CY1107803T1 - Μεθοδοι για τη ληψη paclitaxel απο φυτα taxus - Google Patents
Μεθοδοι για τη ληψη paclitaxel απο φυτα taxusInfo
- Publication number
- CY1107803T1 CY1107803T1 CY20071101479T CY071101479T CY1107803T1 CY 1107803 T1 CY1107803 T1 CY 1107803T1 CY 20071101479 T CY20071101479 T CY 20071101479T CY 071101479 T CY071101479 T CY 071101479T CY 1107803 T1 CY1107803 T1 CY 1107803T1
- Authority
- CY
- Cyprus
- Prior art keywords
- paclitaxel
- methods
- plants containing
- taxus plants
- plants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Περιγράφονται μέθοδοι για τη λήψη paclitaxel από φυτά που περιέχουν paclitaxel. Το φυτικό υλικό λαμβάνεται paclitaxel αρχικά από φυτά που περιέχουν paclitaxel. Κατόπιν, το paclitaxel εκχυλίζεται από το φυτικό υλικό. Στη συνέχεια, το paclitaxel διαχωρίζεται από το εκχύλισμα paclitaxel με τη χρήση μιάς σειράς διαχωριστικών σταδίων χρωματογραφίας στήλης ώστε να ληφθεί τουλάχιστον ένα κλάσμα που περιέχει paclitaxel. To paclitaxel σε ένα κλάσμα που λαμβάνεται από το τελικό χρωματογραφικό στάδιο, κρυσταλλώνεται. Με τη χρήση των μεθόδων αυτών, μπορεί αποτελεσματικά να ληφθεί paclitaxel υψηλής καθαρότητας από φυτά που περιέχουν paclitaxel.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04016493A EP1616868B1 (en) | 2004-07-13 | 2004-07-13 | Methods for obtaining paclitaxel from taxus plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1107803T1 true CY1107803T1 (el) | 2013-06-19 |
Family
ID=34925739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071101479T CY1107803T1 (el) | 2004-07-13 | 2007-11-15 | Μεθοδοι για τη ληψη paclitaxel απο φυτα taxus |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1616868B1 (el) |
| JP (1) | JP4890455B2 (el) |
| KR (1) | KR101142565B1 (el) |
| CN (1) | CN100546986C (el) |
| AT (1) | ATE372993T1 (el) |
| AU (1) | AU2005261970B2 (el) |
| CA (1) | CA2573601C (el) |
| CY (1) | CY1107803T1 (el) |
| DE (1) | DE602004008903T2 (el) |
| DK (1) | DK1616868T3 (el) |
| ES (1) | ES2293129T3 (el) |
| HK (1) | HK1101822A1 (el) |
| IL (1) | IL180643A (el) |
| NO (1) | NO20070192L (el) |
| NZ (1) | NZ552549A (el) |
| PL (1) | PL1616868T3 (el) |
| PT (1) | PT1616868E (el) |
| RU (1) | RU2373198C2 (el) |
| SI (1) | SI1616868T1 (el) |
| WO (1) | WO2006005429A1 (el) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102250047B (zh) * | 2011-08-26 | 2013-06-05 | 贺金凤 | 一种紫杉醇化合物的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1258838B (it) * | 1992-01-31 | 1996-02-29 | Indena Spa | Processo per l'estrazione di tassolo e derivati da cultivar del genere taxus |
| US6136989A (en) * | 1998-12-30 | 2000-10-24 | Phytogen Life Sciences, Incorporated | Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material |
| US5969165A (en) * | 1999-01-07 | 1999-10-19 | 508037 (Nb) Inc. | Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column |
| CA2299149C (fr) * | 1999-06-22 | 2010-09-21 | Chaichem Pharmaceuticals International | Procede d'isolation et de purification du paclitaxel a partir de sources naturelles |
