CY1108411T1 - Συνθεση περιεχουσα νικοτινη ελεγχομενης απελευθερωσης και μεθοδος - Google Patents

Συνθεση περιεχουσα νικοτινη ελεγχομενης απελευθερωσης και μεθοδος

Info

Publication number
CY1108411T1
CY1108411T1 CY20081101133T CY081101133T CY1108411T1 CY 1108411 T1 CY1108411 T1 CY 1108411T1 CY 20081101133 T CY20081101133 T CY 20081101133T CY 081101133 T CY081101133 T CY 081101133T CY 1108411 T1 CY1108411 T1 CY 1108411T1
Authority
CY
Cyprus
Prior art keywords
nicotine
controlled
aqueous solution
functional groups
product
Prior art date
Application number
CY20081101133T
Other languages
English (en)
Inventor
John A Walling
Original Assignee
Cambrex Charles City, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22602397&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1108411(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cambrex Charles City, Inc. filed Critical Cambrex Charles City, Inc.
Publication of CY1108411T1 publication Critical patent/CY1108411T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465Nicotine; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Προïόν νικοτίνης έχον βαθμό απελευθέρωσης νικοτίνης όχι μικρότερο του 70% σε διάστημα 10 λεπτών, καθώς και μέθοδος παραγωγής ενός τέτοιου προïόντος. Τέτοιο προïόν παράγεται με μέθοδο περιλαμβάνουσα τα εξής στάδια: α) παρασκευή υδατικού διαλύματος οργανικής πολυόλης • β) ανάμειξη του εν λόγω υδατικού διαλύματος της οργανικής πολυόλης με ρητίνη κατιονο-ανταλλαγής, εκλεγόμενη από την ομάδα την αποτελούμενη από: i) μεθακρυλική, ασθενώς όξινου τύπου, ρητίνη περιέχουσα καρβοξυλικές χαρακτηριστικές ομάδες • ii) πολυστυρολίου, ισχυρώς όξινου τύπου, ρητίνη περιέχουσα σουλφονικές χαρακτηριστικές ομάδες . iii) πολυστυρολίου, ενδιάμεσης οξύτητας τύπου, ρητίνη περιέχουσα φωσφονικές χαρακτηριστικές ομάδες, οπότε σχηματίζεται μείγμα ρητίνης κατιονο-ανταλλαγής που έχει μερικές από τις θέσεις ιονο-ανταλλαγής αυτής μερικώς δεσμευμένες με την εν λόγω πολυόλη • γ) πρόσμειξη, με το εν λόγω μείγμα του σταδίου (β), ενός υδατικού διαλύματος νικοτίνης για να σχηματισθεί ένα μείγμα ρητίνης κατιονο-ανταλλαγής επιχρισμένο με νικοτίνη • και δ) απομάκρυνση του νερού από το εν λόγω μείγμα. Προκύπτει η σύνθεση νικοτίνης που έχει βαθμό απελευθέρωσης νικοτίνης όχι μικρότερο του 70% σε διάστημα 10 λεπτών.
CY20081101133T 2002-05-28 2008-10-13 Συνθεση περιεχουσα νικοτινη ελεγχομενης απελευθερωσης και μεθοδος CY1108411T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/166,236 US6586449B1 (en) 2002-05-28 2002-05-28 Nicotine-containing, controlled release composition and method
EP03724037A EP1549633B1 (en) 2002-05-28 2003-04-15 Nicotine-containing, controlled release composition and method

Publications (1)

Publication Number Publication Date
CY1108411T1 true CY1108411T1 (el) 2014-02-12

Family

ID=22602397

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101133T CY1108411T1 (el) 2002-05-28 2008-10-13 Συνθεση περιεχουσα νικοτινη ελεγχομενης απελευθερωσης και μεθοδος

Country Status (10)

