CY1107997T1 - Νεες μεθοδοι που χρησιμοποιουν αναστολεις της χολινεστepασης - Google Patents
Νεες μεθοδοι που χρησιμοποιουν αναστολεις της χολινεστepασηςInfo
- Publication number
- CY1107997T1 CY1107997T1 CY20071100121T CY071100121T CY1107997T1 CY 1107997 T1 CY1107997 T1 CY 1107997T1 CY 20071100121 T CY20071100121 T CY 20071100121T CY 071100121 T CY071100121 T CY 071100121T CY 1107997 T1 CY1107997 T1 CY 1107997T1
- Authority
- CY
- Cyprus
- Prior art keywords
- dementia
- syndrome
- prevention
- treatment
- novel methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000725 suspension Substances 0.000 title 1
- 206010012289 Dementia Diseases 0.000 abstract 3
- 230000002265 prevention Effects 0.000 abstract 3
- 208000020016 psychiatric disease Diseases 0.000 abstract 3
- 229940122041 Cholinesterase inhibitor Drugs 0.000 abstract 2
- 239000000544 cholinesterase inhibitor Substances 0.000 abstract 2
- 208000010877 cognitive disease Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000001356 surgical procedure Methods 0.000 abstract 2
- 206010065040 AIDS dementia complex Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010002942 Apathy Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 206010003805 Autism Diseases 0.000 abstract 1
- 208000020706 Autistic disease Diseases 0.000 abstract 1
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 206010012218 Delirium Diseases 0.000 abstract 1
- 201000010374 Down Syndrome Diseases 0.000 abstract 1
- 201000011240 Frontotemporal dementia Diseases 0.000 abstract 1
- 208000009829 Lewy Body Disease Diseases 0.000 abstract 1
- 201000002832 Lewy body dementia Diseases 0.000 abstract 1
- 206010026749 Mania Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000007542 Paresis Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 201000004810 Vascular dementia Diseases 0.000 abstract 1
- 210000001367 artery Anatomy 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 230000006931 brain damage Effects 0.000 abstract 1
- 231100000874 brain damage Toxicity 0.000 abstract 1
- 208000029028 brain injury Diseases 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 230000003920 cognitive function Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 206010013932 dyslexia Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 208000027061 mild cognitive impairment Diseases 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 206010028417 myasthenia gravis Diseases 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 230000000750 progressive effect Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 201000002859 sleep apnea Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000009529 traumatic brain injury Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Η παρούσα εφεύρεση περιγράφει νέες μεθόδους για τη θεραπεία και τη πρόληψη της άνοιας που προκαλείται από αγγειακές νόσους, της άνοιας που συνδέεται με τη νόσο του Parkinson, της άνοιας του Σώματος Lewy, της άνοιας ένεκα του AIDS, των ήπιων νοητικών βλαβών, των βλαβών της μνήμης που συνδέονται με την ηλικία, των νοητικών βλαβών και/ή της άνοιας που συνδέονται με νευρολογικές και/ή ψυχιατρικές παθήσεις, που συμπεριλαμβάνουν την επιληψία, τους εγκεφαλικούς όγκους, τις εγκεφαλικές βλάβες (αλλοιώσεις), τη σκλήρυνση κατά πλάκας, το σύνδρομο Down, το σύνδρομο Rett, τη προοδευτική υπερπυρηνική πάρεση, το σύνδρομο του μετωπικού λοβού, και τη σχιζοφρένια και των σχετικών ψυχιατρικών διαταραχών, των νοητικών βλαβών που προκαλούνται από τραυματική εγκεφαλική βλάβη, χειρουργική επέμβαση μοσχεύματος μετα-στεφανιαίας παράκαμψης (by-pass), ηλεκτροσπασμωδική θεραπεία με σοκ και χημειοθεραπεία, χορηγώντας μια θεραπευτικά αποτελεσματική ποσότητα τουλάχιστον