CY1108447T1 - Προφαρμακο αμιδιου της γεμσιταβινης, οι συνθεσεις και η χρηση τους - Google Patents

Προφαρμακο αμιδιου της γεμσιταβινης, οι συνθεσεις και η χρηση τους

Info

Publication number
CY1108447T1
CY1108447T1 CY20081101194T CY081101194T CY1108447T1 CY 1108447 T1 CY1108447 T1 CY 1108447T1 CY 20081101194 T CY20081101194 T CY 20081101194T CY 081101194 T CY081101194 T CY 081101194T CY 1108447 T1 CY1108447 T1 CY 1108447T1
Authority
CY
Cyprus
Prior art keywords
compositions
gemsitabin
amidide
product
methods
Prior art date
Application number
CY20081101194T
Other languages
Greek (el)
English (en)
Inventor
David Michael Bender
David Michael Remick
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of CY1108447T1 publication Critical patent/CY1108447T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
CY20081101194T 2004-12-17 2008-10-23 Προφαρμακο αμιδιου της γεμσιταβινης, οι συνθεσεις και η χρηση τους CY1108447T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63742204P 2004-12-17 2004-12-17
EP05852411A EP1831237B1 (en) 2004-12-17 2005-11-30 Amide prodrug of gemcitabine, compositions and use thereof

Publications (1)

Publication Number Publication Date
CY1108447T1 true CY1108447T1 (el) 2014-04-09

Family

ID=36168678

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101194T CY1108447T1 (el) 2004-12-17 2008-10-23 Προφαρμακο αμιδιου της γεμσιταβινης, οι συνθεσεις και η χρηση τους

Country Status (31)

Country Link
US (1) US7691827B2 (enExample)
EP (1) EP1831237B1 (enExample)
JP (1) JP5022911B2 (enExample)
KR (1) KR100874052B1 (enExample)
CN (1) CN101080417B (enExample)
AR (1) AR055009A1 (enExample)
AT (1) ATE405573T1 (enExample)
AU (1) AU2005316922B2 (enExample)
BR (1) BRPI0519117A2 (enExample)
CA (1) CA2589850C (enExample)
CY (1) CY1108447T1 (enExample)
DE (1) DE602005009255D1 (enExample)
DK (1) DK1831237T3 (enExample)
EA (1) EA011868B1 (enExample)
ES (1) ES2310860T3 (enExample)
HR (1) HRP20080529T3 (enExample)
IL (1) IL183666A (enExample)
MA (1) MA29154B1 (enExample)
MX (1) MX2007007228A (enExample)
MY (1) MY143677A (enExample)
NO (1) NO20073368L (enExample)
NZ (1) NZ554732A (enExample)
PE (1) PE20060771A1 (enExample)
PL (1) PL1831237T3 (enExample)
PT (1) PT1831237E (enExample)
RS (1) RS50629B (enExample)
SI (1) SI1831237T1 (enExample)
TW (1) TWI326687B (enExample)
UA (1) UA86119C2 (enExample)
WO (1) WO2006065525A1 (enExample)
ZA (1) ZA200705019B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2652633C (en) * 2006-06-21 2014-03-25 Eli Lilly And Company Crystalline forms of gemcitabine amide prodrug, compositions and use thereof
TWI436775B (zh) 2007-08-24 2014-05-11 Oncotherapy Science Inc 以抗原胜肽合併化療藥劑治療胰臟癌
CN101525361B (zh) * 2009-04-21 2010-11-17 济南圣鲁金药物技术开发有限公司 基于吉西他滨结构的前药及其合成方法及应用
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
CA2890359A1 (en) 2012-11-07 2014-05-15 Zucai SUO Substituted gemcitabine aryl amide analogs and treatment methods using same
KR20150082606A (ko) 2012-11-13 2015-07-15 보옌 테라퓨틱스, 인크. 겜시타빈 전구약물 및 그의 용도
US10059733B2 (en) 2014-03-03 2018-08-28 Nucorion Pharmaceuticals, Inc. Gemcitabine analogs
WO2016078160A1 (zh) * 2014-11-17 2016-05-26 常州方圆制药有限公司 胞苷衍生物及其应用
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
AU2019207626B2 (en) 2018-01-10 2023-10-05 Nucorion Pharmaceuticals, Inc. Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
AU2019216531A1 (en) 2018-02-02 2020-09-24 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
CN113166189A (zh) * 2018-04-26 2021-07-23 纳米医学控股有限公司 吉西他滨两亲性前体药物
CN108864250A (zh) * 2018-05-29 2018-11-23 北京大学 一种FAPα酶敏感的吉西他滨前体药物及其制备方法和应用
KR20210057025A (ko) * 2018-08-03 2021-05-20 셀릭스 바이오 프라이빗 리미티드 암의 치료를 위한 조성물 및 방법
MX2022000573A (es) 2019-07-17 2022-02-10 Nucorion Pharmaceuticals Inc Compuestos ciclicos de desoxirribonucleotido.
CN115605492B (zh) 2020-04-21 2025-09-16 配体制药股份有限公司 核苷酸前药化合物
PL442924A1 (pl) * 2022-11-23 2024-05-27 Politechnika Śląska Prolek - glikokoniugat pochodny gemcytabiny, jako związek o działaniu przeciwnowotworowym, sposób otrzymywania i zastosowanie

