CY1108411T1 - Συνθεση περιεχουσα νικοτινη ελεγχομενης απελευθερωσης και μεθοδος - Google Patents
Συνθεση περιεχουσα νικοτινη ελεγχομενης απελευθερωσης και μεθοδοςInfo
- Publication number
- CY1108411T1 CY1108411T1 CY20081101133T CY081101133T CY1108411T1 CY 1108411 T1 CY1108411 T1 CY 1108411T1 CY 20081101133 T CY20081101133 T CY 20081101133T CY 081101133 T CY081101133 T CY 081101133T CY 1108411 T1 CY1108411 T1 CY 1108411T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nicotine
- controlled
- aqueous solution
- functional groups
- product
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Addiction (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Προïόν νικοτίνης έχον βαθμό απελευθέρωσης νικοτίνης όχι μικρότερο του 70% σε διάστημα 10 λεπτών, καθώς και μέθοδος παραγωγής ενός τέτοιου προïόντος. Τέτοιο προïόν παράγεται με μέθοδο περιλαμβάνουσα τα εξής στάδια: α) παρασκευή υδατικού διαλύματος οργανικής πολυόλης • β) ανάμειξη του εν λόγω υδατικού διαλύματος της οργανικής πολυόλης με ρητίνη κατιονο-ανταλλαγής, εκλεγόμενη από την ομάδα την αποτελούμενη από: i) μεθακρυλική, ασθενώς όξινου τύπου, ρητίνη περιέχουσα καρβοξυλικές χαρακτηριστικές ομάδες • ii) πολυστυρολίου, ισχυρώς όξινου τύπου, ρητίνη περιέχουσα σουλφονικές χαρακτηριστικές ομάδες . iii) πολυστυρολίου, ενδιάμεσης οξύτητας τύπου, ρητίνη περιέχουσα φωσφονικές χαρακτηριστικές ομάδες, οπότε σχηματίζεται μείγμα ρητίνης κατιονο-ανταλλαγής που έχει μερικές από τις θέσεις ιονο-ανταλλαγής αυτής μερικώς δεσμευμένες με την εν λόγω πολυόλη • γ) πρόσμειξη, με το εν λόγω μείγμα του σταδίου (β), ενός υδατικού διαλύματος νικοτίνης για να σχηματισθεί ένα μείγμα ρητίνης κατιονο-ανταλλαγής επιχρισμένο με νικοτίνη • και δ) απομάκρυνση του νερού από το εν λόγω μείγμα. Προκύπτει η σύνθεση νικοτίνης που έχει βαθμό απελευθέρωσης νικοτίνης όχι μικρότερο του 70% σε διάστημα 10 λεπτών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/166,236 US6586449B1 (en) | 2002-05-28 | 2002-05-28 | Nicotine-containing, controlled release composition and method |
EP03724037A EP1549633B1 (en) | 2002-05-28 | 2003-04-15 | Nicotine-containing, controlled release composition and method |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108411T1 true CY1108411T1 (el) | 2014-02-12 |
Family
ID=22602397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081101133T CY1108411T1 (el) | 2002-05-28 | 2008-10-13 | Συνθεση περιεχουσα νικοτινη ελεγχομενης απελευθερωσης και μεθοδος |
Country Status (10)
Country | Link |
---|---|
US (2) | US6586449B1 (el) |
EP (1) | EP1549633B1 (el) |
AT (1) | ATE401885T1 (el) |
CY (1) | CY1108411T1 (el) |
DE (2) | DE03724037T1 (el) |
DK (1) | DK1549633T3 (el) |
ES (1) | ES2285969T3 (el) |
PT (1) | PT1549633E (el) |
SI (1) | SI1549633T1 (el) |
WO (1) | WO2003101982A1 (el) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE355854T1 (de) * | 2000-08-03 | 2007-03-15 | Antares Pharma Ipl Ag | Neue zusammensetzung zur transdermalen und/oder transmukosalen wirkstoffanwendung mit geeignetem therapeutischen spiegel |
US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
SE521512C2 (sv) | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
PT1578422E (pt) | 2002-12-20 | 2007-06-14 | Niconovum Ab | Material particulado contendo nicotina fisicamente e quimicamente estável |
US7387788B1 (en) | 2003-10-10 | 2008-06-17 | Antares Pharma Ipl Ag | Pharmaceutical compositions of nicotine and methods of use thereof |
BRPI0414551B8 (pt) | 2003-10-10 | 2021-05-25 | Antares Pharma Ipl Ag | formulação farmacêutica transdérmica ou transmucosa e método de protelação ou inibição da cristalização de um agente ativo |
DK1696923T3 (da) * | 2003-12-02 | 2009-12-21 | Fertin Pharma As | Nikotinafgivelsesprodukt og fremgangsmåde til fremstilling deraf |