| US6452024B1 (en) * | 2000-02-22 | 2002-09-17 | Chaichem Pharmaceuticals International | Process for extraction and purification of paclitaxel from natural sources |
| US6229027B1 (en) * | 2000-03-10 | 2001-05-08 | Jian Liu | Process for manufacturing paclitaxel and 13-acetyl-9-dihydrobaccatin IV |
| US6333419B1 (en) * | 2000-11-28 | 2001-12-25 | Indena Spa | Chromatographic separation method of paclitaxel and cephalomannin |
-
2004
- 2004-07-13 ES ES04016493T patent/ES2293129T3/es not_active Expired - Lifetime
- 2004-07-13 PL PL04016493T patent/PL1616868T3/pl unknown
- 2004-07-13 DK DK04016493T patent/DK1616868T3/da active
- 2004-07-13 DE DE602004008903T patent/DE602004008903T2/de not_active Expired - Lifetime
- 2004-07-13 PT PT04016493T patent/PT1616868E/pt unknown
- 2004-07-13 EP EP04016493A patent/EP1616868B1/en not_active Expired - Lifetime
- 2004-07-13 AT AT04016493T patent/ATE372993T1/de active
- 2004-07-13 SI SI200430492T patent/SI1616868T1/sl unknown
- 2004-07-21 KR KR1020040056725A patent/KR101142565B1/ko active IP Right Grant
-
2005
- 2005-06-24 NZ NZ552549A patent/NZ552549A/en unknown
- 2005-06-24 AU AU2005261970A patent/AU2005261970B2/en active Active
- 2005-06-24 RU RU2007101233/04A patent/RU2373198C2/ru active
- 2005-06-24 WO PCT/EP2005/006846 patent/WO2006005429A1/en active Application Filing
- 2005-06-24 JP JP2007520696A patent/JP4890455B2/ja active Active
- 2005-06-24 CN CNB2005800234145A patent/CN100546986C/zh active Active
- 2005-06-24 CA CA2573601A patent/CA2573601C/en active Active
-
2007
- 2007-01-11 NO NO20070192A patent/NO20070192L/no not_active Application Discontinuation
- 2007-01-11 IL IL180643A patent/IL180643A/en unknown
- 2007-09-03 HK HK07109527.6A patent/HK1101822A1/xx unknown
- 2007-11-15 CY CY20071101479T patent/CY1107803T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ552549A (en) | 2008-12-24 |
| JP4890455B2 (ja) | 2012-03-07 |
| DK1616868T3 (da) | 2008-01-21 |
| KR20060005958A (ko) | 2006-01-18 |
| AU2005261970A1 (en) | 2006-01-19 |
| DE602004008903T2 (de) | 2008-06-19 |
| CA2573601C (en) | 2012-12-18 |
| IL180643A (en) | 2010-12-30 |
| RU2007101233A (ru) | 2008-08-20 |
| WO2006005429A1 (en) | 2006-01-19 |
| DE602004008903D1 (de) | 2007-10-25 |
| CA2573601A1 (en) | 2006-01-19 |
| SI1616868T1 (sl) | 2008-02-29 |
| CN100546986C (zh) | 2009-10-07 |
| JP2008505946A (ja) | 2008-02-28 |
| IL180643A0 (en) | 2007-06-03 |
| PT1616868E (pt) | 2007-12-10 |
| AU2005261970B2 (en) | 2011-04-21 |
| ES2293129T3 (es) | 2008-03-16 |
| EP1616868A1 (en) | 2006-01-18 |
| ATE372993T1 (de) | 2007-09-15 |
| RU2373198C2 (ru) | 2009-11-20 |
| CN1984896A (zh) | 2007-06-20 |
| NO20070192L (no) | 2007-02-13 |
| EP1616868B1 (en) | 2007-09-12 |
| KR101142565B1 (ko) | 2012-05-03 |
| HK1101822A1 (en) | 2007-10-26 |
| PL1616868T3 (pl) | 2008-02-29 |
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