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
RU2131880C1 (ru) * 1992-06-22 1999-06-20 Эли Лилли Энд Компани Способ получения обогащенных бета-аномером нуклеозидов
GB2321454A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Gemcitabine esters and amides
ATE236188T1 (de) * 1997-01-24 2003-04-15 Conpharma As Gemcitabin-derivate
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6376470B1 (en) * 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
WO2004041203A2 (en) * 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US7846436B2 (en) * 2003-11-28 2010-12-07 Chemgenes Corporation Oligonucleotides and related compounds

Also Published As

Publication number Publication date
ES2310860T3 (es) 2009-01-16
HK1109903A1 (en) 2008-06-27
HRP20080529T3 (en) 2008-12-31
UA86119C2 (ru) 2009-03-25
DK1831237T3 (da) 2008-10-27
ZA200705019B (en) 2008-10-29
ATE405573T1 (de) 2008-09-15
IL183666A0 (en) 2007-09-20
NZ554732A (en) 2010-09-30
PT1831237E (pt) 2008-09-22
CA2589850A1 (en) 2006-06-22
TW200634023A (en) 2006-10-01
DE602005009255D1 (de) 2008-10-02
TWI326687B (en) 2010-07-01
EA200701300A1 (ru) 2007-10-26
BRPI0519117A2 (pt) 2008-12-23
EA011868B1 (ru) 2009-06-30
PE20060771A1 (es) 2006-09-23
CN101080417A (zh) 2007-11-28
RS50629B (sr) 2010-06-30
KR100874052B1 (ko) 2008-12-12
KR20070086308A (ko) 2007-08-27
EP1831237A1 (en) 2007-09-12
MY143677A (en) 2011-06-30
CN101080417B (zh) 2011-01-19
AU2005316922B2 (en) 2011-08-25
MA29154B1 (fr) 2008-01-02
US20090156547A1 (en) 2009-06-18
IL183666A (en) 2011-09-27
EP1831237B1 (en) 2008-08-20
JP5022911B2 (ja) 2012-09-12
JP2008524218A (ja) 2008-07-10
WO2006065525A1 (en) 2006-06-22
CA2589850C (en) 2012-05-01
AR055009A1 (es) 2007-08-01
MX2007007228A (es) 2007-08-14
SI1831237T1 (sl) 2009-02-28
PL1831237T3 (pl) 2009-01-30
NO20073368L (no) 2007-07-16
AU2005316922A1 (en) 2006-06-22
US7691827B2 (en) 2010-04-06

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