US7425340B2 (en) | 2004-05-07 | 2008-09-16 | Antares Pharma Ipl Ag | Permeation enhancing compositions for anticholinergic agents |
WO2006125642A1 (en) | 2005-05-27 | 2006-11-30 | Antares Pharma Ipl Ag | Methods and apparatus for transdermal or transmucosal application of testosterone |
WO2006128468A1 (en) * | 2005-06-01 | 2006-12-07 | Fertin Pharma A/S | A method of manufacturing a nicotine delivery product |
KR100699582B1 (ko) | 2005-07-11 | 2007-03-23 | 삼성전기주식회사 | 출력 버퍼회로 |
JP5694645B2 (ja) | 2006-03-16 | 2015-04-01 | ニコノヴァム エービーNiconovum Ab | 改善された嗅ぎたばこ組成物 |
CN101426475A (zh) | 2006-04-21 | 2009-05-06 | 安塔雷斯制药Ipl股份公司 | 使用用于经皮或经粘膜应用的制剂治疗热潮红的方法 |
US20070286903A1 (en) * | 2006-06-13 | 2007-12-13 | Becicka Brian T | Composition and method for taste masking |
US8642016B2 (en) | 2006-07-21 | 2014-02-04 | Jsrnti, Llc | Medicinal delivery system, and related methods |
MY185299A (en) * | 2007-10-11 | 2021-04-30 | Philip Morris Products Sa | Smokeless tobacco product |
US9125434B2 (en) | 2007-10-11 | 2015-09-08 | Philip Morris Products S.A. | Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet |
PL2198865T3 (pl) | 2008-12-19 | 2012-04-30 | Siegfried Ltd | Produkt zawierający nikotynę |
DK2575759T3 (en) | 2010-05-31 | 2017-01-23 | Fertin Pharma As | Formulation comprising nicotine and a cation exchange resin |
WO2011150959A1 (en) * | 2010-05-31 | 2011-12-08 | Fertin Pharma A/S | Formulation comprising nicotine and a cation exchange resin |
US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
US9044035B2 (en) | 2012-04-17 | 2015-06-02 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
US11311623B2 (en) | 2016-04-21 | 2022-04-26 | Fertin Pharma A/S | Nicotine delivery product, related uses and oral dosage forms, and methods of production |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3901248A (en) * | 1970-07-22 | 1975-08-26 | Leo Ab | Chewable smoking substitute composition |
US3845217A (en) * | 1972-11-16 | 1974-10-29 | Helsingborg L Ab | Buffered smoking substitute compositions |
US4692462A (en) | 1985-03-18 | 1987-09-08 | Menley & James Laboratories, Ltd. | Compositions and method of controlling transdermal penetration of topical and systemic agents |
WO1994008572A1 (en) * | 1992-10-15 | 1994-04-28 | Alza Corporation | Delayed onset transdermal delivery device |
GB9310412D0 (en) * | 1993-05-20 | 1993-07-07 | Danbiosyst Uk | Nasal nicotine system |
-
2002
- 2002-05-28 US US10/166,236 patent/US6586449B1/en not_active Expired - Lifetime
-
2003
- 2003-04-15 EP EP03724037A patent/EP1549633B1/en not_active Revoked
- 2003-04-15 DE DE03724037T patent/DE03724037T1/de active Pending
- 2003-04-15 DE DE60322405T patent/DE60322405D1/de not_active Expired - Lifetime
- 2003-04-15 WO PCT/US2003/011607 patent/WO2003101982A1/en not_active Application Discontinuation
- 2003-04-15 AT AT03724037T patent/ATE401885T1/de active
- 2003-04-15 PT PT03724037T patent/PT1549633E/pt unknown
- 2003-04-15 SI SI200331402T patent/SI1549633T1/sl unknown
- 2003-04-15 DK DK03724037T patent/DK1549633T3/da active
- 2003-04-15 ES ES03724037T patent/ES2285969T3/es not_active Expired - Lifetime
- 2003-05-05 US US10/429,420 patent/US6828336B2/en not_active Expired - Lifetime
-
2008
- 2008-10-13 CY CY20081101133T patent/CY1108411T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2285969T1 (es) | 2007-12-01 |
PT1549633E (pt) | 2008-10-02 |
US6828336B2 (en) | 2004-12-07 |
EP1549633A1 (en) | 2005-07-06 |
DE60322405D1 (de) | 2008-09-04 |
SI1549633T1 (sl) | 2009-02-28 |
WO2003101982A1 (en) | 2003-12-11 |
EP1549633B1 (en) | 2008-07-23 |
ES2285969T3 (es) | 2008-12-16 |
ATE401885T1 (de) | 2008-08-15 |
EP1549633A4 (en) | 2007-04-04 |
US20030224048A1 (en) | 2003-12-04 |
US6586449B1 (en) | 2003-07-01 |
DE03724037T1 (de) | 2007-10-11 |
DK1549633T3 (da) | 2008-10-06 |
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