μιας από τις ενώσεις του αναστολέα της χολινεστεράσης που περιγράφονται εδώ. Η παρούσα εφεύρεση περιγράφει επίσης νέες μεθόδους για τη θεραπεία και τη πρόληψη του παραληρήματος, του συνδρόμου Tourette, της μυασθένειας gravis, της διαταραχής της υπερενεργότητας με έλλειψης προσοχής, του αυτισμού, της δυσλεξίας, της μανίας, της κατάθλιψης, της απάθειας και της μυοπάθειας που συνδέεται με τον διαβήτη, χορηγώντας μια θεραπευτικά αποτελεσματική ποσότητα τουλάχιστον μιας από τις ενώσεις του αναστολέα της χολινεστεράσης που περιγράφονται εδώ. Η παρούσα εφεύρεση περιγράφει επίσης νέες μεθόδους για τη καθυστέρηση της έναρξης της νόσου του Alzheimer, ώστε να ενισχυθούν οι νοητικές λειτουργίες, για τη θεραπεία και τη πρόληψη της άπνοιας του ύπνου, για την
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18674400P | 2000-03-03 | 2000-03-03 | |
US19761000P | 2000-04-18 | 2000-04-18 | |
US22078300P | 2000-07-25 | 2000-07-25 | |
US25922601P | 2001-01-03 | 2001-01-03 | |
EP01922272A EP1311272B1 (en) | 2000-03-03 | 2001-03-05 | Novel methods using cholinesterase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107997T1 true CY1107997T1 (el) | 2013-09-04 |
Family
ID=27497683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100121T CY1107997T1 (el) | 2000-03-03 | 2007-01-29 | Νεες μεθοδοι που χρησιμοποιουν αναστολεις της χολινεστepασης |
Country Status (11)
Country | Link |
---|---|
US (7) | US20020035128A1 (el) |
EP (5) | EP2140868A1 (el) |
JP (1) | JP2003525903A (el) |
AT (1) | ATE345803T1 (el) |
AU (1) | AU2001249091A1 (el) |
CY (1) | CY1107997T1 (el) |
DE (1) | DE60124730T2 (el) |
DK (1) | DK1311272T3 (el) |
ES (1) | ES2275670T3 (el) |
PT (1) | PT1311272E (el) |
WO (1) | WO2001066114A1 (el) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2275670T3 (es) * | 2000-03-03 | 2007-06-16 | EISAI R&D MANAGEMENT CO., LTD. | Metodos novedosos utilizando inhibidores de colinesterasa. |
US20030153598A1 (en) * | 2000-07-25 | 2003-08-14 | Raymond Pratt | Methods for treating Parkinson's disease with cholinesterase inhibitors |
US20060183776A9 (en) * | 2000-03-03 | 2006-08-17 | Eisai Co., Ltd. | Liquid dosage formulations of donepezil |
CA2442717A1 (en) * | 2001-03-15 | 2002-09-26 | Saegis Pharmaceuticals, Inc. | Methods for restoring cognitive function following systemic stress |
JP2005502680A (ja) * | 2001-08-30 | 2005-01-27 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 抗痙攣剤およびアセチルコリンエステラーゼ阻害剤による痴呆および記憶障害の処置 |
WO2003032914A2 (en) * | 2001-10-17 | 2003-04-24 | Eisai Co., Ltd. | Methods for treating substance abuse with cholinesterase inhibitors |
JPWO2003061658A1 (ja) * | 2002-01-22 | 2005-05-19 | エーザイ株式会社 | インダノン誘導体を含有するシグマ受容体結合剤 |
US20030162770A1 (en) * | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
AU2003298514A1 (en) * | 2002-05-17 | 2004-05-04 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
US20070053976A1 (en) * | 2002-05-17 | 2007-03-08 | Eisai R & D Management Co., Ltd. | Novel combination of drugs as antidepressant |
WO2004009026A2 (en) * | 2002-07-22 | 2004-01-29 | Duke University | Cholinergic therapy for individuals with learning disabilities |
US20040142970A1 (en) * | 2002-11-01 | 2004-07-22 | Kathryn Chung | Treatment of hyperkinetic movement disorder with donepezil |
WO2004075916A1 (en) * | 2003-02-27 | 2004-09-10 | Shirankai Kyoto University Faculty Of Medicine Alumni Association Inc. | Pharmaceutical composition for treatment of drug dependence |
RU2379303C2 (ru) | 2003-04-24 | 2010-01-20 | Инсайт Корпорейшн | Производные азаспироалканов в качестве ингибиторов металлопротеаз |
US9119846B2 (en) * | 2003-04-29 | 2015-09-01 | Neurim Pharmaceuticals (1991) Ltd. | Method and composition for enhancing cognition in alzheimer's patients |
