590E (pt) 2009-02-02
EP2016952A2 (en) 2009-01-21
CA2422429C (en) 2014-03-11
DE60040616D1 (de) 2008-12-04
EP2016952B1 (en) 2013-12-25
US20150037287A1 (en) 2015-02-05
US20160250268A1 (en) 2016-09-01
EP1235590A4 (en) 2004-12-29
DK1235590T3 (da) 2009-02-23
JP5085825B2 (ja) 2012-11-28
ES2442000T3 (es) 2014-02-07
US20090123427A1 (en) 2009-05-14
JP2011190266A (ja) 2011-09-29
ATE411814T1 (de) 2008-11-15
EP2016952A3 (en) 2010-05-19
JP2003514870A (ja) 2003-04-22
ES2316394T3 (es) 2009-04-16
EP1235590B1 (en) 2008-10-22
US20170348366A1 (en) 2017-12-07
WO2001037866A1 (en) 2001-05-31
US8722036B2 (en) 2014-05-13

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