Country Link
US (2) US6586449B1 (el)
EP (1) EP1549633B1 (el)
AT (1) ATE401885T1 (el)
CY (1) CY1108411T1 (el)
DE (2) DE03724037T1 (el)
DK (1) DK1549633T3 (el)
ES (1) ES2285969T3 (el)
PT (1) PT1549633E (el)
SI (1) SI1549633T1 (el)
WO (1) WO2003101982A1 (el)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE355854T1 (de) * 2000-08-03 2007-03-15 Antares Pharma Ipl Ag Neue zusammensetzung zur transdermalen und/oder transmukosalen wirkstoffanwendung mit geeignetem therapeutischen spiegel
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
SE521512C2 (sv) 2001-06-25 2003-11-11 Niconovum Ab Anordning för administrering av en substans till främre delen av en individs munhåla
PT1578422E (pt) 2002-12-20 2007-06-14 Niconovum Ab Material particulado contendo nicotina fisicamente e quimicamente estável
US7387788B1 (en) 2003-10-10 2008-06-17 Antares Pharma Ipl Ag Pharmaceutical compositions of nicotine and methods of use thereof
BRPI0414551B8 (pt) 2003-10-10 2021-05-25 Antares Pharma Ipl Ag formulação farmacêutica transdérmica ou transmucosa e método de protelação ou inibição da cristalização de um agente ativo
DK1696923T3 (da) * 2003-12-02 2009-12-21 Fertin Pharma As Nikotinafgivelsesprodukt og fremgangsmåde til fremstilling deraf
US7425340B2 (en) 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
WO2006128468A1 (en) * 2005-06-01 2006-12-07 Fertin Pharma A/S A method of manufacturing a nicotine delivery product
KR100699582B1 (ko) 2005-07-11 2007-03-23 삼성전기주식회사 출력 버퍼회로
JP5694645B2 (ja) 2006-03-16 2015-04-01 ニコノヴァム エービーNiconovum Ab 改善された嗅ぎたばこ組成物
CN101426475A (zh) 2006-04-21 2009-05-06 安塔雷斯制药Ipl股份公司 使用用于经皮或经粘膜应用的制剂治疗热潮红的方法
US20070286903A1 (en) * 2006-06-13 2007-12-13 Becicka Brian T Composition and method for taste masking
US8642016B2 (en) 2006-07-21 2014-02-04 Jsrnti, Llc Medicinal delivery system, and related methods
MY185299A (en) * 2007-10-11 2021-04-30 Philip Morris Products Sa Smokeless tobacco product
US9125434B2 (en) 2007-10-11 2015-09-08 Philip Morris Products S.A. Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet
PL2198865T3 (pl) 2008-12-19 2012-04-30 Siegfried Ltd Produkt zawierający nikotynę
DK2575759T3 (en) 2010-05-31 2017-01-23 Fertin Pharma As Formulation comprising nicotine and a cation exchange resin
WO2011150959A1 (en) * 2010-05-31 2011-12-08 Fertin Pharma A/S Formulation comprising nicotine and a cation exchange resin
US9629392B2 (en) 2011-09-22 2017-04-25 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US9084439B2 (en) 2011-09-22 2015-07-21 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US20130078307A1 (en) 2011-09-22 2013-03-28 Niconovum Usa, Inc. Nicotine-containing pharmaceutical composition
US9474303B2 (en) 2011-09-22 2016-10-25 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US9763928B2 (en) 2012-02-10 2017-09-19 Niconovum Usa, Inc. Multi-layer nicotine-containing pharmaceutical composition
US9044035B2 (en) 2012-04-17 2015-06-02 R.J. Reynolds Tobacco Company Remelted ingestible products
US11311623B2 (en) 2016-04-21 2022-04-26 Fertin Pharma A/S Nicotine delivery product, related uses and oral dosage forms, and methods of production

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901248A (en) * 1970-07-22 1975-08-26 Leo Ab Chewable smoking substitute composition
US3845217A (en) * 1972-11-16 1974-10-29 Helsingborg L Ab Buffered smoking substitute compositions
US4692462A (en) 1985-03-18 1987-09-08 Menley & James Laboratories, Ltd. Compositions and method of controlling transdermal penetration of topical and systemic agents
WO1994008572A1 (en) * 1992-10-15 1994-04-28 Alza Corporation Delayed onset transdermal delivery device
GB9310412D0 (en) * 1993-05-20 1993-07-07 Danbiosyst Uk Nasal nicotine system

Also Published As

Publication number Publication date
ES2285969T1 (es) 2007-12-01
PT1549633E (pt) 2008-10-02
US6828336B2 (en) 2004-12-07
EP1549633A1 (en) 2005-07-06
DE60322405D1 (de) 2008-09-04
SI1549633T1 (sl) 2009-02-28
WO2003101982A1 (en) 2003-12-11
EP1549633B1 (en) 2008-07-23
ES2285969T3 (es) 2008-12-16
ATE401885T1 (de) 2008-08-15
EP1549633A4 (en) 2007-04-04
US20030224048A1 (en) 2003-12-04
US6586449B1 (en) 2003-07-01
DE03724037T1 (de) 2007-10-11
DK1549633T3 (da) 2008-10-06

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