IL155666A (en) * | 2003-04-29 | 2013-12-31 | Neurim Pharma 1991 | Insomnia treatment |
AU2004251596B2 (en) * | 2003-05-23 | 2008-04-17 | Cognition Pharmaceuticals Llc | Methods for treating cognitive impairment and improving cognition |
SI1638933T1 (sl) | 2003-06-17 | 2008-10-31 | Pfizer | Derivati N-pirolidin-3-il-amida kot inhibitorji ponovnega privzema serotonina in noradrenalina |
EP1666066A4 (en) * | 2003-09-19 | 2007-03-28 | Eisai R&D Man Co Ltd | DRUG AGAINST THE DOWN SYNDROME |
US20050232990A1 (en) * | 2003-12-31 | 2005-10-20 | Garth Boehm | Donepezil formulations |
US20050277129A1 (en) * | 2004-01-22 | 2005-12-15 | Genaissance Pharmaceuticals | APOE genetic markers associated with age of onset of Alzheimer's disease |
JP2007519733A (ja) * | 2004-01-26 | 2007-07-19 | コーテックス ファーマシューティカルズ インコーポレーティッド | アンパカインにより誘導されるシナプス応答促通のコリンエステラーゼ阻害剤による増強方法 |
US20070129350A1 (en) * | 2004-01-30 | 2007-06-07 | Axonyx, Inc. | Methods for treatment of diabetes |
EP1732549A4 (en) * | 2004-03-18 | 2009-11-11 | Brigham & Womens Hospital | METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES |
US20050272722A1 (en) * | 2004-03-18 | 2005-12-08 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
CA2559221A1 (en) * | 2004-03-18 | 2005-09-29 | Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
US20050277629A1 (en) * | 2004-03-18 | 2005-12-15 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies (Lansbury) |
US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
TW200533371A (en) * | 2004-04-15 | 2005-10-16 | Dainippon Pharmaceutical Co | Medicament comprising a combination of an acetylcholinesterase inhibitor and a 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1h)-one derivative |
US20060135507A1 (en) * | 2004-08-13 | 2006-06-22 | Osamu Yokoyama | Therapeutic agent for overactive bladder involved in aging |
WO2006037047A2 (en) * | 2004-09-27 | 2006-04-06 | Bridge Pharma, Inc. | The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents |
US7718674B2 (en) * | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
ATE511843T1 (de) * | 2005-04-04 | 2011-06-15 | Eisai R&D Man Co Ltd | Dihydropyridin-verbindungen für neurodegenerative erkrankungen und demenz |
GB0605544D0 (en) * | 2006-03-20 | 2006-04-26 | Univ Nottingham | Genetic Markers For Alzheimer Disease |
US7858611B2 (en) * | 2006-05-09 | 2010-12-28 | Braincells Inc. | Neurogenesis by modulating angiotensin |
US7910108B2 (en) * | 2006-06-05 | 2011-03-22 | Incyte Corporation | Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases |
CA2655809C (en) * | 2006-07-21 | 2013-10-01 | Bridge Pharma, Inc. | Dermal anesthetic compounds |
US8012994B1 (en) | 2006-09-22 | 2011-09-06 | Sevastyanov Victor V | Method for the treatment of sensorineural hearing loss with donepezil hydrochloride (ARICEPT®) |
US20100048628A1 (en) * | 2006-12-01 | 2010-02-25 | Sumiyo Nishi | Method for suppressing discoloration over time of adhesive preparation containing donepezil |
RU2452474C2 (ru) * | 2006-12-01 | 2012-06-10 | Нитто Денко Корпорейшн | Стабилизированная адгезивная композиция, содержащая донепезил |
JP2010520154A (ja) * | 2007-03-05 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経変性疾患のためのampaレセプターアンタゴニストおよびnmdaレセプターアンタゴニスト |
EP2148673A1 (en) * | 2007-04-26 | 2010-02-03 | Eisai R&D Management Co., Ltd. | Cinnamide compounds for dementia |
CA2685860A1 (en) * | 2007-05-10 | 2008-11-20 | Amr Technology, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
EP2211911A4 (en) * | 2007-10-31 | 2012-11-14 | Alseres Pharmaceuticals Inc | METHOD FOR DIAGNOSIS AND MONITORING OF THE TREATMENT OF LEWY BODILY DAMAGE BY EVALUATING THE DOPAMIN TRANSPORTER MIRROR |
US20090156561A1 (en) * | 2007-12-13 | 2009-06-18 | Seed John C | Use of Cholinesterase Inhibitors In Smoking Cessation |
US8232402B2 (en) * | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
WO2009128057A2 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
WO2009128058A1 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
US20090291127A1 (en) * | 2008-05-21 | 2009-11-26 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
EP2279739B2 (en) * | 2008-05-30 | 2018-02-28 | Nitto Denko Corporation | Donepezil-containing patch preparation and packaging thereof |
RU2483729C2 (ru) * | 2008-05-30 | 2013-06-10 | Нитто Денко Корпорейшн | Чрескожно абсорбируемый препарат |
BRPI0917862A2 (pt) * | 2008-09-30 | 2015-11-24 | Teikoku Pharma Usa Inc | composições transdérmicas de donepezil com distribuição prolongada e métodos para usar as mesmas |
WO2010057006A1 (en) * | 2008-11-13 | 2010-05-20 | Link Medicine Corporation | Azaquinolinone derivatives and uses thereof |
US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
AU2010236734B2 (en) * | 2009-04-13 | 2015-06-11 | Theravance Biopharma R&D Ip, Llc | 5-HT4 receptor agonist compounds for treatment of cognitive disorders |
US20100178307A1 (en) * | 2010-01-13 | 2010-07-15 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
CN102905532A (zh) | 2010-02-09 | 2013-01-30 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
EP2366378A1 (en) | 2010-03-01 | 2011-09-21 | Dexcel Pharma Technologies Ltd. | Sustained-release donepezil formulations |
WO2011127235A1 (en) | 2010-04-07 | 2011-10-13 | Eisai Inc. | Combination therapy for the treatment of dementia |
GR1007368B (el) | 2010-05-27 | 2011-08-02 | Alapis Α.Β.Ε.Ε., | Ποσιμα φαρμακευτικα διαλυματα για τη θεραπεια των συμπτωματων της ανοιας |
WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
EP2642998B1 (en) | 2010-11-24 | 2020-09-16 | The Trustees of Columbia University in the City of New York | A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease |
US20120225922A1 (en) | 2011-03-04 | 2012-09-06 | Qr Pharma | Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration |
WO2013109543A1 (en) * | 2012-01-20 | 2013-07-25 | The Board Of Trustees Of The Leland Stanford Junior University | Small molecule cmklr1 antagonists in demyelinating disease |
WO2013166037A1 (en) | 2012-05-01 | 2013-11-07 | The Trustees Of Columbia University In The City Of New York | Non-retinoid antagonists for treatment of eye disorders |
CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
WO2014151936A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles, their preparation and use |
US9938291B2 (en) | 2013-03-14 | 2018-04-10 | The Trustess Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
EP2968304B1 (en) | 2013-03-14 | 2018-10-10 | The Trustees of Columbia University in the City of New York | 4-phenylpiperidines, their preparation and use |
WO2014152018A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Octahydrocyclopentapyrroles, their preparation and use |
WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
WO2014144801A1 (en) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Methods and compositions for improving cognitive function |
US9359315B2 (en) | 2013-09-10 | 2016-06-07 | Arrien Pharmaceuticals Llc | Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis |
SG11201608943VA (en) | 2014-04-30 | 2016-11-29 | Univ Columbia | Substituted 4-phenylpiperidines, their preparaiton and use |
TWI698436B (zh) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶7抑制劑之吡咯并及吡唑并嘧啶 |
MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
WO2016126935A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
US9840491B2 (en) | 2015-02-05 | 2017-12-12 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
US9932351B2 (en) | 2015-02-05 | 2018-04-03 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
EA034167B8 (ru) | 2015-05-22 | 2021-04-27 | Эйджинбайо, Инк. | Фармацевтические композиции леветирацетама пролонгированного высвобождения |
CN107921024B (zh) * | 2015-08-14 | 2021-09-10 | Qr制药公司 | 治疗或预防急性脑损伤或神经损伤的方法 |
US20180338950A1 (en) | 2017-05-24 | 2018-11-29 | Qr Pharma, Inc. | Prevention or Treatment of Disease States Due to Metal Dis-Homeostasis Via Administration of Posiphen to Healthy or Sick Humans |
JP2021501210A (ja) | 2017-10-30 | 2021-01-14 | モントリオール ハート インスティテュート | 血漿コレステロールの上昇を処置する方法 |
EP3999051A4 (en) * | 2019-07-16 | 2023-08-02 | Rush University Medical Center | USE OF A COMPOSITION CONTAINING BENZOATE FOR TREATING NEURODEGENERATIVE DISORDERS |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL74497A (en) * | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
US4826843A (en) * | 1985-07-08 | 1989-05-02 | Bristol-Myers | Cerebral function enhancing diazinylpiperidine derivatives |
FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
JP2777159B2 (ja) * | 1988-12-22 | 1998-07-16 | エーザイ株式会社 | 環状アミン誘導体を含有する医薬 |
JP3075566B2 (ja) | 1990-05-15 | 2000-08-14 | エーザイ株式会社 | 光学活性インダノン誘導体 |
JP2965675B2 (ja) | 1990-11-21 | 1999-10-18 | エーザイ株式会社 | (―)―1―ベンジル―4―〔(5,6―ジメトキシ―1―インダノン)―2―イル〕メチルピペリジンの製造方法 |
US5668117A (en) * | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
CA2113115A1 (en) * | 1991-07-29 | 1993-02-18 | Vlad E. Gregor | Quinazoline derivatives as acetylcholinesterase inhibitors |
SE9103752D0 (sv) * | 1991-12-18 | 1991-12-18 | Astra Ab | New compounds |
AU1153097A (en) | 1996-06-07 | 1998-01-05 | Eisai Co. Ltd. | Stable polymorphs of donepezil (1-benzyl-4-{(5,6-dimethoxy-1-indanon)-2-yl}methylpiperidine ) hydrochloride and process for production |
CA2252806C (en) | 1996-06-07 | 2005-11-22 | Eisai Co., Ltd. | Polymorphs of donepezil hydrochloride and process for production |
TW513409B (en) | 1996-06-07 | 2002-12-11 | Eisai Co Ltd | Polymorphs of donepezil hydrochloride |
AU4078997A (en) * | 1996-08-22 | 1998-03-06 | New York University | Cholinesterase inhibitors for treatment of parkinson's disease |
WO1998039000A1 (en) | 1997-03-03 | 1998-09-11 | Eisai Co., Ltd. | Use of cholinesterase inhibitors to treat disorders of attention |
AU9454098A (en) * | 1997-09-24 | 1999-04-12 | Nova Molecular, Inc. | Methods for increasing apoe levels for the treatment of neurodegenerative disease |
DE69822218T2 (de) | 1997-12-05 | 2005-02-03 | Eisai Co., Ltd. | Donepezil polykristalle und verfharen zu ihrer herstellung |
ATE292116T1 (de) | 1998-01-16 | 2005-04-15 | Eisai Co Ltd | Verfahren zur herstellung von donepezilderivaten |
US6193993B1 (en) | 1998-03-03 | 2001-02-27 | Eisai Co., Ltd. | Suppository containing an antidementia medicament |
KR100746753B1 (ko) | 1998-08-28 | 2007-08-06 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 고미 등을 경감한 의약조성물 |
IT1304904B1 (it) | 1998-09-11 | 2001-04-05 | Eisai Co Ltd | Derivati anticolinesterasici per il trattamento delle sindromidolorose funzionali e/o organiche |
US6372760B1 (en) | 1999-03-31 | 2002-04-16 | Eisai Co., Ltd. | Stabilized composition comprising antidementia medicament |
US20060183776A9 (en) * | 2000-03-03 | 2006-08-17 | Eisai Co., Ltd. | Liquid dosage formulations of donepezil |
ES2275670T3 (es) * | 2000-03-03 | 2007-06-16 | EISAI R&D MANAGEMENT CO., LTD. | Metodos novedosos utilizando inhibidores de colinesterasa. |
US20030153598A1 (en) * | 2000-07-25 | 2003-08-14 | Raymond Pratt | Methods for treating Parkinson's disease with cholinesterase inhibitors |
AU2001239052A1 (en) | 2000-03-06 | 2001-09-17 | Immune Network Ltd. | Compositions for prevention and treatment of dementia |
US20010036949A1 (en) | 2000-05-09 | 2001-11-01 | Coe Jotham Wadsworth | Pharmaceutical composition and method of treatment of diseases of cognitive dysfunction in a mammal |
WO2003024450A1 (en) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating prion diseases |
WO2003024456A1 (en) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating and preventing migraines |
WO2003032914A2 (en) | 2001-10-17 | 2003-04-24 | Eisai Co., Ltd. | Methods for treating substance abuse with cholinesterase inhibitors |
GB2405336A (en) | 2002-05-01 | 2005-03-02 | Eisai Co Ltd | Cholinesterase inhibitors to prevent injuries caused by chemicals |
AU2003298514A1 (en) | 2002-05-17 | 2004-05-04 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
US20040142970A1 (en) * | 2002-11-01 | 2004-07-22 | Kathryn Chung | Treatment of hyperkinetic movement disorder with donepezil |
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2001
- 2001-03-05 ES ES01922272T patent/ES2275670T3/es not_active Expired - Lifetime
- 2001-03-05 AT AT01922272T patent/ATE345803T1/de active
- 2001-03-05 AU AU2001249091A patent/AU2001249091A1/en not_active Abandoned
- 2001-03-05 EP EP09011085A patent/EP2140868A1/en not_active Withdrawn
- 2001-03-05 PT PT01922272T patent/PT1311272E/pt unknown
- 2001-03-05 EP EP09011051A patent/EP2138177A1/en not_active Withdrawn
- 2001-03-05 EP EP01922272A patent/EP1311272B1/en not_active Expired - Lifetime
- 2001-03-05 DK DK01922272T patent/DK1311272T3/da active
- 2001-03-05 EP EP09011050A patent/EP2130538A1/en not_active Withdrawn
- 2001-03-05 EP EP09011084A patent/EP2133078A1/en not_active Withdrawn
- 2001-03-05 WO PCT/US2001/007027 patent/WO2001066114A1/en active IP Right Grant
- 2001-03-05 DE DE60124730T patent/DE60124730T2/de not_active Expired - Lifetime
- 2001-03-05 JP JP2001564766A patent/JP2003525903A/ja active Pending
- 2001-07-06 US US09/899,028 patent/US20020035128A1/en not_active Abandoned
- 2001-09-04 US US09/947,086 patent/US6458807B1/en not_active Expired - Lifetime
- 2001-09-04 US US09/947,087 patent/US6482838B2/en not_active Expired - Fee Related
-
2002
- 2002-01-25 US US10/054,931 patent/US6576646B1/en not_active Expired - Fee Related
- 2002-09-03 US US10/232,406 patent/US6689795B2/en not_active Expired - Fee Related
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2003
- 2003-12-11 US US10/732,349 patent/US7563808B2/en not_active Expired - Fee Related
-
2005
- 2005-07-15 US US11/181,855 patent/US20050250812A1/en not_active Abandoned
-
2007
- 2007-01-29 CY CY20071100121T patent/CY1107997T1/el unknown
Also Published As
Publication number | Publication date |
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EP1311272A4 (en) | 2003-05-21 |
ATE345803T1 (de) | 2006-12-15 |
AU2001249091A1 (en) | 2001-09-17 |
EP1311272A1 (en) | 2003-05-21 |
US20020035128A1 (en) | 2002-03-21 |
WO2001066114A1 (en) | 2001-09-13 |
US6458807B1 (en) | 2002-10-01 |
DE60124730D1 (de) | 2007-01-04 |
DE60124730T2 (de) | 2007-10-04 |
EP2138177A1 (en) | 2009-12-30 |
PT1311272E (pt) | 2007-02-28 |
US6689795B2 (en) | 2004-02-10 |
US7563808B2 (en) | 2009-07-21 |
US6576646B1 (en) | 2003-06-10 |
US20040122051A1 (en) | 2004-06-24 |
JP2003525903A (ja) | 2003-09-02 |
EP2133078A1 (en) | 2009-12-16 |
US20050250812A1 (en) | 2005-11-10 |
US20020035129A1 (en) | 2002-03-21 |
ES2275670T3 (es) | 2007-06-16 |
EP2140868A1 (en) | 2010-01-06 |
DK1311272T3 (da) | 2007-02-26 |
US20030040532A1 (en) | 2003-02-27 |
US6482838B2 (en) | 2002-11-19 |
EP2130538A1 (en) | 2009-12-09 |
US20020040038A1 (en) | 2002-04-04 |
EP1311272B1 (en) | 2006-11-22 |
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